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Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } } }, "data": { "key": "A2BP5AZE", "version": 242, "parentItem": "4WKR35SR", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-01-21T18:47:48Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/24434527", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-02-02T01:44:32Z", "dateModified": "2014-02-02T01:44:32Z" } }, { "key": "4WKR35SR", "version": 242, "library": { "type": "group", "id": 77051, "name": "Matthew Smith's ADHD Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77051/items/4WKR35SR", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles/items/4WKR35SR", "type": "text/html" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } }, "creatorSummary": "Sepede et al.", "parsedDate": "2014", "numChildren": 1 }, "data": { "key": "4WKR35SR", "version": 242, "itemType": "journalArticle", "title": "Bupropion as an Add-on Therapy in Depressed Bipolar Disorder Type I Patients With Comorbid Cocaine Dependence", "creators": [ { "creatorType": "author", "firstName": "Gianna", "lastName": "Sepede" }, { "creatorType": "author", "firstName": "Giuseppe", "lastName": "Di Lorio" }, { "creatorType": "author", "firstName": "Matteo", "lastName": "Lupi" }, { "creatorType": "author", "firstName": "Fabiola", "lastName": "Sarchione" }, { "creatorType": "author", "firstName": "Tiziano", "lastName": "Acciavatti" }, { "creatorType": "author", "firstName": "Federica", "lastName": "Fiori" }, { "creatorType": "author", "firstName": "Rita", "lastName": "Santacroce" }, { "creatorType": "author", "firstName": "Giovanni", "lastName": "Martinotti" }, { "creatorType": "author", "firstName": "Francesco", "lastName": "Gambi" }, { "creatorType": "author", "firstName": "Massimo", "lastName": "Di Giannantonio" } ], "abstractNote": "OBJECTIVES: The treatment of bipolar disorder type I (BD-I) with a comorbid cocaine dependence disorder (CDD) is a challenge in current psychiatric practice. Drugs with proven efficacy in manic/mixed episodes, such as atypical antipsychotics and mood stabilizers, sometimes do not prevent depressive relapses; on the other hand, the use of antidepressants during acute depressive episodes may increase the risk of a manic switch. The aim of the present study was to investigate the short-term efficacy of bupropion augmentation in acutely depressed BD-I patients with co-occurring CDD.\nMETHODS: Twelve depressed BD-I patients, with a comorbid CDD, treated with valproate 1000 to 1500 mg/d and aripiprazole 10 mg/d, were randomly assigned to receive bupropion 150 mg/d as an open-label add-on therapy (n = 5) or to continue their previous treatment (n = 7).\nRESULTS: After 4 weeks of observation, patients receiving add-on therapy with bupropion have improved in terms of Hamilton Depression Rating Scale scores and Drug Abuse Screening Test scores, with respect to those of the comparison group, whereas no significant increase of Young Mania Rating Scale scores over time was observed.\nCONCLUSIONS: Our preliminary findings suggest that combining bupropion with mood stabilizers and atypical antipsychotics may be a good therapeutic option in short-term treatment of depressed BD-I patients with comorbid CDD.", "publicationTitle": "Clinical neuropharmacology", "publisher": "", "place": "", "date": "2014", "volume": "37", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "17-21", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Clin Neuropharmacol", "DOI": "10.1097/WNF.0000000000000011", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1537-162X", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 24434527", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-02-02T01:44:32Z", "dateModified": "2014-02-02T01:44:32Z" } }, { "key": "FE3QFKMI", "version": 242, "library": { "type": "group", "id": 77051, "name": "Matthew Smith's ADHD Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77051/items/FE3QFKMI", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles/items/FE3QFKMI", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/77051/items/P8N4ZMCR", "type": "application/json" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } } }, "data": { "key": "FE3QFKMI", "version": 242, "parentItem": "P8N4ZMCR", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2013-12-24T00:47:11Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/24345721", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-02-02T01:43:38Z", "dateModified": "2014-02-02T01:43:38Z" } }, { "key": "P8N4ZMCR", "version": 242, "library": { "type": "group", "id": 77051, "name": "Matthew Smith's ADHD Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77051/items/P8N4ZMCR", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles/items/P8N4ZMCR", "type": "text/html" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } }, "creatorSummary": "Onnink et al.", "parsedDate": "2013-12-01", "numChildren": 1 }, "data": { "key": "P8N4ZMCR", "version": 242, "itemType": "journalArticle", "title": "Brain alterations in adult ADHD: Effects of gender, treatment and comorbid depression", "creators": [ { "creatorType": "author", "firstName": "A Marten H", "lastName": "Onnink" }, { "creatorType": "author", "firstName": "Marcel P", "lastName": "Zwiers" }, { "creatorType": "author", "firstName": "Martine", "lastName": "Hoogman" }, { "creatorType": "author", "firstName": "Jeanette C", "lastName": "Mostert" }, { "creatorType": "author", "firstName": "Cornelis C", "lastName": "Kan" }, { "creatorType": "author", "firstName": "Jan", "lastName": "Buitelaar" }, { "creatorType": "author", "firstName": "Barbara", "lastName": "Franke" } ], "abstractNote": "Children with attention-deficit/hyperactivity disorder (ADHD) have smaller volumes of total brain matter and subcortical regions, but it is unclear whether these represent delayed maturation or persist into adulthood. We performed a structural MRI study in 119 adult ADHD patients and 107 controls and investigated total gray and white matter and volumes of accumbens, caudate, globus pallidus, putamen, thalamus, amygdala and hippocampus. Additionally, we investigated effects of gender, stimulant treatment and history of major depression (MDD). There was no main effect of ADHD on the volumetric measures, nor was any effect observed in a secondary voxel-based morphometry (VBM) analysis of the entire brain. However, in the volumetric analysis a significant gender by diagnosis interaction was found for caudate volume. Male patients showed reduced right caudate volume compared to male controls, and caudate volume correlated with hyperactive/impulsive symptoms. Furthermore, patients using stimulant treatment had a smaller right hippocampus volume compared to medication-naïve patients and controls. ADHD patients with previous MDD showed smaller hippocampus volume compared to ADHD patients with no MDD. While these data were obtained in a cross-sectional sample and need to be replicated in a longitudinal study, the findings suggest that developmental brain differences in ADHD largely normalize in adulthood. Reduced caudate volume in male patients may point to distinct neurobiological deficits underlying ADHD in the two genders. Smaller hippocampus volume in ADHD patients with previous MDD is consistent with neurobiological alterations observed in MDD.", "publicationTitle": "European neuropsychopharmacology: the journal of the European College of Neuropsychopharmacology", "publisher": "", "place": "", "date": "Dec 1, 2013", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Eur Neuropsychopharmacol", "DOI": "10.1016/j.euroneuro.2013.11.011", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1873-7862", "archive": "", "archiveLocation": "", "shortTitle": "Brain alterations in adult ADHD", "language": "ENG", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 24345721", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-02-02T01:43:38Z", "dateModified": "2014-02-02T01:43:38Z" } }, { "key": "TVG9XSV2", "version": 241, "library": { "type": "group", "id": 77051, "name": "Matthew Smith's ADHD Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77051/items/TVG9XSV2", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles/items/TVG9XSV2", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/77051/items/DMDVZ6ZU", "type": "application/json" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } } }, "data": { "key": "TVG9XSV2", "version": 241, "parentItem": "DMDVZ6ZU", "itemType": "attachment", "linkMode": "imported_url", "title": "Snapshot", "accessDate": "2014-01-09T17:25:48Z", "url": "http://onlinelibrary.wiley.com/doi/10.1111/add.12086/abstract", "note": "", "contentType": "text/html", "charset": "utf-8", "filename": "abstract.html", "md5": null, "mtime": null, "tags": [], "relations": {}, "dateAdded": "2014-02-02T01:40:39Z", "dateModified": "2014-02-02T01:40:39Z" } }, { "key": "IPTDZRMD", "version": 241, "library": { "type": "group", "id": 77051, "name": "Matthew Smith's ADHD Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77051/items/IPTDZRMD", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles/items/IPTDZRMD", "type": "text/html" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } }, "creatorSummary": "McCarthy H et al.", "parsedDate": "2013-10-16", "numChildren": 0 }, "data": { "key": "IPTDZRMD", "version": 241, "itemType": "journalArticle", "title": "ATtention network hypoconnectivity with default and affective network hyperconnectivity in adults diagnosed with attention-deficit/hyperactivity disorder in childhood", "creators": [ { "creatorType": "author", "name": "McCarthy H" }, { "creatorType": "author", "name": "Skokauskas N" }, { "creatorType": "author", "name": "Mulligan A" }, { "creatorType": "author", "name": "et al" } ], "abstractNote": "Importance \nThe neurobiological underpinnings of attention-deficit/hyperactivity disorder (ADHD) and particularly those associated with the persistence of ADHD into adulthood are not yet well understood. The correlation patterns in spontaneous neural fluctuations at rest are known as resting-state functional connectivity (RSFC) and could characterize ADHD-specific connectivity changes.Objective\nTo determine the specific location of possible ADHD-related differences in RSFC between adults diagnosed as having ADHD in childhood and control subjects.Design\nUsing resting-state functional magnetic resonance imaging, we calculated and compared functional connectivity from attention, affective, default, and cognitive control networks involved in the psychopathology of ADHD between the ADHD and control groups.Setting\nUniversity psychiatric service and magnetic resonance imaging research center.Participants\nSixteen drug-free adults (5 women and 11 men; mean age, 24.5 years) diagnosed with combined-type ADHD in childhood and 16 healthy controls matched for age (mean age, 24.4 years), sex, handedness, and educational level recruited from the community.Intervention\nFunctional magnetic resonance imaging.Main Outcomes and Measures\nConnectivity data from ventral and dorsal attention, affective, default, and cognitive control networks and ADHD symptoms derived from ADHD-specific rating instruments.Results\nAdults with ADHD showed significantly decreased RSFC within the attention networks and increased RSFC within the affective and default mode and the right lateralized cognitive control networks compared with healthy controls (P < .01, familywise error for whole-brain cluster correction). Lower RSFC in the ventral and dorsal attention network was significantly correlated with higher levels of ADHD symptoms (P < .001).Conclusions and Relevance\nThese RSFC findings might underpin a biological basis for adult ADHD and are functionally related to persistent inattention, disturbance in cognitive control, and emotional dysregulation in adults with ADHD. These findings need to be understood in the context of all aspects of brain function in ADHD.", "publicationTitle": "JAMA Psychiatry", "publisher": "", "place": "", "date": "October 16, 2013", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "-", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "JAMA Psychiatry", "DOI": "10.1001/jamapsychiatry.2013.2174", "citationKey": "", "url": "http://dx.doi.org/10.1001/jamapsychiatry.2013.2174", "accessDate": "2013-10-22T00:20:26Z", "PMID": "", "PMCID": "", "ISSN": "2168-622X", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "Silverchair", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-02-02T01:40:39Z", "dateModified": "2014-02-02T01:40:39Z" } }, { "key": "DMDVZ6ZU", "version": 241, "library": { "type": "group", "id": 77051, "name": "Matthew Smith's ADHD Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77051/items/DMDVZ6ZU", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles/items/DMDVZ6ZU", "type": "text/html" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } }, "creatorSummary": "Kaye et al.", "parsedDate": "2013", "numChildren": 1 }, "data": { "key": "DMDVZ6ZU", "version": 241, "itemType": "journalArticle", "title": "Attention deficit hyperactivity disorder (ADHD) among illicit psychostimulant users: a hidden disorder?", "creators": [ { "creatorType": "author", "firstName": "Sharlene", "lastName": "Kaye" }, { "creatorType": "author", "firstName": "Shane", "lastName": "Darke" }, { "creatorType": "author", "firstName": "Michelle", "lastName": "Torok" } ], "abstractNote": "Aims To estimate the prevalence, nature and correlates of symptomatology consistent with adult attention deficit hyperactivity disorder (ADHD) among illicit psychostimulant users. Design Cross-section survey. Setting Sydney, Australia. Participants 269 regular illicit psychostimulant users. Measurements Structured interview assessing demographics, drug use and treatment history, psychostimulant dependence and self-reported symptoms consistent with adult ADHD. Findings Almost half (45%) screened positive for adult ADHD (ADHD+). Symptoms of inattention (90%) were more prevalent than symptoms of hyperactivity/impulsivity (57%). Of those who screened positive for adult ADHD, only 17% had received a prior diagnosis of ADHD. The ADHD+ group differed from other participants in several respects: an earlier initiation of substance use and injecting drug use; more extensive polydrug use; a higher frequency of recent stimulant use and injecting drug use; a greater likelihood of stimulant dependence; and a greater likelihood of having received treatment for drug dependence. After controlling for other factors, screening positive for ADHD was associated independently with fewer years of education, earlier initiation of regular tobacco use and more extensive life-time polydrug use. Conclusions Clinicians should be aware of the potential for patients of drug and alcohol treatment services to have undiagnosed and/or untreated ADHD that may impact on their compliance with, and retention in, treatment.", "publicationTitle": "Addiction", "publisher": "", "place": "", "date": "2013", "volume": "108", "issue": "5", "section": "", "partNumber": "", "partTitle": "", "pages": "923–931", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1111/add.12086", "citationKey": "", "url": "http://onlinelibrary.wiley.com/doi/10.1111/add.12086/abstract", "accessDate": "2014-01-09T17:25:48Z", "PMID": "", "PMCID": "", "ISSN": "1360-0443", "archive": "", "archiveLocation": "", "shortTitle": "Attention deficit hyperactivity disorder (ADHD) among illicit psychostimulant users", "language": "en", "libraryCatalog": "Wiley Online Library", "callNumber": "", "rights": "© 2012 The Authors, Addiction © 2012 Society for the Study of Addiction", "extra": "", "tags": [ { "tag": "ADHD", "type": 1 }, { "tag": "ASRS", "type": 1 }, { "tag": "illicit", "type": 1 }, { "tag": "psychostimulant", "type": 1 }, { "tag": "substance use disorders", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2014-02-02T01:40:39Z", "dateModified": "2014-02-02T01:40:39Z" } }, { "key": "D9GIBW5Q", "version": 240, "library": { "type": "group", "id": 77051, "name": "Matthew Smith's ADHD Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77051/items/D9GIBW5Q", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles/items/D9GIBW5Q", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/77051/items/NPA2BMGX", "type": "application/json" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } } }, "data": { "key": "D9GIBW5Q", "version": 240, "parentItem": "NPA2BMGX", "itemType": "attachment", "linkMode": "imported_url", "title": "Are Motivation Deficits Underestimated in Patients With ADHD? A Review of the Literature | Postgraduate Medicine", "accessDate": "2014-01-09T17:27:02Z", "url": "https://postgradmed.org/doi/10.3810/pgm.2013.07.2677", "note": "", "contentType": "text/html", "charset": "utf-8", "filename": "pgm.2013.07.html", "md5": null, "mtime": null, "tags": [], "relations": {}, "dateAdded": "2014-02-02T01:39:33Z", "dateModified": "2014-02-02T01:39:33Z" } }, { "key": "NPA2BMGX", "version": 240, "library": { "type": "group", "id": 77051, "name": "Matthew Smith's ADHD Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77051/items/NPA2BMGX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles/items/NPA2BMGX", "type": "text/html" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } }, "creatorSummary": "Modesto-Lowe et al.", "parsedDate": "2013-07-15", "numChildren": 1 }, "data": { "key": "NPA2BMGX", "version": 240, "itemType": "journalArticle", "title": "Are Motivation Deficits Underestimated in Patients With ADHD? A Review of the Literature", "creators": [ { "creatorType": "author", "firstName": "Vania", "lastName": "Modesto-Lowe" }, { "creatorType": "author", "firstName": "Margaret", "lastName": "Chaplin" }, { "creatorType": "author", "firstName": "Victoria", "lastName": "Soovajian" }, { "creatorType": "author", "firstName": "Andrea", "lastName": "Meyer" } ], "abstractNote": "", "publicationTitle": "Postgraduate Medicine", "publisher": "", "place": "", "date": "2013-07-15", "volume": "125", "issue": "4", "section": "", "partNumber": "", "partTitle": "", "pages": "47-52", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.3810/pgm.2013.07.2677", "citationKey": "", "url": "https://postgradmed.org/doi/10.3810/pgm.2013.07.2677", "accessDate": "2014-01-09T17:27:02Z", "PMID": "", "PMCID": "", "ISSN": "0032-5481", "archive": "", "archiveLocation": "", "shortTitle": "Are Motivation Deficits Underestimated in Patients With ADHD?", "language": "", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-02-02T01:39:33Z", "dateModified": "2014-02-02T01:39:33Z" } }, { "key": "E3S2C9QW", "version": 239, "library": { "type": "group", "id": 77051, "name": "Matthew Smith's ADHD Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77051/items/E3S2C9QW", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles/items/E3S2C9QW", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/77051/items/36VRZ8DT", "type": "application/json" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } } }, "data": { "key": "E3S2C9QW", "version": 239, "parentItem": "36VRZ8DT", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-01-31T18:11:48Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/24378745", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-02-02T01:03:25Z", "dateModified": "2014-02-02T01:03:25Z" } }, { "key": "36VRZ8DT", "version": 239, "library": { "type": "group", "id": 77051, "name": "Matthew Smith's ADHD Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77051/items/36VRZ8DT", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles/items/36VRZ8DT", "type": "text/html" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } }, "creatorSummary": "Cherkasova et al.", "parsedDate": "2013-12-30", "numChildren": 1 }, "data": { "key": "36VRZ8DT", "version": 239, "itemType": "journalArticle", "title": "Amphetamine-Induced Dopamine Release and Neurocognitive Function in Treatment-Naive Adults with ADHD", "creators": [ { "creatorType": "author", "firstName": "Mariya V", "lastName": "Cherkasova" }, { "creatorType": "author", "firstName": "Nazlie", "lastName": "Faridi" }, { "creatorType": "author", "firstName": "Kevin F", "lastName": "Casey" }, { "creatorType": "author", "firstName": "Gillian A", "lastName": "O'Driscoll" }, { "creatorType": "author", "firstName": "Lily", "lastName": "Hechtman" }, { "creatorType": "author", "firstName": "Ridha", "lastName": "Joober" }, { "creatorType": "author", "firstName": "Glen B", "lastName": "Baker" }, { "creatorType": "author", "firstName": "Jennifer", "lastName": "Palmer" }, { "creatorType": "author", "firstName": "Alain", "lastName": "Dagher" }, { "creatorType": "author", "firstName": "Marco", "lastName": "Leyton" }, { "creatorType": "author", "firstName": "Chawki", "lastName": "Benkelfat" } ], "abstractNote": "Converging evidence from clinical, preclinical, neuroimaging, and genetic research implicates dopamine neurotransmission in the pathophysiology of attention deficit hyperactivity disorder (ADHD). The in vivo neuroreceptor imaging evidence also suggests alterations in the dopamine system in ADHD; however, the nature and behavioral significance of those have not yet been established. Here, we investigated striatal dopaminergic function in ADHD using [(11)C]raclopride PET with a d-amphetamine challenge. We also examined the relationship of striatal dopamine responses to ADHD symptoms and neurocognitive function. A total of 15 treatment-free, noncomorbid adult males with ADHD (age: 29.87±8.65) and 18 healthy male controls (age: 25.44±6.77) underwent two PET scans: one following a lactose placebo and the other following d-amphetamine (0.3 mg/kg, p.o.), administered double blind and in random order counterbalanced across groups. In a separate session without a drug, participants performed a battery of neurocognitive tests. Relative to the healthy controls, the ADHD patients, as a group, showed greater d-amphetamine-induced decreases in striatal [(11)C]raclopride binding and performed more poorly on measures of response inhibition. Across groups, a greater magnitude of d-amphetamine-induced change in [(11)C]raclopride binding potential was associated with poorer performance on measures of response inhibition and ADHD symptoms. Our findings suggest an augmented striatal dopaminergic response in treatment-naive ADHD. Though in contrast to results of a previous study, this finding appears consistent with a model proposing exaggerated phasic dopamine release in ADHD. A susceptibility to increased phasic dopamine responsivity may contribute to such characteristics of ADHD as poor inhibition and impulsivity.Neuropsychopharmacology advance online publication, 29 January 2014; doi:10.1038/npp.2013.349.", "publicationTitle": "Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology", "publisher": "", "place": "", "date": "Dec 30, 2013", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Neuropsychopharmacology", "DOI": "10.1038/npp.2013.349", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1740-634X", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "ENG", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 24378745", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-02-02T01:03:25Z", "dateModified": "2014-02-02T01:03:25Z" } }, { "key": "JI2MV29Z", "version": 238, "library": { "type": "group", "id": 77051, "name": "Matthew Smith's ADHD Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77051/items/JI2MV29Z", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles/items/JI2MV29Z", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/77051/items/86JE8Z9V", "type": "application/json" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } } }, "data": { "key": "JI2MV29Z", "version": 238, "parentItem": "86JE8Z9V", "itemType": "attachment", "linkMode": "imported_url", "title": "Snapshot", "accessDate": "2013-12-28T16:05:37Z", "url": "http://blogs.nejm.org/now/index.php/adult-adhd/2013/11/15/?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+Nownejm+%28Now%40NEJM%29", "note": "", "contentType": "text/html", "charset": "utf-8", "filename": "15.html", "md5": null, "mtime": null, "tags": [], "relations": {}, "dateAdded": "2014-02-02T01:00:59Z", "dateModified": "2014-02-02T01:00:59Z" } }, { "key": "86JE8Z9V", "version": 238, "library": { "type": "group", "id": 77051, "name": "Matthew Smith's ADHD Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77051/items/86JE8Z9V", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles/items/86JE8Z9V", "type": "text/html" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } }, "numChildren": 1 }, "data": { "key": "86JE8Z9V", "version": 238, "itemType": "blogPost", "title": "Adult ADHD | Now@NEJM", "creators": [], "abstractNote": "Short-term trials involving adults with ADHD have shown significant improvements in symptoms with stimulants and atomoxetine; however, data on long-term", "blogTitle": "", "websiteType": "", "date": "", "DOI": "", "citationKey": "", "url": "http://blogs.nejm.org/now/index.php/adult-adhd/2013/11/15/?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+Nownejm+%28Now%40NEJM%29", "accessDate": "2013-12-28T16:05:37Z", "ISSN": "", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [ { "tag": "adult adhd", "type": 1 }, { "tag": "clinical practice", "type": 1 }, { "tag": "physicians-in-training", "type": 1 }, { "tag": "pit", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2014-02-02T01:00:59Z", "dateModified": "2014-02-02T01:00:59Z" } }, { "key": "RQWCNEER", "version": 237, "library": { "type": "group", "id": 77051, "name": "Matthew Smith's ADHD Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77051/items/RQWCNEER", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles/items/RQWCNEER", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/77051/items/5Z6MQ5V3", "type": "application/json" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } } }, "data": { "key": "RQWCNEER", "version": 237, "parentItem": "5Z6MQ5V3", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-01-09T01:09:36Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/22617860", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-02-02T00:57:57Z", "dateModified": "2014-02-02T00:57:57Z" } }, { "key": "5Z6MQ5V3", "version": 237, "library": { "type": "group", "id": 77051, "name": "Matthew Smith's ADHD Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77051/items/5Z6MQ5V3", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles/items/5Z6MQ5V3", "type": "text/html" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } }, "creatorSummary": "Arnold et al.", "parsedDate": "2014-02", "numChildren": 1 }, "data": { "key": "5Z6MQ5V3", "version": 237, "itemType": "journalArticle", "title": "A 9-week, randomized, double-blind, placebo-controlled, parallel-group, dose-finding study to evaluate the efficacy and safety of modafinil as treatment for adults with ADHD", "creators": [ { "creatorType": "author", "firstName": "Valerie K", "lastName": "Arnold" }, { "creatorType": "author", "firstName": "David", "lastName": "Feifel" }, { "creatorType": "author", "firstName": "Craig Q", "lastName": "Earl" }, { "creatorType": "author", "firstName": "Ronghua", "lastName": "Yang" }, { "creatorType": "author", "firstName": "Lenard A", "lastName": "Adler" } ], "abstractNote": "Objective: This study evaluated the efficacy and tolerability of modafinil at a range of doses, versus placebo, in alleviating symptoms of ADHD in adults. Method: Adult patients with ADHD were randomized in 1:1:1:1:1 fashion to double-blind treatment with modafinil 255, 340, 425, or 510 mg daily or placebo for 9 weeks. The primary efficacy outcome was the change from baseline at final visit in the Adult ADHD Investigator Symptom Rating Scale (AISRS) total score. Results: A total of 338 patients were enrolled, of whom 330 received at least 1 dose of study medication (modafinil or placebo). No statistically significant difference in the AISRS total score was observed at final visit between any modafinil group and placebo; however, some observations among patients who completed the trial may warrant further investigation. Conclusion: Modafinil was reasonably tolerated but did not demonstrate a benefit on ADHD symptoms in adults.", "publicationTitle": "Journal of attention disorders", "publisher": "", "place": "", "date": "Feb 2014", "volume": "18", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "133-144", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Atten Disord", "DOI": "10.1177/1087054712441969", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1557-1246", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 22617860", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-02-02T00:57:57Z", "dateModified": "2014-02-02T00:57:57Z" } }, { "key": "ZIPGU5BK", "version": 236, "library": { "type": "group", "id": 77051, "name": "Matthew Smith's ADHD Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77051/items/ZIPGU5BK", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles/items/ZIPGU5BK", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/77051/items/UGCGKTJI", "type": "application/json" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. 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Smith", "links": { "alternate": { "href": "https://www.zotero.org/drmbsmith", "type": "text/html" } } }, "creatorSummary": "Valdizán-Usón", "parsedDate": "2013", "numChildren": 1 }, "data": { "key": "UGCGKTJI", "version": 236, "itemType": "journalArticle", "title": "Response to methylphenidate by adult and pediatric patients with attention-deficit/hyperactivity disorder: the Spanish multicenter DIHANA study", "creators": [ { "creatorType": "author", "firstName": "José-Ramón", "lastName": "Valdizán-Usón" } ], "abstractNote": "", "publicationTitle": "Neuropsychiatric Disease and Treatment", "publisher": "", "place": "", "date": "02/2013", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "211", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.2147/NDT.S35836", "citationKey": "", "url": "http://www.dovepress.com/response-to-methylphenidate-by-adult-and-pediatric-patients-with-atten-peer-reviewed-article-NDT", "accessDate": "2013-02-18T15:28:30Z", "PMID": "", "PMCID": "", "ISSN": "1176-6328", "archive": "", "archiveLocation": "", "shortTitle": "Response to methylphenidate by adult and pediatric patients with attention-deficit/hyperactivity disorder", "language": "", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-02-01T02:08:45Z", "dateModified": "2014-02-01T02:08:45Z" } }, { "key": "D53P5UMC", "version": 248, "library": { "type": "group", "id": 77051, "name": "Matthew Smith's ADHD Articles", "links": { "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/77051/items/D53P5UMC", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/matthew_smiths_adhd_articles/items/D53P5UMC", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/77051/items/IANTFGTM", "type": "application/json" } }, "meta": { "createdByUser": { "id": 176549, "username": "drmbsmith", "name": "Matthew B. 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