[ { "key": "3KCT8Q9V", "version": 31, "library": { "type": "group", "id": 77054, "name": "Matthew Smith's Prenatal Influences on Behavior Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77054/items/3KCT8Q9V", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles/items/3KCT8Q9V", "type": "text/html" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } }, "creatorSummary": "Müller KU et al.", "parsedDate": "2013-08-01", "numChildren": 0 }, "data": { "key": "3KCT8Q9V", "version": 31, "itemType": "journalArticle", "title": "ALtered reward processing in adolescents with prenatal exposure to maternal cigarette smoking", "creators": [ { "creatorType": "author", "name": "Müller KU" }, { "creatorType": "author", "name": "Mennigen E" }, { "creatorType": "author", "name": "Ripke S" }, { "creatorType": "author", "name": "et al" } ], "abstractNote": "Importance \nHigher rates of substance use and dependence have been observed in the offspring of mothers who smoked during pregnancy. Animal studies indicate that prenatal exposure to nicotine alters the development of brain areas related to reward processing, which might be a risk factor for substance use and addiction later in life. However, no study has examined the effect of maternal smoking on the offspring’s brain response during reward processing.Objective\nTo determine whether adolescents with prenatal exposure to maternal cigarette smoking differ from their nonexposed peers in the response of the ventral striatum to the anticipation or the receipt of a reward.Design\nAn observational case-control study.Setting\nData were obtained from the IMAGEN Study, a European multicenter study of impulsivity, reinforcement sensitivity, and emotional reactivity in adolescents. The IMAGEN sample consists of 2078 healthy adolescents (age range, 13-15 years) recruited from March 1, 2008, through December 31, 2011, in local schools.Participants\nWe assessed an IMAGEN subsample of 177 adolescents with prenatal exposure to maternal cigarette smoking and 177 nonexposed peers (age range, 13-15 years) matched by sex, maternal educational level, and imaging site.Main Outcome and Measure\nResponse to reward in the ventral striatum measured with functional magnetic resonance imaging.Results\nIn prenatally exposed adolescents, we observed a weaker response in the ventral striatum during reward anticipation (left side, F = 14.98 [P < .001]; right side, F = 15.95 [P < .001]) compared with their nonexposed peers. No differences were found regarding the responsivity of the ventral striatum to the receipt of a reward (left side, F = 0.21 [P = .65]; right side, F = 0.47 [P = .49]).Conclusions\nThe weaker responsivity of the ventral striatum to reward anticipation in prenatally exposed adolescents may represent a risk factor for substance use and development of addiction later in life. This result highlights the need for education and preventive measures to reduce smoking during pregnancy. Future analyses should assess whether prenatally exposed adolescents develop an increased risk for substance use and addiction and which role the reported neuronal differences during reward anticipation plays in this development.", "publicationTitle": "JAMA Psychiatry", "publisher": "", "place": "", "date": "August 1, 2013", "volume": "70", "issue": "8", "section": "", "partNumber": "", "partTitle": "", "pages": "847-856", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "JAMA Psychiatry", "DOI": "10.1001/jamapsychiatry.2013.44", "citationKey": "", "url": "http://dx.doi.org/10.1001/jamapsychiatry.2013.44", "accessDate": "2013-11-17T22:36:31Z", "PMID": "", "PMCID": "", "ISSN": "2168-622X", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "Silverchair", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-02-02T01:03:10Z", "dateModified": "2014-02-02T01:03:10Z" } }, { "key": "I2D5WHHE", "version": 30, "library": { "type": "group", "id": 77054, "name": "Matthew Smith's Prenatal Influences on Behavior Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77054/items/I2D5WHHE", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles/items/I2D5WHHE", "type": "text/html" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } }, "creatorSummary": "Kesmodel et al.", "parsedDate": "2013", "numChildren": 0 }, "data": { "key": "I2D5WHHE", "version": 30, "itemType": "journalArticle", "title": "Does Binge Drinking During Early Pregnancy Increase the Risk of Psychomotor Deficits?", "creators": [ { "creatorType": "author", "firstName": "Ulrik Schiøler", "lastName": "Kesmodel" }, { "creatorType": "author", "firstName": "Bjørn", "lastName": "Bay" }, { "creatorType": "author", "firstName": "Theresa", "lastName": "Wimberley" }, { "creatorType": "author", "firstName": "Hanne-Lise F.", "lastName": "Eriksen" }, { "creatorType": "author", "firstName": "Erik Lykke", "lastName": "Mortensen" } ], "abstractNote": "Background The potential effects of binge drinking during pregnancy on child motor function have only been assessed in a few, small studies. We aimed to examine the effects of binge alcohol consumption during early pregnancy, including number of binge episodes and timing of binge drinking, on child motor function at age 5. Methods We performed a prospective follow-up study of 678 women and their children sampled from the Danish National Birth Cohort based on maternal alcohol consumption during pregnancy. At 5 years of age, the children were tested with the Movement Assessment Battery for Children. Parental education, maternal IQ, prenatal maternal smoking, the child's age at testing, sex of child, and tester were considered core confounders, while the full model also controlled for prenatal maternal average alcohol intake, maternal age and prepregnancy body mass index, parity, home environment, postnatal parental smoking, health status, participation in organized sport, and indicators for hearing and vision impairment. Results There were no systematic or significant differences in motor function between children of mothers reporting isolated episodes of binge drinking and children of mothers with no binge episodes. No association was observed with respect to the number of binge episodes (maximum of 12) and timing of binge drinking. Conclusions In this study, we found no systematic association between isolated episodes of binge drinking during early pregnancy and child motor function at age 5.", "publicationTitle": "Alcoholism: Clinical and Experimental Research", "publisher": "", "place": "", "date": "2013", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "n/a–n/a", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1111/acer.12072", "citationKey": "", "url": "http://onlinelibrary.wiley.com/doi/10.1111/acer.12072/abstract", "accessDate": "2013-02-18T15:12:44Z", "PMID": "", "PMCID": "", "ISSN": "1530-0277", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "Wiley Online Library", "callNumber": "", "rights": "Copyright © 2013 by the Research Society on Alcoholism", "extra": "", "tags": [ { "tag": "Binge Drinking", "type": 1 }, { "tag": "Low–Moderate Alcohol Consumption", "type": 1 }, { "tag": "Motor Function", "type": 1 }, { "tag": "Prenatal Exposures", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2014-02-01T02:08:13Z", "dateModified": "2014-02-01T02:08:13Z" } }, { "key": "FWGQIM4C", "version": 32, "library": { "type": "group", "id": 77054, "name": "Matthew Smith's Prenatal Influences on Behavior Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77054/items/FWGQIM4C", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles/items/FWGQIM4C", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/77054/items/JW7G6JXW", "type": "application/json" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. 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Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } }, "creatorSummary": "Chaudron", "parsedDate": "2013-01-01", "numChildren": 1 }, "data": { "key": "U2ZF4384", "version": 28, "itemType": "journalArticle", "title": "Complex challenges in treating depression during pregnancy", "creators": [ { "creatorType": "author", "firstName": "Linda H", "lastName": "Chaudron" } ], "abstractNote": "The treatment of depression during pregnancy can be challenging for patients and providers alike. An increasing attention to perinatal mood disorders has led to an expanding literature that is often difficult for providers to navigate. It can be a challenge for providers to feel comfortable reviewing the broad scope of the risks and benefits of treatments in the context of the limitations of the literature. Women who are depressed during pregnancy have been found to have an elevated risk of poor obstetrical outcomes, although studies of the relationship between depression and outcomes are limited. Women who are treated with antidepressants during pregnancy are also at risk for a host of poor obstetrical and fetal outcomes. The risks for these outcomes are often confused by confounding factors and study design limitations. Understanding the current data and their limitations will allow providers to guide their patients in choosing treatment options. Consistent and simple strategies should be used when discussing the risk-benefit analysis with the patient.", "publicationTitle": "The American journal of psychiatry", "publisher": "", "place": "", "date": "Jan 1, 2013", "volume": "170", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "12-20", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Am J Psychiatry", "DOI": "10.1176/appi.ajp.2012.12040440", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1535-7228", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 23288385", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-02-14T20:40:26Z", "dateModified": "2013-02-14T20:40:26Z" } }, { "key": "HWEEXEMN", "version": 1, "library": { "type": "group", "id": 77054, "name": "Matthew Smith's Prenatal Influences on Behavior Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77054/items/HWEEXEMN", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles/items/HWEEXEMN", "type": "text/html" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } }, "creatorSummary": "Fernandes et al.", "parsedDate": "2012-12-01", "numChildren": 0 }, "data": { "key": "HWEEXEMN", "version": 1, "itemType": "journalArticle", "title": "Prenatal exposure to maternal obesity leads to hyperactivity in offspring", "creators": [ { "creatorType": "author", "firstName": "C.", "lastName": "Fernandes" }, { "creatorType": "author", "firstName": "H.", "lastName": "Grayton" }, { "creatorType": "author", "firstName": "L.", "lastName": "Poston" }, { "creatorType": "author", "firstName": "A.-M.", "lastName": "Samuelsson" }, { "creatorType": "author", "firstName": "P. D.", "lastName": "Taylor" }, { "creatorType": "author", "firstName": "D. A.", "lastName": "Collier" }, { "creatorType": "author", "firstName": "A.", "lastName": "Rodriguez" } ], "abstractNote": "Epidemiological findings show that maternal overweight or obesity at the time of pregnancy is associated with an increase in risk of child neurobehavioral disturbances, including attention deficit hyperactivity disorder (ADHD) symptoms and emotional problems.1, 2 However, these studies leave the question of causality unanswered.", "publicationTitle": "Molecular Psychiatry", "publisher": "", "place": "", "date": "12/01/2012", "volume": "17", "issue": "12", "section": "", "partNumber": "", "partTitle": "", "pages": "1159-1160", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1038/mp.2011.164", "citationKey": "", "url": "http://www.nature.com/mp/journal/v17/n12/full/mp2011164a.html", "accessDate": "2012-12-01T21:10:18Z", "PMID": "", "PMCID": "", "ISSN": "1359-4184", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "www.nature.com", "callNumber": "", "rights": "© 2011 Nature Publishing Group", "extra": "", "tags": [ { "tag": "addictive disorders", "type": 1 }, { "tag": "alzheimer's disease", "type": 1 }, { "tag": "behavioral medicine", "type": 1 }, { "tag": "dementia", "type": 1 }, { "tag": "psychiatric disorders", "type": 1 }, { "tag": "psychopharmacology", "type": 1 }, { "tag": "schizophrenia", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2012-12-03T16:14:52Z", "dateModified": "2012-12-03T16:14:52Z" } }, { "key": "VZ4PZJXZ", "version": 33, "library": { "type": "group", "id": 77054, "name": "Matthew Smith's Prenatal Influences on Behavior Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77054/items/VZ4PZJXZ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles/items/VZ4PZJXZ", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/77054/items/TU9N5SR7", "type": "application/json" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. 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Kim", "lastName": "Penberthy" } ], "abstractNote": "", "publicationTitle": "Journal of Substance Abuse Treatment", "publisher": "", "place": "", "date": "11/2012", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1016/j.jsat.2012.10.001", "citationKey": "", "url": "http://www.journalofsubstanceabusetreatment.com/article/PIIS0740547212004175/abstract?rss=yes", "accessDate": "2012-11-29T15:53:11Z", "PMID": "", "PMCID": "", "ISSN": "07405472", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2012-11-29T23:05:29Z", "dateModified": "2012-11-29T23:05:29Z" } }, { "key": "UGSE34AW", "version": 33, "library": { "type": "group", "id": 77054, "name": "Matthew Smith's Prenatal Influences on Behavior Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77054/items/UGSE34AW", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles/items/UGSE34AW", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/77054/items/K9TTQQFQ", "type": "application/json" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. 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Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } }, "numChildren": 1 }, "data": { "key": "H9GUC8FE", "version": 1, "itemType": "webpage", "title": "Depression During Pregnancy Linked to Future Mental Health Problems for Mom | Psych Central News", "creators": [], "abstractNote": "", "websiteTitle": "", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://psychcentral.com/news/2012/11/13/depression-during-pregnancy-linked-to-future-mental-health-problems-for-mom/47550.html", "accessDate": "2012-11-14T22:56:31Z", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2012-11-16T00:21:37Z", "dateModified": "2012-11-16T00:21:37Z" } }, { "key": "9ERPB4EQ", "version": 1, "library": { "type": "group", "id": 77054, "name": "Matthew Smith's Prenatal Influences on Behavior Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77054/items/9ERPB4EQ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles/items/9ERPB4EQ", "type": "text/html" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } }, "creatorSummary": "Hepper et al.", "parsedDate": "2012-09-14", "numChildren": 0 }, "data": { "key": "9ERPB4EQ", "version": 1, "itemType": "journalArticle", "title": "Fetal Brain Function in Response to Maternal Alcohol Consumption: Early Evidence of Damage", "creators": [ { "creatorType": "author", "firstName": "Peter G", "lastName": "Hepper" }, { "creatorType": "author", "firstName": "James C", "lastName": "Dornan" }, { "creatorType": "author", "firstName": "Catherine", "lastName": "Lynch" } ], "abstractNote": "BACKGROUND: Studies of the adverse neurobehavioral effects of maternal alcohol consumption on the fetus have been largely confined to the postnatal period, after exposure to alcohol has finished. This study explored the brain function of the fetus, at the time of exposure to alcohol, to examine its effect on information processing and stability of performance. METHODS: Five groups of fetuses, defined by maternal alcohol consumption patterns, were examined: control (no alcohol); moderate (5 to 10 units/wk either drunk evenly across the week or as a binge, in 2 to 3 days); heavy (20+ units/wk drunk evenly or as a binge). Fetal habituation performance was examined on 3 occasions, separated by 7 days, beginning at 35 weeks of gestation. The number of trials required to habituate on each test session and the difference in performance across test sessions were recorded. RESULTS: Fetuses exposed to heavy binge drinking required significantly more trials to habituate and exhibited a greater variability in performance across all test sessions than the other groups. Maternal drinking, either heavily but evenly or moderately as a binge, resulted in poorer habituation, and moderate binge drinking resulted in greater variability compared with no, or even, drinking. CONCLUSIONS: Decreased information processing, reflected by poorer habituation, and increased variability in performance may reflect the initial manifestations of structural damage caused by alcohol to the brain. These results will lead to a greater understanding of the effects of alcohol on the fetus's brain, enable the antenatal identification of fetal alcohol spectrum disorders, and lead to the early implementation of better management strategies.", "publicationTitle": "Alcoholism, clinical and experimental research", "publisher": "", "place": "", "date": "Sep 14, 2012", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Alcohol. Clin. Exp. Res.", "DOI": "10.1111/j.1530-0277.2012.01832.x", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/22978459", "accessDate": "2012-09-18T16:39:50Z", "PMID": "", "PMCID": "", "ISSN": "1530-0277", "archive": "", "archiveLocation": "", "shortTitle": "Fetal Brain Function in Response to Maternal Alcohol Consumption", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 22978459", "tags": [], "collections": [], "relations": {}, "dateAdded": "2012-09-18T18:05:18Z", "dateModified": "2012-09-18T18:05:18Z" } }, { "key": "698EFWPT", "version": 1, "library": { "type": "group", "id": 77054, "name": "Matthew Smith's Prenatal Influences on Behavior Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77054/items/698EFWPT", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles/items/698EFWPT", "type": "text/html" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } }, "creatorSummary": "Ware et al.", "parsedDate": "2012-09-13", "numChildren": 0 }, "data": { "key": "698EFWPT", "version": 1, "itemType": "journalArticle", "title": "The Effects of Prenatal Alcohol Exposure and Attention-Deficit/Hyperactivity Disorder on Psychopathology and Behavior", "creators": [ { "creatorType": "author", "firstName": "Ashley L", "lastName": "Ware" }, { "creatorType": "author", "firstName": "Jessica W", "lastName": "O'Brien" }, { "creatorType": "author", "firstName": "Nicole", "lastName": "Crocker" }, { "creatorType": "author", "firstName": "Benjamin N", "lastName": "Deweese" }, { "creatorType": "author", "firstName": "Scott C", "lastName": "Roesch" }, { "creatorType": "author", "firstName": "Claire D", "lastName": "Coles" }, { "creatorType": "author", "firstName": "Julie A", "lastName": "Kable" }, { "creatorType": "author", "firstName": "Philip A", "lastName": "May" }, { "creatorType": "author", "firstName": "Wendy O", "lastName": "Kalberg" }, { "creatorType": "author", "firstName": "Elizabeth R", "lastName": "Sowell" }, { "creatorType": "author", "firstName": "Kenneth Lyons", "lastName": "Jones" }, { "creatorType": "author", "firstName": "Edward P", "lastName": "Riley" }, { "creatorType": "author", "firstName": "Sarah N", "lastName": "Mattson" } ], "abstractNote": "BACKGROUND: This study examined prevalence of psychiatric disorders and behavioral problems in children with and without prenatal alcohol exposure (AE) and attention-deficit/hyperactivity disorder (ADHD). METHODS: Primary caregivers of 344 children (8 to 16 years, M = 12.28) completed the Computerized Diagnostic Interview Schedule for Children-IV (C-DISC-4.0) and the Child Behavior Checklist (CBCL). Subjects comprised 4 groups: AE with ADHD (AE+, n = 85) and without ADHD (AE-, n = 52), and nonexposed with ADHD (ADHD, n = 74) and without ADHD (CON, n = 133). The frequency of specific psychiatric disorders, number of psychiatric disorders (comorbidity), and CBCL behavioral scores were examined using chi-square and analysis of covariance techniques. RESULTS: Clinical groups had greater frequency of all psychiatric disorders, except for anxiety, where the AE- and CON groups did not differ. There was a combined effect of AE and ADHD on conduct disorder. For comorbidity, children with ADHD had increased psychiatric disorders regardless of AE, which did not have an independent effect on comorbidity. For CBCL scores, there were significant main effects of AE and ADHD on all scores and significant AE × ADHD interactions for Withdrawn/Depressed, Somatic Complaints, Attention, and all Summary scores. There was a combined effect of AE and ADHD on Externalizing, Total Problems, and Attention Problems. CONCLUSIONS: Findings indicate that ADHD diagnosis elevates children's risk of psychiatric diagnoses, regardless of AE, but suggest an exacerbated relation between AE and ADHD on conduct disorder and externalizing behavioral problems in children. Findings affirm a poorer behavioral prognosis for alcohol-exposed children with ADHD and suggest that more than 1 neurobehavioral profile may exist for individuals with AE.", "publicationTitle": "Alcoholism, clinical and experimental research", "publisher": "", "place": "", "date": "Sep 13, 2012", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Alcohol. Clin. Exp. Res.", "DOI": "10.1111/j.1530-0277.2012.01953.x", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/22974279", "accessDate": "2012-09-18T16:40:16Z", "PMID": "", "PMCID": "", "ISSN": "1530-0277", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 22974279", "tags": [], "collections": [], "relations": {}, "dateAdded": "2012-09-18T18:05:18Z", "dateModified": "2012-09-18T18:05:18Z" } }, { "key": "WHI288SJ", "version": 2, "library": { "type": "group", "id": 77054, "name": "Matthew Smith's Prenatal Influences on Behavior Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77054/items/WHI288SJ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles/items/WHI288SJ", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/77054/items/FN97RTKR", "type": "application/json" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } } }, "data": { "key": "WHI288SJ", "version": 2, "parentItem": "FN97RTKR", "itemType": "attachment", "linkMode": "imported_url", "title": "Snapshot", "accessDate": "2012-07-25T19:39:38Z", "url": "http://onlinelibrary.wiley.com/doi/10.1111/j.1399-5618.2012.01041.x/abstract;jsessionid=F4FF56588D2EA6A9C5178C7004D957C2.d04t03", "note": "", "contentType": "text/html", "charset": "utf-8", "filename": "abstract;jsessionid=F4FF56588D2EA6A9C5178C7004D957C2.html", "md5": "9e0c7d765a667d468823db9e6b78050c", "mtime": 1343246383000, "tags": [], "relations": {}, "dateAdded": "2012-07-25T19:59:43Z", "dateModified": "2012-07-25T19:59:43Z" } }, { "key": "FN97RTKR", "version": 1, "library": { "type": "group", "id": 77054, "name": "Matthew Smith's Prenatal Influences on Behavior Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77054/items/FN97RTKR", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles/items/FN97RTKR", "type": "text/html" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } }, "creatorSummary": "Fiedorowicz et al.", "parsedDate": "2012", "numChildren": 1 }, "data": { "key": "FN97RTKR", "version": 1, "itemType": "journalArticle", "title": "Course of illness following prospectively observed mania or hypomania in individuals presenting with unipolar depression", "creators": [ { "creatorType": "author", "firstName": "Jess G", "lastName": "Fiedorowicz" }, { "creatorType": "author", "firstName": "Jean", "lastName": "Endicott" }, { "creatorType": "author", "firstName": "David A", "lastName": "Solomon" }, { "creatorType": "author", "firstName": "Martin B", "lastName": "Keller" }, { "creatorType": "author", "firstName": "William H", "lastName": "Coryell" } ], "abstractNote": "Fiedorowicz JG, Endicott J, Solomon DA, Keller MB, Coryell WH. Course of illness following prospectively observed mania or hypomania in individuals presenting with unipolar depression. Bipolar Disord 2012: 00: 000–000. © 2012 The Authors. Journal compilation © 2012 John Wiley & Sons A/S.Objectives: In a well-defined sample, we sought to determine which clinical variables, some of potential nosological relevance, influence subsequent course following prospectively observed initial episodes of hypomania or mania (H/M).Methods: We identified 108 individuals in the National Institute of Mental Health Collaborative Depression Study diagnosed with unipolar major depression at intake who subsequently developed H/M. We assessed time to repeat H/M based on whether one had been started on an antidepressant or electroconvulsive therapy within eight weeks of developing H/M, had longer episodes, or had a family history of bipolar disorder.Results: Modeling age of onset, treatment-associated H/M, family history of bipolar disorder, duration of index H/M episode, and psychosis in Cox regression analysis, family history of bipolar disorder (n = 21) was strongly associated with repeat episodes of H/M [hazard ratio (HR) = 2.01, 95% confidence interval (CI): 1.06–3.83, p = 0.03]. Those with treatment-associated episodes (n = 12) were less likely to experience subsequent episodes of H/M, although this was not significant in the multivariate model (HR = 0.25, 95% CI: 0.06–1.05, p = 0.06). These individuals also had a later age of onset for affective illness and were more likely to be depressed. Duration of illness with a temporal resolution of one week, psychosis, and age of onset were not associated with time to repeat H/M episode.Conclusions: A family history of bipolar disorder influences the course of illness, even after an initial H/M episode. In this select sample, treatment-associated H/M did not appear to convey the same risk for a course of illness characterized by recurrent H/M episodes.", "publicationTitle": "Bipolar Disorders", "publisher": "", "place": "", "date": "2012", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "no–no", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1111/j.1399-5618.2012.01041.x", "citationKey": "", "url": "http://onlinelibrary.wiley.com/doi/10.1111/j.1399-5618.2012.01041.x/abstract", "accessDate": "2012-07-25T19:39:38Z", "PMID": "", "PMCID": "", "ISSN": "1399-5618", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "Wiley Online Library", "callNumber": "", "rights": "© 2012 John Wiley and Sons A/S", "extra": "", "tags": [ { "tag": "Bipolar disorder", "type": 1 }, { "tag": "antidepressants", "type": 1 }, { "tag": "depressive disorder", "type": 1 }, { "tag": "prospective studies", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2012-07-25T19:59:43Z", "dateModified": "2012-07-25T19:59:43Z" } }, { "key": "77EUNWEX", "version": 2, "library": { "type": "group", "id": 77054, "name": "Matthew Smith's Prenatal Influences on Behavior Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77054/items/77EUNWEX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles/items/77EUNWEX", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/77054/items/IJSXHGUU", "type": "application/json" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } } }, "data": { "key": "77EUNWEX", "version": 2, "parentItem": "IJSXHGUU", "itemType": "attachment", "linkMode": "imported_url", "title": "ingentaconnect Methadone and perinatal outcomes: a prospective cohort study", "accessDate": "2012-07-17T13:06:52Z", "url": "http://www.ingentaconnect.com/content/bsc/add/2012/00000107/00000008/art00022", "note": "", "contentType": "text/html", "charset": "windows-1252", "filename": "art00022.html", "md5": "071936cfbb50eb21699563f069efc6c7", "mtime": 1342530883000, "tags": [], "relations": {}, "dateAdded": "2012-07-17T13:14:43Z", "dateModified": "2012-07-17T13:14:43Z" } }, { "key": "IJSXHGUU", "version": 1, "library": { "type": "group", "id": 77054, "name": "Matthew Smith's Prenatal Influences on Behavior Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77054/items/IJSXHGUU", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles/items/IJSXHGUU", "type": "text/html" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } }, "creatorSummary": "Cleary et al.", "parsedDate": "2012", "numChildren": 1 }, "data": { "key": "IJSXHGUU", "version": 1, "itemType": "journalArticle", "title": "Methadone and perinatal outcomes: a prospective cohort study", "creators": [ { "creatorType": "author", "firstName": "Brian J.", "lastName": "Cleary" }, { "creatorType": "author", "firstName": "Maeve", "lastName": "Eogan" }, { "creatorType": "author", "firstName": "Michael P.", "lastName": "O'Connell" }, { "creatorType": "author", "firstName": "Tom", "lastName": "Fahey" }, { "creatorType": "author", "firstName": "Paul J.", "lastName": "Gallagher" }, { "creatorType": "author", "firstName": "Tom", "lastName": "Clarke" }, { "creatorType": "author", "firstName": "Martin J.", "lastName": "White" }, { "creatorType": "author", "firstName": "Christine", "lastName": "McDermott" }, { "creatorType": "author", "firstName": "Anne", "lastName": "O'Sullivan" }, { "creatorType": "author", "firstName": "Deirdre", "lastName": "Carmody" }, { "creatorType": "author", "firstName": "Justin", "lastName": "Gleeson" }, { "creatorType": "author", "firstName": "Deirdre J.", "lastName": "Murphy" } ], "abstractNote": "ABSTRACT Aims Methadone use in pregnancy has been associated with adverse perinatal outcomes and neonatal abstinence syndrome (NAS). This study aimed to examine perinatal outcomes and NAS in relation to (i) concomitant drug use and (ii) methadone dose.Design Prospective cohort study.Setting Two tertiary care maternity hospitals.Participants A total of 117 pregnant women on methadone maintenance treatment recruited between July 2009 and July 2010.Measurements Information on concomitant drug use was recorded with the Addiction Severity Index. Perinatal outcomes included pre-term birth (<37 weeks' gestation), small-for-gestational-age (<10th centile) and neonatal unit admission. NAS outcomes included: incidence of medically treated NAS, peak Finnegan score, cumulative dose of NAS treatment and duration of hospitalization.Findings Of the 114 liveborn infants 11 (9.6%) were born pre-term, 49 (42.9%) were small-for-gestational-age, 56 (49.1%) had a neonatal unit admission and 29 (25.4%) were treated medically for NAS. Neonates exposed to methadone-only had a shorter hospitalization than those exposed to methadone and concomitant drugs (median 5.0 days versus 6.0 days, P = 0.03). Neonates exposed to methadone doses ≥80 mg required higher cumulative doses of morphine treatment for NAS (median 13.2 mg versus 19.3 mg, P = 0.03). The incidence and duration of NAS did not differ between the two dosage groups.Conclusions The incidence and duration of the neonatal abstinence syndrome is not associated with maternal methadone dose, but maternal opiate, benzodiazepine or cocaine use is associated with longer neonatal hospitalization.", "publicationTitle": "Addiction", "publisher": "", "place": "", "date": "2012", "volume": "107", "issue": "8", "section": "", "partNumber": "", "partTitle": "", "pages": "1482-1492", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1111/j.1360-0443.2012.03844.x", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "Methadone and perinatal outcomes", "language": "", "libraryCatalog": "IngentaConnect", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2012-07-17T13:14:43Z", "dateModified": "2012-07-17T13:14:43Z" } }, { "key": "XJUDAH9N", "version": 2, "library": { "type": "group", "id": 77054, "name": "Matthew Smith's Prenatal Influences on Behavior Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77054/items/XJUDAH9N", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles/items/XJUDAH9N", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/77054/items/SBUXAPVI", "type": "application/json" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. 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Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "KCP3WCM6", "version": 2, "parentItem": "SBUXAPVI", "itemType": "attachment", "linkMode": "imported_url", "title": "Full Text PDF", "accessDate": "2012-07-13T18:56:44Z", "url": "http://www.jneurosci.org/content/31/46/16709.full.pdf", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Darling et al. - 2011 - Perinatal Citalopram Exposure Selectively Increase.pdf", "md5": "a8c24d36fb9efe5d4eaab58c708d196c", "mtime": 1342209558000, "tags": [], "relations": {}, "dateAdded": "2012-07-13T19:59:17Z", "dateModified": "2012-07-13T19:59:17Z" } }, { "key": "SBUXAPVI", "version": 1, "library": { "type": "group", "id": 77054, "name": "Matthew Smith's Prenatal Influences on Behavior Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77054/items/SBUXAPVI", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles/items/SBUXAPVI", "type": "text/html" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } }, "creatorSummary": "Darling et al.", "parsedDate": "2011-11-16", "numChildren": 2 }, "data": { "key": "SBUXAPVI", "version": 1, "itemType": "journalArticle", "title": "Perinatal Citalopram Exposure Selectively Increases Locus Ceruleus Circuit Function in Male Rats", "creators": [ { "creatorType": "author", "firstName": "Ryan D.", "lastName": "Darling" }, { "creatorType": "author", "firstName": "Loai", "lastName": "Alzghoul" }, { "creatorType": "author", "firstName": "Junlin", "lastName": "Zhang" }, { "creatorType": "author", "firstName": "Nidhi", "lastName": "Khatri" }, { "creatorType": "author", "firstName": "Ian A.", "lastName": "Paul" }, { "creatorType": "author", "firstName": "Kimberly L.", "lastName": "Simpson" }, { "creatorType": "author", "firstName": "Rick C. S.", "lastName": "Lin" } ], "abstractNote": "Selective serotonin reuptake inhibitors (SSRIs), such as citalopram (CTM), have been widely prescribed for major depressive disorder, not only for adult populations, but also for children and pregnant mothers. Recent evidence suggests that chronic SSRI exposure in adults increases serotonin (5-HT) levels in the raphe system and decreases norepinephrine (NE) locus ceruleus (LC) neural activity, suggesting a robust opposing interaction between these two monoamines. In contrast, perinatal SSRI exposure induces a long-lasting downregulation of the 5-HT-raphe system, which is opposite to that seen with chronic adult treatment. Therefore, the goal of the present investigation was to test the hypothesis that perinatal CTM exposure (20 mg/kg/d) from postnatal day 1 (PN1) to PN10 leads to hyperexcited NE-LC circuit function in adult rats (>PN90). Our single-neuron LC electrophysiological data demonstrated an increase in spontaneous and stimulus-driven neural activity, including an increase in phasic bursts in CTM-exposed animals. In addition, we demonstrated a corresponding immunoreactive increase in the rate-limiting catalyzing catecholamine enzyme (tyrosine hydroxylase) within the LC and their neocortical target sites compared to saline controls. Moreover, these effects were only evident in male exposed rats, suggesting a sexual dimorphism in neural development after SSRI exposure. Together, these results indicate that administration of SSRIs during a sensitive period of brain development results in long-lasting alterations in NE-LC circuit function in adults and may be useful in understanding the etiology of pervasive developmental disorders such as autism spectrum disorder.", "publicationTitle": "The Journal of Neuroscience", "publisher": "", "place": "", "date": "11/16/2011", "volume": "31", "issue": "46", "section": "", "partNumber": "", "partTitle": "", "pages": "16709-16715", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J. Neurosci.", "DOI": "10.1523/JNEUROSCI.3736-11.2011", "citationKey": "", "url": "http://www.jneurosci.org/content/31/46/16709", "accessDate": "2012-07-13T18:56:44Z", "PMID": "", "PMCID": "", "ISSN": "0270-6474, 1529-2401", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "www.jneurosci.org", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2012-07-13T19:59:17Z", "dateModified": "2012-07-13T19:59:17Z" } }, { "key": "S4GWETUH", "version": 1, "library": { "type": "group", "id": 77054, "name": "Matthew Smith's Prenatal Influences on Behavior Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77054/items/S4GWETUH", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_prenatal_influences_on_behavior_articles/items/S4GWETUH", "type": "text/html" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } }, "creatorSummary": "Croen et al.", "parsedDate": "2011-07-04", "numChildren": 0 }, "data": { "key": "S4GWETUH", "version": 1, "itemType": "journalArticle", "title": "Antidepressant Use During Pregnancy and Childhood Autism Spectrum Disorders", "creators": [ { "creatorType": "author", "firstName": "L. A.", "lastName": "Croen" }, { "creatorType": "author", "firstName": "J. K.", "lastName": "Grether" }, { "creatorType": "author", "firstName": "C. K.", "lastName": "Yoshida" }, { "creatorType": "author", "firstName": "R.", "lastName": "Odouli" }, { "creatorType": "author", "firstName": "V.", "lastName": "Hendrick" } ], "abstractNote": "", "publicationTitle": "Archives of General Psychiatry", "publisher": "", "place": "", "date": "2011-07-04", "volume": "68", "issue": "11", "section": "", "partNumber": "", "partTitle": "", "pages": "1104-1112", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1001/archgenpsychiatry.2011.73", "citationKey": "", "url": "http://archpsyc.jamanetwork.com/article.aspx?articleid=1107329", "accessDate": "2012-07-12T19:19:09Z", "PMID": "", "PMCID": "", "ISSN": "0003-990X", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2012-07-12T19:20:30Z", "dateModified": "2012-07-12T19:20:30Z" } } ]