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Cichutek" }, { "creatorType": "author", "name": "Peter H. Duesberg" }, { "creatorType": "author", "name": "P H Duesberg" }, { "creatorType": "author", "name": "Peter H. Duesberg" } ], "abstractNote": "The cellular precursor of Harvey and Balb sarcoma virus, termed proto-ras, from certain tumors registers most frequently as an apparent cancer gene in the gene transfer assay with NIH 3T3 cells [1–4]. The viral ras gene is a dominant transforming gene that elicits all features of oncogenic transformation in a single step upon transfer into established and primary human and animal fibroblast cells [5]. This encodes a single transforming protein of 21 kDA, p21 Ha-ras, which is presumed to be involved in the growth regulation of cells similar to G-proteins [6, 7]. However, the role of the cellular ras gene as a human cancer gene is debatable, as only 10% of the DNAs from certain cancer cells produce foci of transformed NIH 3T3 cells in the transfection assay. 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