[ { "key": "K7MCQSI3", "version": 158878, "library": { "type": "user", "id": 6212901, "name": "Nick Petosky", "links": { "alternate": { "href": "https://www.zotero.org/foxsayswhat", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/users/6212901/items/K7MCQSI3", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/foxsayswhat/items/K7MCQSI3", "type": "text/html" } }, "meta": { "creatorSummary": "Koh et al.", "parsedDate": "2023-05-10", "numChildren": 0 }, "data": { "key": "K7MCQSI3", "version": 158878, "itemType": "journalArticle", "title": "The Role of Mitochondria in Phytochemically Mediated Disease Amelioration.", "creators": [ { "creatorType": "author", "firstName": "Yen-Chun", "lastName": "Koh" }, { "creatorType": "author", "firstName": "Chi-Tang", "lastName": "Ho" }, { "creatorType": "author", "firstName": "Min-Hsiung", "lastName": "Pan" } ], "abstractNote": "Mitochondrial dysfunction may cause cell death, which has recently emerged as a cancer prevention and treatment strategy mediated by chemotherapy drugs or phytochemicals. However, most existing drugs cannot target cancerous cells and may adversely affect normal cells via side effects. Mounting studies have revealed that phytochemicals such as resveratrol could ameliorate various diseases with dysfunctional or damaged mitochondria. For instance, resveratrol can regulate mitophagy, inhibit oxidative stress and preserve membrane potential, induce mitochondrial biogenesis, balance mitochondrial fusion and fission, and enhance the functionality of the electron transport chain. However, there are only a few studies suggesting that phytochemicals could potentially protect against the cytotoxicity of some current cancer drugs, especially those that damage mitochondria. Besides, COVID-19 and long COVID have also been reported to be correlated to mitochondrial dysfunction. Curcumin has been reported bringing a positive impact on COVID-19 and long COVID. Therefore, in this study, the benefits of resveratrol and curcumin to be applied for cancer treatment/prevention and disease amelioration were reviewed. Besides, this review also provides some perspectives on phytochemicals to be considered as a treatment adjuvant for COVID-19 and long COVID by targeting mitochondrial rescue. Hopefully, this review can provide new insight into disease treatment with phytochemicals targeting mitochondria.", "publicationTitle": "Journal of agricultural and food chemistry", "publisher": "", "place": "", "date": "2023 May 10", "volume": "71", "issue": "18", "section": "", "partNumber": "", "partTitle": "", "pages": "6775-6788", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Agric Food Chem", "DOI": "10.1021/acs.jafc.2c08921", "citationKey": "", "url": "", "accessDate": "", "PMID": "37125676", "PMCID": "", "ISSN": "1520-5118 0021-8561", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "Place: United States", "tags": [ { "tag": "*COVID-19/metabolism" }, { "tag": "*Curcumin/pharmacology/metabolism" }, { "tag": "COVID-19" }, { "tag": "Humans" }, { "tag": "Mitochondria" }, { "tag": "Mitochondria/metabolism" }, { "tag": "Mitochondrial Dynamics" }, { "tag": "Post-Acute COVID-19 Syndrome" }, { "tag": "Resveratrol/pharmacology" }, { "tag": "cancer" }, { "tag": "mitochondrial rescue" }, { "tag": "mitophagy" }, { "tag": "phytochemical" } ], "collections": [ "AB8Q6U3P" ], "relations": {}, "dateAdded": "2023-09-10T03:30:27Z", "dateModified": "2026-05-14T02:49:36Z" } }, { "key": "SA4JW3XG", "version": 158876, "library": { "type": "user", "id": 6212901, "name": "Nick Petosky", "links": { "alternate": { "href": "https://www.zotero.org/foxsayswhat", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/users/6212901/items/SA4JW3XG", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/foxsayswhat/items/SA4JW3XG", "type": "text/html" } }, "meta": { "creatorSummary": "ASSALI and CHAUVIN", "parsedDate": "1951", "numChildren": 0 }, "data": { "key": "SA4JW3XG", "version": 158876, "itemType": "journalArticle", "title": "[Clinical history and radiologic picture of unusual case of mastic kidney].", "creators": [ { "creatorType": "author", "firstName": "J.", "lastName": "ASSALI" }, { "creatorType": "author", "firstName": "E.", "lastName": "CHAUVIN" } ], "abstractNote": "", "publicationTitle": "Journal d'urologie medicale et chirurgicale", "publisher": "", "place": "France", "date": "1951", "volume": "57", "issue": "10", "section": "", "partNumber": "", "partTitle": "", "pages": "733-734", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Urol Medicale Chir", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "14928287", "PMCID": "", "ISSN": "0368-4679", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "und", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "*KIDNEYS/diseases" }, { "tag": "*Kidney" }, { "tag": "*Kidney Diseases" }, { "tag": "*Resins, Plant" }, { "tag": "Humans" }, { "tag": "Mastic Resin" } ], "collections": [ "MITKBFZS" ], "relations": {}, "dateAdded": "2026-05-09T21:17:40Z", "dateModified": "2026-05-09T21:17:40Z" } }, { "key": "WKQZKTGD", "version": 158875, "library": { "type": "user", "id": 6212901, "name": "Nick Petosky", "links": { "alternate": { "href": "https://www.zotero.org/foxsayswhat", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/users/6212901/items/WKQZKTGD", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/foxsayswhat/items/WKQZKTGD", "type": "text/html" } }, "meta": { "creatorSummary": "BILGER et al.", "parsedDate": "1950", "numChildren": 0 }, "data": { "key": "WKQZKTGD", "version": 158875, "itemType": "journalArticle", "title": "[Partial mastic kidney; difficulties of radiological diagnosis; partial nephrectomy].", "creators": [ { "creatorType": "author", "firstName": "F.", "lastName": "BILGER" }, { "creatorType": "author", "firstName": "A.", "lastName": "GROSS" }, { "creatorType": "author", "firstName": "J. C.", "lastName": "RAIGA" } ], "abstractNote": "", "publicationTitle": "Journal d'urologie medicale et chirurgicale", "publisher": "", "place": "France", "date": "1950", "volume": "56", "issue": "11-12", "section": "", "partNumber": "", "partTitle": "", "pages": "903-907", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Urol Medicale Chir", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "14832941", "PMCID": "", "ISSN": "0368-4679", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "und", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "*KIDNEYS" }, { "tag": "*Kidney" }, { "tag": "*Nephrectomy" }, { "tag": "*Resins, Plant" }, { "tag": "Humans" }, { "tag": "Mastic Resin" } ], "collections": [ "MITKBFZS" ], "relations": {}, "dateAdded": "2026-05-09T21:17:40Z", "dateModified": "2026-05-09T21:17:40Z" } }, { "key": "W6VKU6R7", "version": 158874, "library": { "type": "user", "id": 6212901, "name": "Nick Petosky", "links": { "alternate": { "href": "https://www.zotero.org/foxsayswhat", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/users/6212901/items/W6VKU6R7", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/foxsayswhat/items/W6VKU6R7", "type": "text/html" } }, "meta": { "creatorSummary": "MODLINSKI", "parsedDate": "1956-05-28", "numChildren": 0 }, "data": { "key": "W6VKU6R7", "version": 158874, "itemType": "journalArticle", "title": "[Case of mastic kidney].", "creators": [ { "creatorType": "author", "firstName": "L.", "lastName": "MODLINSKI" } ], "abstractNote": "", "publicationTitle": "Polski tygodnik lekarski", "publisher": "", "place": "Poland", "date": "1956 May 28", "volume": "11", "issue": "22", "section": "", "partNumber": "", "partTitle": "", "pages": "990-991", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Pol Tyg Lek (Wars)", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "13349784", "PMCID": "", "ISSN": "0860-8857", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "pol", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "*Kidney" }, { "tag": "*Medical Records" }, { "tag": "*Resins, Plant" }, { "tag": "*TUBERCULOSIS, RENAL/case reports" }, { "tag": "*Tuberculosis" }, { "tag": "*Tuberculosis, Renal" }, { "tag": "Humans" }, { "tag": "Mastic Resin" } ], "collections": [ "MITKBFZS" ], "relations": {}, "dateAdded": "2026-05-09T21:17:40Z", "dateModified": "2026-05-09T21:17:40Z" } }, { "key": "XI7MLWAB", "version": 158873, "library": { "type": "user", "id": 6212901, "name": "Nick Petosky", "links": { "alternate": { "href": "https://www.zotero.org/foxsayswhat", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/users/6212901/items/XI7MLWAB", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/foxsayswhat/items/XI7MLWAB", "type": "text/html" } }, "meta": { "creatorSummary": "GRIMAUD and MORAND", "parsedDate": "1952-04", "numChildren": 0 }, "data": { "key": "XI7MLWAB", "version": 158873, "itemType": "journalArticle", "title": "[The preparation of mastic suspensions of definite turbidity].", "creators": [ { "creatorType": "author", "firstName": "L.", "lastName": "GRIMAUD" }, { "creatorType": "author", "firstName": "P.", "lastName": "MORAND" } ], "abstractNote": "", "publicationTitle": "Annales de biologie clinique", "publisher": "", "place": "France", "date": "1952 Mar-Apr", "volume": "10", "issue": "3-4", "section": "", "partNumber": "", "partTitle": "", "pages": "191-194", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Ann Biol Clin (Paris)", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "14952907", "PMCID": "", "ISSN": "0003-3898", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "und", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "*Resins, Plant" }, { "tag": "*Suspensions" }, { "tag": "*WATER SUPPLY" }, { "tag": "*Water Supply" }, { "tag": "Mastic Resin" } ], "collections": [ "MITKBFZS" ], "relations": {}, "dateAdded": "2026-05-09T21:17:40Z", "dateModified": "2026-05-09T21:17:40Z" } }, { "key": "RVQ8R6E2", "version": 158872, "library": { "type": "user", "id": 6212901, "name": "Nick Petosky", "links": { "alternate": { "href": "https://www.zotero.org/foxsayswhat", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/users/6212901/items/RVQ8R6E2", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/foxsayswhat/items/RVQ8R6E2", "type": "text/html" } }, "meta": { "creatorSummary": "NARBONA ARNAU and GIL NOVERQUES", "parsedDate": "1955-01", "numChildren": 0 }, "data": { "key": "RVQ8R6E2", "version": 158872, "itemType": "journalArticle", "title": "[Mastic kidney in a 10-year-old child].", "creators": [ { "creatorType": "author", "firstName": "B.", "lastName": "NARBONA ARNAU" }, { "creatorType": "author", "firstName": "D.", "lastName": "GIL NOVERQUES" } ], "abstractNote": "", "publicationTitle": "Archivos espanoles de urologia", "publisher": "", "place": "Spain", "date": "1955 Jan", "volume": "11", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "51-58", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Arch Esp Urol", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "13239419", "PMCID": "", "ISSN": "0004-0614", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "spa", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "*KIDNEYS/diseases" }, { "tag": "*Kidney" }, { "tag": "*Kidney Diseases" }, { "tag": "*Resins, Plant" }, { "tag": "Child" }, { "tag": "Humans" }, { "tag": "Mastic Resin" } ], "collections": [ "MITKBFZS" ], "relations": {}, "dateAdded": "2026-05-09T21:17:40Z", "dateModified": "2026-05-09T21:17:40Z" } }, { "key": "DHJTNGHS", "version": 158871, "library": { "type": "user", "id": 6212901, "name": "Nick Petosky", "links": { "alternate": { "href": "https://www.zotero.org/foxsayswhat", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/users/6212901/items/DHJTNGHS", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/foxsayswhat/items/DHJTNGHS", "type": "text/html" } }, "meta": { "creatorSummary": "CLEMENS", "parsedDate": "1955-06-30", "numChildren": 0 }, "data": { "key": "DHJTNGHS", "version": 158871, "itemType": "journalArticle", "title": "[Mastic substances in the cornea of cattle].", "creators": [ { "creatorType": "author", "firstName": "H. J.", "lastName": "CLEMENS" } ], "abstractNote": "", "publicationTitle": "Acta histochemica", "publisher": "", "place": "Germany", "date": "1955 Jun 30", "volume": "1", "issue": "8", "section": "", "partNumber": "", "partTitle": "", "pages": "287-302", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Acta Histochem", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "13248443", "PMCID": "", "ISSN": "0065-1281", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "ger", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "*CORNEA/metabolism" }, { "tag": "*Resins, Plant" }, { "tag": "Animals" }, { "tag": "Cattle" }, { "tag": "Cornea/*metabolism" }, { "tag": "Mastic Resin" } ], "collections": [ "MITKBFZS" ], "relations": {}, "dateAdded": "2026-05-09T21:17:40Z", "dateModified": "2026-05-09T21:17:40Z" } }, { "key": "55RIY43L", "version": 158870, "library": { "type": "user", "id": 6212901, "name": "Nick Petosky", "links": { "alternate": { "href": "https://www.zotero.org/foxsayswhat", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/users/6212901/items/55RIY43L", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/foxsayswhat/items/55RIY43L", "type": "text/html" } }, "meta": { "creatorSummary": "Ferreira et al.", "parsedDate": "2023-06-28", "numChildren": 0 }, "data": { "key": "55RIY43L", "version": 158870, "itemType": "journalArticle", "title": "Toxic profile of marinobufagin from poisonous Amazon toads and antitumoral effects on human colorectal carcinomas.", "creators": [ { "creatorType": "author", "firstName": "Paulo Michel Pinheiro", "lastName": "Ferreira" }, { "creatorType": "author", "firstName": "Lívia Queiroz de", "lastName": "Sousa" }, { "creatorType": "author", "firstName": "Rayran Walter Ramos de", "lastName": "Sousa" }, { "creatorType": "author", "firstName": "Domingos de Jesus", "lastName": "Rodrigues" }, { "creatorType": "author", "firstName": "Evaldo Dos Santos", "lastName": "Monção Filho" }, { "creatorType": "author", "firstName": "Mariana Helena", "lastName": "Chaves" }, { "creatorType": "author", "firstName": "Gerardo Magela", "lastName": "Vieira Júnior" }, { "creatorType": "author", "firstName": "Márcia Dos Santos", "lastName": "Rizzo" }, { "creatorType": "author", "firstName": "Lívia Alves", "lastName": "Filgueiras" }, { "creatorType": "author", "firstName": "Anderson Nogueira", "lastName": "Mendes" }, { "creatorType": "author", "firstName": "Daisy Jereissati Barbosa", "lastName": "Lima" }, { "creatorType": "author", "firstName": "Cláudia", "lastName": "Pessoa" }, { "creatorType": "author", "firstName": "João Marcelo de Castro E.", "lastName": "Sousa" }, { "creatorType": "author", "firstName": "Ana Carolina Borges da Cruz", "lastName": "Rodrigues" }, { "creatorType": "author", "firstName": "Milena Botelho Pereira", "lastName": "Soares" }, { "creatorType": "author", "firstName": "Daniel Pereira", "lastName": "Bezerra" } ], "abstractNote": "ETHNOPHARMACOLOGICAL RELEVANCE: South Americans natives have extensively used the toad \"kururu\" to reduce/treat skin infections, cutaneous lesions and sores. They release secretions rich in bufadienolides, polyhydroxy steroids with well-documented cardiotonic and antiproliferative actions, but in vivo antitumoral evaluations in mammals are rare, and toxicological safety has been left in second place. AIMS OF THE STUDY: This investigation used in silico, in vitro and in vivo tools to evaluate acute and subacute toxic effects of marinobufagin and the anticancer action in tumor-bearing mice models. MATERIALS AND METHODS: Initially, in silico toxic predictions were performed, followed by in vitro assays using human and murine normal and tumor lines. Next, acute and subacute studies on mice investigated the behavior, hematological and intestinal transit profile and antitumoral activity of marinobufagin in sarcoma 180- and HCT-116 colorectal carcinoma-transplanted mice for 7 and 15 days, respectively. Ex vivo and in vivo cytogenetic assays in Sarcoma 180 and bone marrow cells and histopathological examinations were also executed. RESULTS: In silico studies revealed ecotoxicological effects on crustaceans (Daphnia sp.), fishes (Pimephales promelas and Oryzias latipes), and algae. A 24-h marinobufagin-induced acute toxicity included signals of central activity, mainly (vocal frenzy, absence of body tonus, increased ventilation, ataxia, and equilibrium loss), and convulsions and death at 10 mg/kg. The bufadienolide presented effective in vitro cytotoxic action on human lines of colorectal carcinomas in a similar way to ouabain and tumor reduction in marinobufagin-treated SCID-bearing HCT-116 heterotopic xenografts. Animals under subacute nonlethal doses exhibited a decrease in creatinine clearance with normal levels of blood urea, probably as a result of a marinobufagin-induced renal perfusion fall. Nevertheless, only minor morphological side effects were identified in kidneys, livers, hearts and lungs. CONCLUSIONS: Marinobufagin has in vitro and in vivo anticancer action on colorectal carcinoma and mild and reversible alterations in key metabolic organs without direct chemotherapy-induced gastrointestinal effects at subacute exposure, but it causes acute ataxia, equilibrium loss, convulsions and death at higher acute exposure.", "publicationTitle": "Journal of ethnopharmacology", "publisher": "", "place": "Ireland", "date": "2023 Jun 28", "volume": "310", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "116406", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Ethnopharmacol", "DOI": "10.1016/j.jep.2023.116406", "citationKey": "", "url": "", "accessDate": "", "PMID": "36965547", "PMCID": "", "ISSN": "1872-7573 0378-8741", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "", "callNumber": "", "rights": "Copyright © 2023 Elsevier B.V. All rights reserved.", "extra": "", "tags": [ { "tag": "*Colorectal Neoplasms/drug therapy" }, { "tag": "*Poisons" }, { "tag": "*Sarcoma 180" }, { "tag": "Animals" }, { "tag": "Ataxia" }, { "tag": "Bufadienolides" }, { "tag": "Bufonidae" }, { "tag": "Cardenolides" }, { "tag": "Histological analyses" }, { "tag": "Humans" }, { "tag": "Mammals" }, { "tag": "Mice" }, { "tag": "Mice, SCID" }, { "tag": "Murine cells" }, { "tag": "Pharmacological safety" }, { "tag": "Xenograft model" } ], "collections": [ "MITKBFZS" ], "relations": {}, "dateAdded": "2026-05-09T21:17:40Z", "dateModified": "2026-05-09T21:17:40Z" } }, { "key": "ZYNC9QC2", "version": 158869, "library": { "type": "user", "id": 6212901, "name": "Nick Petosky", "links": { "alternate": { "href": "https://www.zotero.org/foxsayswhat", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/users/6212901/items/ZYNC9QC2", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/foxsayswhat/items/ZYNC9QC2", "type": "text/html" } }, "meta": { "creatorSummary": "Orengo and Lee", "parsedDate": "1998-05", "numChildren": 0 }, "data": { "key": "ZYNC9QC2", "version": 158869, "itemType": "journalArticle", "title": "Surgical pearl: the \"unsuture\" technique for skin grafts.", "creators": [ { "creatorType": "author", "firstName": "I.", "lastName": "Orengo" }, { "creatorType": "author", "firstName": "M. W.", "lastName": "Lee" } ], "abstractNote": "", "publicationTitle": "Journal of the American Academy of Dermatology", "publisher": "", "place": "United States", "date": "1998 May", "volume": "38", "issue": "5 Pt 1", "section": "", "partNumber": "", "partTitle": "", "pages": "758-759", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Am Acad Dermatol", "DOI": "10.1016/s0190-9622(98)70595-x", "citationKey": "", "url": "", "accessDate": "", "PMID": "9591821", "PMCID": "", "ISSN": "0190-9622", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "*Bandages" }, { "tag": "*Stents" }, { "tag": "Absorption" }, { "tag": "Dermatologic Agents/administration & dosage/therapeutic use" }, { "tag": "Humans" }, { "tag": "Mastic Resin" }, { "tag": "Plant Extracts/administration & dosage/therapeutic use" }, { "tag": "Resins, Plant/administration & dosage/therapeutic use" }, { "tag": "Skin Transplantation/*methods" }, { "tag": "Surgical Mesh" }, { "tag": "Sutures" } ], "collections": [ "MITKBFZS" ], "relations": {}, "dateAdded": "2026-05-09T21:17:40Z", "dateModified": "2026-05-09T21:17:40Z" } }, { "key": "IADMA39Y", "version": 158868, "library": { "type": "user", "id": 6212901, "name": "Nick Petosky", "links": { "alternate": { "href": "https://www.zotero.org/foxsayswhat", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/users/6212901/items/IADMA39Y", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/foxsayswhat/items/IADMA39Y", "type": "text/html" } }, "meta": { "creatorSummary": "Fewkes and Salasche", "parsedDate": "1993-10", "numChildren": 0 }, "data": { "key": "IADMA39Y", "version": 158868, "itemType": "journalArticle", "title": "Surgical pearl: a user-friendly dressing.", "creators": [ { "creatorType": "author", "firstName": "J. L.", "lastName": "Fewkes" }, { "creatorType": "author", "firstName": "S. J.", "lastName": "Salasche" } ], "abstractNote": "", "publicationTitle": "Journal of the American Academy of Dermatology", "publisher": "", "place": "United States", "date": "1993 Oct", "volume": "29", "issue": "4", "section": "", "partNumber": "", "partTitle": "", "pages": "633-635", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Am Acad Dermatol", "DOI": "10.1016/s0190-9622(08)81868-3", "citationKey": "", "url": "", "accessDate": "", "PMID": "8408799", "PMCID": "", "ISSN": "0190-9622", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "*Ambulatory Surgical Procedures" }, { "tag": "*Bandages" }, { "tag": "*Dermatologic Surgical Procedures" }, { "tag": "*Patient Participation" }, { "tag": "Dermatologic Agents/administration & dosage" }, { "tag": "Humans" }, { "tag": "Mastic Resin" }, { "tag": "Plant Extracts/administration & dosage" }, { "tag": "Postoperative Care/methods" }, { "tag": "Resins, Plant/administration & dosage" } ], "collections": [ "MITKBFZS" ], "relations": {}, "dateAdded": "2026-05-09T21:17:40Z", "dateModified": "2026-05-09T21:17:40Z" } }, { "key": "TLSPPFXF", "version": 158867, "library": { "type": "user", "id": 6212901, "name": "Nick Petosky", "links": { "alternate": { "href": "https://www.zotero.org/foxsayswhat", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/users/6212901/items/TLSPPFXF", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/foxsayswhat/items/TLSPPFXF", "type": "text/html" } }, "meta": { "creatorSummary": "Gortzi et al.", "parsedDate": "2022-01-20", "numChildren": 0 }, "data": { "key": "TLSPPFXF", "version": 158867, "itemType": "journalArticle", "title": "Study of Stability, Cytotoxic and Antimicrobial Activity of Chios Mastic Gum Fractions (Neutral, Acidic) after Encapsulation in Liposomes.", "creators": [ { "creatorType": "author", "firstName": "Olga", "lastName": "Gortzi" }, { "creatorType": "author", "firstName": "Magdalini", "lastName": "Rovoli" }, { "creatorType": "author", "firstName": "Konstantinos", "lastName": "Katsoulis" }, { "creatorType": "author", "firstName": "Konstantia", "lastName": "Graikou" }, { "creatorType": "author", "firstName": "Despoina-Aikaterini", "lastName": "Karagkini" }, { "creatorType": "author", "firstName": "Dimitrios", "lastName": "Stagos" }, { "creatorType": "author", "firstName": "Dimitrios", "lastName": "Kouretas" }, { "creatorType": "author", "firstName": "John", "lastName": "Tsaknis" }, { "creatorType": "author", "firstName": "Ioanna", "lastName": "Chinou" } ], "abstractNote": "Mastic gum is a resinous sap produced by Pistacia lentiscus growing in the island of Chios (Greece) and has been recognized since Antiquity for its distinctive aroma as well as medical properties (antimicrobial, antioxidant, anti-inflammatory ones). The oral absorption of Chios Mastic gum (an insoluble polymer of poly-β-myrcene is among the most abundant contents) is poor due to its low water-solubility. We report in this study, two different Chios mastic gum extracts, the acidic mastic gum extract-AMGE-and the neutral one-NMGE, both prepared after removal of the contained polymer in order to ameliorate solubility and enhance in vivo activity. Liposomes are presented as a promising delivery system due to their physicochemical and biophysical properties to increase stability and absorption efficiency of the mastic gum extracts within the gastrointestinal (GI) tract. The aim of this study was to evaluate the stability in GI simulated conditions together with cytotoxic and antimicrobial activity of the two extracts (AMGE and NMGE) after encapsulation in a well characterized liposome formulation. Liposomes-AMGE complex showed an improved stability behavior in GI simulated conditions. Both assayed extracts showed significant dose dependent inhibition against the growth of liver cancer HepG2 cells and an interesting antimicrobial activity against several microorganisms. Conclusively, encapsulation could be evaluated as a beneficial procedure for further applications of mastic resin.", "publicationTitle": "Foods (Basel, Switzerland)", "publisher": "", "place": "Switzerland", "date": "2022 Jan 20", "volume": "11", "issue": "3", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Foods", "DOI": "10.3390/foods11030271", "citationKey": "", "url": "", "accessDate": "", "PMID": "35159423", "PMCID": "PMC8834444", "ISSN": "2304-8158", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "antimicrobial activity" }, { "tag": "chios mastic gum" }, { "tag": "cytotoxic activity" }, { "tag": "encapsulation" }, { "tag": "liposomes" }, { "tag": "stability" } ], "collections": [ "MITKBFZS" ], "relations": {}, "dateAdded": "2026-05-09T21:17:40Z", "dateModified": "2026-05-09T21:17:40Z" } }, { "key": "S8MML3YR", "version": 158866, "library": { "type": "user", "id": 6212901, "name": "Nick Petosky", "links": { "alternate": { "href": "https://www.zotero.org/foxsayswhat", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/users/6212901/items/S8MML3YR", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/foxsayswhat/items/S8MML3YR", "type": "text/html" } }, "meta": { "creatorSummary": "Ramot et al.", "parsedDate": "2018-08", "numChildren": 0 }, "data": { "key": "S8MML3YR", "version": 158866, "itemType": "journalArticle", "title": "Toxicity and Toxicokinetic Study of Subcutaneously Administered RPh201 in Minipigs.", "creators": [ { "creatorType": "author", "firstName": "Yuval", "lastName": "Ramot" }, { "creatorType": "author", "firstName": "Zadik", "lastName": "Hazan" }, { "creatorType": "author", "firstName": "Andre", "lastName": "Lucassen" }, { "creatorType": "author", "firstName": "Konstantin", "lastName": "Adamsky" }, { "creatorType": "author", "firstName": "Vanessa", "lastName": "Ross" }, { "creatorType": "author", "firstName": "Nigel", "lastName": "Young" }, { "creatorType": "author", "firstName": "Matt", "lastName": "Saunders" }, { "creatorType": "author", "firstName": "Helmut", "lastName": "Ehall" }, { "creatorType": "author", "firstName": "Abraham", "lastName": "Nyska" } ], "abstractNote": "Mastic gum extracts are widely used as herbal remedies and are being tested for several clinical indications. Nevertheless, information on their safety is limited. RPh201 is an extract of the mastic gum, formulated and stabilized in a proprietary method, which is being developed as a novel drug candidate for neurological indications. The aim of this study was to assess the systemic toxic potential of RPh201, administered twice weekly by subcutaneous injections to minipigs, after 39 weeks of administration followed by a recovery period of 6 weeks. No clinical or dose-related signs were observed, but treatment-related findings were seen at the injection sites of the high-dose animals, composed of abscesses, chronic inflammation, and subcutaneous fibrosis. Abscesses >30 mm in size, graded as marked severity, were confined to the high-dose group and were considered as adverse. Minimal-slight subcutaneous and lymph nodes abscesses seen in control, low, and intermediate doses, related to the vehicle (cottonseed oil), were not considered as adverse. Additionally, minimal-to-slight cystic spaces or vacuolation related to the vehicle were observed in the skin, lymph nodes, kidney, and lungs. These findings were considered not to be adverse. The no-observed-adverse-effect level was considered to be 12.5 mg/kg/occasion.", "publicationTitle": "Toxicologic pathology", "publisher": "", "place": "United States", "date": "2018 Aug", "volume": "46", "issue": "6", "section": "", "partNumber": "", "partTitle": "", "pages": "693-705", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Toxicol Pathol", "DOI": "10.1177/0192623318786428", "citationKey": "", "url": "", "accessDate": "", "PMID": "30009686", "PMCID": "", "ISSN": "1533-1601 0192-6233", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Animals" }, { "tag": "Dose-Response Relationship, Drug" }, { "tag": "Female" }, { "tag": "Hemoglobins/analysis" }, { "tag": "Injection Site Reaction/*etiology/pathology" }, { "tag": "Injections, Subcutaneous" }, { "tag": "Leukocyte Count" }, { "tag": "Male" }, { "tag": "Mastic Resin/*chemistry" }, { "tag": "Neutrophils/cytology" }, { "tag": "No-Observed-Adverse-Effect Level" }, { "tag": "Organ Size/drug effects" }, { "tag": "Pistacia lentiscus" }, { "tag": "RPh201" }, { "tag": "Swine" }, { "tag": "Swine, Miniature" }, { "tag": "Toxicity Tests" }, { "tag": "Toxicokinetics" }, { "tag": "mastic gum" }, { "tag": "minipigs" }, { "tag": "safety" }, { "tag": "toxicity" }, { "tag": "toxicokinetics" } ], "collections": [ "MITKBFZS" ], "relations": {}, "dateAdded": "2026-05-09T21:17:40Z", "dateModified": "2026-05-09T21:17:40Z" } }, { "key": "4RY32UGV", "version": 158865, "library": { "type": "user", "id": 6212901, "name": "Nick Petosky", "links": { "alternate": { "href": "https://www.zotero.org/foxsayswhat", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/users/6212901/items/4RY32UGV", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/foxsayswhat/items/4RY32UGV", "type": "text/html" } }, "meta": { "creatorSummary": "CANNEFAX and TOW", "parsedDate": "1952-05", "numChildren": 0 }, "data": { "key": "4RY32UGV", "version": 158865, "itemType": "journalArticle", "title": "Temperature effect on the colloidal mastic test.", "creators": [ { "creatorType": "author", "firstName": "G. R.", "lastName": "CANNEFAX" }, { "creatorType": "author", "firstName": "C. W.", "lastName": "TOW" } ], "abstractNote": "", "publicationTitle": "Public health reports (Washington, D.C. : 1896)", "publisher": "", "place": "United States", "date": "1952 May", "volume": "67", "issue": "5", "section": "", "partNumber": "", "partTitle": "", "pages": "490-491", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Public Health Rep (1896)", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "14930179", "PMCID": "PMC2030785", "ISSN": "0094-6214", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "*Pistacia" }, { "tag": "*Resins, Plant" }, { "tag": "*SYPHILIS/diagnosis" }, { "tag": "*Temperature" }, { "tag": "Humans" }, { "tag": "Mastic Resin" }, { "tag": "Syphilis/*diagnosis" } ], "collections": [ "MITKBFZS" ], "relations": {}, "dateAdded": "2026-05-09T21:17:39Z", "dateModified": "2026-05-09T21:17:39Z" } }, { "key": "SQKDFWPN", "version": 158864, "library": { "type": "user", "id": 6212901, "name": "Nick Petosky", "links": { "alternate": { "href": "https://www.zotero.org/foxsayswhat", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/users/6212901/items/SQKDFWPN", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/foxsayswhat/items/SQKDFWPN", "type": "text/html" } }, "meta": { "creatorSummary": "FOLKERS and MOEBIUS", "parsedDate": "1951-10-15", "numChildren": 0 }, "data": { "key": "SQKDFWPN", "version": 158864, "itemType": "journalArticle", "title": "[A modified mastic test].", "creators": [ { "creatorType": "author", "firstName": "B.", "lastName": "FOLKERS" }, { "creatorType": "author", "firstName": "S.", "lastName": "MOEBIUS" } ], "abstractNote": "", "publicationTitle": "Klinische Wochenschrift", "publisher": "", "place": "Germany", "date": "1951 Oct 15", "volume": "29", "issue": "39-40", "section": "", "partNumber": "", "partTitle": "", "pages": "668-670", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Klin Wochenschr", "DOI": "10.1007/BF01483957", "citationKey": "", "url": "", "accessDate": "", "PMID": "14909438", "PMCID": "", "ISSN": "0023-2173", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "und", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "*BLOOD PROTEINS" }, { "tag": "*Blood Proteins" }, { "tag": "*Pistacia" }, { "tag": "*Resins, Plant" }, { "tag": "Humans" }, { "tag": "Mastic Resin" } ], "collections": [ "MITKBFZS" ], "relations": {}, "dateAdded": "2026-05-09T21:17:39Z", "dateModified": "2026-05-09T21:17:39Z" } }, { "key": "BSUC7CFS", "version": 158863, "library": { "type": "user", "id": 6212901, "name": "Nick Petosky", "links": { "alternate": { "href": "https://www.zotero.org/foxsayswhat", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/users/6212901/items/BSUC7CFS", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/foxsayswhat/items/BSUC7CFS", "type": "text/html" } }, "meta": { "creatorSummary": "Mikhail et al.", "parsedDate": "1986-09", "numChildren": 0 }, "data": { "key": "BSUC7CFS", "version": 158863, "itemType": "journalArticle", "title": "Reinforcement of surgical adhesive strips.", "creators": [ { "creatorType": "author", "firstName": "G. R.", "lastName": "Mikhail" }, { "creatorType": "author", "firstName": "L.", "lastName": "Selak" }, { "creatorType": "author", "firstName": "S.", "lastName": "Salo" } ], "abstractNote": "Surgical adhesive strips are often used for closure of some wounds or to minimize tension on sutures after closures. The package insert of the type most commonly used (Steri-Strip), indicates that the application of compound tincture of benzoin, U.S.P. (CTB) increases strip adhesion. The increase in adhesive power by CTB was compared with a preparation containing gum mastic (Mastisol). The study clearly demonstrated that the latter preparation provided a markedly more adhesive strength than that obtained with CTB.", "publicationTitle": "The Journal of dermatologic surgery and oncology", "publisher": "", "place": "United States", "date": "1986 Sep", "volume": "12", "issue": "9", "section": "", "partNumber": "", "partTitle": "", "pages": "904-905, 908", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Dermatol Surg Oncol", "DOI": "10.1111/j.1524-4725.1986.tb02128.x", "citationKey": "", "url": "", "accessDate": "", "PMID": "3528256", "PMCID": "", "ISSN": "0148-0812", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "*Bandages" }, { "tag": "Adhesiveness" }, { "tag": "Evaluation Studies as Topic" }, { "tag": "Humans" }, { "tag": "Mastic Resin" }, { "tag": "Plant Extracts/pharmacology" }, { "tag": "Resins, Plant/pharmacology" }, { "tag": "Styrax" }, { "tag": "Suture Techniques" } ], "collections": [ "MITKBFZS" ], "relations": {}, "dateAdded": "2026-05-09T21:17:39Z", "dateModified": "2026-05-09T21:17:39Z" } }, { "key": "ENQ6R35P", "version": 158862, "library": { "type": "user", "id": 6212901, "name": "Nick Petosky", "links": { "alternate": { "href": "https://www.zotero.org/foxsayswhat", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/users/6212901/items/ENQ6R35P", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/foxsayswhat/items/ENQ6R35P", "type": "text/html" } }, "meta": { "creatorSummary": "SCHMITT", "parsedDate": "1950-04-15", "numChildren": 0 }, "data": { "key": "ENQ6R35P", "version": 158862, "itemType": "journalArticle", "title": "[Emanuel's mastic test].", "creators": [ { "creatorType": "author", "firstName": "W.", "lastName": "SCHMITT" } ], "abstractNote": "", "publicationTitle": "Zeitschrift fur Haut- und Geschlechtskrankheiten", "publisher": "", "place": "Germany", "date": "1950 Apr 15", "volume": "8", "issue": "8", "section": "", "partNumber": "", "partTitle": "", "pages": "300-310", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Z Haut Geschlechtskr", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "15425186", "PMCID": "", "ISSN": "0044-2844", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "und", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "*CEREBROSPINAL FLUID" }, { "tag": "*Cerebrospinal Fluid" }, { "tag": "*NEUROSYPHILIS" }, { "tag": "*Neurosyphilis" }, { "tag": "*Pistacia" }, { "tag": "*Resins, Plant" }, { "tag": "Humans" }, { "tag": "Mastic Resin" } ], "collections": [ "MITKBFZS" ], "relations": {}, "dateAdded": "2026-05-09T21:17:39Z", "dateModified": "2026-05-09T21:17:39Z" } }, { "key": "PUL7YJSE", "version": 158861, "library": { "type": "user", "id": 6212901, "name": "Nick Petosky", "links": { "alternate": { "href": "https://www.zotero.org/foxsayswhat", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/users/6212901/items/PUL7YJSE", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/foxsayswhat/items/PUL7YJSE", "type": "text/html" } }, "meta": { "creatorSummary": "SCHUBERTH", "parsedDate": "1953-03-06", "numChildren": 0 }, "data": { "key": "PUL7YJSE", "version": 158861, "itemType": "journalArticle", "title": "[An improvement in the mastic reaction of cerebrospinal fluid].", "creators": [ { "creatorType": "author", "firstName": "H.", "lastName": "SCHUBERTH" } ], "abstractNote": "", "publicationTitle": "Munchener medizinische Wochenschrift (1950)", "publisher": "", "place": "Germany", "date": "1953 Mar 6", "volume": "95", "issue": "10", "section": "", "partNumber": "", "partTitle": "", "pages": "296-297", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Munch Med Wochenschr", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "13072352", "PMCID": "", "ISSN": "0027-2973", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "und", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "*CEREBROSPINAL FLUID" }, { "tag": "*Cerebrospinal Fluid" }, { "tag": "*Pistacia" }, { "tag": "*Resins, Plant" }, { "tag": "Humans" }, { "tag": "Mastic Resin" } ], "collections": [ "MITKBFZS" ], "relations": {}, "dateAdded": "2026-05-09T21:17:39Z", "dateModified": "2026-05-09T21:17:39Z" } }, { "key": "C92K9YT7", "version": 158860, "library": { "type": "user", "id": 6212901, "name": "Nick Petosky", "links": { "alternate": { "href": "https://www.zotero.org/foxsayswhat", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/users/6212901/items/C92K9YT7", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/foxsayswhat/items/C92K9YT7", "type": "text/html" } }, "meta": { "creatorSummary": "GASANOV", "parsedDate": "1945", "numChildren": 0 }, "data": { "key": "C92K9YT7", "version": 158860, "itemType": "journalArticle", "title": "[Experimental therapy of wounds using naphthamastic].", "creators": [ { "creatorType": "author", "firstName": "S. M.", "lastName": "GASANOV" } ], "abstractNote": "", "publicationTitle": "Gospital'noe delo", "publisher": "", "place": "Russia (Federation)", "date": "1945", "volume": "", "issue": "12", "section": "", "partNumber": "", "partTitle": "", "pages": "37-39", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Gosp Delo", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "20280952", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "und", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "*Alkanes" }, { "tag": "*MASTIC" }, { "tag": "*NAPHTHA-MASTIC" }, { "tag": "*Pistacia" }, { "tag": "*Resins, Plant" }, { "tag": "*Therapies, Investigational" }, { "tag": "*WOUNDS/therapy" }, { "tag": "Humans" }, { "tag": "Mastic Resin" }, { "tag": "Wounds and Injuries/*therapy" } ], "collections": [ "MITKBFZS" ], "relations": {}, "dateAdded": "2026-05-09T21:17:39Z", "dateModified": "2026-05-09T21:17:39Z" } }, { "key": "9ZRUCZNA", "version": 158859, "library": { "type": "user", "id": 6212901, "name": "Nick Petosky", "links": { "alternate": { "href": "https://www.zotero.org/foxsayswhat", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/users/6212901/items/9ZRUCZNA", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/foxsayswhat/items/9ZRUCZNA", "type": "text/html" } }, "meta": { "creatorSummary": "THROUVALAS", "parsedDate": "1950", "numChildren": 0 }, "data": { "key": "9ZRUCZNA", "version": 158859, "itemType": "journalArticle", "title": "[Case of mastic kidney].", "creators": [ { "creatorType": "author", "firstName": "A.", "lastName": "THROUVALAS" } ], "abstractNote": "", "publicationTitle": "Journal de radiologie, d'electrologie & archives d'electricite medicale", "publisher": "", "place": "France", "date": "1950", "volume": "31", "issue": "11-12", "section": "", "partNumber": "", "partTitle": "", "pages": "673-674", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Radiol Electrol Arch Electr Medicale", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "14825316", "PMCID": "", "ISSN": "0368-394X", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "und", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "*KIDNEYS" }, { "tag": "*Kidney" }, { "tag": "*Pistacia" }, { "tag": "*Resins, Plant" }, { "tag": "Humans" }, { "tag": "Mastic Resin" } ], "collections": [ "MITKBFZS" ], "relations": {}, "dateAdded": "2026-05-09T21:17:39Z", "dateModified": "2026-05-09T21:17:39Z" } }, { "key": "8NBZZ2FX", "version": 158858, "library": { "type": "user", "id": 6212901, "name": "Nick Petosky", "links": { "alternate": { "href": "https://www.zotero.org/foxsayswhat", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/users/6212901/items/8NBZZ2FX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/foxsayswhat/items/8NBZZ2FX", "type": "text/html" } }, "meta": { "creatorSummary": "WEIHE", "parsedDate": "1951", "numChildren": 0 }, "data": { "key": "8NBZZ2FX", "version": 158858, "itemType": "journalArticle", "title": "[A modified mastic colloid reaction as a blood test].", "creators": [ { "creatorType": "author", "firstName": "W. H.", "lastName": "WEIHE" } ], "abstractNote": "", "publicationTitle": "Zeitschrift fur die gesamte experimentelle Medizin", "publisher": "", "place": "Germany", "date": "1951", "volume": "116", "issue": "6", "section": "", "partNumber": "", "partTitle": "", "pages": "513-521", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Z Gesamte Exp Med", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "14818227", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "und", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "*BLOOD" }, { "tag": "*Blood" }, { "tag": "*Colloids" }, { "tag": "*Hematologic Tests" }, { "tag": "*MASTIC" }, { "tag": "*Pistacia" }, { "tag": "*Resins, Plant" }, { "tag": "*SERODIAGNOSIS" }, { "tag": "*Serologic Tests" }, { "tag": "Humans" }, { "tag": "Mastic Resin" } ], "collections": [ "MITKBFZS" ], "relations": {}, "dateAdded": "2026-05-09T21:17:39Z", "dateModified": "2026-05-09T21:17:39Z" } }, { "key": "F3937Z8L", "version": 158857, "library": { "type": "user", "id": 6212901, "name": "Nick Petosky", "links": { "alternate": { "href": "https://www.zotero.org/foxsayswhat", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/users/6212901/items/F3937Z8L", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/foxsayswhat/items/F3937Z8L", "type": "text/html" } }, "meta": { "creatorSummary": "WEIHE and BOTHE", "parsedDate": "1951-05-15", "numChildren": 0 }, "data": { "key": "F3937Z8L", "version": 158857, "itemType": "journalArticle", "title": "[Results obtained with the mastic serum test].", "creators": [ { "creatorType": "author", "firstName": "W. H.", "lastName": "WEIHE" }, { "creatorType": "author", "firstName": "J.", "lastName": "BOTHE" } ], "abstractNote": "", "publicationTitle": "Klinische Wochenschrift", "publisher": "", "place": "Germany", "date": "1951 May 15", "volume": "29", "issue": "19-20", "section": "", "partNumber": "", "partTitle": "", "pages": "352-354", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Klin Wochenschr", "DOI": "10.1007/BF01477038", "citationKey": "", "url": "", "accessDate": "", "PMID": "14851628", "PMCID": "", "ISSN": "0023-2173", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "und", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "*BLOOD" }, { "tag": "*Blood" }, { "tag": "*MASTIC" }, { "tag": "*Pistacia" }, { "tag": "*Resins, Plant" }, { "tag": "*SERUM" }, { "tag": "*Serum" }, { "tag": "Humans" }, { "tag": "Mastic Resin" } ], "collections": [ "MITKBFZS" ], "relations": {}, "dateAdded": "2026-05-09T21:17:39Z", "dateModified": "2026-05-09T21:17:39Z" } }, { "key": "WSPYSSIT", "version": 158856, "library": { "type": "user", "id": 6212901, "name": "Nick Petosky", "links": { "alternate": { "href": "https://www.zotero.org/foxsayswhat", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/users/6212901/items/WSPYSSIT", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/foxsayswhat/items/WSPYSSIT", "type": "text/html" } }, "meta": { "creatorSummary": "Brieudes et al.", "parsedDate": "2021-10", "numChildren": 0 }, "data": { "key": "WSPYSSIT", "version": 158856, "itemType": "journalArticle", "title": "Development, Validation and Application of a UHPLC-MS Method for the Quantification of Chios Mastic Gum Triterpenoids in Human Plasma.", "creators": [ { "creatorType": "author", "firstName": "Vincent", "lastName": "Brieudes" }, { "creatorType": "author", "firstName": "Eleni V.", "lastName": "Mikropoulou" }, { "creatorType": "author", "firstName": "Errikos", "lastName": "Kallergis" }, { "creatorType": "author", "firstName": "Andriana C.", "lastName": "Kaliora" }, { "creatorType": "author", "firstName": "Efstathia", "lastName": "Papada" }, { "creatorType": "author", "firstName": "Petros", "lastName": "Gkiouvetidis" }, { "creatorType": "author", "firstName": "Apostolis", "lastName": "Angelis" }, { "creatorType": "author", "firstName": "Maria", "lastName": "Halabalaki" } ], "abstractNote": "Chios mastic gum is the resinous secretion obtained from the barks of the shrub Pistacia lentiscus var. Chia, which is endemic to the Greek island of Chios. Since antiquity, Chios mastic gum has found several uses as a phytotherapeutic remedy, primarily for the treatment of gastrointestinal disorders while recently, Chios mastic gum was also recognized by EMA as an herbal medicinal product with specific indications. Chios mastic gum's biological properties are attributed to triterpenes which comprise the major chemical group (approx. 70%) and notably isomasticadienonic acid and masticadienonic acid. However, due to their structural characteristics, the isolation thereof in high yield and purity is challenging and since they are not commercially available, pharmacological studies aiming to assess their biological properties are limited. In the present work, mastic's phytochemical investigation by UPLC-HRMS is followed by the isolation and characterization of isomasticadienonic acid and masticadienonic acid to be used as analytical standards for their accurate and reliable quantification in human plasma. A UHPLC-tQ-MS method that was developed and validated (in terms of specificity, linearity, limit of quantification, accuracy and precision), for the direct quantification of the targeted compounds in the low ng/mL range of concentration, was subsequently implemented on plasma samples of healthy volunteers thus demonstrating its fitness for purpose. The results presented herein might provide insight to the understanding of this traditional natural product consumed notably for its anti-inflammatory, antioxidant and lipid lowering properties. Moreover, this method might serve as a starting point for any study aiming to monitor bioactive triterpenes in biological fluids.", "publicationTitle": "Planta medica", "publisher": "", "place": "Germany", "date": "2021 Oct", "volume": "87", "issue": "12-13", "section": "", "partNumber": "", "partTitle": "", "pages": "1101-1109", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Planta Med", "DOI": "10.1055/a-1408-9338", "citationKey": "", "url": "", "accessDate": "", "PMID": "33784768", "PMCID": "", "ISSN": "1439-0221 0032-0943", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "", "callNumber": "", "rights": "Thieme. All rights reserved.", "extra": "", "tags": [ { "tag": "*Pistacia/chemistry" }, { "tag": "*Triterpenes/blood" }, { "tag": "Chromatography, High Pressure Liquid" }, { "tag": "Greece" }, { "tag": "Humans" }, { "tag": "Mastic Resin/chemistry" }, { "tag": "Plant Extracts" } ], "collections": [ "MITKBFZS" ], "relations": {}, "dateAdded": "2026-05-09T21:17:39Z", "dateModified": "2026-05-09T21:17:39Z" } }, { "key": "PPE97WPS", "version": 158855, "library": { "type": "user", "id": 6212901, "name": "Nick Petosky", "links": { "alternate": { "href": "https://www.zotero.org/foxsayswhat", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/users/6212901/items/PPE97WPS", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/foxsayswhat/items/PPE97WPS", "type": "text/html" } }, "meta": { "creatorSummary": "Langdon et al.", "parsedDate": "1998-02", "numChildren": 0 }, "data": { "key": "PPE97WPS", "version": 158855, "itemType": "journalArticle", "title": "Antitumour activity and schedule dependency of 8-chloroadenosine-3',5'-monophosphate (8-ClcAMP) against human tumour xenografts.", "creators": [ { "creatorType": "author", "firstName": "S. P.", "lastName": "Langdon" }, { "creatorType": "author", "firstName": "A. A.", "lastName": "Ritchie" }, { "creatorType": "author", "firstName": "M.", "lastName": "Muir" }, { "creatorType": "author", "firstName": "M.", "lastName": "Dodds" }, { "creatorType": "author", "firstName": "A. F.", "lastName": "Howie" }, { "creatorType": "author", "firstName": "R. C.", "lastName": "Leonard" }, { "creatorType": "author", "firstName": "P. K.", "lastName": "Stockman" }, { "creatorType": "author", "firstName": "W. R.", "lastName": "Miller" } ], "abstractNote": "8-Chloroadenosine-3',5'-monophosphate (8-ClcAMP) is a novel antitumour agent currently undergoing phase I clinical trials in several European centres. In this study, its antitumour activity against human tumour xenografts and its dependence on schedule were investigated. When administered by continuous infusion at doses of 100 or 50 mg/kg/day to nude mice bearing human tumour xenografts, 8-ClcAMP inhibited the growth of the HT 29 colorectal, ZR-75-1 breast, HOX 60 and PE04 ovarian and PANC-1 pancreatic carcinoma xenografts. However, these infusion schedules produced hypercalcaemia and severe weight loss. In an attempt to optimise antitumour activity and minimise toxicity, several other schedules were studied. In comparison with continuous administration of 8-ClcAMP at 50 mg/kg/day for 14 days which, although producing complete growth inhibition in the HOX 60 model, was associated with a marked body weight loss, schedules in which the infusion was interrupted (infusion on either days 0-4; 7-11 or days 0-2; 6-8) produced minimal weight loss but also reduced antitumour activity. However, co-administration of salmon calcitonin with continuous infusion of 8-ClcAMP prevented both hypercalcaemia and body weight loss in 3/6 animals while still producing marked inhibition of tumour growth. These data indicate that 8-ClcAMP has broad-spectrum antitumour activity and the major side-effect of hypercalcaemia may at least in part be ameliorated by the use of salmon calcitonin.", "publicationTitle": "European journal of cancer (Oxford, England : 1990)", "publisher": "", "place": "England", "date": "1998 Feb", "volume": "34", "issue": "3", "section": "", "partNumber": "", "partTitle": "", "pages": "384-388", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Eur J Cancer", "DOI": "10.1016/s0959-8049(97)00372-9", "citationKey": "", "url": "", "accessDate": "", "PMID": "9640227", "PMCID": "", "ISSN": "0959-8049", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "8-Bromo Cyclic Adenosine Monophosphate/administration & dosage/*analogs & derivatives" }, { "tag": "Animals" }, { "tag": "Antineoplastic Agents/*administration & dosage" }, { "tag": "Colorectal Neoplasms/*drug therapy" }, { "tag": "Dose-Response Relationship, Drug" }, { "tag": "Drug Administration Schedule" }, { "tag": "Female" }, { "tag": "Humans" }, { "tag": "Hypercalcemia/chemically induced" }, { "tag": "Infusions, Intravenous" }, { "tag": "Male" }, { "tag": "Mice" }, { "tag": "Neoplasm Transplantation" }, { "tag": "Ovarian Neoplasms/*drug therapy" }, { "tag": "Prostatic Neoplasms/*drug therapy" }, { "tag": "Transplantation, Heterologous" }, { "tag": "Weight Loss" } ], "collections": [ "MITKBFZS" ], "relations": {}, "dateAdded": "2026-05-09T21:17:39Z", "dateModified": "2026-05-09T21:17:39Z" } }, { "key": "TGABT7HQ", "version": 158854, "library": { "type": "user", "id": 6212901, "name": "Nick Petosky", "links": { "alternate": { "href": "https://www.zotero.org/foxsayswhat", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/users/6212901/items/TGABT7HQ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/foxsayswhat/items/TGABT7HQ", "type": "text/html" } }, "meta": { "creatorSummary": "Valtorta et al.", "parsedDate": "2014-12", "numChildren": 0 }, "data": { "key": "TGABT7HQ", "version": 158854, "itemType": "journalArticle", "title": "A novel AMPK activator reduces glucose uptake and inhibits tumor progression in a mouse xenograft model of colorectal cancer.", "creators": [ { "creatorType": "author", "firstName": "Silvia", "lastName": "Valtorta" }, { "creatorType": "author", "firstName": "Gabriella", "lastName": "Nicolini" }, { "creatorType": "author", "firstName": "Farida", "lastName": "Tripodi" }, { "creatorType": "author", "firstName": "Cristina", "lastName": "Meregalli" }, { "creatorType": "author", "firstName": "Guido", "lastName": "Cavaletti" }, { "creatorType": "author", "firstName": "Federica", "lastName": "Avezza" }, { "creatorType": "author", "firstName": "Luca", "lastName": "Crippa" }, { "creatorType": "author", "firstName": "Gloria", "lastName": "Bertoli" }, { "creatorType": "author", "firstName": "Francesca", "lastName": "Sanvito" }, { "creatorType": "author", "firstName": "Paola", "lastName": "Fusi" }, { "creatorType": "author", "firstName": "Roberto", "lastName": "Pagliarin" }, { "creatorType": "author", "firstName": "Fulvia", "lastName": "Orsini" }, { "creatorType": "author", "firstName": "Rosa Maria", "lastName": "Moresco" }, { "creatorType": "author", "firstName": "Paola", "lastName": "Coccetti" } ], "abstractNote": "The anticancer activity of a novel pure 1,4-Diaryl-2-azetidinone (1), endowed with a higher solubility than the well known Combretastatin A4, is tested in mice. We previously reported that Compound (1) showed specific antiproliferative activity against duodenal and colon cancer cells, inducing activation of AMP-activated protein kinase and apoptosis. Here we estimate that the maximum tolerated dose in a mouse model is 40 mg/kg; the drug is well tolerated both in single dose and in repeated administration schedules. The drug displays a significant antitumor activity and a tumor growth delay when administered at the MTD both in single and fractionated i.v. administration in a mouse xenograft model of colorectal cancer. Arrest of tumor growth and relapse after drug suspension are parallel to modification in glucose demand as shown by PET studies with [(18)F] FDG. These data strongly support Compound (1) as a promising molecule for in vivo treatment of colorectal cancer.", "publicationTitle": "Investigational new drugs", "publisher": "", "place": "United States", "date": "2014 Dec", "volume": "32", "issue": "6", "section": "", "partNumber": "", "partTitle": "", "pages": "1123-1133", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Invest New Drugs", "DOI": "10.1007/s10637-014-0148-8", "citationKey": "", "url": "", "accessDate": "", "PMID": "25134489", "PMCID": "", "ISSN": "1573-0646 0167-6997", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "*Antineoplastic Agents/blood/pharmacokinetics/pharmacology/therapeutic use" }, { "tag": "*Azetidines/blood/pharmacokinetics/pharmacology/therapeutic use" }, { "tag": "AMP-Activated Protein Kinases/*metabolism" }, { "tag": "Animals" }, { "tag": "Cell Line, Tumor" }, { "tag": "Cell Survival/drug effects" }, { "tag": "Colorectal Neoplasms/*drug therapy/metabolism/pathology" }, { "tag": "Glucose/*metabolism" }, { "tag": "Guaiacol/*analogs & derivatives/blood/pharmacokinetics/pharmacology/therapeutic use" }, { "tag": "Humans" }, { "tag": "Male" }, { "tag": "Mice" }, { "tag": "Xenograft Model Antitumor Assays" } ], "collections": [ "MITKBFZS" ], "relations": {}, "dateAdded": "2026-05-09T21:17:39Z", "dateModified": "2026-05-09T21:17:39Z" } }, { "key": "4G2TVGR8", "version": 158853, "library": { "type": "user", "id": 6212901, "name": "Nick Petosky", "links": { "alternate": { "href": "https://www.zotero.org/foxsayswhat", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/users/6212901/items/4G2TVGR8", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/foxsayswhat/items/4G2TVGR8", "type": "text/html" } }, "meta": { "creatorSummary": "Blomquist and Fernandez", "parsedDate": "2024-09-02", "numChildren": 0 }, "data": { "key": "4G2TVGR8", "version": 158853, "itemType": "journalArticle", "title": "Chios Mastic Gum: A Promising Phytotherapeutic for Cardiometabolic Health.", "creators": [ { "creatorType": "author", "firstName": "Sarah A.", "lastName": "Blomquist" }, { "creatorType": "author", "firstName": "Maria Luz", "lastName": "Fernandez" } ], "abstractNote": "Chios mastic gum (CMG) is a resin obtained from the Pistacia lentiscus var. Chia tree that grows in the Mediterranean. For millennia, it has been renowned for its medicinal properties, but recently, CMG has gained attention due to its pronounced anti-inflammatory and antioxidative properties and its use in oral health, inflammatory bowel disease, cancer, and risk factors related to cardiovascular and metabolic diseases. This narrative review seeks to briefly overview its bioactive constituents and examine and describe its potential as a cardiometabolic disease (CMD) phytotherapeutic. The results of clinical trials and in vivo, in vitro, and in silico studies provide accumulating evidence of the mechanisms underlying CMG's impacts on lipid and glucose metabolism, cardiovascular and hepatic health, inflammation, oxidative stress, body composition, and microbiota. Despite the relatively limited studies with mixed results, they have provided the foundation to understand the strengths, weaknesses, and opportunities moving forward that may help to establish CMG and its bioactives as viable therapeutics for CMD.", "publicationTitle": "Nutrients", "publisher": "", "place": "Switzerland", "date": "2024 Sep 2", "volume": "16", "issue": "17", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Nutrients", "DOI": "10.3390/nu16172941", "citationKey": "", "url": "", "accessDate": "", "PMID": "39275256", "PMCID": "PMC11397435", "ISSN": "2072-6643", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "*Mastic Resin" }, { "tag": "*Phytotherapy" }, { "tag": "*Pistacia/chemistry" }, { "tag": "Animals" }, { "tag": "Antioxidants/pharmacology" }, { "tag": "Cardiovascular Diseases/drug therapy" }, { "tag": "Chios mastic gum" }, { "tag": "Humans" }, { "tag": "Metabolic Diseases/drug therapy" }, { "tag": "Plant Extracts/pharmacology/therapeutic use" }, { "tag": "anti-inflammatory" }, { "tag": "antioxidant" }, { "tag": "cardiometabolic protection" }, { "tag": "mastiha" } ], "collections": [ "MITKBFZS" ], "relations": {}, "dateAdded": "2026-05-09T21:17:39Z", "dateModified": "2026-05-09T21:17:39Z" } } ]