[ { "key": "IUMIU34X", "version": 1, "library": { "type": "group", "id": 7576, "name": "Journal Club Cardiology", "links": { "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/7576/items/IUMIU34X", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology/items/IUMIU34X", "type": "text/html" } }, "meta": { "createdByUser": { "id": 8053, "username": "jssgdejong", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jssgdejong", "type": "text/html" } } }, "creatorSummary": "Hattori Y. et al.", "parsedDate": "1160", "numChildren": 0 }, "data": { "key": "IUMIU34X", "version": 1, "itemType": "journalArticle", "title": "Inhibition by 5-hydroxytryptamine of the beta adrenoceptor-mediated positive inotropic responses to catecholamines in rabbit papillary muscles: Direct interaction with beta adrenoceptors.", "creators": [ { "creatorType": "author", "firstName": "", "lastName": "Hattori Y." }, { "creatorType": "author", "firstName": "", "lastName": "Endou M." }, { "creatorType": "author", "firstName": "", "lastName": "Kanno M." } ], "abstractNote": "The effects of 5-hydroxytryptamine (5-HT) on the positive inotropic responses to catecholamines were investigated in isolated rabbit papillary muscles. 5-HT produced a concentration-dependent positive inotropic effect, an effect which was antagonized by prazosin, but not by propranolol. The positive inotropic effect of 5-HT diminished greatly in muscles from rabbits pretreated with 6-hydroxydopamine. Thus, it is likely that 5-HT causes a release of norepinephrine and increases force of contraction indirectly through alpha-1 adrenoceptors. In the presence of prazosin, 5-HT exerted a concentration-dependent inhibition of the positive inotropic response to isoproterenol. The positive inotropic responses to tyramine and a beta-1 adrenoceptor agonist T-1583 were also inhibited by the addition of 5-HT. The inhibitory effect of 5-HT on the beta adrenoceptor-mediated responses was unaffected by methysergide, ketanserin, ICS 205-930 or atropine. Pretreatment with pertussis toxin did not block the inhibitory effect of 5-HT on the inotropic response to isoproterenol, while abolishing the cholinergic interaction against the isoproterenol response. In contrast to its antagonizing effect on the inotropic response to isoproterenol, 5-HT produced an additive effect on the positive inotropic response to norepinephrine. However, when neuronal amine uptake was blocked by cocaine, the positive inotropic response to norepinephrine was suppressed by the addition of 5-HT. 5-HT inhibited (-)-[125I]iodocyanopindolol binding to the membranes from rabbit ventricles with a monophasic displacement curve. These results indicate that, although 5-HT is taken up into the sympathetic nerves and induces norepinephrine release, 5-HT directly blocks cardiac beta adrenoceptors and thereby inhibits the beta adrenoceptor-mediated positive inotropic responses to catecholamines in rabbit papillary muscles.", "publicationTitle": "Journal of Pharmacology and Experimental Therapeutics", "publisher": "", "place": "", "date": "1160", "volume": "261", "issue": "3", "section": "", "partNumber": "", "partTitle": "", "pages": "1160-1166", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0022-3565", "archive": "", "archiveLocation": "", "shortTitle": "Inhibition by 5-hydroxytryptamine of the beta adrenoceptor-mediated positive inotropic responses to catecholamines in rabbit papillary muscles", "language": "", "libraryCatalog": "Ovid (EMBASE)", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "8V6HA5Q9" ], "relations": {}, "dateAdded": "2010-02-21T20:25:23Z", "dateModified": "2010-02-21T20:25:23Z" } }, { "key": "DWGNMZDF", "version": 1, "library": { "type": "group", "id": 7576, "name": "Journal Club Cardiology", "links": { "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/7576/items/DWGNMZDF", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology/items/DWGNMZDF", "type": "text/html" } }, "meta": { "createdByUser": { "id": 8053, "username": "jssgdejong", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jssgdejong", "type": "text/html" } } }, "creatorSummary": "Rassen et al.", "parsedDate": "2009", "numChildren": 0 }, "data": { "key": "DWGNMZDF", "version": 1, "itemType": "journalArticle", "title": "Cardiovascular Outcomes and Mortality in Patients Using Clopidogrel With Proton Pump Inhibitors After Percutaneous Coronary Intervention or Acute Coronary Syndrome", "creators": [ { "creatorType": "author", "firstName": "J. A.", "lastName": "Rassen" }, { "creatorType": "author", "firstName": "N. K.", "lastName": "Choudhry" }, { "creatorType": "author", "firstName": "J.", "lastName": "Avorn" }, { "creatorType": "author", "firstName": "S.", "lastName": "Schneeweiss" } ], "abstractNote": "", "publicationTitle": "Circulation", "publisher": "", "place": "", "date": "11/2009", "volume": "120", "issue": "23", "section": "", "partNumber": "", "partTitle": "", "pages": "2322-2329", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Circulation", "DOI": "10.1161/CIRCULATIONAHA.109.873497", "citationKey": "", "url": "https://literatuur.amc.nl/http/circ.ahajournals.org/cgi/content/abstract/120/23/2322", "accessDate": "2009-12-09T18:56:09Z", "PMID": "", "PMCID": "", "ISSN": "0009-7322", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "8V6HA5Q9" ], "relations": {}, "dateAdded": "2009-12-09T18:56:09Z", "dateModified": "2009-12-09T18:56:09Z" } }, { "key": "T2Q38T4T", "version": 1, "library": { "type": "group", "id": 7576, "name": "Journal Club Cardiology", "links": { "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/7576/items/T2Q38T4T", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology/items/T2Q38T4T", "type": "text/html" } }, "meta": { "createdByUser": { "id": 8053, "username": "jssgdejong", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jssgdejong", "type": "text/html" } } }, "creatorSummary": "Slaughter et al.", "parsedDate": "2009-12-03", "numChildren": 0 }, "data": { "key": "T2Q38T4T", "version": 1, "itemType": "journalArticle", "title": "Advanced Heart Failure Treated with Continuous-Flow Left Ventricular Assist Device", "creators": [ { "creatorType": "author", "firstName": "Mark S.", "lastName": "Slaughter" }, { "creatorType": "author", "firstName": "Joseph G.", "lastName": "Rogers" }, { "creatorType": "author", "firstName": "Carmelo A.", "lastName": "Milano" }, { "creatorType": "author", "firstName": "Stuart D.", "lastName": "Russell" }, { "creatorType": "author", "firstName": "John V.", "lastName": "Conte" }, { "creatorType": "author", "firstName": "David", "lastName": "Feldman" }, { "creatorType": "author", "firstName": "Benjamin", "lastName": "Sun" }, { "creatorType": "author", "firstName": "Antone J.", "lastName": "Tatooles" }, { "creatorType": "author", "firstName": "Reynolds M.", "lastName": "Delgado" }, { "creatorType": "author", "firstName": "James W.", "lastName": "Long" }, { "creatorType": "author", "firstName": "Thomas C.", "lastName": "Wozniak" }, { "creatorType": "author", "firstName": "Waqas", "lastName": "Ghumman" }, { "creatorType": "author", "firstName": "David J.", "lastName": "Farrar" }, { "creatorType": "author", "firstName": "O. Howard", "lastName": "Frazier" }, { "creatorType": "author", "firstName": "", "lastName": "the HeartMate II Investigators" } ], "abstractNote": "Background Patients with advanced heart failure have improved survival rates and quality of life when treated with implanted pulsatile-flow left ventricular assist devices as compared with medical therapy. New continuous-flow devices are smaller and may be more durable than the pulsatile-flow devices. Methods In this randomized trial, we enrolled patients with advanced heart failure who were ineligible for transplantation, in a 2:1 ratio, to undergo implantation of a continuous-flow device (134 patients) or the currently approved pulsatile-flow device (66 patients). The primary composite end point was, at 2 years, survival free from disabling stroke and reoperation to repair or replace the device. Secondary end points included survival, frequency of adverse events, the quality of life, and functional capacity. Results Preoperative characteristics were similar in the two treatment groups, with a median age of 64 years (range, 26 to 81), a mean left ventricular ejection fraction of 17%, and nearly 80% of patients receiving intravenous inotropic agents. The primary composite end point was achieved in more patients with continuous-flow devices than with pulsatile-flow devices (62 of 134 [46%] vs. 7 of 66 [11%]; P<0.001; hazard ratio, 0.38; 95% confidence interval, 0.27 to 0.54; P<0.001), and patients with continuous-flow devices had superior actuarial survival rates at 2 years (58% vs. 24%, P=0.008). Adverse events and device replacements were less frequent in patients with the continuous-flow device. The quality of life and functional capacity improved significantly in both groups. Conclusions Treatment with a continuous-flow left ventricular assist device in patients with advanced heart failure significantly improved the probability of survival free from stroke and device failure at 2 years as compared with a pulsatile device. Both devices significantly improved the quality of life and functional capacity. (ClinicalTrials.gov number, NCT00121485 .)", "publicationTitle": "N Engl J Med", "publisher": "", "place": "", "date": "December 3, 2009", "volume": "361", "issue": "23", "section": "", "partNumber": "", "partTitle": "", "pages": "2241-2251", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1056/NEJMoa0909938", "citationKey": "", "url": "http://content.nejm.org/cgi/content/abstract/361/23/2241", "accessDate": "2009-12-09T18:44:47Z", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "HighWire", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "8V6HA5Q9" ], "relations": {}, "dateAdded": "2009-12-09T18:44:47Z", "dateModified": "2009-12-09T18:44:47Z" } }, { "key": "P3TE5JHI", "version": 1, "library": { "type": "group", "id": 7576, "name": "Journal Club Cardiology", "links": { "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/7576/items/P3TE5JHI", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology/items/P3TE5JHI", "type": "text/html" } }, "meta": { "createdByUser": { "id": 8053, "username": "jssgdejong", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jssgdejong", "type": "text/html" } } }, "creatorSummary": "Strazzullo et al.", "parsedDate": "2009", "numChildren": 0 }, "data": { "key": "P3TE5JHI", "version": 1, "itemType": "journalArticle", "title": "Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies", "creators": [ { "creatorType": "author", "firstName": "P.", "lastName": "Strazzullo" }, { "creatorType": "author", "firstName": "L.", "lastName": "D'Elia" }, { "creatorType": "author", "firstName": "N.-B.", "lastName": "Kandala" }, { "creatorType": "author", "firstName": "F. P", "lastName": "Cappuccio" } ], "abstractNote": "", "publicationTitle": "BMJ", "publisher": "", "place": "", "date": "11/2009", "volume": "339", "issue": "nov24 1", "section": "", "partNumber": "", "partTitle": "", "pages": "b4567-b4567", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "BMJ", "DOI": "10.1136/bmj.b4567", "citationKey": "", "url": "https://literatuur.amc.nl/http/www.bmj.com/cgi/content/abstract/339/nov24_1/b4567", "accessDate": "2009-12-09T18:32:55Z", "PMID": "", "PMCID": "", "ISSN": "0959-8138", "archive": "", "archiveLocation": "", "shortTitle": "Salt intake, stroke, and cardiovascular disease", "language": "", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "8V6HA5Q9" ], "relations": {}, "dateAdded": "2009-12-09T18:32:55Z", "dateModified": "2009-12-09T18:32:55Z" } }, { "key": "5ZMG29X5", "version": 1, "library": { "type": "group", "id": 7576, "name": "Journal Club Cardiology", "links": { "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/7576/items/5ZMG29X5", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology/items/5ZMG29X5", "type": "text/html" } }, "meta": { "createdByUser": { "id": 8053, "username": "jssgdejong", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jssgdejong", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "5ZMG29X5", "version": 1, "itemType": "webpage", "title": "ScienceDirect - The Lancet : Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomised, double-blind trial", "creators": [], "abstractNote": "", "websiteTitle": "", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "https://literatuur.amc.nl/http/www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1B-4XPW109-1&_user=496085&_coverDate=12%2F04%2F2009&_rdoc=30&_fmt=high&_orig=browse&_srch=doc-info(%23toc%234886%232009%23996250295%231571234%23FLA%23display%23Volume)&_cdi=4886&_sort=d&_docanchor=&_ct=34&_acct=C000024218&_version=1&_urlVersion=0&_userid=496085&md5=7bf39628919b4e512b1d6af0fabc48a9", "accessDate": "2009-12-09T18:31:04Z", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [ "8V6HA5Q9" ], "relations": {}, "dateAdded": "2009-12-09T18:31:04Z", "dateModified": "2009-12-09T18:31:04Z" } }, { "key": "TTJ5FWPF", "version": 1, "library": { "type": "group", "id": 7576, "name": "Journal Club Cardiology", "links": { "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/7576/items/TTJ5FWPF", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology/items/TTJ5FWPF", "type": "text/html" } }, "meta": { "createdByUser": { "id": 8053, "username": "jssgdejong", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jssgdejong", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "TTJ5FWPF", "version": 1, "itemType": "webpage", "title": "ScienceDirect - The Lancet : Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomised, double-blind trial", "creators": [], "abstractNote": "", "websiteTitle": "", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "https://literatuur.amc.nl/http/www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1B-4XPW109-1&_user=496085&_coverDate=12%2F04%2F2009&_rdoc=30&_fmt=high&_orig=browse&_srch=doc-info(%23toc%234886%232009%23996250295%231571234%23FLA%23display%23Volume)&_cdi=4886&_sort=d&_docanchor=&_ct=34&_acct=C000024218&_version=1&_urlVersion=0&_userid=496085&md5=7bf39628919b4e512b1d6af0fabc48a9", "accessDate": "2009-12-09T18:30:58Z", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2009-12-09T18:30:58Z", "dateModified": "2009-12-09T18:30:58Z" } }, { "key": "TWIT9C97", "version": 1, "library": { "type": "group", "id": 7576, "name": "Journal Club Cardiology", "links": { "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/7576/items/TWIT9C97", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology/items/TWIT9C97", "type": "text/html" } }, "meta": { "createdByUser": { "id": 8053, "username": "jssgdejong", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jssgdejong", "type": "text/html" } } }, "creatorSummary": "Frink et al.", "parsedDate": "1988-02", "numChildren": 0 }, "data": { "key": "TWIT9C97", "version": 1, "itemType": "journalArticle", "title": "Coronary thrombosis and platelet/fibrin microemboli in death associated with acute myocardial infarction", "creators": [ { "creatorType": "author", "firstName": "R J", "lastName": "Frink" }, { "creatorType": "author", "firstName": "P A", "lastName": "Rooney" }, { "creatorType": "author", "firstName": "J O", "lastName": "Trowbridge" }, { "creatorType": "author", "firstName": "J P", "lastName": "Rose" } ], "abstractNote": "The frequency and clinical significance of platelet/fibrin microemboli in the microcirculation were investigated in 24 patients whose deaths (before and during hospital admission) were associated with acute myocardial infarction. An acute coronary thrombus was present in all the hearts. In nine hearts an acute thrombus was found in more than one major epicardial coronary artery. A total of 35 acute thrombi were found in the 24 hearts. Platelet/fibrin microemboli were found in 19 (79%) hearts. Eighteen patients died in hospital. The hearts of 16 of these cases showed microemboli; 16 had important arrhythmias or various forms of heart block; 13 showed acute pathological changes in the conduction system. Fourteen of the deaths in hospital were primarily the result of cardiogenic shock and four were primarily caused by arrhythmia. Six of the deaths that occurred before admission to hospital were regarded as being arrhythmic in origin. Three of these showed microemboli and the other three had acute pathological changes in the conduction system. Microemboli were found in two (24%) of 12 control hearts. Coronary thrombosis was found in most deaths caused by acute myocardial infarction and platelet/fibrin microemboli were present in the majority of such hearts. These may arise from the coronary thrombus in the larger upstream vessel supplying the microcirculation.", "publicationTitle": "British Heart Journal", "publisher": "", "place": "", "date": "Feb 1988", "volume": "59", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "196-200", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Br Heart J", "DOI": "", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/3342160", "accessDate": "2009-11-29T10:07:06Z", "PMID": "", "PMCID": "", "ISSN": "0007-0769", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 3342160", "tags": [ { "tag": "Adult", "type": 1 }, { "tag": "Aged", "type": 1 }, { "tag": "Aged, 80 and over", "type": 1 }, { "tag": "Blood Platelets", "type": 1 }, { "tag": "Coronary Disease", "type": 1 }, { "tag": "Coronary Thrombosis", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Fibrin", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Middle Aged", "type": 1 }, { "tag": "Myocardial Infarction", "type": 1 }, { "tag": "Myocardium", "type": 1 } ], "collections": [ "XKJJBPTC" ], "relations": {}, "dateAdded": "2009-11-29T10:07:06Z", "dateModified": "2009-11-29T10:07:06Z" } }, { "key": "XSENAUVR", "version": 1, "library": { "type": "group", "id": 7576, "name": "Journal Club Cardiology", "links": { "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/7576/items/XSENAUVR", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology/items/XSENAUVR", "type": "text/html" } }, "meta": { "createdByUser": { "id": 8053, "username": "jssgdejong", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jssgdejong", "type": "text/html" } } }, "creatorSummary": "Davies and Thomas", "parsedDate": "1984-05-03", "numChildren": 0 }, "data": { "key": "XSENAUVR", "version": 1, "itemType": "journalArticle", "title": "Thrombosis and acute coronary-artery lesions in sudden cardiac ischemic death", "creators": [ { "creatorType": "author", "firstName": "M J", "lastName": "Davies" }, { "creatorType": "author", "firstName": "A", "lastName": "Thomas" } ], "abstractNote": "The nature of the pathologic lesion in sudden cardiac ischemic death is in dispute. Among 100 subjects who died of ischemic heart disease in less than six hours, coronary thrombi were found in 74. There was no difference in incidence between those who died in less than 15 minutes, those who died in 15 to 60 minutes, and those who died after one hour. Among 26 cases without an intraluminal thrombus, plaque fissuring was found in 21; thus, in only 5 cases was no acute arterial lesion demonstrated. No intraluminal thrombi were found in age-matched controls. Forty-eight of the 74 thrombi were found at sites of preexisting high-grade stenosis; 14 were found at points of previous stenosis of less than 50 per cent of the diameter of the lumen. Forty-seven per cent of the thrombi were found in the right coronary artery. Only 30 per cent were found in the left anterior descending coronary artery. The pathologic process in sudden ischemic death involves a rapidly evolving coronary-artery lesion in which plaque fissuring and resultant thrombus formation are present. These findings have implications for the prevention of sudden cardiac death by antithrombotic therapy.", "publicationTitle": "The New England Journal of Medicine", "publisher": "", "place": "", "date": "May 3, 1984", "volume": "310", "issue": "18", "section": "", "partNumber": "", "partTitle": "", "pages": "1137-1140", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "N. Engl. J. Med", "DOI": "", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/6709008", "accessDate": "2009-11-29T10:06:41Z", "PMID": "", "PMCID": "", "ISSN": "0028-4793", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 6709008", "tags": [ { "tag": "Aged", "type": 1 }, { "tag": "Coronary Disease", "type": 1 }, { "tag": "Coronary Vessels", "type": 1 }, { "tag": "Death, Sudden", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Myocardial Infarction", "type": 1 }, { "tag": "Thrombosis", "type": 1 }, { "tag": "Time Factors", "type": 1 } ], "collections": [ "XKJJBPTC" ], "relations": {}, "dateAdded": "2009-11-29T10:06:41Z", "dateModified": "2009-11-29T10:06:41Z" } }, { "key": "FSMMFTPX", "version": 1, "library": { "type": "group", "id": 7576, "name": "Journal Club Cardiology", "links": { "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/7576/items/FSMMFTPX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology/items/FSMMFTPX", "type": "text/html" } }, "meta": { "createdByUser": { "id": 8053, "username": "jssgdejong", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jssgdejong", "type": "text/html" } } }, "creatorSummary": "Zipes et al.", "parsedDate": "2006-09", "numChildren": 0 }, "data": { "key": "FSMMFTPX", "version": 1, "itemType": "journalArticle", "title": "ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death--executive summary: A report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death) Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society", "creators": [ { "creatorType": "author", "firstName": "Douglas P", "lastName": "Zipes" }, { "creatorType": "author", "firstName": "A John", "lastName": "Camm" }, { "creatorType": "author", "firstName": "Martin", "lastName": "Borggrefe" }, { "creatorType": "author", "firstName": "Alfred E", "lastName": "Buxton" }, { "creatorType": "author", "firstName": "Bernard", "lastName": "Chaitman" }, { "creatorType": "author", "firstName": "Martin", "lastName": "Fromer" }, { "creatorType": "author", "firstName": "Gabriel", "lastName": "Gregoratos" }, { "creatorType": "author", "firstName": "George", "lastName": "Klein" }, { "creatorType": "author", "firstName": "Arthur J", "lastName": "Moss" }, { "creatorType": "author", "firstName": "Robert J", "lastName": "Myerburg" }, { "creatorType": "author", "firstName": "Silvia G", "lastName": "Priori" }, { "creatorType": "author", "firstName": "Miguel A", "lastName": "Quinones" }, { "creatorType": "author", "firstName": "Dan M", "lastName": "Roden" }, { "creatorType": "author", "firstName": "Michael J", "lastName": "Silka" }, { "creatorType": "author", "firstName": "Cynthia", "lastName": "Tracy" }, { "creatorType": "author", "firstName": "Jean-Jacques", "lastName": "Blanc" }, { "creatorType": "author", "firstName": "Andrzej", "lastName": "Budaj" }, { "creatorType": "author", "firstName": "Veronica", "lastName": "Dean" }, { "creatorType": "author", "firstName": "Jaap W", "lastName": "Deckers" }, { "creatorType": "author", "firstName": "Catherine", "lastName": "Despres" }, { "creatorType": "author", "firstName": "Kenneth", "lastName": "Dickstein" }, { "creatorType": "author", "firstName": "John", "lastName": "Lekakis" }, { "creatorType": "author", "firstName": "Keith", "lastName": "McGregor" }, { "creatorType": "author", "firstName": "Marco", "lastName": "Metra" }, { "creatorType": "author", "firstName": "Joao", "lastName": "Morais" }, { "creatorType": "author", "firstName": "Ady", "lastName": "Osterspey" }, { "creatorType": "author", "firstName": "Juan Luis", "lastName": "Tamargo" }, { "creatorType": "author", "firstName": "José Luis", "lastName": "Zamorano" }, { "creatorType": "author", "firstName": "Sidney C", "lastName": "Smith" }, { "creatorType": "author", "firstName": "Alice K", "lastName": "Jacobs" }, { "creatorType": "author", "firstName": "Cynthia D", "lastName": "Adams" }, { "creatorType": "author", "firstName": "Elliott M", "lastName": "Antman" }, { "creatorType": "author", "firstName": "Jeffrey L", "lastName": "Anderson" }, { "creatorType": "author", "firstName": "Sharon A", "lastName": "Hunt" }, { "creatorType": "author", "firstName": "Jonathan L", "lastName": "Halperin" }, { "creatorType": "author", "firstName": "Rick", "lastName": "Nishimura" }, { "creatorType": "author", "firstName": "Joseph P", "lastName": "Ornato" }, { "creatorType": "author", "firstName": "Richard L", "lastName": "Page" }, { "creatorType": "author", "firstName": "Barbara", "lastName": "Riegel" } ], "abstractNote": "", "publicationTitle": "European Heart Journal", "publisher": "", "place": "", "date": "Sep 2006", "volume": "27", "issue": "17", "section": "", "partNumber": "", "partTitle": "", "pages": "2099-2140", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Eur. Heart J", "DOI": "10.1093/eurheartj/ehl199", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/16923744", "accessDate": "2009-11-29T10:00:41Z", "PMID": "", "PMCID": "", "ISSN": "0195-668X", "archive": "", "archiveLocation": "", "shortTitle": "ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death--executive summary", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 16923744", "tags": [ { "tag": "Anti-Arrhythmia Agents", "type": 1 }, { "tag": "Arrhythmias, Cardiac", "type": 1 }, { "tag": "Cardiomyopathies", "type": 1 }, { "tag": "Death, Sudden, Cardiac", "type": 1 }, { "tag": "Diagnostic Imaging", "type": 1 }, { "tag": "Echocardiography", "type": 1 }, { "tag": "Electric Countershock", "type": 1 }, { "tag": "Electrocardiography", "type": 1 }, { "tag": "Electrophysiologic Techniques, Cardiac", "type": 1 }, { "tag": "Exercise Test", "type": 1 }, { "tag": "Heart Failure", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Risk Factors", "type": 1 } ], "collections": [ "XKJJBPTC" ], "relations": {}, "dateAdded": "2009-11-29T10:00:41Z", "dateModified": "2009-11-29T10:00:41Z" } }, { "key": "QDJ6KQ35", "version": 1, "library": { "type": "group", "id": 7576, "name": "Journal Club Cardiology", "links": { "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/7576/items/QDJ6KQ35", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology/items/QDJ6KQ35", "type": "text/html" } }, "meta": { "createdByUser": { "id": 8053, "username": "jssgdejong", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jssgdejong", "type": "text/html" } } }, "parsedDate": "2009-11-18", "numChildren": 0 }, "data": { "key": "QDJ6KQ35", "version": 1, "itemType": "webpage", "title": "Does This Patient With Palpitations Have a Cardiac Arrhythmia?", "creators": [], "abstractNote": "", "websiteTitle": "", "websiteType": "", "date": "11/18/2009", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "https://literatuur.amc.nl/http/jama.ama-assn.org/cgi/content/abstract/302/19/2135", "accessDate": "2009-11-26T21:36:48Z", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [ "8V6HA5Q9" ], "relations": {}, "dateAdded": "2009-11-26T21:36:48Z", "dateModified": "2009-11-26T21:36:48Z" } }, { "key": "3Z4ZMXP8", "version": 1, "library": { "type": "group", "id": 7576, "name": "Journal Club Cardiology", "links": { "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/7576/items/3Z4ZMXP8", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology/items/3Z4ZMXP8", "type": 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1, "library": { "type": "group", "id": 7576, "name": "Journal Club Cardiology", "links": { "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/7576/items/B8MBZ9PW", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology/items/B8MBZ9PW", "type": "text/html" } }, "meta": { "createdByUser": { "id": 8053, "username": "jssgdejong", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jssgdejong", "type": "text/html" } } }, "parsedDate": "2009-11-25", "numChildren": 0 }, "data": { "key": "B8MBZ9PW", "version": 1, "itemType": "webpage", "title": "Association of Hospital Primary Angioplasty Volume in ST-Segment Elevation Myocardial Infarction With Quality and Outcomes", "creators": [], "abstractNote": "", "websiteTitle": "", "websiteType": "", "date": "11/25/2009", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "https://literatuur.amc.nl/http/jama.ama-assn.org/cgi/content/abstract/302/20/2207", "accessDate": "2009-11-26T21:33:38Z", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [ "8V6HA5Q9" ], "relations": {}, "dateAdded": "2009-11-26T21:33:38Z", "dateModified": "2009-11-26T21:33:38Z" } }, { "key": "I2SFX98H", "version": 1, "library": { "type": "group", "id": 7576, "name": "Journal Club Cardiology", "links": { "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/7576/items/I2SFX98H", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology/items/I2SFX98H", "type": "text/html" } }, "meta": { "createdByUser": { "id": 8053, "username": "jssgdejong", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jssgdejong", "type": "text/html" } } }, "creatorSummary": "Rodes-Cabau et al.", "parsedDate": "2009", "numChildren": 0 }, "data": { "key": "I2SFX98H", "version": 1, "itemType": "journalArticle", "title": "Comparison of Plaque Sealing With Paclitaxel-Eluting Stents Versus Medical Therapy for the Treatment of Moderate Nonsignificant Saphenous Vein Graft Lesions: The Moderate VEin Graft LEsion Stenting With the Taxus Stent and Intravascular Ultrasound (VELETI) Pilot Trial", "creators": [ { "creatorType": "author", "firstName": "J.", "lastName": "Rodes-Cabau" }, { "creatorType": "author", "firstName": "O. F.", "lastName": "Bertrand" }, { "creatorType": "author", "firstName": "E.", "lastName": "Larose" }, { "creatorType": "author", "firstName": "J.-P.", "lastName": "Dery" }, { "creatorType": "author", "firstName": "S.", "lastName": "Rinfret" }, { "creatorType": "author", "firstName": "R.", "lastName": "Bagur" }, { "creatorType": "author", "firstName": "G.", "lastName": "Proulx" }, { "creatorType": "author", "firstName": "C. M.", "lastName": "Nguyen" }, { "creatorType": "author", "firstName": "M.", "lastName": "Cote" }, { "creatorType": "author", "firstName": "M.-C.", "lastName": "Landcop" }, { "creatorType": "author", "firstName": "J.-R.", "lastName": "Boudreault" }, { "creatorType": "author", "firstName": "J.", "lastName": "Rouleau" }, { "creatorType": "author", "firstName": "L.", "lastName": "Roy" }, { "creatorType": "author", "firstName": "O.", "lastName": "Gleeton" }, { "creatorType": "author", "firstName": "G.", "lastName": "Barbeau" }, { "creatorType": "author", "firstName": "B.", "lastName": "Noel" }, { "creatorType": "author", "firstName": "J.", "lastName": "Courtis" }, { "creatorType": "author", "firstName": "G. R.", "lastName": "Dagenais" }, { "creatorType": "author", "firstName": "J.-P.", "lastName": "Despres" }, { "creatorType": "author", "firstName": "R.", "lastName": "DeLarochelliere" } ], "abstractNote": "", "publicationTitle": "Circulation", "publisher": "", "place": "", "date": "11/2009", "volume": "120", "issue": "20", "section": "", "partNumber": "", "partTitle": "", "pages": "1978-1986", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Circulation", "DOI": "10.1161/CIRCULATIONAHA.109.874057", "citationKey": "", "url": "https://literatuur.amc.nl/http/circ.ahajournals.org/cgi/content/abstract/120/20/1978", "accessDate": "2009-11-26T20:32:58Z", "PMID": "", "PMCID": "", "ISSN": "0009-7322", "archive": "", "archiveLocation": "", "shortTitle": "Comparison of Plaque Sealing With Paclitaxel-Eluting Stents Versus Medical Therapy for the Treatment of Moderate Nonsignificant Saphenous Vein Graft Lesions", "language": "", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "8V6HA5Q9" ], "relations": {}, "dateAdded": "2009-11-26T20:32:58Z", "dateModified": "2009-11-26T20:32:58Z" } }, { "key": "QFQ9QXZ2", "version": 1, "library": { "type": "group", "id": 7576, "name": "Journal Club Cardiology", "links": { "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/7576/items/QFQ9QXZ2", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology/items/QFQ9QXZ2", "type": "text/html" } }, "meta": { "createdByUser": { "id": 8053, "username": "jssgdejong", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jssgdejong", "type": "text/html" } } }, "creatorSummary": "Anker et al.", "parsedDate": "2009-11-17", "numChildren": 0 }, "data": { "key": "QFQ9QXZ2", "version": 1, "itemType": "journalArticle", "title": "Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency", "creators": [ { "creatorType": "author", "firstName": "Stefan D.", "lastName": "Anker" }, { "creatorType": "author", "firstName": "Josep", "lastName": "Comin Colet" }, { "creatorType": "author", "firstName": "Gerasimos", "lastName": "Filippatos" }, { "creatorType": "author", "firstName": "Ronnie", "lastName": "Willenheimer" }, { "creatorType": "author", "firstName": "Kenneth", "lastName": "Dickstein" }, { "creatorType": "author", "firstName": "Helmut", "lastName": "Drexler" }, { "creatorType": "author", "firstName": "Thomas F.", "lastName": "Luscher" }, { "creatorType": "author", "firstName": "Boris", "lastName": "Bart" }, { "creatorType": "author", "firstName": "Waldemar", "lastName": "Banasiak" }, { "creatorType": "author", "firstName": "Joanna", "lastName": "Niegowska" }, { "creatorType": "author", "firstName": "Bridget-Anne", "lastName": "Kirwan" }, { "creatorType": "author", "firstName": "Claudio", "lastName": "Mori" }, { "creatorType": "author", "firstName": "Barbara", "lastName": "von Eisenhart Rothe" }, { "creatorType": "author", "firstName": "Stuart J.", "lastName": "Pocock" }, { "creatorType": "author", "firstName": "Philip A.", "lastName": "Poole-Wilson" }, { "creatorType": "author", "firstName": "Piotr", "lastName": "Ponikowski" }, { "creatorType": "author", "firstName": "", "lastName": "the FAIR-HF Trial Investigators" } ], "abstractNote": "Background Iron deficiency may impair aerobic performance. This study aimed to determine whether treatment with intravenous iron (ferric carboxymaltose) would improve symptoms in patients who had heart failure, reduced left ventricular ejection fraction, and iron deficiency, either with or without anemia. Methods We enrolled 459 patients with chronic heart failure of New York Heart Association (NYHA) functional class II or III, a left ventricular ejection fraction of 40% or less (for patients with NYHA class II) or 45% or less (for NYHA class III), iron deficiency (ferritin level <100 {micro}g per liter or between 100 and 299 {micro}g per liter, if the transferrin saturation was <20%), and a hemoglobin level of 95 to 135 g per liter. Patients were randomly assigned, in a 2:1 ratio, to receive 200 mg of intravenous iron (ferric carboxymaltose) or saline (placebo). The primary end points were the self-reported Patient Global Assessment and NYHA functional class, both at week 24. Secondary end points included the distance walked in 6 minutes and the health-related quality of life. Results Among the patients receiving ferric carboxymaltose, 50% reported being much or moderately improved, as compared with 28% of patients receiving placebo, according to the Patient Global Assessment (odds ratio for improvement, 2.51; 95% confidence interval [CI], 1.75 to 3.61). Among the patients assigned to ferric carboxymaltose, 47% had an NYHA functional class I or II at week 24, as compared with 30% of patients assigned to placebo (odds ratio for improvement by one class, 2.40; 95% CI, 1.55 to 3.71). Results were similar in patients with anemia and those without anemia. Significant improvements were seen with ferric carboxymaltose in the distance on the 6-minute walk test and quality-of-life assessments. The rates of death, adverse events, and serious adverse events were similar in the two study groups. Conclusions Treatment with intravenous ferric carboxymaltose in patients with chronic heart failure and iron deficiency, with or without anemia, improves symptoms, functional capacity, and quality of life; the side-effect profile is acceptable. (ClinicalTrials.gov number, NCT00520780 .)", "publicationTitle": "N Engl J Med", "publisher": "", "place": "", "date": "November 17, 2009", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "NEJMoa0908355", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1056/NEJMoa0908355", "citationKey": "", "url": "http://content.nejm.org/cgi/content/abstract/NEJMoa0908355v1", "accessDate": "2009-11-26T20:10:12Z", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "HighWire", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "8V6HA5Q9" ], "relations": {}, "dateAdded": "2009-11-26T20:10:12Z", "dateModified": "2009-11-26T20:10:12Z" } }, { "key": "PE7CP8A6", "version": 1, "library": { "type": "group", "id": 7576, "name": "Journal Club Cardiology", "links": { "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/7576/items/PE7CP8A6", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology/items/PE7CP8A6", "type": "text/html" } }, "meta": { "createdByUser": { "id": 8053, "username": "jssgdejong", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jssgdejong", "type": "text/html" } } }, "creatorSummary": "Yu et al.", "parsedDate": "2009-11-26", "numChildren": 0 }, "data": { "key": "PE7CP8A6", "version": 1, "itemType": "journalArticle", "title": "Biventricular Pacing in Patients with Bradycardia and Normal Ejection Fraction", "creators": [ { "creatorType": "author", "firstName": "Cheuk-Man", "lastName": "Yu" }, { "creatorType": "author", "firstName": "Joseph Yat-Sun", "lastName": "Chan" }, { "creatorType": "author", "firstName": "Qing", "lastName": "Zhang" }, { "creatorType": "author", "firstName": "Razali", "lastName": "Omar" }, { "creatorType": "author", "firstName": "Gabriel Wai-Kwok", "lastName": "Yip" }, { "creatorType": "author", "firstName": "Azlan", "lastName": "Hussin" }, { "creatorType": "author", "firstName": "Fang", "lastName": "Fang" }, { "creatorType": "author", "firstName": "Kai Huat", "lastName": "Lam" }, { "creatorType": "author", "firstName": "Hamish Chi-Kin", "lastName": "Chan" }, { "creatorType": "author", "firstName": "Jeffrey Wing-Hong", "lastName": "Fung" } ], "abstractNote": "Background Observational studies suggest that conventional right ventricular apical pacing may have a deleterious effect on left ventricular function. In this study, we examined whether biventricular pacing is superior to right ventricular apical pacing in preventing deterioration of left ventricular systolic function and cardiac remodeling in patients with bradycardia and a normal ejection fraction. Methods In this prospective, double-blind, multicenter study, we randomly assigned 177 patients in whom a biventricular pacemaker had been successfully implanted to receive biventricular pacing (89 patients) or right ventricular apical pacing (88 patients). The primary end points were the left ventricular ejection fraction and left ventricular end-systolic volume at 12 months. Results At 12 months, the mean left ventricular ejection fraction was significantly lower in the right-ventricular-pacing group than in the biventricular-pacing group (54.8{+/-}9.1% vs. 62.2{+/-}7.0%, P<0.001), with an absolute difference of 7.4 percentage points, whereas the left ventricular end-systolic volume was significantly higher in the right-ventricular-pacing group than in the biventricular-pacing group (35.7{+/-}16.3 ml vs. 27.6{+/-}10.4 ml, P<0.001), with a relative difference between the groups in the change from baseline of 25% (P<0.001). The deleterious effect of right ventricular apical pacing occurred in prespecified subgroups, including patients with and patients without preexisting left ventricular diastolic dysfunction. Eight patients in the right-ventricular-pacing group (9%) and one in the biventricular-pacing group (1%) had ejection fractions of less than 45% (P=0.02). There was one death in the right-ventricular-pacing group, and six patients in the right-ventricular-pacing group and five in the biventricular-pacing group were hospitalized for heart failure (P=0.74). Conclusions In patients with normal systolic function, conventional right ventricular apical pacing resulted in adverse left ventricular remodeling and in a reduction in the left ventricular ejection fraction; these effects were prevented by biventricular pacing. (Centre for Clinical Trials number, CUHK_CCT00037.)", "publicationTitle": "N Engl J Med", "publisher": "", "place": "", "date": "November 26, 2009", "volume": "361", "issue": "22", "section": "", "partNumber": "", "partTitle": "", "pages": "2123-2134", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1056/NEJMoa0907555", "citationKey": "", "url": "http://content.nejm.org/cgi/content/abstract/361/22/2123", "accessDate": "2009-11-26T20:09:08Z", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "HighWire", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "8V6HA5Q9" ], "relations": {}, "dateAdded": "2009-11-26T20:09:08Z", "dateModified": "2009-11-26T20:09:08Z" } }, { "key": "AQBINBRH", "version": 1, "library": { "type": "group", "id": 7576, "name": "Journal Club Cardiology", "links": { "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/7576/items/AQBINBRH", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology/items/AQBINBRH", "type": "text/html" } }, "meta": { "createdByUser": { "id": 8053, "username": "jssgdejong", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jssgdejong", "type": "text/html" } } }, "creatorSummary": "Michels et al.", "parsedDate": "2009-11", "numChildren": 0 }, "data": { "key": "AQBINBRH", "version": 1, "itemType": "journalArticle", "title": "Disease penetrance and risk stratification for sudden cardiac death in asymptomatic hypertrophic cardiomyopathy mutation carriers", "creators": [ { "creatorType": "author", "firstName": "Michelle", "lastName": "Michels" }, { "creatorType": "author", "firstName": "Osama I I", "lastName": "Soliman" }, { "creatorType": "author", "firstName": "Judith", "lastName": "Phefferkorn" }, { "creatorType": "author", "firstName": "Yvonne M", "lastName": "Hoedemaekers" }, { "creatorType": "author", "firstName": "Marcel J", "lastName": "Kofflard" }, { "creatorType": "author", "firstName": "Dennis", "lastName": "Dooijes" }, { "creatorType": "author", "firstName": "Danielle", "lastName": "Majoor-Krakauer" }, { "creatorType": "author", "firstName": "Folkert J", "lastName": "Ten Cate" } ], "abstractNote": "AIMS: To investigate the outcome of cardiac evaluation and the risk stratification for sudden cardiac death (SCD) in asymptomatic hypertrophic cardiomyopathy (HCM) mutation carriers. METHODS AND RESULTS: Seventy-six HCM mutation carriers from 32 families identified by predictive DNA testing underwent cardiac evaluation including history, examination, electrocardiography, Doppler echocardiography, exercise testing, and 24 h Holter monitoring. The published diagnostic criteria for HCM in adult members of affected families were used to diagnose HCM. Thirty-three (43%) men and 43 (57%) women with a mean age of 42 years (range 16-79) were examined; in 31 (41%) HCM was diagnosed. Disease penetrance was age related and men were more often affected than women (P = 0.04). Myosin Binding Protein C (MYBPC3) mutation carriers were affected at higher age than Myosin Heavy Chain (MYH7) mutation carriers (P = 0.01). Risk factors for SCD were present in affected and unaffected carriers. CONCLUSION: Hypertrophic cardiomyopathy was diagnosed in 41% of carriers. Disease penetrance was age dependent, warranting repeated cardiologic evaluation. The MYBPC3 mutation carriers were affected at higher age than MYH7 mutation carriers. Risk factors for SCD were present in carriers with and without HCM. Follow-up studies are necessary to evaluate the effectiveness of risk stratification for SCD in this population.", "publicationTitle": "European Heart Journal", "publisher": "", "place": "", "date": "Nov 2009", "volume": "30", "issue": "21", "section": "", "partNumber": "", "partTitle": "", "pages": "2593-2598", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Eur. Heart J", "DOI": "10.1093/eurheartj/ehp306", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/19666645", "accessDate": "2009-11-12T22:33:11Z", "PMID": "", "PMCID": "", "ISSN": "1522-9645", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 19666645", "tags": [], "collections": [ "XKJJBPTC" ], "relations": {}, "dateAdded": "2009-11-12T22:33:11Z", "dateModified": "2009-11-12T22:33:11Z" } }, { "key": "9CE7UGIQ", "version": 1, "library": { "type": "group", "id": 7576, "name": "Journal Club Cardiology", "links": { "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/7576/items/9CE7UGIQ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology/items/9CE7UGIQ", "type": "text/html" } }, "meta": { "createdByUser": { "id": 8053, "username": "jssgdejong", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jssgdejong", "type": "text/html" } } }, "creatorSummary": "Beels et al.", "parsedDate": "2009-11-10", "numChildren": 0 }, "data": { "key": "9CE7UGIQ", "version": 1, "itemType": "journalArticle", "title": "gamma-H2AX foci as a biomarker for patient X-ray exposure in pediatric cardiac catheterization: are we underestimating radiation risks?", "creators": [ { "creatorType": "author", "firstName": "Laurence", "lastName": "Beels" }, { "creatorType": "author", "firstName": "Klaus", "lastName": "Bacher" }, { "creatorType": "author", "firstName": "Daniël", "lastName": "De Wolf" }, { "creatorType": "author", "firstName": "Joke", "lastName": "Werbrouck" }, { "creatorType": "author", "firstName": "Hubert", "lastName": "Thierens" } ], "abstractNote": "BACKGROUND: A better knowledge of patient x-ray dose and the associated radiation risk in pediatric interventional cardiology is warranted in view of the extensive use of x-rays and the higher radiosensitivity of children. In the present study, gamma-H2AX foci were used as a biomarker for radiation-induced effects. Patient-specific dose was assessed and radiation risks were estimated according to the linear-no-threshold model, commonly used in radiation protection, and the gamma-H2AX foci data. METHODS AND RESULTS: In 49 pediatric patients (median age, 0.75 years) with congenital heart disease who underwent cardiac catheterization procedures, blood samples were taken before and shortly after the procedure. gamma-H2AX foci were determined in peripheral blood T lymphocytes. In each patient, a net increase in gamma-H2AX foci, representing DNA double-strand breaks induced by interventional x-rays, was observed. In addition, a patient-specific Monte Carlo simulation of the procedure was performed, resulting in individual blood, organ, and tissue doses. Plotting of gamma-H2AX foci versus blood dose indicated a low-dose hypersensitivity. Median effective doses calculated according to the International Commission on Radiological Protection 60 and 103 publications are 5.6 and 6.4 mSv, respectively. The lifetime-attributable risk of cancer mortality was calculated from the linear-no-threshold model and the gamma-H2AX foci data. This resulted in lifetime-attributable risk values of 1% and 4%, respectively, for the patient population under study. CONCLUSIONS: gamma-H2AX foci as a biomarker for DNA damage indicate that radiation risk estimates according to the linear-no-threshold hypothesis are possibly underestimates. Great care should be taken to minimize and optimize patient radiation exposure.", "publicationTitle": "Circulation", "publisher": "", "place": "", "date": "Nov 10, 2009", "volume": "120", "issue": "19", "section": "", "partNumber": "", "partTitle": "", "pages": "1903-1909", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Circulation", "DOI": "10.1161/CIRCULATIONAHA.109.880385", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/19858412", "accessDate": "2009-11-12T22:32:58Z", "PMID": "", "PMCID": "", "ISSN": "1524-4539", "archive": "", "archiveLocation": "", "shortTitle": "gamma-H2AX foci as a biomarker for patient X-ray exposure in pediatric cardiac catheterization", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 19858412", "tags": [], "collections": [ "XKJJBPTC" ], "relations": {}, "dateAdded": "2009-11-12T22:32:58Z", "dateModified": "2009-11-12T22:32:58Z" } }, { "key": "C3WTXF75", "version": 1, "library": { "type": "group", "id": 7576, "name": "Journal Club Cardiology", "links": { "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/7576/items/C3WTXF75", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology/items/C3WTXF75", "type": "text/html" } }, "meta": { "createdByUser": { "id": 8053, "username": "jssgdejong", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jssgdejong", "type": "text/html" } } }, "creatorSummary": "Tamborero et al.", "parsedDate": "2009-11-15", "numChildren": 0 }, "data": { "key": "C3WTXF75", "version": 1, "itemType": "journalArticle", "title": "Optimization of the interventricular delay in cardiac resynchronization therapy using the QRS width", "creators": [ { "creatorType": "author", "firstName": "David", "lastName": "Tamborero" }, { "creatorType": "author", "firstName": "Lluís", "lastName": "Mont" }, { "creatorType": "author", "firstName": "Marta", "lastName": "Sitges" }, { "creatorType": "author", "firstName": "Etelvino", "lastName": "Silva" }, { "creatorType": "author", "firstName": "Antonio", "lastName": "Berruezo" }, { "creatorType": "author", "firstName": "Barbara", "lastName": "Vidal" }, { "creatorType": "author", "firstName": "Victoria", "lastName": "Delgado" }, { "creatorType": "author", "firstName": "Jose M", "lastName": "Tolosana" }, { "creatorType": "author", "firstName": "Miguel", "lastName": "Godoy" }, { "creatorType": "author", "firstName": "Angeles", "lastName": "Castel" }, { "creatorType": "author", "firstName": "Josep", "lastName": "Brugada" } ], "abstractNote": "Optimization of the interventricular pacing delay (VV) in cardiac resynchronization therapy is time-consuming and not routinely performed. The aim of the present study was to compare the acute hemodynamic response obtained by different VV programming methods. Several methods for optimizing the VV using electrocardiographic or echocardiographic measurements were performed. The effect of programming an empirical prefixed VV of 0 ms was also evaluated. Invasive first derivative of left ventricular (LV) pressure over time (dP/dt max) was measured at several VV values, and the hemodynamic response that could be obtained by each noninvasive VV selection method was extrapolated from the curve of LV dP/dt max versus VV. The study included 25 patients (80% men, age 66 +/- 9 years, 44% ischemic). The maximum achievable LV dP/dt during biventricular pacing was obtained by a median left ventricular preactivation of 30 ms and increased the baseline unpaced LV dP/dt from 774 +/- 181 to 934 +/- 179 mm Hg/s (p <0.001). The noninvasive optimization method selected the VV leading to the narrowest QRS measured from the earliest deflection and obtained the smallest difference with regard to the maximum achievable LV dP/dt. Furthermore, of all the VV optimization methods tested, this was the only 1 that significantly improved on the hemodynamic response obtained by programming a predefined VV of 0 ms in all patients (925 +/- 178 vs 906 +/- 183 mm Hg/s; p = 0.003). In conclusion, achieving the narrowest QRS measured from the earliest deflection obtained a better acute hemodynamic response than the other VV optimization methods. It also improved the response obtained by default simultaneous biventricular pacing, although this improvement was limited in magnitude.", "publicationTitle": "The American Journal of Cardiology", "publisher": "", "place": "", "date": "Nov 15, 2009", "volume": "104", "issue": "10", "section": "", "partNumber": "", "partTitle": "", "pages": "1407-1412", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Am. J. Cardiol", "DOI": "10.1016/j.amjcard.2009.07.006", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/19892059", "accessDate": "2009-11-12T22:32:44Z", "PMID": "", "PMCID": "", "ISSN": "1879-1913", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 19892059", "tags": [], "collections": [ "XKJJBPTC" ], "relations": {}, "dateAdded": "2009-11-12T22:32:44Z", "dateModified": "2009-11-12T22:32:44Z" } }, { "key": "37JD8VCE", "version": 1, "library": { "type": "group", "id": 7576, "name": "Journal Club Cardiology", "links": { "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/7576/items/37JD8VCE", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology/items/37JD8VCE", "type": "text/html" } }, "meta": { "createdByUser": { "id": 8053, "username": "jssgdejong", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jssgdejong", "type": "text/html" } } }, "creatorSummary": "Tanzilli et al.", "parsedDate": "2009-11-15", "numChildren": 0 }, "data": { "key": "37JD8VCE", "version": 1, "itemType": "journalArticle", "title": "Effectiveness of two-year clopidogrel + aspirin in abolishing the risk of very late thrombosis after drug-eluting stent implantation (from the TYCOON [two-year ClOpidOgrel need] study)", "creators": [ { "creatorType": "author", "firstName": "Gaetano", "lastName": "Tanzilli" }, { "creatorType": "author", "firstName": "Cesare", "lastName": "Greco" }, { "creatorType": "author", "firstName": "Francesco", "lastName": "Pelliccia" }, { "creatorType": "author", "firstName": "Vincenzo", "lastName": "Pasceri" }, { "creatorType": "author", "firstName": "Francesco", "lastName": "Barillà" }, { "creatorType": "author", "firstName": "Vincenzo", "lastName": "Paravati" }, { "creatorType": "author", "firstName": "Gaetano", "lastName": "Pannitteri" }, { "creatorType": "author", "firstName": "Carlo", "lastName": "Gaudio" }, { "creatorType": "author", "firstName": "Enrico", "lastName": "Mangieri" } ], "abstractNote": "It remains unclear whether dual antiplatelet therapy >12 months might carry a better prognosis after percutaneous coronary intervention (PCI) with drug-eluting stents (DESs). To address the hypothesis that in the real world the risk of very late thrombosis after PCI with DESs can be decreased by an extended use of clopidogrel, we set up the Two-Year ClOpidOgrel Need (TYCOON) registry and prospectively investigated the impact on very late thrombosis of 12- versus 24-month dual antiplatelet regimens in an unselected population. The registry enrolled 897 consecutive patients who underwent PCI with stenting from January 1, 2003, to December 31, 2004, and had dual antiplatelet therapy. All patients had a 4-year clinical follow-up. In the 447 patients with DES implantation, the dual antiplatelet regimen after PCI was given for 12 months in the 173 patients treated in 2003 (12-month group) and for 24 months in the 274 patients treated in 2004 (24-month group). Comparison between groups did not reveal any significant difference in baseline clinical characteristics, angiographic and procedural features, and major adverse cardiac events. During follow-up, there were 5 cases of stent thrombosis after PCI in the 12-month DES group and 1 case in the 24-month DES group (p = 0.02). Specifically, there were 2 cases of subacute thrombosis (1 in each group), no case of late thrombosis, and 4 cases of very late thrombosis occurring at 13, 15, 17, and 23 months after DES implantation in the 12-month group only. In conclusion, a 2-year dual antiplatelet regimen with aspirin and clopidogrel can prevent the occurrence of very late stent thrombosis after PCI with DESs.", "publicationTitle": "The American Journal of Cardiology", "publisher": "", "place": "", "date": "Nov 15, 2009", "volume": "104", "issue": "10", "section": "", "partNumber": "", "partTitle": "", "pages": "1357-1361", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Am. J. Cardiol", "DOI": "10.1016/j.amjcard.2009.07.002", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/19892050", "accessDate": "2009-11-12T22:32:33Z", "PMID": "", "PMCID": "", "ISSN": "1879-1913", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 19892050", "tags": [], "collections": [ "XKJJBPTC" ], "relations": {}, "dateAdded": "2009-11-12T22:32:33Z", "dateModified": "2009-11-12T22:32:33Z" } }, { "key": "2BPGEN8U", "version": 1, "library": { "type": "group", "id": 7576, "name": "Journal Club Cardiology", "links": { "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/7576/items/2BPGEN8U", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology/items/2BPGEN8U", "type": "text/html" } }, "meta": { "createdByUser": { "id": 8053, "username": "jssgdejong", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jssgdejong", "type": "text/html" } } }, "creatorSummary": "Ang et al.", "parsedDate": "2009-11", "numChildren": 0 }, "data": { "key": "2BPGEN8U", "version": 1, "itemType": "journalArticle", "title": "A comparison between B-type natriuretic peptide, global registry of acute coronary events (GRACE) score and their combination in ACS risk stratification", "creators": [ { "creatorType": "author", "firstName": "D S C", "lastName": "Ang" }, { "creatorType": "author", "firstName": "L", "lastName": "Wei" }, { "creatorType": "author", "firstName": "M P C", "lastName": "Kao" }, { "creatorType": "author", "firstName": "C C", "lastName": "Lang" }, { "creatorType": "author", "firstName": "A D", "lastName": "Struthers" } ], "abstractNote": "BACKGROUND: In acute coronary syndrome (ACS), both the Global Registry of Acute Coronary Events (GRACE) score and B-type natriuretic peptide (BNP) predict cardiovascular events. However, it is unknown how BNP compares with GRACE and how their combination performs in ACS. METHODS: The authors recruited 449 consecutive ACS patients and measured admission GRACE score and bedside BNP levels. The main outcome measure was all-cause mortality, readmission with ACS or congestive heart failure (defined as a cardiovascular event) at 10 months from presentation. RESULTS: Of the 449 patients, 120 patients presented with ST-elevation myocardial infarction (MI) (27%). There were 90 cardiovascular events at 10 months. Both higher GRACE terciles and higher BNP terciles predicted cardiovascular events. There was a significant but only partial correlation between the GRACE score and log BNP (R = 0.552, p<0.001). On multivariate analyses, after adjusting for the GRACE score itself, increasing BNP terciles independently predicted cardiovascular events (second BNP tercile adjusted RR 2.28 (95% CI 1.15 to 4.51) and third BNP tercile adjusted RR 4.91 (95% CI 2.62 to 9.22)). Patients with high GRACE score-high BNP were more likely to experience cardiovascular events at 10 months (RR 6.00 (95% CI 2.40 to 14.83)) compared to those with high GRACE score-low BNP (RR 2.40 (95% CI 0.76 to 7.56)). CONCLUSION: In ACS, most but not all of our analyses suggest that BNP can predict cardiovascular events over and above the GRACE score. The combined use of both the GRACE score and BNP can identify a subset of ACS patients at particularly high risk. This implies that both the GRACE score and BNP reflect somewhat different risk attributes when predicting adverse prognosis in ACS and their synergistic use can enhance risk stratification in ACS to a small but potentially useful extent.", "publicationTitle": "Heart (British Cardiac Society)", "publisher": "", "place": "", "date": "Nov 2009", "volume": "95", "issue": "22", "section": "", "partNumber": "", "partTitle": "", "pages": "1836-1842", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Heart", "DOI": "10.1136/hrt.2008.160234", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/19321492", "accessDate": "2009-11-12T22:32:32Z", "PMID": "", "PMCID": "", "ISSN": "1468-201X", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 19321492", "tags": [], "collections": [ "XKJJBPTC" ], "relations": {}, "dateAdded": "2009-11-12T22:32:32Z", "dateModified": "2009-11-12T22:32:32Z" } }, { "key": "MMUMXKT6", "version": 1, "library": { "type": "group", "id": 7576, "name": "Journal Club Cardiology", "links": { "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/7576/items/MMUMXKT6", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology/items/MMUMXKT6", "type": "text/html" } }, "meta": { "createdByUser": { "id": 8053, "username": "jssgdejong", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jssgdejong", "type": "text/html" } } }, "creatorSummary": "Spargias et al.", "parsedDate": "2009-11-03", "numChildren": 0 }, "data": { "key": "MMUMXKT6", "version": 1, "itemType": "journalArticle", "title": "Iloprost prevents contrast-induced nephropathy in patients with renal dysfunction undergoing coronary angiography or intervention", "creators": [ { "creatorType": "author", "firstName": "Konstantinos", "lastName": "Spargias" }, { "creatorType": "author", "firstName": "Elias", "lastName": "Adreanides" }, { "creatorType": "author", "firstName": "Eftihia", "lastName": "Demerouti" }, { "creatorType": "author", "firstName": "Angeliki", "lastName": "Gkouziouta" }, { "creatorType": "author", "firstName": "Athanassios", "lastName": "Manginas" }, { "creatorType": "author", "firstName": "Gregory", "lastName": "Pavlides" }, { "creatorType": "author", "firstName": "Vassilis", "lastName": "Voudris" }, { "creatorType": "author", "firstName": "Dennis V", "lastName": "Cokkinos" } ], "abstractNote": "BACKGROUND: The prevention of contrast-induced nephropathy, which accounts for considerable morbidity and mortality, remains a vexing problem. Contrast-induced renal vasoconstriction is believed to play a pivotal role in the pathogenesis of contrast-induced nephropathy. The aim of this study was to examine the efficacy of the prostacyclin analog iloprost in preventing contrast-induced nephropathy in patients with renal dysfunction undergoing a coronary procedure. METHODS AND RESULTS: We conducted a randomized, double-blind, placebo-controlled trial of iloprost in 208 patients with a serum creatinine concentration >or=1.4 mg/dL who underwent coronary angiography and/or intervention. Iloprost 1 ng kg(-1) min(-1) or placebo was administered intravenously beginning 30 to 90 minutes before and ending 4 hours after the procedure. Contrast-induced nephropathy was defined by an absolute increase in serum creatinine >or=0.5 mg/dL or a relative increase >or=25% measured 2 to 5 days after the procedure. Contrast-induced nephropathy occurred in 23 of the 105 patients (22%) in the control group and in 8 of the 103 patients (8%) in the iloprost group (odds ratio, 0.29; 95% confidence interval, 0.12 to 0.69; P=0.005). In the control group, the estimated glomerular filtration rate declined from 49.7+/-15.5 to 46.6+/-16.6 mL min(-1) 1.73 m(-2) (P=0.01). In the iloprost group, the estimated glomerular filtration rate increased marginally from 47.5+/-14.5 to 48.6+/-16.1 mL min(-1) 1.73 m(-2) (P=0.26). The mean absolute estimated glomerular filtration rate decline in the control group was greater than its change in the iloprost group (difference, 4.2 mL min(-1) 1.73 m(-2); 95% confidence interval, 1.1 to 7.3; P=0.008). CONCLUSIONS: Prophylactic administration of iloprost may protect against contrast-induced nephropathy in high-risk patients undergoing a coronary procedure.", "publicationTitle": "Circulation", "publisher": "", "place": "", "date": "Nov 3, 2009", "volume": "120", "issue": "18", "section": "", "partNumber": "", "partTitle": "", "pages": "1793-1799", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Circulation", "DOI": "10.1161/CIRCULATIONAHA.109.863159", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/19841299", "accessDate": "2009-11-12T22:32:31Z", "PMID": "", "PMCID": "", "ISSN": "1524-4539", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 19841299", "tags": [], "collections": [ "XKJJBPTC" ], "relations": {}, "dateAdded": "2009-11-12T22:32:31Z", "dateModified": "2009-11-12T22:32:31Z" } }, { "key": "DJG2P467", "version": 1, "library": { "type": "group", "id": 7576, "name": "Journal Club Cardiology", "links": { "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/7576/items/DJG2P467", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology/items/DJG2P467", "type": "text/html" } }, "meta": { "createdByUser": { "id": 8053, "username": "jssgdejong", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jssgdejong", "type": "text/html" } } }, "creatorSummary": "Schwartz et al.", "parsedDate": "2009-11-03", "numChildren": 0 }, "data": { "key": "DJG2P467", "version": 1, "itemType": "journalArticle", "title": "Prevalence of the congenital long-QT syndrome", "creators": [ { "creatorType": "author", "firstName": "Peter J", "lastName": "Schwartz" }, { "creatorType": "author", "firstName": "Marco", "lastName": "Stramba-Badiale" }, { "creatorType": "author", "firstName": "Lia", "lastName": "Crotti" }, { "creatorType": "author", "firstName": "Matteo", "lastName": "Pedrazzini" }, { "creatorType": "author", "firstName": "Alessandra", "lastName": "Besana" }, { "creatorType": "author", "firstName": "Giuliano", "lastName": "Bosi" }, { "creatorType": "author", "firstName": "Fulvio", "lastName": "Gabbarini" }, { "creatorType": "author", "firstName": "Karine", "lastName": "Goulene" }, { "creatorType": "author", "firstName": "Roberto", "lastName": "Insolia" }, { "creatorType": "author", "firstName": "Savina", "lastName": "Mannarino" }, { "creatorType": "author", "firstName": "Fabio", "lastName": "Mosca" }, { "creatorType": "author", "firstName": "Luigi", "lastName": "Nespoli" }, { "creatorType": "author", "firstName": "Alessandro", "lastName": "Rimini" }, { "creatorType": "author", "firstName": "Enrico", "lastName": "Rosati" }, { "creatorType": "author", "firstName": "Patrizia", "lastName": "Salice" }, { "creatorType": "author", "firstName": "Carla", "lastName": "Spazzolini" } ], "abstractNote": "BACKGROUND: The prevalence of genetic arrhythmogenic diseases is unknown. For the long-QT syndrome (LQTS), figures ranging from 1:20 000 to 1:5000 were published, but none was based on actual data. Our objective was to define the prevalence of LQTS. METHODS AND RESULTS: In 18 maternity hospitals, an ECG was performed in 44 596 infants 15 to 25 days old (43 080 whites). In infants with a corrected QT interval (QTc) >450 ms, the ECG was repeated within 1 to 2 weeks. Genetic analysis, by screening 7 LQTS genes, was performed in 28 of 31 (90%) and in 14 of 28 infants (50%) with, respectively, a QTc >470 ms or between 461 and 470 ms. A QTc of 451 to 460, 461 to 470, and >470 ms was observed in 177 (0.41%), 28 (0.06%), and 31 infants (0.07%). Among genotyped infants, disease-causing mutations were found in 12 of 28 (43%) with a QTc >470 ms and in 4 of 14 (29%) with a QTc of 461 to 470 ms. One genotype-negative infant (QTc 482 ms) was diagnosed as affected by LQTS on clinical grounds. Among family members of genotype-positive infants, 51% were found to carry disease-causing mutations. In total, 17 of 43 080 white infants were affected by LQTS, demonstrating a prevalence of at least 1:2534 apparently healthy live births (95% confidence interval, 1:1583 to 1:4350). CONCLUSIONS: This study provides the first data-based estimate of the prevalence of LQTS among whites. On the basis of the nongenotyped infants with QTc between 451 and 470 ms, we advance the hypothesis that this prevalence might be close to 1:2000. ECG-guided molecular screening can identify most infants affected by LQTS and unmask affected relatives, thus allowing effective preventive measures.", "publicationTitle": "Circulation", "publisher": "", "place": "", "date": "Nov 3, 2009", "volume": "120", "issue": "18", "section": "", "partNumber": "", "partTitle": "", "pages": "1761-1767", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Circulation", "DOI": "10.1161/CIRCULATIONAHA.109.863209", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/19841298", "accessDate": "2009-11-12T22:32:30Z", "PMID": "", "PMCID": "", "ISSN": "1524-4539", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 19841298", "tags": [], "collections": [ "XKJJBPTC" ], "relations": {}, "dateAdded": "2009-11-12T22:32:30Z", "dateModified": "2009-11-12T22:32:30Z" } }, { "key": "DU96AHTA", "version": 1, "library": { "type": "group", "id": 7576, "name": "Journal Club Cardiology", "links": { "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/7576/items/DU96AHTA", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/journal_club_cardiology/items/DU96AHTA", "type": "text/html" } }, "meta": { "createdByUser": { "id": 8053, "username": "jssgdejong", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jssgdejong", "type": "text/html" } } }, "creatorSummary": "Moya et al.", "parsedDate": "2009-11", "numChildren": 0 }, "data": { "key": "DU96AHTA", "version": 1, "itemType": "journalArticle", "title": "Guidelines for the diagnosis and management of syncope (version 2009): the Task Force for the Diagnosis and Management of Syncope of the European Society of Cardiology (ESC)", "creators": [ { "creatorType": "author", "firstName": "Angel", "lastName": "Moya" }, { "creatorType": "author", "firstName": "Richard", "lastName": "Sutton" }, { "creatorType": "author", "firstName": "Fabrizio", "lastName": "Ammirati" }, { "creatorType": "author", "firstName": "Jean-Jacques", "lastName": "Blanc" }, { "creatorType": "author", "firstName": "Michele", "lastName": "Brignole" }, { "creatorType": "author", "firstName": "Johannes B", "lastName": "Dahm" }, { "creatorType": "author", "firstName": "Jean-Claude", "lastName": "Deharo" }, { "creatorType": "author", "firstName": "Jacek", "lastName": "Gajek" }, { "creatorType": "author", "firstName": "Knut", "lastName": "Gjesdal" }, { "creatorType": "author", "firstName": "Andrew", "lastName": "Krahn" }, { "creatorType": "author", "firstName": "Martial", "lastName": "Massin" }, { "creatorType": "author", "firstName": "Mauro", "lastName": "Pepi" }, { "creatorType": "author", "firstName": "Thomas", "lastName": "Pezawas" }, { "creatorType": "author", "firstName": "Ricardo Ruiz", "lastName": "Granell" }, { "creatorType": "author", "firstName": "Francois", "lastName": "Sarasin" }, { "creatorType": "author", "firstName": "Andrea", "lastName": "Ungar" }, { "creatorType": "author", "firstName": "J Gert", "lastName": "van Dijk" }, { "creatorType": "author", "firstName": "Edmond P", "lastName": "Walma" }, { "creatorType": "author", "firstName": "Wouter", "lastName": "Wieling" }, { "creatorType": "author", "firstName": "Haruhiko", "lastName": "Abe" }, { "creatorType": "author", "firstName": "David G", "lastName": "Benditt" }, { "creatorType": "author", "firstName": "Wyatt W", "lastName": "Decker" }, { "creatorType": "author", "firstName": "Blair P", "lastName": "Grubb" }, { "creatorType": "author", "firstName": "Horacio", "lastName": "Kaufmann" }, { "creatorType": "author", "firstName": "Carlos", "lastName": "Morillo" }, { "creatorType": "author", "firstName": "Brian", "lastName": "Olshansky" }, { "creatorType": "author", "firstName": "Steve W", "lastName": "Parry" }, { "creatorType": "author", "firstName": "Robert", "lastName": "Sheldon" }, { "creatorType": "author", "firstName": "Win K", "lastName": "Shen" }, { "creatorType": "author", "firstName": "Alec", "lastName": "Vahanian" }, { "creatorType": "author", "firstName": "Angelo", "lastName": "Auricchio" }, { "creatorType": "author", "firstName": "Jeroen", "lastName": "Bax" }, { "creatorType": "author", "firstName": "Claudio", "lastName": "Ceconi" }, { "creatorType": "author", "firstName": "Veronica", "lastName": "Dean" }, { "creatorType": "author", "firstName": "Gerasimos", "lastName": "Filippatos" }, { "creatorType": "author", "firstName": "Christian", "lastName": "Funck-Brentano" }, { "creatorType": "author", "firstName": "Richard", "lastName": "Hobbs" }, { "creatorType": "author", "firstName": "Peter", "lastName": "Kearney" }, { "creatorType": "author", "firstName": "Theresa", "lastName": "McDonagh" }, { "creatorType": "author", "firstName": "Keith", "lastName": "McGregor" }, { "creatorType": "author", "firstName": "Bogdan A", "lastName": "Popescu" }, { "creatorType": "author", "firstName": "Zeljko", "lastName": "Reiner" }, { "creatorType": "author", "firstName": "Udo", "lastName": "Sechtem" }, { "creatorType": "author", "firstName": "Per Anton", "lastName": "Sirnes" }, { "creatorType": "author", "firstName": "Michal", "lastName": "Tendera" }, { "creatorType": "author", "firstName": "Panos", "lastName": "Vardas" }, { "creatorType": "author", "firstName": "Petr", "lastName": "Widimsky" }, { "creatorType": "author", "firstName": "Angelo", "lastName": "Auricchio" }, { "creatorType": "author", "firstName": "Esmeray", "lastName": "Acarturk" }, { "creatorType": "author", "firstName": "Felicita", "lastName": "Andreotti" }, { "creatorType": "author", "firstName": "Riccardo", "lastName": "Asteggiano" }, { "creatorType": "author", "firstName": "Urs", "lastName": "Bauersfeld" }, { "creatorType": "author", "firstName": "Abdelouahab", "lastName": "Bellou" }, { "creatorType": "author", "firstName": "Athanase", "lastName": "Benetos" }, { "creatorType": "author", "firstName": "Johan", "lastName": "Brandt" }, { "creatorType": "author", "firstName": "Mina K", "lastName": "Chung" }, { "creatorType": "author", "firstName": "Pietro", "lastName": "Cortelli" }, { "creatorType": "author", "firstName": "Antoine", "lastName": "Da Costa" }, { "creatorType": "author", "firstName": "Fabrice", "lastName": "Extramiana" }, { "creatorType": "author", "firstName": "José", "lastName": "Ferro" }, { "creatorType": "author", "firstName": "Bulent", "lastName": "Gorenek" }, { "creatorType": "author", "firstName": "Antti", "lastName": "Hedman" }, { "creatorType": "author", "firstName": "Rafael", "lastName": "Hirsch" }, { "creatorType": "author", "firstName": "Gabriela", "lastName": "Kaliska" }, { "creatorType": "author", "firstName": "Rose Anne", "lastName": "Kenny" }, { "creatorType": "author", "firstName": "Keld Per", "lastName": "Kjeldsen" }, { "creatorType": "author", "firstName": "Rachel", "lastName": "Lampert" }, { "creatorType": "author", "firstName": "Henning", "lastName": "Mølgard" }, { "creatorType": "author", "firstName": "Rain", "lastName": "Paju" }, { "creatorType": "author", "firstName": "Aras", "lastName": "Puodziukynas" }, { "creatorType": "author", "firstName": "Antonio", "lastName": "Raviele" }, { "creatorType": "author", "firstName": "Pilar", "lastName": "Roman" }, { "creatorType": "author", "firstName": "Martin", "lastName": "Scherer" }, { "creatorType": "author", "firstName": "Ronald", "lastName": "Schondorf" }, { "creatorType": "author", "firstName": "Rosa", "lastName": "Sicari" }, { "creatorType": "author", "firstName": "Peter", "lastName": "Vanbrabant" }, { "creatorType": "author", "firstName": "Christian", "lastName": "Wolpert" }, { "creatorType": "author", "firstName": "Jose Luis", "lastName": "Zamorano" } ], "abstractNote": "", "publicationTitle": "European Heart Journal", "publisher": "", "place": "", "date": "Nov 2009", "volume": "30", "issue": "21", "section": "", "partNumber": "", "partTitle": "", "pages": "2631-2671", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Eur. Heart J", "DOI": "10.1093/eurheartj/ehp298", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/19713422", "accessDate": "2009-11-12T22:32:29Z", "PMID": "", "PMCID": "", "ISSN": "1522-9645", "archive": "", "archiveLocation": "", "shortTitle": "Guidelines for the diagnosis and management of syncope (version 2009)", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 19713422", "tags": [], "collections": [ "XKJJBPTC" ], "relations": {}, "dateAdded": "2009-11-12T22:32:29Z", "dateModified": "2009-11-12T22:32:29Z" } } ]