[ { "key": "Q9FFU7TW", "version": 121, "library": { "type": "group", "id": 84313, "name": "Cancer-research", "links": { "alternate": { "href": "https://www.zotero.org/groups/cancer-research", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/84313/items/Q9FFU7TW", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cancer-research/items/Q9FFU7TW", "type": "text/html" } }, "meta": { "createdByUser": { "id": 978552, "username": "tomhodder", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/tomhodder", "type": "text/html" } } }, "creatorSummary": "Namba et al.", "parsedDate": "2003-09-01", "numChildren": 2 }, "data": { "key": "Q9FFU7TW", "version": 121, "itemType": "journalArticle", "title": "Clinical Implication of Hot Spot BRAF Mutation, V599E, in Papillary Thyroid Cancers", "creators": [ { "creatorType": "author", "firstName": "Hiroyuki", "lastName": "Namba" }, { "creatorType": "author", "firstName": "Masahiro", "lastName": "Nakashima" }, { "creatorType": "author", "firstName": "Tomayoshi", "lastName": "Hayashi" }, { "creatorType": "author", "firstName": "Naomi", "lastName": "Hayashida" }, { "creatorType": "author", "firstName": "Shigeto", "lastName": "Maeda" }, { "creatorType": "author", "firstName": "Tatiana I.", "lastName": "Rogounovitch" }, { "creatorType": "author", "firstName": "Akira", "lastName": "Ohtsuru" }, { "creatorType": "author", "firstName": "Vladimir A.", "lastName": "Saenko" }, { "creatorType": "author", "firstName": "Takashi", "lastName": "Kanematsu" }, { "creatorType": "author", "firstName": "Shunichi", "lastName": "Yamashita" } ], "abstractNote": "Activating mutations in the BRAF kinase gene have recently been reported in human cancers. The aim of the present study was to determine the frequency of BRAF mutations in thyroid cancer and their correlation with clinicopathological parameters. We analyzed exons 11 and 15 of BRAF gene in six human thyroid cancer cell lines and 207 paraffin-embedded thyroid tumor tissues. A missense mutation was found at T1796A (V599E) in exon 15 in four of the six cell lines and 51 of 207 thyroid tumors (24.6%; 0 of 20 follicular adenoma, 0 of 11 follicular carcinoma, 49 of 170 papillary carcinomas, and 2 of 6 undifferentiated carcinomas). Activation of MAPK kinase-MAPK pathway was observed in cell lines harboring BRAF mutation. BRAF mutation-associated enhanced cell growth was suppressed by MAPK kinase inhibitor, U0126. Examination of 126 patients with papillary thyroid cancer showed that BRAF mutation correlated significantly with distant metastasis (P = 0.033) and clinical stage (P = 0.049). Our results indicate that activating mutation of BRAF gene could be a potentially useful marker of prognosis of patients with advanced thyroid cancers.", "publicationTitle": "Journal of Clinical Endocrinology & Metabolism", "publisher": "", "place": "", "date": "09/01/2003", "volume": "88", "issue": "9", "section": "", "partNumber": "", "partTitle": "", "pages": "4393-4397", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "JCEM", "DOI": "10.1210/jc.2003-030305", "citationKey": "", "url": "http://jcem.endojournals.org/content/88/9/4393", "accessDate": "2012-08-01T11:52:42Z", "PMID": "", "PMCID": "", "ISSN": "0021-972X, 1945-7197", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "jcem.endojournals.org", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "#nosource" } ], "collections": [ "KMMRHKK3" ], "relations": {}, "dateAdded": "2012-08-01T11:52:42Z", "dateModified": "2026-03-06T19:05:14Z" } }, { "key": "US7DP6XC", "version": 121, "library": { "type": "group", "id": 84313, "name": "Cancer-research", "links": { "alternate": { "href": "https://www.zotero.org/groups/cancer-research", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/84313/items/US7DP6XC", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cancer-research/items/US7DP6XC", "type": "text/html" } }, "meta": { "createdByUser": { "id": 978552, "username": "tomhodder", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/tomhodder", "type": "text/html" } } }, "creatorSummary": "Wan et al.", "parsedDate": "2004-03-19", "numChildren": 2 }, "data": { "key": "US7DP6XC", "version": 121, "itemType": "journalArticle", "title": "Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF", "creators": [ { "creatorType": "author", "firstName": "Paul T.C", "lastName": "Wan" }, { "creatorType": "author", "firstName": "Mathew J", "lastName": "Garnett" }, { "creatorType": "author", "firstName": "S.Mark", "lastName": "Roe" }, { "creatorType": "author", "firstName": "Sharlene", "lastName": "Lee" }, { "creatorType": "author", "firstName": "Dan", "lastName": "Niculescu-Duvaz" }, { "creatorType": "author", "firstName": "Valerie M", "lastName": "Good" }, { "creatorType": "author", "firstName": "Cancer Genome", "lastName": "Project" }, { "creatorType": "author", "firstName": "C.Michael", "lastName": "Jones" }, { "creatorType": "author", "firstName": "Christopher J", "lastName": "Marshall" }, { "creatorType": "author", "firstName": "Caroline J", "lastName": "Springer" }, { "creatorType": "author", "firstName": "David", "lastName": "Barford" }, { "creatorType": "author", "firstName": "Richard", "lastName": "Marais" } ], "abstractNote": "Over 30 mutations of the B-RAF gene associated with human cancers have been identified, the majority of which are located within the kinase domain. Here we show that of 22 B-RAF mutants analyzed, 18 have elevated kinase activity and signal to ERK in vivo. Surprisingly, three mutants have reduced kinase activity towards MEK in vitro but, by activating C-RAF in vivo, signal to ERK in cells. The structures of wild type and oncogenic V599EB-RAF kinase domains in complex with the RAF inhibitor BAY43-9006 show that the activation segment is held in an inactive conformation by association with the P loop. The clustering of most mutations to these two regions suggests that disruption of this interaction converts B-RAF into its active conformation. The high activity mutants signal to ERK by directly phosphorylating MEK, whereas the impaired activity mutants stimulate MEK by activating endogenous C-RAF, possibly via an allosteric or transphosphorylation mechanism.", "publicationTitle": "Cell", "publisher": "", "place": "", "date": "March 19, 2004", "volume": "116", "issue": "6", "section": "", "partNumber": "", "partTitle": "", "pages": "855-867", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1016/S0092-8674(04)00215-6", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/S0092867404002156", "accessDate": "2012-08-01T11:50:28Z", "PMID": "", "PMCID": "", "ISSN": "0092-8674", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "#nosource" } ], "collections": [ "KMMRHKK3" ], "relations": {}, "dateAdded": "2012-08-01T11:50:28Z", "dateModified": "2026-03-06T19:05:14Z" } }, { "key": "BGAXZ2UW", "version": 121, "library": { "type": "group", "id": 84313, "name": "Cancer-research", "links": { "alternate": { "href": "https://www.zotero.org/groups/cancer-research", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/84313/items/BGAXZ2UW", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cancer-research/items/BGAXZ2UW", "type": "text/html" } }, "meta": { "createdByUser": { "id": 978552, "username": "tomhodder", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/tomhodder", "type": "text/html" } } }, "creatorSummary": "Ein-Dor et al.", "parsedDate": "2005-01-15", "numChildren": 2 }, "data": { "key": "BGAXZ2UW", "version": 121, "itemType": "journalArticle", "title": "Outcome signature genes in breast cancer: is there a unique set?", "creators": [ { "creatorType": "author", "firstName": "Liat", "lastName": "Ein-Dor" }, { "creatorType": "author", "firstName": "Itai", "lastName": "Kela" }, { "creatorType": "author", "firstName": "Gad", "lastName": "Getz" }, { "creatorType": "author", "firstName": "David", "lastName": "Givol" }, { "creatorType": "author", "firstName": "Eytan", "lastName": "Domany" } ], "abstractNote": "Motivation: Predicting the metastatic potential of primary malignant tissues has direct bearing on the choice of therapy. Several microarray studies yielded gene sets whose expression profiles successfully predicted survival. Nevertheless, the overlap between these gene sets is almost zero. Such small overlaps were observed also in other complex diseases, and the variables that could account for the differences had evoked a wide interest. One of the main open questions in this context is whether the disparity can be attributed only to trivial reasons such as different technologies, different patients and different types of analyses.\nResults: To answer this question, we concentrated on a single breast cancer dataset, and analyzed it by a single method, the one which was used by van't Veer et al. to produce a set of outcome-predictive genes. We showed that, in fact, the resulting set of genes is not unique; it is strongly influenced by the subset of patients used for gene selection. Many equally predictive lists could have been produced from the same analysis. Three main properties of the data explain this sensitivity: (1) many genes are correlated with survival; (2) the differences between these correlations are small; (3) the correlations fluctuate strongly when measured over different subsets of patients. A possible biological explanation for these properties is discussed.\nContact: eytan.domany@weizmann.ac.il\nSupplementary information: http://www.weizmann.ac.il/physics/complex/compphys/downloads/liate/", "publicationTitle": "Bioinformatics", "publisher": "", "place": "", "date": "01/15/2005", "volume": "21", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "171-178", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Bioinformatics", "DOI": "10.1093/bioinformatics/bth469", "citationKey": "", "url": "http://bioinformatics.oxfordjournals.org.libezproxy.open.ac.uk/content/21/2/171", "accessDate": "2012-08-01T09:25:09Z", "PMID": "", "PMCID": "", "ISSN": "1367-4803, 1460-2059", "archive": "", "archiveLocation": "", "shortTitle": "Outcome signature genes in breast cancer", "language": "en", "libraryCatalog": "bioinformatics.oxfordjournals.org.libezproxy.open.ac.uk", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "#nosource" } ], "collections": [ "VTVF23M7" ], "relations": {}, "dateAdded": "2012-08-01T09:25:09Z", "dateModified": "2026-03-06T19:05:14Z" } }, { "key": "JFT4SH3R", "version": 120, "library": { "type": "group", "id": 84313, "name": "Cancer-research", "links": { "alternate": { "href": "https://www.zotero.org/groups/cancer-research", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/84313/items/JFT4SH3R", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cancer-research/items/JFT4SH3R", "type": "text/html" } }, "meta": { "createdByUser": { "id": 978552, "username": "tomhodder", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/tomhodder", "type": "text/html" } } }, "creatorSummary": "Murphy and Morris", "parsedDate": "2012", "numChildren": 0 }, "data": { "key": "JFT4SH3R", "version": 120, "itemType": "journalArticle", "title": "Recent advances in novel targeted therapies for HER2-positive breast cancer", "creators": [ { "creatorType": "author", "firstName": "Conleth G.", "lastName": "Murphy" }, { "creatorType": "author", "firstName": "Patrick G.", "lastName": "Morris" } ], "abstractNote": "", "publicationTitle": "Anti-Cancer Drugs", "publisher": "", "place": "", "date": "09/2012", "volume": "23", "issue": "8", "section": "", "partNumber": "", "partTitle": "", "pages": "765-776", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1097/CAD.0b013e328352d292", "citationKey": "", "url": "http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00001813-201209000-00001", "accessDate": "2012-08-03T02:30:29Z", "PMID": "", "PMCID": "", "ISSN": "0959-4973", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "#nosource" } ], "collections": [ "T9E782TR" ], "relations": {}, "dateAdded": "2012-08-03T02:30:29Z", "dateModified": "2026-03-06T19:05:14Z" } }, { "key": "TSQ7FJIB", "version": 120, "library": { "type": "group", "id": 84313, "name": "Cancer-research", "links": { "alternate": { "href": "https://www.zotero.org/groups/cancer-research", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/84313/items/TSQ7FJIB", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cancer-research/items/TSQ7FJIB", "type": "text/html" } }, "meta": { "createdByUser": { "id": 978552, "username": "tomhodder", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/tomhodder", "type": "text/html" } } }, "creatorSummary": "Trafalis et al.", "parsedDate": "2012", "numChildren": 0 }, "data": { "key": "TSQ7FJIB", "version": 120, "itemType": "journalArticle", "title": "Indications for an alternative effective treatment of head and neck squamous cell carcinoma with temsirolimus plus bevacizumab", "creators": [ { "creatorType": "author", "firstName": "Dimitrios T.", "lastName": "Trafalis" }, { "creatorType": "author", "firstName": "Constantinos", "lastName": "Alifieris" }, { "creatorType": "author", "firstName": "Panayiotis", "lastName": "Dalezis" }, { "creatorType": "author", "firstName": "George", "lastName": "Geromichalos" }, { "creatorType": "author", "firstName": "Nikolaos M.", "lastName": "Sitaras" } ], "abstractNote": "", "publicationTitle": "Anti-Cancer Drugs", "publisher": "", "place": "", "date": "09/2012", "volume": "23", "issue": "8", "section": "", "partNumber": "", "partTitle": "", "pages": "874-882", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1097/CAD.0b013e3283538c3d", "citationKey": "", "url": "http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00001813-201209000-00011", "accessDate": "2012-08-03T02:30:29Z", "PMID": "", "PMCID": "", "ISSN": "0959-4973", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "#nosource" } ], "collections": [ "T9E782TR" ], "relations": {}, "dateAdded": "2012-08-03T02:30:29Z", "dateModified": "2026-03-06T19:05:14Z" } }, { "key": "NPPCZPR5", "version": 120, "library": { "type": "group", "id": 84313, "name": "Cancer-research", "links": { "alternate": { "href": "https://www.zotero.org/groups/cancer-research", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/84313/items/NPPCZPR5", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cancer-research/items/NPPCZPR5", "type": "text/html" } }, "meta": { "createdByUser": { "id": 978552, "username": "tomhodder", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/tomhodder", "type": "text/html" } } }, "creatorSummary": "Baker", "parsedDate": "2012-08-01", "numChildren": 0 }, "data": { "key": "NPPCZPR5", "version": 120, "itemType": "journalArticle", "title": "Cancer stem cells tracked", "creators": [ { "creatorType": "author", "firstName": "Monya", "lastName": "Baker" } ], "abstractNote": "", "publicationTitle": "Nature", "publisher": "", "place": "", "date": "2012-8-1", "volume": "488", "issue": "7409", "section": "", "partNumber": "", "partTitle": "", "pages": "13-14", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1038/488013a", "citationKey": "", "url": "http://www.nature.com/doifinder/10.1038/488013a", "accessDate": "2012-08-02T12:35:25Z", "PMID": "", "PMCID": "", "ISSN": "0028-0836, 1476-4687", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "#nosource" } ], "collections": [ "HIJ7ZJ3H" ], "relations": {}, "dateAdded": "2012-08-02T12:35:25Z", "dateModified": "2026-03-06T19:05:14Z" } }, { "key": "UHR43H45", "version": 120, "library": { "type": "group", "id": 84313, "name": "Cancer-research", "links": { "alternate": { "href": "https://www.zotero.org/groups/cancer-research", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/84313/items/UHR43H45", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cancer-research/items/UHR43H45", "type": "text/html" } }, "meta": { "createdByUser": { "id": 978552, "username": "tomhodder", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/tomhodder", "type": "text/html" } } }, "creatorSummary": "Schepers et al.", "parsedDate": "2012-08-01", "numChildren": 0 }, "data": { "key": "UHR43H45", "version": 120, "itemType": "journalArticle", "title": "Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas", "creators": [ { "creatorType": "author", "firstName": "A. G.", "lastName": "Schepers" }, { "creatorType": "author", "firstName": "H. J.", "lastName": "Snippert" }, { "creatorType": "author", "firstName": "D. E.", "lastName": "Stange" }, { "creatorType": "author", "firstName": "M.", "lastName": "van den Born" }, { "creatorType": "author", "firstName": "J. H.", "lastName": "van Es" }, { "creatorType": "author", "firstName": "M.", "lastName": "van de Wetering" }, { "creatorType": "author", "firstName": "H.", "lastName": "Clevers" } ], "abstractNote": "", "publicationTitle": "Science", "publisher": "", "place": "", "date": "2012-08-01", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1126/science.1224676", "citationKey": "", "url": "http://www.sciencemag.org/cgi/doi/10.1126/science.1224676", "accessDate": "2012-08-02T12:35:25Z", "PMID": "", "PMCID": "", "ISSN": "0036-8075, 1095-9203", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "#nosource" } ], "collections": [ "HIJ7ZJ3H" ], "relations": {}, "dateAdded": "2012-08-02T12:35:25Z", "dateModified": "2026-03-06T19:05:14Z" } }, { "key": "HDASMV9K", "version": 120, "library": { "type": "group", "id": 84313, "name": "Cancer-research", "links": { "alternate": { "href": "https://www.zotero.org/groups/cancer-research", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/84313/items/HDASMV9K", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cancer-research/items/HDASMV9K", "type": "text/html" } }, "meta": { "createdByUser": { "id": 978552, "username": "tomhodder", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/tomhodder", "type": "text/html" } } }, "creatorSummary": "Driessens et al.", "parsedDate": "2012-08-01", "numChildren": 0 }, "data": { "key": "HDASMV9K", "version": 120, "itemType": "journalArticle", "title": "Defining the mode of tumour growth by clonal analysis", "creators": [ { "creatorType": "author", "firstName": "Gregory", "lastName": "Driessens" }, { "creatorType": "author", "firstName": "Benjamin", "lastName": "Beck" }, { "creatorType": "author", "firstName": "Amélie", "lastName": "Caauwe" }, { "creatorType": "author", "firstName": "Benjamin D.", "lastName": "Simons" }, { "creatorType": "author", "firstName": "Cédric", "lastName": "Blanpain" } ], "abstractNote": "", "publicationTitle": "Nature", "publisher": "", "place": "", "date": "2012-8-1", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1038/nature11344", "citationKey": "", "url": "http://www.nature.com/doifinder/10.1038/nature11344", "accessDate": "2012-08-02T12:35:25Z", "PMID": "", "PMCID": "", "ISSN": "0028-0836, 1476-4687", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "#nosource" } ], "collections": [ "HIJ7ZJ3H" ], "relations": {}, "dateAdded": "2012-08-02T12:35:25Z", "dateModified": "2026-03-06T19:05:14Z" } }, { "key": "DNNDDRBV", "version": 120, "library": { "type": "group", "id": 84313, "name": "Cancer-research", "links": { "alternate": { "href": "https://www.zotero.org/groups/cancer-research", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/84313/items/DNNDDRBV", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cancer-research/items/DNNDDRBV", "type": "text/html" } }, "meta": { "createdByUser": { "id": 978552, "username": "tomhodder", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/tomhodder", "type": "text/html" } } }, "creatorSummary": "Chen et al.", "parsedDate": "2012-08-01", "numChildren": 0 }, "data": { "key": "DNNDDRBV", "version": 120, "itemType": "journalArticle", "title": "A restricted cell population propagates glioblastoma growth after chemotherapy", "creators": [ { "creatorType": "author", "firstName": "Jian", "lastName": "Chen" }, { "creatorType": 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Andrew", "lastName": "Futreal" } ], "abstractNote": "Cancers arise owing to the accumulation of mutations in critical genes that alter normal programmes of cell proliferation, differentiation and death. As the first stage of a systematic genome-wide screen for these genes, we have prioritized for analysis signalling pathways in which at least one gene is mutated in human cancer. The RAS–RAF–MEK–ERK–MAP kinase pathway mediates cellular responses to growth signals. RAS is mutated to an oncogenic form in about 15% of human cancer. The three RAF genes code for cytoplasmic serine/threonine kinases that are regulated by binding RAS. Here we report BRAF somatic missense mutations in 66% of malignant melanomas and at lower frequency in a wide range of human cancers. All mutations are within the kinase domain, with a single substitution (V599E) accounting for 80%. Mutated BRAF proteins have elevated kinase activity and are transforming in NIH3T3 cells. Furthermore, RAS function is not required for the growth of cancer cell lines with the V599E mutation. As BRAF is a serine/threonine kinase that is commonly activated by somatic point mutation in human cancer, it may provide new therapeutic opportunities in malignant melanoma.", "publicationTitle": "Nature", "publisher": "", "place": "", "date": "06/9/2002", "volume": "417", "issue": "6892", "section": "", "partNumber": "", "partTitle": "", "pages": "949-954", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1038/nature00766", "citationKey": "", "url": "http://www.nature.com.libezproxy.open.ac.uk/nature/journal/v417/n6892/full/nature00766.html", "accessDate": "2012-08-02T00:28:24Z", "PMID": "", "PMCID": "", "ISSN": "0028-0836", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "www.nature.com.libezproxy.open.ac.uk", "callNumber": "", "rights": "© 2002 Nature Publishing Group", "extra": "", "tags": [ { "tag": "#nosource" }, { "tag": "DNA", "type": 1 }, { "tag": "Nature", "type": 1 }, { "tag": "RNA", "type": 1 }, { "tag": "Signal Transduction", "type": 1 }, { "tag": "astronomy", "type": 1 }, { "tag": "astrophysics", "type": 1 }, { "tag": "biochemistry", "type": 1 }, { "tag": "bioinformatics", "type": 1 }, { "tag": "biology", "type": 1 }, { "tag": "biotechnology", "type": 1 }, { "tag": "cancer", "type": 1 }, { "tag": "cell cycle", "type": 1 }, { "tag": "cell signalling", "type": 1 }, { "tag": "climate change", "type": 1 }, { "tag": "computational biology", "type": 1 }, { "tag": "development", "type": 1 }, { "tag": "developmental biology", "type": 1 }, { "tag": "drug discovery", "type": 1 }, { "tag": "earth science", "type": 1 }, { "tag": "ecology", "type": 1 }, { "tag": "environmental science", "type": 1 }, { "tag": "evolution", "type": 1 }, { "tag": "evolutionary biology", "type": 1 }, { "tag": "functional genomics", "type": 1 }, { "tag": "genetics", "type": 1 }, { "tag": "genomics", "type": 1 }, { "tag": "geophysics", "type": 1 }, { "tag": "immunology", "type": 1 }, { "tag": "interdisciplinary science", "type": 1 }, { "tag": "life", "type": 1 }, { "tag": "marine biology", "type": 1 }, { "tag": "materials science", "type": 1 }, { "tag": "medical research", "type": 1 }, { "tag": "medicine", "type": 1 }, { "tag": "metabolomics", "type": 1 }, { "tag": "molecular biology", "type": 1 }, { "tag": "molecular interactions", "type": 1 }, { "tag": "nanotechnology", "type": 1 }, { "tag": "neurobiology", "type": 1 }, { "tag": "neuroscience", "type": 1 }, { "tag": "palaeobiology", "type": 1 }, { "tag": "pharmacology", "type": 1 }, { "tag": "physics", "type": 1 }, { "tag": "proteomics", "type": 1 }, { "tag": "quantum physics", "type": 1 }, { "tag": "science", "type": 1 }, { "tag": "science news", "type": 1 }, { "tag": "science policy", "type": 1 }, { "tag": "structural biology", "type": 1 }, { "tag": "systems biology", "type": 1 }, { "tag": "transcriptomics", "type": 1 } ], "collections": [ "HDW365WC" ], "relations": {}, "dateAdded": "2012-08-02T00:28:24Z", "dateModified": "2026-03-06T19:05:14Z" } }, { "key": "TWHUVWU6", "version": 120, "library": { "type": "group", "id": 84313, "name": "Cancer-research", "links": { "alternate": { "href": "https://www.zotero.org/groups/cancer-research", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/84313/items/TWHUVWU6", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cancer-research/items/TWHUVWU6", "type": "text/html" } }, "meta": { "createdByUser": { "id": 978552, "username": "tomhodder", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/tomhodder", "type": "text/html" } } }, "creatorSummary": "Tiacci et al.", "parsedDate": "2011-06-16", "numChildren": 1 }, "data": { "key": "TWHUVWU6", "version": 120, "itemType": "journalArticle", "title": "BRAF Mutations in Hairy-Cell Leukemia", "creators": [ { "creatorType": "author", "firstName": "Enrico", "lastName": "Tiacci" }, { "creatorType": "author", "firstName": "Vladimir", "lastName": "Trifonov" }, { "creatorType": "author", "firstName": "Gianluca", "lastName": "Schiavoni" }, { "creatorType": "author", "firstName": "Antony", "lastName": "Holmes" }, { "creatorType": "author", "firstName": "Wolfgang", "lastName": "Kern" }, { "creatorType": "author", "firstName": "Maria Paola", "lastName": "Martelli" }, { "creatorType": "author", "firstName": "Alessandra", "lastName": "Pucciarini" }, { "creatorType": "author", "firstName": "Barbara", "lastName": "Bigerna" }, { "creatorType": "author", "firstName": "Roberta", "lastName": "Pacini" }, { "creatorType": "author", "firstName": "Victoria A.", "lastName": "Wells" }, { "creatorType": "author", "firstName": "Paolo", "lastName": "Sportoletti" }, { "creatorType": "author", "firstName": "Valentina", "lastName": "Pettirossi" }, { "creatorType": "author", "firstName": "Roberta", "lastName": "Mannucci" }, { "creatorType": "author", "firstName": "Oliver", "lastName": "Elliott" }, { "creatorType": "author", "firstName": "Arcangelo", "lastName": "Liso" }, { "creatorType": "author", "firstName": "Achille", "lastName": "Ambrosetti" }, { "creatorType": "author", "firstName": "Alessandro", "lastName": "Pulsoni" }, { "creatorType": "author", "firstName": "Francesco", "lastName": "Forconi" }, { "creatorType": "author", "firstName": "Livio", "lastName": "Trentin" }, { "creatorType": "author", "firstName": "Gianpietro", "lastName": "Semenzato" }, { "creatorType": "author", "firstName": "Giorgio", "lastName": "Inghirami" }, { "creatorType": "author", "firstName": "Monia", "lastName": "Capponi" }, { "creatorType": "author", "firstName": "Francesco", "lastName": "Di Raimondo" }, { "creatorType": "author", "firstName": "Caterina", "lastName": "Patti" }, { "creatorType": "author", "firstName": "Luca", "lastName": "Arcaini" }, { "creatorType": "author", "firstName": "Pellegrino", "lastName": "Musto" }, { "creatorType": "author", "firstName": "Stefano", "lastName": "Pileri" }, { "creatorType": "author", "firstName": "Claudia", "lastName": "Haferlach" }, { "creatorType": "author", "firstName": "Susanne", "lastName": "Schnittger" }, { "creatorType": "author", "firstName": "Giovanni", "lastName": "Pizzolo" }, { "creatorType": "author", "firstName": "Robin", "lastName": "Foà" }, { "creatorType": "author", "firstName": "Laurent", "lastName": "Farinelli" }, { "creatorType": "author", "firstName": "Torsten", "lastName": "Haferlach" }, { "creatorType": "author", "firstName": "Laura", "lastName": "Pasqualucci" }, { "creatorType": "author", "firstName": "Raul", "lastName": "Rabadan" }, { "creatorType": "author", "firstName": "Brunangelo", "lastName": "Falini" } ], "abstractNote": "", "publicationTitle": "New England Journal of Medicine", "publisher": "", "place": "", "date": "2011-06-16", "volume": "364", "issue": "24", "section": "", "partNumber": "", "partTitle": "", "pages": "2305-2315", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1056/NEJMoa1014209", "citationKey": "", "url": "http://www.nejm.org/doi/full/10.1056/NEJMoa1014209", "accessDate": "2012-08-01T23:56:55Z", "PMID": "", "PMCID": "", "ISSN": "0028-4793, 1533-4406", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "#nosource" } ], "collections": [ "KMMRHKK3" ], "relations": {}, "dateAdded": "2012-08-01T23:56:55Z", "dateModified": "2026-03-06T19:05:14Z" } }, { "key": "VT56DPXC", "version": 119, "library": { "type": "group", "id": 84313, "name": "Cancer-research", "links": { "alternate": { "href": "https://www.zotero.org/groups/cancer-research", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/84313/items/VT56DPXC", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cancer-research/items/VT56DPXC", "type": "text/html" } }, "meta": { "createdByUser": { "id": 978552, "username": "tomhodder", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/tomhodder", "type": "text/html" } } }, "creatorSummary": "Schindler et al.", "parsedDate": "2011-03", "numChildren": 0 }, "data": { "key": "VT56DPXC", "version": 119, "itemType": "journalArticle", "title": "Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma", "creators": [ { "creatorType": "author", "firstName": "Genevieve", "lastName": "Schindler" }, { "creatorType": "author", "firstName": "David", "lastName": "Capper" }, { "creatorType": "author", "firstName": "Jochen", "lastName": "Meyer" }, { "creatorType": "author", "firstName": "Wibke", "lastName": "Janzarik" }, { "creatorType": "author", "firstName": "Heymut", "lastName": "Omran" }, { "creatorType": "author", "firstName": "Christel", "lastName": "Herold-Mende" }, { "creatorType": "author", "firstName": "Kirsten", "lastName": "Schmieder" }, { "creatorType": "author", "firstName": "Pieter", "lastName": "Wesseling" }, { "creatorType": "author", "firstName": "Christian", "lastName": "Mawrin" }, { "creatorType": "author", "firstName": "Martin", "lastName": "Hasselblatt" }, { "creatorType": "author", "firstName": "David N", "lastName": "Louis" }, { "creatorType": "author", "firstName": "Andrey", "lastName": "Korshunov" }, { "creatorType": "author", "firstName": "Stefan", "lastName": "Pfister" }, { "creatorType": "author", "firstName": "Christian", "lastName": "Hartmann" }, { "creatorType": "author", "firstName": "Werner", "lastName": "Paulus" }, { "creatorType": "author", "firstName": "Guido", "lastName": "Reifenberger" }, { "creatorType": "author", "firstName": "Andreas", "lastName": "von Deimling" } ], "abstractNote": "Missense mutations of the V600E type constitute the vast majority of tumor-associated somatic alterations in the v-RAF murine sarcoma viral oncogene homolog B1 (BRAF) gene. Initially described in melanoma, colon and papillary thyroid carcinoma, these alterations have also been observed in primary nervous system tumors albeit at a low frequency. We analyzed exon 15 of BRAF spanning the V600 locus by direct sequencing in 1,320 adult and pediatric tumors of the nervous system including various types of glial, embryonal, neuronal and glioneuronal, meningeal, adenohypophyseal/sellar, and peripheral nervous system tumors. A total of 96 BRAF mutations were detected; 93 of the V600E type and 3 cases with a three base pair insertion between codons 599 and 600. The highest frequencies of BRAF (V600E) mutations were found in WHO grade II pleomorphic xanthoastrocytomas (42/64; 66%) and pleomorphic xanthoastrocytomas with anaplasia (15/23; 65%), as well as WHO grade I gangliogliomas (14/77; 18%), WHO grade III anaplastic gangliogliomas (3/6) and pilocytic astrocytomas (9/97; 9%). In pilocytic astrocytomas BRAF (V600E) mutation was strongly associated with extra-cerebellar location (p = 0.009) and was most frequent in diencephalic tumors (4/12; 33%). Glioblastomas and other gliomas were characterized by a low frequency or absence of mutations. No mutations were detected in non-glial tumors, including embryonal tumors, meningiomas, nerve sheath tumors and pituitary adenomas. The high mutation frequencies in pleomorphic xanthoastrocytomas, gangliogliomas and extra-cerebellar pilocytic astrocytomas implicate BRAF (V600E) mutation as a valuable diagnostic marker for these rare tumor entities. Future clinical trials should address whether BRAF (V600E) mutant brain tumor patients will benefit from BRAF (V600E)-directed targeted therapies.", "publicationTitle": "Acta neuropathologica", "publisher": "", "place": "", "date": "Mar 2011", "volume": "121", "issue": "3", "section": "", "partNumber": "", "partTitle": "", "pages": "397-405", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Acta Neuropathol.", "DOI": "10.1007/s00401-011-0802-6", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/21274720", "accessDate": "2012-08-05T01:14:20Z", "PMID": "21274720", "PMCID": "", "ISSN": "1432-0533", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "#nosource" }, { "tag": "Adolescent", "type": 1 }, { "tag": "Adult", "type": 1 }, { "tag": "Astrocytoma", "type": 1 }, { "tag": "Brain Neoplasms", "type": 1 }, { "tag": "Child", "type": 1 }, { "tag": "Child, Preschool", "type": 1 }, { "tag": "Exons", "type": 1 }, { "tag": "Ganglioglioma", "type": 1 }, { "tag": "Gene Frequency", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Mutation, Missense", "type": 1 }, { "tag": "Nervous System Neoplasms", "type": 1 }, { "tag": "Proto-Oncogene Proteins B-raf", "type": 1 }, { "tag": "Retrospective Studies", "type": 1 }, { "tag": "Signal Transduction", "type": 1 }, { "tag": "World Health Organization", "type": 1 }, { "tag": "Young Adult", "type": 1 } ], "collections": [ "6BGQPPJ6" ], "relations": {}, "dateAdded": "2012-08-05T01:14:20Z", "dateModified": "2026-03-06T19:05:14Z" } }, { "key": "FTS5DTX9", "version": 119, "library": { "type": "group", "id": 84313, "name": "Cancer-research", "links": { "alternate": { "href": "https://www.zotero.org/groups/cancer-research", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/84313/items/FTS5DTX9", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cancer-research/items/FTS5DTX9", "type": "text/html" } }, "meta": { "createdByUser": { "id": 978552, "username": "tomhodder", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/tomhodder", "type": "text/html" } } }, "creatorSummary": "Arcaini et al.", "parsedDate": "2011-11-09", "numChildren": 2 }, "data": { "key": "FTS5DTX9", "version": 119, "itemType": "journalArticle", "title": "The BRAF V600E mutation in hairy cell leukemia and other mature B-cell neoplasms", "creators": [ { "creatorType": "author", "firstName": "Luca", "lastName": "Arcaini" }, { "creatorType": "author", "firstName": "Silvia", "lastName": "Zibellini" }, { "creatorType": "author", "firstName": "Emanuela", "lastName": "Boveri" }, { "creatorType": "author", "firstName": "Roberta", "lastName": "Riboni" }, { "creatorType": "author", "firstName": "Sara", "lastName": "Rattotti" }, { "creatorType": "author", "firstName": "Marzia", "lastName": "Varettoni" }, { "creatorType": "author", "firstName": "Maria Luisa", "lastName": "Guerrera" }, { "creatorType": "author", "firstName": "Marco", "lastName": "Lucioni" }, { "creatorType": "author", "firstName": "Annamaria", "lastName": "Tenore" }, { "creatorType": "author", "firstName": "Michele", "lastName": "Merli" }, { "creatorType": "author", "firstName": "Silvia", "lastName": "Rizzi" }, { "creatorType": "author", "firstName": "Lucia", "lastName": "Morello" }, { "creatorType": "author", "firstName": "Chiara", "lastName": "Cavalloni" }, { "creatorType": "author", "firstName": "Matteo C. Da", "lastName": "Vià" }, { "creatorType": "author", "firstName": "Marco", "lastName": "Paulli" }, { "creatorType": "author", "firstName": "Mario", "lastName": "Cazzola" } ], "abstractNote": "The somatically acquired V600E mutation of the BRAF gene has been recently described as a molecular marker of hairy cell leukemia (HCL). We developed an allele-specific PCR for this mutation, and studied 62 patients with HCL, one with HCL variant, 91 with splenic marginal zone lymphoma, 29 with Waldenström macroglobulinemia, and 57 with B-cell chronic lymphoproliferative disorders. The BRAF V600E mutation was detected in all HCL cases, and in only two of the remaining 178 patients. These two subjects had a B-cell chronic lymphoproliferative disorders that did not fulfill the diagnostic criteria for HCL. Despite the PCR positivity, the mutation could not be detected by Sanger sequencing in these two cases, suggesting that it was associated with a small subclone. We conclude that the BRAF V600E mutation is present in all HCL patients and that, in combination with clinical and morphological features, represents a reliable molecular marker for this condition.", "publicationTitle": "Blood", "publisher": "", "place": "", "date": "2011-11-09", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Blood", "DOI": "10.1182/blood-2011-08-368209", "citationKey": "", "url": "http://bloodjournal.hematologylibrary.org/content/early/2011/11/08/blood-2011-08-368209", "accessDate": "2012-08-05T01:14:40Z", "PMID": "", "PMCID": "", "ISSN": "0006-4971, 1528-0020", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "bloodjournal.hematologylibrary.org", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "#nosource" } ], "collections": [ "6BGQPPJ6" ], "relations": {}, "dateAdded": "2012-08-05T01:14:40Z", "dateModified": "2026-03-06T19:05:14Z" } }, { "key": "IQKMNA87", "version": 119, "library": { "type": "group", "id": 84313, "name": "Cancer-research", "links": { "alternate": { "href": "https://www.zotero.org/groups/cancer-research", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/84313/items/IQKMNA87", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cancer-research/items/IQKMNA87", "type": "text/html" } }, "meta": { "createdByUser": { "id": 978552, "username": "tomhodder", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/tomhodder", "type": "text/html" } } }, "creatorSummary": "Frasca et al.", "parsedDate": "2008-03", "numChildren": 0 }, "data": { "key": "IQKMNA87", "version": 119, "itemType": "journalArticle", "title": "BRAF(V600E) mutation and the biology of papillary thyroid cancer", "creators": [ { "creatorType": "author", "firstName": "F", "lastName": "Frasca" }, { "creatorType": "author", "firstName": "C", "lastName": "Nucera" }, { "creatorType": "author", "firstName": "G", "lastName": "Pellegriti" }, { "creatorType": "author", "firstName": "P", "lastName": "Gangemi" }, { "creatorType": "author", "firstName": "M", "lastName": "Attard" }, { "creatorType": "author", "firstName": "M", "lastName": "Stella" }, { "creatorType": "author", "firstName": "M", "lastName": "Loda" }, { "creatorType": "author", "firstName": "V", "lastName": "Vella" }, { "creatorType": "author", "firstName": "C", "lastName": "Giordano" }, { "creatorType": "author", "firstName": "F", "lastName": "Trimarchi" }, { "creatorType": "author", "firstName": "E", "lastName": "Mazzon" }, { "creatorType": "author", "firstName": "A", "lastName": "Belfiore" }, { "creatorType": "author", "firstName": "R", "lastName": "Vigneri" } ], "abstractNote": "BRAF((V600E)) mutation is the most frequent genetic alteration in papillary thyroid carcinomas (PTCs) that are 80-90% of all thyroid cancers. We evaluated the relationship between BRAF((V600E)) and tumor, host, and environmental factors in PTCs from all geographical areas of Sicily. By PCR, BRAF((V600E)) was investigated in a series of 323 PTCs diagnosed in 2002-2005. The correlation between clinicopathological tumor, host, and environmental characteristics and the presence of BRAF((V600E)) were evaluated by both univariate and multivariate analyses. BRAF((V600E)) was found in 38.6% PTCs, with a 52% frequency in the classical PTCs and 26.4% in the tall cell variant. Univariate analysis indicated that BRAF((V600E)) was associated with greater tumor size (P=0.0048), extra-thyroid invasion (P<0.0001), and cervical lymph nodal metastases (P=0.0001). Multivariate logistic regression analysis confirmed that BRAF((V600E)) was an independent predictor of extra-thyroid invasion (P=0.0001) and cervical lymph nodal metastasis (P=0.0005). The association between BRAF((V600E)) and extra-thyroid invasion was also found in micro-PTCs (P=0.006). In 60 classical PTCs, BRAF((V600E)) was positively correlated with matrix metalloproteinase-9 expression (P=0.0047), suggesting a possible mechanism for BRAF((V600E)) effect on PTC invasiveness. No association was found between BRAF((V600E)) and patient age, gender, or iodine intake. In contrast, a strong association was found with residency in Eastern Sicily (P<0.0001 compared with Western Sicily). These results indicate that BRAF((V600E)) mutation is a marker of aggressive disease in both micro- and macro-PTCs. Moreover, for the first time, a possible link between BRAF((V600E)) mutation and environmental carcinogens is suggested.", "publicationTitle": "Endocrine-related cancer", "publisher": "", "place": "", "date": "Mar 2008", "volume": "15", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "191-205", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Endocr. Relat. 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M.", "lastName": "Brown" }, { "creatorType": "author", "firstName": "L.", "lastName": "Zhang" }, { "creatorType": "author", "firstName": "J.-y.", "lastName": "Li" }, { "creatorType": "author", "firstName": "M.-l.", "lastName": "Jin" }, { "creatorType": "author", "firstName": "Y.-s.", "lastName": "Chang" }, { "creatorType": "author", "firstName": "J.-l.", "lastName": "Ma" }, { "creatorType": "author", "firstName": "K.-f.", "lastName": "Pan" }, { "creatorType": "author", "firstName": "W.-d.", "lastName": "Liu" }, { "creatorType": "author", "firstName": "Y.", "lastName": "Hu" }, { "creatorType": "author", "firstName": "S.", "lastName": "Crystal-Mansour" }, { "creatorType": "author", "firstName": "D.", "lastName": "Pee" }, { "creatorType": "author", "firstName": "W. J.", "lastName": "Blot" }, { "creatorType": "author", "firstName": "J. F.", "lastName": "Fraumeni" }, { "creatorType": "author", "firstName": "G.-w.", "lastName": "Xu" }, { "creatorType": "author", "firstName": "M. 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Only 5–10% of all cancer cases can be attributed to genetic defects, whereas the remaining 90–95% have their roots in the environment and lifestyle. The lifestyle factors include cigarette smoking, diet (fried foods, red meat), alcohol, sun exposure, environmental pollutants, infections, stress, obesity, and physical inactivity. The evidence indicates that of all cancer-related deaths, almost 25–30% are due to tobacco, as many as 30–35% are linked to diet, about 15–20% are due to infections, and the remaining percentage are due to other factors like radiation, stress, physical activity, environmental pollutants etc. Therefore, cancer prevention requires smoking cessation, increased ingestion of fruits and vegetables, moderate use of alcohol, caloric restriction, exercise, avoidance of direct exposure to sunlight, minimal meat consumption, use of whole grains, use of vaccinations, and regular check-ups. In this review, we present evidence that inflammation is the link between the agents/factors that cause cancer and the agents that prevent it. In addition, we provide evidence that cancer is a preventable disease that requires major lifestyle changes.", "publicationTitle": "Pharmaceutical Research", "publisher": "", "place": "", "date": "2008-9", "volume": "25", "issue": "9", "section": "", "partNumber": "", "partTitle": "", "pages": "2097-2116", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Pharm Res", "DOI": "10.1007/s11095-008-9661-9", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515569/", "accessDate": "2012-08-04T17:00:34Z", "PMID": "18626751", "PMCID": "PMC2515569", "ISSN": "0724-8741", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "PubMed Central", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "#nosource" } ], "collections": [ "J8XB9H35" ], "relations": {}, "dateAdded": "2012-08-04T17:00:34Z", "dateModified": "2026-03-06T19:05:14Z" } }, { "key": "9SW5STZM", "version": 119, "library": { "type": "group", "id": 84313, "name": "Cancer-research", "links": { "alternate": { "href": "https://www.zotero.org/groups/cancer-research", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/84313/items/9SW5STZM", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cancer-research/items/9SW5STZM", "type": "text/html" } }, "meta": { "createdByUser": { "id": 978552, "username": "tomhodder", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/tomhodder", "type": "text/html" } } }, "creatorSummary": "Blaser", "parsedDate": "2008-06-01", "numChildren": 2 }, "data": { "key": "9SW5STZM", "version": 119, "itemType": "journalArticle", "title": "Understanding Microbe-Induced Cancers", "creators": [ { "creatorType": "author", "firstName": "Martin J.", "lastName": "Blaser" } ], "abstractNote": "Microbes are important causes of human cancers, and our estimation of their significance continues to grow as cancer biology is better dissected. A classification system is proposed that highlights common and proposed microbe-induced pathways toward oncogenesis, with an emphasis on types of targeted cells and host-microbial interactions. The central principlesthat underlie oncogenesis induced by the many diverse microbes and the major mechanisms involved are outlined. The phenomenon of microbe-induced cancers raises a number of important biological questions, the solving of which may inform other fields, including aging and degenerative disorders. Finally, our challenge for the future is to better understand the steps in microbe-induced cancers to optimize both prevention and therapy.", "publicationTitle": "Cancer Prevention Research", "publisher": "", "place": "", "date": "06/01/2008", "volume": "1", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "15-20", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Cancer Prev Res", "DOI": "10.1158/1940-6207.CAPR-08-0024", "citationKey": "", "url": "http://cancerpreventionresearch.aacrjournals.org/content/1/1/15", "accessDate": "2012-08-04T13:09:13Z", "PMID": "", "PMCID": "", "ISSN": "1940-6207, 1940-6215", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "cancerpreventionresearch.aacrjournals.org", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "#nosource" } ], "collections": [ "IDTF273H" ], "relations": {}, "dateAdded": "2012-08-04T13:09:13Z", "dateModified": "2026-03-06T19:05:14Z" } }, { "key": "G2AZUCCJ", "version": 119, "library": { "type": "group", "id": 84313, "name": "Cancer-research", "links": { "alternate": { "href": "https://www.zotero.org/groups/cancer-research", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/84313/items/G2AZUCCJ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cancer-research/items/G2AZUCCJ", "type": "text/html" } }, "meta": { "createdByUser": { "id": 978552, "username": "tomhodder", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/tomhodder", "type": "text/html" } } }, "creatorSummary": "Sen et al.", "parsedDate": "2011-12-21", "numChildren": 1 }, "data": { "key": "G2AZUCCJ", "version": 119, "itemType": "journalArticle", "title": "Signal transducer and activator of transcription 3 (STAT3) and survivin induction by varicella-zoster virus promote replication and skin pathogenesis", "creators": [ { "creatorType": "author", "firstName": "N.", "lastName": "Sen" }, { "creatorType": "author", "firstName": "X.", "lastName": "Che" }, { "creatorType": "author", "firstName": "J.", "lastName": "Rajamani" }, { "creatorType": "author", "firstName": "L.", "lastName": "Zerboni" }, { "creatorType": "author", "firstName": "P.", "lastName": "Sung" }, { "creatorType": "author", "firstName": "J.", "lastName": "Ptacek" }, { "creatorType": "author", "firstName": "A. 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"callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "#nosource" } ], "collections": [ "T9E782TR" ], "relations": {}, "dateAdded": "2012-08-03T02:30:29Z", "dateModified": "2026-03-06T19:05:14Z" } }, { "key": "IGCT64J3", "version": 118, "library": { "type": "group", "id": 84313, "name": "Cancer-research", "links": { "alternate": { "href": "https://www.zotero.org/groups/cancer-research", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/84313/items/IGCT64J3", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cancer-research/items/IGCT64J3", "type": "text/html" } }, "meta": { "createdByUser": { "id": 978552, "username": "tomhodder", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/tomhodder", "type": "text/html" } } }, "creatorSummary": "Pallini et al.", "parsedDate": "2011-01-01", "numChildren": 1 }, "data": { "key": "IGCT64J3", "version": 118, "itemType": "journalArticle", "title": "Expression of the stem cell marker CD133 in recurrent glioblastoma and its value for prognosis", "creators": [ { "creatorType": "author", "firstName": "Roberto", "lastName": "Pallini" }, { "creatorType": "author", "firstName": "Lucia", "lastName": "Ricci-Vitiani" }, { "creatorType": "author", "firstName": "Nicola", "lastName": "Montano" }, { "creatorType": "author", "firstName": "Cristiana", "lastName": "Mollinari" }, { "creatorType": "author", "firstName": "Mauro", "lastName": "Biffoni" }, { "creatorType": "author", "firstName": "Tonia", "lastName": "Cenci" }, { "creatorType": "author", "firstName": "Francesco", "lastName": "Pierconti" }, { "creatorType": "author", "firstName": "Maurizio", "lastName": "Martini" }, { "creatorType": "author", "firstName": "Ruggero", "lastName": "De Maria" }, { "creatorType": "author", "firstName": "Luigi Maria", "lastName": "Larocca" } ], "abstractNote": "", "publicationTitle": "Cancer", "publisher": "", "place": "", "date": "2011-01-01", "volume": "117", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "162-174", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1002/cncr.25581", "citationKey": "", "url": "http://atlasgeneticsoncology.org/Deep/CancerStemCellGliomID20099.html", "accessDate": "2012-08-05T01:22:35Z", "PMID": "", "PMCID": "", "ISSN": "0008543X", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "#nosource" } ], "collections": [ "HIJ7ZJ3H" ], "relations": {}, "dateAdded": "2012-08-05T01:22:35Z", "dateModified": "2026-03-06T19:05:14Z" } }, { "key": "367E79XT", "version": 118, "library": { "type": "group", "id": 84313, "name": "Cancer-research", "links": { "alternate": { "href": "https://www.zotero.org/groups/cancer-research", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/84313/items/367E79XT", "type": 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