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            "creatorSummary": "Holtz et al.",
            "parsedDate": "2003-10",
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        },
        "data": {
            "key": "XBU4XQ9G",
            "version": 1,
            "itemType": "journalArticle",
            "title": "Care seeking behaviour and treatment of febrile illness in children aged less than five years: a household survey in Blantyre District, Malawi",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Timothy H",
                    "lastName": "Holtz"
                },
                {
                    "creatorType": "author",
                    "firstName": "S Patrick",
                    "lastName": "Kachur"
                },
                {
                    "creatorType": "author",
                    "firstName": "Lawrence H",
                    "lastName": "Marum"
                },
                {
                    "creatorType": "author",
                    "firstName": "Christopher",
                    "lastName": "Mkandala"
                },
                {
                    "creatorType": "author",
                    "firstName": "Nyson",
                    "lastName": "Chizani"
                },
                {
                    "creatorType": "author",
                    "firstName": "Jacquelin M",
                    "lastName": "Roberts"
                },
                {
                    "creatorType": "author",
                    "firstName": "Allan",
                    "lastName": "Macheso"
                },
                {
                    "creatorType": "author",
                    "firstName": "Monica E",
                    "lastName": "Parise"
                }
            ],
            "abstractNote": "Malaria is a leading cause of death in children aged < 5 years in Malawi. As part of the Roll Back Malaria initiative, African heads of state have pledged that by 2005, 60% of children will receive an effective antimalarial drug within 24 h of developing fever. In 1993, Malawi switched from chloroquine to sulfadoxine-pyrimethamine (SP) in its recommendations of home treatment of febrile illness in children. To study care seeking behaviour and home treatment in Blantyre District, and provide valuable follow-up to the chloroquine to SP transition, we performed a 2-stage cluster-sample survey in February 2000. Our sample of 1080 households included 672 households with children aged < 5 years; 292 (32.2%, 95% CI 28.7-35.8%) of the 912 children in these households had completed a febrile episode within the past 14 d. Among recently febrile children, 210 (72.0%, 95% CI 67.0-77.1%) received medication at home during their illness, but only 36 (12.2%, 95% CI 8.4-16.0%) received an appropriate antimalarial drug. Overall, 111 (37.4%, 95% CI 30.9-43.9%) received prompt, appropriate treatment. Only rural location was statistically associated with failure to receive prompt appropriate treatment (risk ratio estimate 1.2, 95% CI 1.01-1.5). A greater effort to improve the quality of malaria home treatment or to expand health facility utilization will be necessary to achieve Roll Back Malaria goals before 2005 in Blantyre District. Current care seeking practices suggest interventions should stress promptness of health facility visits, improved access to appropriate drugs, and accurate dosing for home-based treatments.",
            "publicationTitle": "Transactions of the Royal Society of Tropical Medicine and Hygiene",
            "publisher": "",
            "place": "",
            "date": "2003 Sep-Oct",
            "volume": "97",
            "issue": "5",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "491-497",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "Trans. R. Soc. Trop. Med. Hyg",
            "DOI": "",
            "citationKey": "",
            "url": "http://www.ncbi.nlm.nih.gov/pubmed/15307408",
            "accessDate": "2010-11-03T01:39:23Z",
            "PMID": "",
            "PMCID": "",
            "ISSN": "0035-9203",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "Care seeking behaviour and treatment of febrile illness in children aged less than five years",
            "language": "",
            "libraryCatalog": "NCBI PubMed",
            "callNumber": "0016",
            "rights": "",
            "extra": "PMID: 15307408",
            "tags": [
                {
                    "tag": "Ambulatory Care",
                    "type": 1
                },
                {
                    "tag": "Analgesics, Non-Narcotic",
                    "type": 1
                },
                {
                    "tag": "Antimalarials",
                    "type": 1
                },
                {
                    "tag": "CLUSTER analysis",
                    "type": 1
                },
                {
                    "tag": "Child, Preschool",
                    "type": 1
                },
                {
                    "tag": "Female",
                    "type": 1
                },
                {
                    "tag": "Fever",
                    "type": 1
                },
                {
                    "tag": "Health Services Accessibility",
                    "type": 1
                },
                {
                    "tag": "Home Nursing",
                    "type": 1
                },
                {
                    "tag": "Humans",
                    "type": 1
                },
                {
                    "tag": "Infant",
                    "type": 1
                },
                {
                    "tag": "Infant, Newborn",
                    "type": 1
                },
                {
                    "tag": "Malaria",
                    "type": 1
                },
                {
                    "tag": "Malawi",
                    "type": 1
                },
                {
                    "tag": "Male",
                    "type": 1
                },
                {
                    "tag": "Patient Acceptance of Health Care",
                    "type": 1
                },
                {
                    "tag": "Referral and Consultation",
                    "type": 1
                },
                {
                    "tag": "Rural Health",
                    "type": 1
                },
                {
                    "tag": "Time Factors",
                    "type": 1
                }
            ],
            "collections": [],
            "relations": {},
            "dateAdded": "2012-01-13T23:52:30Z",
            "dateModified": "2012-01-13T23:52:30Z"
        }
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    {
        "key": "EU4C4RDF",
        "version": 1,
        "library": {
            "type": "group",
            "id": 65008,
            "name": "Gender and Medicines",
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                }
            },
            "creatorSummary": "Zwarenstein et al.",
            "parsedDate": "1998-10-24",
            "numChildren": 0
        },
        "data": {
            "key": "EU4C4RDF",
            "version": 1,
            "itemType": "journalArticle",
            "title": "Randomised controlled trial of self-supervised and directly observed treatment of tuberculosis",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "M",
                    "lastName": "Zwarenstein"
                },
                {
                    "creatorType": "author",
                    "firstName": "J H",
                    "lastName": "Schoeman"
                },
                {
                    "creatorType": "author",
                    "firstName": "C",
                    "lastName": "Vundule"
                },
                {
                    "creatorType": "author",
                    "firstName": "C J",
                    "lastName": "Lombard"
                },
                {
                    "creatorType": "author",
                    "firstName": "M",
                    "lastName": "Tatley"
                }
            ],
            "abstractNote": "BACKGROUND Tuberculosis is a major public-health problem in South Africa, made worse by poor adherence to and frequent interruption of treatment. Direct observation (DO) of tuberculosis patients taking their drugs is supposed to improve treatment completion and outcome. We compared DO with self-supervision, in which patients on the same drug regimen are not observed taking their pills, to assess the effect of each on the success of tuberculosis treatment. METHODS We undertook an unblinded randomised controlled trial in two communities with large tuberculosis caseloads. The trial included 216 adults who started pulmonary tuberculosis treatment for the first time, or who had a second course of treatment (retreatment patients). No changes to existing treatment delivery were made other than randomisation. Analysis was by intention to treat. Individual patient data from the two communities were combined. FINDINGS Treatment for tuberculosis was more successful among self-supervised patients (60% of patients) than among those on DO (54% of patients, difference between groups 6% [90% CI -5.1 to 17.0]). Retreatment patients had significantly more successful treatment outcomes if self-supervised (74% of patients) than on DO (42% of patients, difference between groups 32% [11%-52%]). INTERPRETATION At high rates of treatment interruption, self-supervision achieved equivalent outcomes to clinic DO at lower cost. Self-supervision achieved better outcomes for retreatment patients. Supportive patient-carer relations, rather than the authoritarian surveillance implicit in DO, may improve treatment outcomes and help to control tuberculosis.",
            "publicationTitle": "Lancet",
            "publisher": "",
            "place": "",
            "date": "Oct 24, 1998",
            "volume": "352",
            "issue": "9137",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "1340-1343",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "Lancet",
            "DOI": "10.1016/S0140-6736(98)04022-7",
            "citationKey": "",
            "url": "http://www.ncbi.nlm.nih.gov/pubmed/9802271",
            "accessDate": "2011-05-19T16:13:26Z",
            "PMID": "",
            "PMCID": "",
            "ISSN": "0140-6736",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "",
            "language": "",
            "libraryCatalog": "NCBI PubMed",
            "callNumber": "",
            "rights": "",
            "extra": "PMID: 9802271",
            "tags": [
                {
                    "tag": "Adult",
                    "type": 1
                },
                {
                    "tag": "Antitubercular Agents",
                    "type": 1
                },
                {
                    "tag": "Female",
                    "type": 1
                },
                {
                    "tag": "Humans",
                    "type": 1
                },
                {
                    "tag": "Male",
                    "type": 1
                },
                {
                    "tag": "Observation",
                    "type": 1
                },
                {
                    "tag": "Patient Compliance",
                    "type": 1
                },
                {
                    "tag": "Self Administration",
                    "type": 1
                },
                {
                    "tag": "South Africa",
                    "type": 1
                },
                {
                    "tag": "Treatment Outcome",
                    "type": 1
                },
                {
                    "tag": "Tuberculosis, Multidrug-Resistant",
                    "type": 1
                },
                {
                    "tag": "Tuberculosis, Pulmonary",
                    "type": 1
                }
            ],
            "collections": [],
            "relations": {},
            "dateAdded": "2012-01-13T23:49:06Z",
            "dateModified": "2012-01-13T23:49:06Z"
        }
    },
    {
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        "version": 1,
        "library": {
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            },
            "creatorSummary": "Yu et al.",
            "parsedDate": "2007-07",
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        "data": {
            "key": "P4T89ATB",
            "version": 1,
            "itemType": "journalArticle",
            "title": "True outcomes for patients on antiretroviral therapy who are \"lost to follow-up\" in Malawi",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Joseph Kwong-Leung",
                    "lastName": "Yu"
                },
                {
                    "creatorType": "author",
                    "firstName": "Solomon Chih-Cheng",
                    "lastName": "Chen"
                },
                {
                    "creatorType": "author",
                    "firstName": "Kuo-Yang",
                    "lastName": "Wang"
                },
                {
                    "creatorType": "author",
                    "firstName": "Chao-Sung",
                    "lastName": "Chang"
                },
                {
                    "creatorType": "author",
                    "firstName": "Simon D",
                    "lastName": "Makombe"
                },
                {
                    "creatorType": "author",
                    "firstName": "Erik J",
                    "lastName": "Schouten"
                },
                {
                    "creatorType": "author",
                    "firstName": "Anthony D",
                    "lastName": "Harries"
                }
            ],
            "abstractNote": "PROBLEM In many resource-poor countries that are scaling up antiretroviral therapy (ART), 5-25% of patients are reported as \"lost to follow-up\". This figure is 9% in Malawi. There is no published information about the true outcome status of these patients. APPROACH In four facilities in northern Malawi, ART registers and master cards were used to identify patients who had not attended the facility for 3 months or more and were thus registered as \"lost to follow-up\". Clinic staff attempted to trace these patients and ascertain their true outcome status. LOCAL SETTING Of 253 patients identified as \"lost to follow-up\", 127 (50%) were dead, 58% of these having died within 3 months of their last clinic visit. Of the 58 patients (23%) found to be alive, 21 were still receiving ART and 37 had stopped treatment (high transport costs being the main reason for 13 patients). Sixty-eight patients (27%) could not be traced, most commonly because of an incorrect address in the register. Fewer patients were alive and more patients could not be traced from the central hospital compared with the peripheral hospitals. RELEVANT CHANGES:Better documentation of patients addresses and prompt follow-up of patients who are late for their appointments are required. LESSONS LEARNED ART clinics in resource-poor countries should ensure that patients addresses are correct and comprehensive. Clinics should also undertake contact tracing as soon as possible in the event of non-attendance, consider facilitating access to ART clinics and take loss to follow-up into consideration when assessing death rates.",
            "publicationTitle": "Bulletin of the World Health Organization",
            "publisher": "",
            "place": "",
            "date": "Jul 2007",
            "volume": "85",
            "issue": "7",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "550-554",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "Bull. World Health Organ",
            "DOI": "",
            "citationKey": "",
            "url": "http://www.ncbi.nlm.nih.gov/pubmed/17768504",
            "accessDate": "2011-05-31T20:32:45Z",
            "PMID": "",
            "PMCID": "",
            "ISSN": "0042-9686",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "",
            "language": "",
            "libraryCatalog": "NCBI PubMed",
            "callNumber": "0083",
            "rights": "",
            "extra": "PMID: 17768504",
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                    "tag": "Adolescent",
                    "type": 1
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                {
                    "tag": "Adult",
                    "type": 1
                },
                {
                    "tag": "Anti-HIV Agents",
                    "type": 1
                },
                {
                    "tag": "Female",
                    "type": 1
                },
                {
                    "tag": "HIV Infections",
                    "type": 1
                },
                {
                    "tag": "Health Services Accessibility",
                    "type": 1
                },
                {
                    "tag": "Humans",
                    "type": 1
                },
                {
                    "tag": "Malawi",
                    "type": 1
                },
                {
                    "tag": "Male",
                    "type": 1
                },
                {
                    "tag": "Patient Dropouts",
                    "type": 1
                },
                {
                    "tag": "Poverty Areas",
                    "type": 1
                },
                {
                    "tag": "Treatment Outcome",
                    "type": 1
                }
            ],
            "collections": [],
            "relations": {},
            "dateAdded": "2012-01-13T23:48:52Z",
            "dateModified": "2012-01-13T23:48:52Z"
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    },
    {
        "key": "P24V5EW9",
        "version": 1,
        "library": {
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            "name": "Gender and Medicines",
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                }
            },
            "creatorSummary": "Yamasaki-Nakagawa et al.",
            "parsedDate": "2001-01",
            "numChildren": 0
        },
        "data": {
            "key": "P24V5EW9",
            "version": 1,
            "itemType": "journalArticle",
            "title": "Gender difference in delays to diagnosis and health care seeking behaviour in a rural area of Nepal",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "M",
                    "lastName": "Yamasaki-Nakagawa"
                },
                {
                    "creatorType": "author",
                    "firstName": "K",
                    "lastName": "Ozasa"
                },
                {
                    "creatorType": "author",
                    "firstName": "N",
                    "lastName": "Yamada"
                },
                {
                    "creatorType": "author",
                    "firstName": "K",
                    "lastName": "Osuga"
                },
                {
                    "creatorType": "author",
                    "firstName": "A",
                    "lastName": "Shimouchi"
                },
                {
                    "creatorType": "author",
                    "firstName": "N",
                    "lastName": "Ishikawa"
                },
                {
                    "creatorType": "author",
                    "firstName": "D S",
                    "lastName": "Bam"
                },
                {
                    "creatorType": "author",
                    "firstName": "T",
                    "lastName": "Mori"
                }
            ],
            "abstractNote": "SETTING Directly observed treatment for tuberculosis using a short-course regimen (DOTS) was introduced in a rural area of Nepal. All new patients assigned to DOTS from mid-December 1997 to mid-June 1999 were eligible for the study. OBJECTIVE To examine delays in tuberculosis (TB) diagnosis and compare health care seeking behaviour between men and women. DESIGN A cross-sectional analysis of patient interviews. RESULTS Women were found to have a significantly longer total delay before diagnosis of tuberculosis (median 2.3 months for men, 3.3 months for women). When they visited traditional healers first, women had a significantly longer delay than men from the first visit to health care providers to diagnosis (median 1.5 months for men, 3.0 months for women). More women (35%) visited traditional healers before diagnosis than men (18%), and were more likely to receive more complicated charms from traditional healers. Men tended to visit the government medical establishment first if they knew that free TB treatment was available, but women did not. CONCLUSION Women were more likely to visit and to believe in traditional healers; this might lead to the longer delays experienced before TB diagnosis.",
            "publicationTitle": "The International Journal of Tuberculosis and Lung Disease: The Official Journal of the International Union Against Tuberculosis and Lung Disease",
            "publisher": "",
            "place": "",
            "date": "Jan 2001",
            "volume": "5",
            "issue": "1",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "24-31",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "Int. J. Tuberc. Lung Dis",
            "DOI": "",
            "citationKey": "",
            "url": "http://www.ncbi.nlm.nih.gov/pubmed/11263512",
            "accessDate": "2011-03-30T14:42:43Z",
            "PMID": "",
            "PMCID": "",
            "ISSN": "1027-3719",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "",
            "language": "",
            "libraryCatalog": "NCBI PubMed",
            "callNumber": "",
            "rights": "",
            "extra": "PMID: 11263512",
            "tags": [
                {
                    "tag": "Adolescent",
                    "type": 1
                },
                {
                    "tag": "Adult",
                    "type": 1
                },
                {
                    "tag": "Aged",
                    "type": 1
                },
                {
                    "tag": "Antitubercular Agents",
                    "type": 1
                },
                {
                    "tag": "Chi-Square Distribution",
                    "type": 1
                },
                {
                    "tag": "Cross-Sectional Studies",
                    "type": 1
                },
                {
                    "tag": "Drug Administration Schedule",
                    "type": 1
                },
                {
                    "tag": "Female",
                    "type": 1
                },
                {
                    "tag": "Health Services Accessibility",
                    "type": 1
                },
                {
                    "tag": "Humans",
                    "type": 1
                },
                {
                    "tag": "Interviews as Topic",
                    "type": 1
                },
                {
                    "tag": "Logistic Models",
                    "type": 1
                },
                {
                    "tag": "Male",
                    "type": 1
                },
                {
                    "tag": "Medicine, Traditional",
                    "type": 1
                },
                {
                    "tag": "Middle Aged",
                    "type": 1
                },
                {
                    "tag": "Nepal",
                    "type": 1
                },
                {
                    "tag": "Patient Acceptance of Health Care",
                    "type": 1
                },
                {
                    "tag": "Rural Population",
                    "type": 1
                },
                {
                    "tag": "Sex Factors",
                    "type": 1
                },
                {
                    "tag": "Statistics, Nonparametric",
                    "type": 1
                },
                {
                    "tag": "Tuberculosis, Pulmonary",
                    "type": 1
                }
            ],
            "collections": [],
            "relations": {},
            "dateAdded": "2012-01-13T23:48:33Z",
            "dateModified": "2012-01-13T23:48:33Z"
        }
    },
    {
        "key": "WTMDX77H",
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            },
            "creatorSummary": "Xu et al.",
            "parsedDate": "2009",
            "numChildren": 0
        },
        "data": {
            "key": "WTMDX77H",
            "version": 1,
            "itemType": "journalArticle",
            "title": "Adherence to anti-tuberculosis treatment among pulmonary tuberculosis patients: a qualitative and quantitative study",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Weiguo",
                    "lastName": "Xu"
                },
                {
                    "creatorType": "author",
                    "firstName": "Wei",
                    "lastName": "Lu"
                },
                {
                    "creatorType": "author",
                    "firstName": "Yang",
                    "lastName": "Zhou"
                },
                {
                    "creatorType": "author",
                    "firstName": "Limei",
                    "lastName": "Zhu"
                },
                {
                    "creatorType": "author",
                    "firstName": "Hongbing",
                    "lastName": "Shen"
                },
                {
                    "creatorType": "author",
                    "firstName": "Jianming",
                    "lastName": "Wang"
                }
            ],
            "abstractNote": "BACKGROUND: Tuberculosis (TB) patients have difficulty following a long-term treatment regimen. Efforts to improve treatment outcomes require better understanding of adherence as a complex behavioral issue and of the particular barriers to and facilitators of patient adherence. METHODS: This study was carried out in Jiangsu Province of China with both quantitative and qualitative approaches. For the quantitative study, 780 sputum-smear positive TB patients consecutively registered since 2006 in 13 counties (districts) were queried with a structured questionnaire. Patients who had missed 10% of their total prescribed doses of TB drugs were deemed as non-adherent. Risks for non-adherence were estimated by computing odds ratios (ORs) and their 95% confidence intervals (95% CIs) using a logistic regression model. We also invited 20 TB patients and 10 local health workers for in-depth interviews. We then used content analysis based on this qualitative study to explore factors associated with non-adherence. RESULTS: The proportion of non-adherence among 670 patients was 12.2%. Univariate analysis showed that patients, who were illiterate, divorced/widowed, lacked health insurance and were migrants, were more likely to be non-adherent. The crude ORs(95%CIs) were 2.38(1.37-4.13), 2.42(1.30-4.52), 1.89(1.07-3.32) and 1.98(1.03-3.83), respectively. The risk of non-adherence was lower among patients whose treatment was given under direct observation by village doctors or regular home visits by health workers, with ORs (95% CIs) of 0.19(0.10-0.36) and 0.23(0.10-0.51), respectively. In multivariate analysis, factors associated with non-adherence included illiteracy (OR: 2.42; 95% CI: 1.25-4.67) and direct observation by village doctors (OR: 0.23; 95% CI: 0.11-0.45). The in-depth interviews indicated that financial burdens and extra medical expenditures, adverse drug reactions, and social stigma were additional potential factors accounted for non-adherence. CONCLUSION: More importance should be given to treatment adherence under the current TB control program. Heavy financial burdens, lack of social support, adverse drug reactions and personal factors are associated with non-adherence. Direct observation and regular home visits by health workers appear to reduce the risk of non-adherence. More patient-centered interventions and greater attention to structural barriers are needed to improve treatment adherence.",
            "publicationTitle": "BMC Health Services Research",
            "publisher": "",
            "place": "",
            "date": "2009",
            "volume": "9",
            "issue": "",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "169",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "BMC Health Serv Res",
            "DOI": "10.1186/1472-6963-9-169",
            "citationKey": "",
            "url": "http://www.ncbi.nlm.nih.gov/pubmed/19765290",
            "accessDate": "2010-11-28T02:47:40Z",
            "PMID": "",
            "PMCID": "",
            "ISSN": "1472-6963",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "Adherence to anti-tuberculosis treatment among pulmonary tuberculosis patients",
            "language": "",
            "libraryCatalog": "NCBI PubMed",
            "callNumber": "",
            "rights": "",
            "extra": "PMID: 19765290",
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            "dateAdded": "2012-01-13T23:48:21Z",
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            "creatorSummary": "Wools-Kaloustian et al.",
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            "title": "Viability and effectiveness of large-scale HIV treatment initiatives in sub-Saharan Africa: experience from western Kenya",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Kara",
                    "lastName": "Wools-Kaloustian"
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                {
                    "creatorType": "author",
                    "firstName": "Silvester",
                    "lastName": "Kimaiyo"
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                {
                    "creatorType": "author",
                    "firstName": "Lameck",
                    "lastName": "Diero"
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                {
                    "creatorType": "author",
                    "firstName": "Abraham",
                    "lastName": "Siika"
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                {
                    "creatorType": "author",
                    "firstName": "John",
                    "lastName": "Sidle"
                },
                {
                    "creatorType": "author",
                    "firstName": "Constantin T",
                    "lastName": "Yiannoutsos"
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                {
                    "creatorType": "author",
                    "firstName": "Beverly",
                    "lastName": "Musick"
                },
                {
                    "creatorType": "author",
                    "firstName": "Robert",
                    "lastName": "Einterz"
                },
                {
                    "creatorType": "author",
                    "firstName": "Kenneth H",
                    "lastName": "Fife"
                },
                {
                    "creatorType": "author",
                    "firstName": "William M",
                    "lastName": "Tierney"
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            ],
            "abstractNote": "OBJECTIVES To determine the clinical and immunological outcomes of a cohort of HIV-infected patients receiving antiretroviral therapy. DESIGN Retrospective study of prospectively collected data from consecutively enrolled adult HIV-infected patients in eight HIV clinics in western Kenya. METHODS CD4 cell counts, weight, mortality, loss to follow-up and adherence to antiretroviral therapy were collected for the 2059 HIV-positive non-pregnant adult patients treated with antiretroviral drugs between November 2001 and February 2005. RESULTS Median duration of follow-up after initiation of antiretroviral therapy was 40 weeks (95% confidence interval, 38-43); 111 patients (5.4%) were documented as deceased and 505 (24.5%) were lost to follow-up. Among 1766 (86%) evaluated for adherence to their antiretroviral regimen, 78% reported perfect adherence at every visit. Although patients with and without perfect adherence gained weight, patients with less than perfect adherence gained 1.04 kg less weight than those reporting perfect adherence (P = 0.059). CD4 cell counts increased by a mean of 109 cells/microl during the first 6 weeks of therapy and increased more slowly thereafter, resulting in overall CD4 cell count increases of 160, 225 and 297 cells/microl at 12, 24, and 36 months respectively. At 1 year, a mean increase of 170 cells/microl was seen among patients reporting perfect adherence compared with 123 cells/microl among those reporting some missed doses (P < 0.001). CONCLUSIONS Antiretroviral treatment of adult Kenyans in this cohort resulted in significant and persistent clinical and immunological benefit. These findings document the viability and effectiveness of large-scale HIV treatment initiatives in resource-limited settings.",
            "publicationTitle": "AIDS (London, England)",
            "publisher": "",
            "place": "",
            "date": "Jan 2, 2006",
            "volume": "20",
            "issue": "1",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "41-48",
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            "seriesTitle": "",
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            "journalAbbreviation": "AIDS",
            "DOI": "",
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            "url": "http://www.ncbi.nlm.nih.gov/pubmed/16327318",
            "accessDate": "2011-05-31T19:32:18Z",
            "PMID": "",
            "PMCID": "",
            "ISSN": "0269-9370",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "Viability and effectiveness of large-scale HIV treatment initiatives in sub-Saharan Africa",
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            "extra": "PMID: 16327318",
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                    "type": 1
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                    "type": 1
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                    "type": 1
                },
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                    "type": 1
                },
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                    "type": 1
                },
                {
                    "tag": "Patient Compliance",
                    "type": 1
                },
                {
                    "tag": "Retrospective Studies",
                    "type": 1
                },
                {
                    "tag": "Sex Factors",
                    "type": 1
                },
                {
                    "tag": "Socioeconomic Factors",
                    "type": 1
                },
                {
                    "tag": "Treatment Outcome",
                    "type": 1
                }
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            "title": "Determinants of provider choice for malaria treatment: experiences from The Gambia",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "V.",
                    "lastName": "Wiseman"
                },
                {
                    "creatorType": "author",
                    "firstName": "A.",
                    "lastName": "Scott"
                },
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                    "firstName": "L.",
                    "lastName": "Conteh"
                },
                {
                    "creatorType": "author",
                    "firstName": "B.",
                    "lastName": "McElroy"
                },
                {
                    "creatorType": "author",
                    "firstName": "W.",
                    "lastName": "Stevens"
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            ],
            "abstractNote": "Malaria is responsible for an estimated one million deaths per year, the vast majority in sub-Saharan Africa. Many of these deaths are attributed to delays in seeking treatment and poor adherence to drug regimes. While there are a growing number of studies describing the factors influencing treatment seeking for malaria, far less is known about the relative weight given to these factors in different settings. This study estimates two models of demand for malaria treatment in the Farafenni region of The Gambia. The first examines the determinants of seeking malaria treatment outside the home versus no treatment or self-care while the second identifies the determinants of provider choice conditional on having decided to seek malaria treatment outside the home. Providers included hospital; health centre; and 'other' which included pharmacies, kiosks; petty traders; neighbours; and traditional healers. Results show that older people were more likely to opt for self-care, or no treatment. The longer the time spent ill or the more severe the fever, the more likely a treatment was sought outside the home. Time of the year and availability of community infrastructure played a key role in both models. Poorer households and those from the Fula ethnic group were much more likely to visit an 'other' provider than a hospital. The policy and methodological implications of these findings are discussed.",
            "publicationTitle": "Social Science and Medicine",
            "publisher": "",
            "place": "",
            "date": "2008",
            "volume": "67",
            "issue": "4",
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            "partNumber": "",
            "partTitle": "",
            "pages": "487-496",
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            "language": "",
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            "tags": [
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                    "tag": "Africa"
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                {
                    "tag": "Fever"
                },
                {
                    "tag": "Health"
                },
                {
                    "tag": "London"
                },
                {
                    "tag": "Malaria"
                },
                {
                    "tag": "Pharmacies"
                },
                {
                    "tag": "Pharmacy"
                },
                {
                    "tag": "Research"
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                {
                    "tag": "article"
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                {
                    "tag": "community"
                },
                {
                    "tag": "death"
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                    "tag": "drug"
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                {
                    "tag": "economic"
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                {
                    "tag": "economics"
                },
                {
                    "tag": "england"
                },
                {
                    "tag": "ethnic group"
                },
                {
                    "tag": "experience"
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                    "tag": "financing"
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                {
                    "tag": "gambia"
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                    "tag": "home"
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                    "tag": "hospital"
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                    "tag": "household"
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                    "tag": "medicine"
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                },
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                    "tag": "traditional"
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            "itemType": "journalArticle",
            "title": "Barriers to antiretroviral adherence for patients living with HIV infection and AIDS in Botswana",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "S.",
                    "lastName": "Weiser"
                },
                {
                    "creatorType": "author",
                    "firstName": "W.",
                    "lastName": "Wolfe"
                },
                {
                    "creatorType": "author",
                    "firstName": "D.R.",
                    "lastName": "Bangsberg"
                },
                {
                    "creatorType": "author",
                    "firstName": "I.",
                    "lastName": "Thior"
                },
                {
                    "creatorType": "author",
                    "firstName": "P.",
                    "lastName": "Gilbert"
                },
                {
                    "creatorType": "author",
                    "firstName": "J.",
                    "lastName": "Makhema"
                },
                {
                    "creatorType": "author",
                    "firstName": "P.",
                    "lastName": "Kebaabetswe"
                },
                {
                    "creatorType": "author",
                    "firstName": "D.",
                    "lastName": "Dickenson"
                },
                {
                    "creatorType": "author",
                    "firstName": "K.",
                    "lastName": "Mompati"
                },
                {
                    "creatorType": "author",
                    "firstName": "M.",
                    "lastName": "Essex"
                },
                {
                    "creatorType": "author",
                    "firstName": "R.",
                    "lastName": "Marlink"
                }
            ],
            "abstractNote": "BACKGROUND: Botswana has the highest rate of HIV infection in the world, estimated at 36% among the population aged 15-49 years. To improve antiretroviral (ARV) treatment delivery, we conducted a cross-sectional study of the social, cultural, and structural determinants of treatment adherence. METHODS: We used both qualitative and quantitative research methodologies, including questionnaires and interviews with patients receiving ARV treatment and their health care providers to elicit principal barriers to adherence. Patient report and provider estimate of adherence (>/=95% doses) were the primary outcomes. RESULTS: One hundred nine patients and 60 health care providers were interviewed between January and July 2000; 54% of patients were adherent by self-report, while 56% were adherent by provider assessment. Observed agreement between patients and providers was 68%. Principal barriers to adherence included financial constraints (44%), stigma (15%), travel/migration (10%), and side effects (9%). On the basis of logistic regression, if cost were removed as a barrier, adherence is predicted to increase from 54% to 74%. CONCLUSIONS: ARV adherence rates in this study were comparable with those seen in developed countries. As elsewhere, health care providers in Botswana were often unable to identify which patients adhere to their ARV regimens. The cost of ARV therapy was the most significant barrier to adherence",
            "publicationTitle": "JAIDS Journal of Acquired Immune Deficiency Syndromes",
            "publisher": "",
            "place": "",
            "date": "November 01, 2003",
            "volume": "34",
            "issue": "3",
            "section": "",
            "partNumber": "",
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            "title": "Assessment of a pilot antiretroviral drug therapy programme in Uganda: patients' response, survival, and drug resistance",
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                    "creatorType": "author",
                    "firstName": "Paul J",
                    "lastName": "Weidle"
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                {
                    "creatorType": "author",
                    "firstName": "Samuel",
                    "lastName": "Malamba"
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                {
                    "creatorType": "author",
                    "firstName": "Raymond",
                    "lastName": "Mwebaze"
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                {
                    "creatorType": "author",
                    "firstName": "Catherine",
                    "lastName": "Sozi"
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                    "lastName": "Rukundo"
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            "publicationTitle": "Lancet",
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            "pages": "34-40",
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            "title": "Association of antiretroviral and clinic adherence with orphan status among HIV-infected children in Western Kenya",
            "creators": [
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                    "firstName": "R.C.",
                    "lastName": "Vreeman"
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                {
                    "creatorType": "author",
                    "firstName": "S.E.",
                    "lastName": "Wiehe"
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                {
                    "creatorType": "author",
                    "firstName": "S.O.",
                    "lastName": "Ayaya"
                },
                {
                    "creatorType": "author",
                    "firstName": "B.S.",
                    "lastName": "Musick"
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                {
                    "creatorType": "author",
                    "firstName": "W.M.",
                    "lastName": "Nyandiko"
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            "abstractNote": "BACKGROUND: Pediatric adherence to antiretroviral therapy (ART) is not well studied in resource-limited settings. Reported ART adherence may be influenced by contextual factors, such as orphan status. OBJECTIVES: The objectives of this study were to describe self- and proxy-reported pediatric ART adherence in a resource-limited population and to investigate associated contextual factors. PATIENTS AND METHODS: This was a retrospective study involving pediatric, HIV-infected patients in Western Kenya. We included patients aged 0-14 years, who were on ART and had at least 1 adherence measurement (N = 1516). We performed logistic regression to assess the association between orphan status and odds of imperfect adherence, adjusting for sex, age, clinic site, number of adherence measures, and ART duration, stratified by age and ART duration. RESULTS: Of the 1516 children, only 33% had both parents living when they started ART. Twenty-one percent had only father dead, 28% had only mother dead, and 18% had both parents dead. Twenty-nine percent reported imperfect ART adherence. The odds of ART nonadherence increase for children with both parents dead. Fifty-seven percent of children had imperfect clinic adherence. There was no significant association between orphan status and imperfect clinic adherence. CONCLUSIONS: The majority of pediatric patients in this resource-limited setting maintained perfect ART adherence, though only half kept all scheduled clinic appointments. Understanding contextual factors, such as orphan status, will strengthen adherence interventions",
            "publicationTitle": "JAIDS Journal of Acquired Immune Deficiency Syndromes",
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            "pages": "163-170",
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            "url": "http://www.ncbi.nlm.nih.gov/pubmed/7801162",
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            "title": "Equality or equity in health care access: a qualitative study of doctors' explanations to a longer doctor's delay among female TB patients in Vietnam",
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            "abstractNote": "Earlier studies from Vietnam have highlighted the importance of studying gender aspects of health-seeking and diagnosis of potential tuberculosis patients. A longer doctor's delay to diagnosis among female TB patients has been shown. The objective of the present study was to explore doctors' views about and explanations for the longer doctor's delay. Five focus group discussions and three in-depth interviews were performed in a rural province in Vietnam. Thematic content analysis was used to interpret the data. The doctors suggest that women are lost or delayed within the health care-seeking chain, mainly because of barriers associated with the female gender. These barriers are identified, but yet the patient-doctor encounter seems to be steered by an equality principle. This results in gender blindness since equal treatment is suggested despite needs being different. We argue that gender equity should be the guiding principle for the tuberculosis patient-doctor encounter. An equity principle emphasises that needs vary with factors like gender or context. We suggest more research into the health care-seeking chain in order to identify the specific steps where TB diagnosis of men and women may be delayed. Interventions are needed in order to reduce delay to TB diagnosis especially for women and the current TB control strategy, (DOTS), needs to be examined from an equity perspective.",
            "publicationTitle": "Health Policy (Amsterdam, Netherlands)",
            "publisher": "",
            "place": "",
            "date": "Apr 2004",
            "volume": "68",
            "issue": "1",
            "section": "",
            "partNumber": "",
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            "pages": "37-46",
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            "seriesTitle": "",
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            "journalAbbreviation": "Health Policy",
            "DOI": "10.1016/j.healthpol.2003.07.010",
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            "PMCID": "",
            "ISSN": "0168-8510",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "Equality or equity in health care access",
            "language": "",
            "libraryCatalog": "NCBI PubMed",
            "callNumber": "0027",
            "rights": "",
            "extra": "PMID: 15033551",
            "tags": [
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                    "tag": "Attitude of Health Personnel",
                    "type": 1
                },
                {
                    "tag": "Female",
                    "type": 1
                },
                {
                    "tag": "Focus Groups",
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                    "tag": "Gender Identity",
                    "type": 1
                },
                {
                    "tag": "Health Services Accessibility",
                    "type": 1
                },
                {
                    "tag": "Humans",
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                },
                {
                    "tag": "Male",
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                {
                    "tag": "Patient Acceptance of Health Care",
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                {
                    "tag": "Physician-Patient Relations",
                    "type": 1
                },
                {
                    "tag": "Qualitative Research",
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                {
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                {
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                    "tag": "Time Factors",
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                {
                    "tag": "Tuberculosis",
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                {
                    "tag": "Vietnam",
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                {
                    "tag": "Women's Health",
                    "type": 1
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            "dateAdded": "2012-01-13T23:43:53Z",
            "dateModified": "2012-01-13T23:43:53Z"
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