[ { "key": "XBJZ68KZ", "version": 1, "library": { "type": "group", "id": 72800, "name": "Dajekatesis2012", "links": { "alternate": { "href": "https://www.zotero.org/groups/dajekatesis2012", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/72800/items/XBJZ68KZ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/dajekatesis2012/items/XBJZ68KZ", "type": "text/html" } }, "meta": { "createdByUser": { "id": 956906, "username": "Jenny Adaos Rojas", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jenny_adaos_rojas", "type": "text/html" } } }, "creatorSummary": "Tate et al.", "parsedDate": "2011-11", "numChildren": 0 }, "data": { "key": "XBJZ68KZ", "version": 1, "itemType": "journalArticle", "title": "Milk stimulates growth of prostate cancer cells in culture", "creators": [ { "creatorType": "author", "firstName": "Patricia L", "lastName": "Tate" }, { "creatorType": "author", "firstName": "Robert", "lastName": "Bibb" }, { "creatorType": "author", "firstName": "Lyndon L", "lastName": "Larcom" } ], "abstractNote": "Concern has been expressed about the fact that cows' milk contains estrogens and could stimulate the growth of hormone-sensitive tumors. In this study, organic cows' milk and two commercial substitutes were digested in vitro and tested for their effects on the growth of cultures of prostate and breast cancer cells. Cows' milk stimulated the growth of LNCaP prostate cancer cells in each of 14 separate experiments, producing an average increase in growth rate of over 30%. In contrast, almond milk suppressed the growth of these cells by over 30%. Neither cows' milk nor almond milk affected the growth of MCF-7 breast cancer cells or AsPC-1 pancreatic cancer cells significantly. Soy milk increased the growth rate of the breast cancer cells. These data indicate that prostate and breast cancer patients should be cautioned about the possible promotional effects of commercial dairy products and their substitutes.", "publicationTitle": "Nutrition and Cancer", "publisher": "", "place": "", "date": "Nov 2011", "volume": "63", "issue": "8", "section": "", "partNumber": "", "partTitle": "", "pages": "1361-1366", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Nutr Cancer", "DOI": "10.1080/01635581.2011.609306", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/22043817", "accessDate": "2012-03-08T19:44:55Z", "PMID": "", "PMCID": "", "ISSN": "1532-7914", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 22043817", "tags": [], "collections": [], "relations": {}, "dateAdded": "2012-03-15T17:40:50Z", "dateModified": "2012-03-15T17:40:50Z" } }, { "key": "RNKE8CC8", "version": 1, "library": { "type": "group", "id": 72800, "name": "Dajekatesis2012", "links": { "alternate": { "href": "https://www.zotero.org/groups/dajekatesis2012", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/72800/items/RNKE8CC8", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/dajekatesis2012/items/RNKE8CC8", "type": "text/html" } }, "meta": { "createdByUser": { "id": 956906, "username": "Jenny Adaos Rojas", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jenny_adaos_rojas", "type": "text/html" } } }, "creatorSummary": "Nielsen et al.", "parsedDate": "2011-05", "numChildren": 0 }, "data": { "key": "RNKE8CC8", "version": 1, "itemType": "journalArticle", "title": "Effects of maternal exposure to cow's milk high or low in isoflavones on carcinogen-induced mammary tumorigenesis among rat offspring", "creators": [ { "creatorType": "author", "firstName": "Tina Skau", "lastName": "Nielsen" }, { "creatorType": "author", "firstName": "Stig", "lastName": "Purup" }, { "creatorType": "author", "firstName": "Anni", "lastName": "Wärri" }, { "creatorType": "author", "firstName": "Roger W", "lastName": "Godschalk" }, { "creatorType": "author", "firstName": "Leena", "lastName": "Hilakivi-Clarke" } ], "abstractNote": "We investigated whether maternal exposure during pregnancy to cow's milk containing endogenous estrogens and insulin-like growth factor 1 (IGF-1) and either high or low levels of isoflavones from dietary legumes (HIM and LIM, respectively) affected carcinogen-induced mammary carcinogenesis in female rat offspring. Pregnant Sprague-Dawley rats were given HIM, LIM, or tap water (control) from gestational day (GD) 11 until birth; hereafter all rats received tap water. Mammary tumorigenesis was induced by administrating 7,12-dimethylbenz[a]anthracene (DMBA) on postnatal day 50. No differences in maternal serum estradiol (P = 0.19) and IGF-1 levels (P = 0.15) at GD 19 or birth weight among the milk and water groups were seen, but estradiol, and IGF-1 levels and birth weight were numerically higher in the LIM group than in the HIM group. Puberty onset occurred earlier in the LIM offspring than in controls (P = 0.03). Although the high isoflavone content seemed to prevent the effect on circulating estradiol and IGF-1 levels and advanced puberty onset seen in the LIM group, HIM increased DMBA-DNA adducts in the mammary gland and tended to increase mammary tumorigenesis. In contrast, offspring exposed to LIM in utero, did not exhibit increased breast cancer risk, despite having higher estradiol and IGF-1 environment and consequently earlier puberty onset. These results indicate that the phytochemical content in the cow's milk, consumed by a pregnant dam, determines how milk affects the offspring.", "publicationTitle": "Cancer Prevention Research (Philadelphia, Pa.)", "publisher": "", "place": "", "date": "May 2011", "volume": "4", "issue": "5", "section": "", "partNumber": "", "partTitle": "", "pages": "694-701", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Cancer Prev Res (Phila)", "DOI": "10.1158/1940-6207.CAPR-10-0220", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/21467133", "accessDate": "2012-03-08T19:27:18Z", "PMID": "", "PMCID": "", "ISSN": "1940-6215", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 21467133", "tags": [ { "tag": "9,10-Dimethyl-1,2-benzanthracene", "type": 1 }, { "tag": "Animals", "type": 1 }, { "tag": "Carcinogens", "type": 1 }, { "tag": "Cattle", "type": 1 }, { "tag": "Disease Susceptibility", "type": 1 }, { "tag": "Dose-Response Relationship, Drug", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Isoflavones", "type": 1 }, { "tag": "Mammary Neoplasms, Experimental", "type": 1 }, { "tag": "Maternal Exposure", "type": 1 }, { "tag": "Milk", "type": 1 }, { "tag": "Pregnancy", "type": 1 }, { "tag": "Pregnancy Complications, Neoplastic", "type": 1 }, { "tag": "Prenatal Exposure Delayed Effects", "type": 1 }, { "tag": "Rats", "type": 1 }, { "tag": "Rats, Sprague-Dawley", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2012-03-15T17:40:50Z", "dateModified": "2012-03-15T17:40:50Z" } } ]