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C.", "lastName": "Cheung" }, { "creatorType": "author", "firstName": "Michael", "lastName": "Otto" } ], "abstractNote": "Biofilms cause significant problems in the environment and during the treatment of infections. However, the molecular mechanisms underlying biofilm formation are poorly understood. There is a particular lack of knowledge about biofilm maturation processes, such as biofilm structuring and detachment, which are deemed crucial for the maintenance of biofilm viability and the dissemination of cells from a biofilm. Here, we identify the phenol-soluble modulin (PSM) surfactant peptides as key biofilm structuring factors in the premier biofilm-forming pathogen Staphylococcus aureus. We provide evidence that all known PSM classes participate in structuring and detachment processes. Specifically, absence of PSMs in isogenic S. aureus psm deletion mutants led to strongly impaired formation of biofilm channels, abolishment of the characteristic waves of biofilm detachment and regrowth, and loss of control of biofilm expansion. In contrast, induced expression of psm loci in preformed biofilms promoted those processes. Furthermore, PSMs facilitated dissemination from an infected catheter in a mouse model of biofilm-associated infection. Moreover, formation of the biofilm structure was linked to strongly variable, quorum sensing-controlled PSM expression in biofilm microenvironments, whereas overall PSM production remained constant to ascertain biofilm homeostasis. Our study describes a mechanism of biofilm structuring in molecular detail, and the general principle (i.e., quorum-sensing controlled expression of surfactants) seems to be conserved in several bacteria, despite the divergence of the respective biofilm-structuring surfactants. These findings provide a deeper understanding of biofilm development processes, which represents an important basis for strategies to interfere with biofilm formation in the environment and human disease.", "publicationTitle": "Proceedings of the National Academy of Sciences", "publisher": "", "place": "", "date": "01/24/2012", "volume": "109", "issue": "4", "section": "", "partNumber": "", "partTitle": "", "pages": "1281-1286", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "PNAS", "DOI": "10.1073/pnas.1115006109", "citationKey": "", "url": "http://www.pnas.org/content/109/4/1281", "accessDate": "2016-10-05T21:12:03Z", "PMID": "", "PMCID": "", "ISSN": "0027-8424, 1091-6490", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "www.pnas.org", "callNumber": "", "rights": "", "extra": "PMID: 22232686", "tags": [], "collections": [ "VXA499JE" ], "relations": {}, "dateAdded": "2016-10-05T21:12:03Z", "dateModified": "2016-10-05T21:12:03Z" } }, { "key": "8P372J9B", "version": 68, "library": { "type": "group", "id": 646550, "name": "Grupo2-6", "links": { "alternate": { "href": "https://www.zotero.org/groups/grupo2-6", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/646550/items/8P372J9B", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/grupo2-6/items/8P372J9B", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/646550/items/PDEW449C", "type": "application/json" } }, "meta": { "createdByUser": { "id": 3269900, "username": "yanci mendoza30", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/yanci_mendoza30", "type": "text/html" } } } }, "data": { "key": "8P372J9B", "version": 68, "parentItem": "PDEW449C", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2016-10-05T21:12:03Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/22232686", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2016-10-05T21:12:03Z", "dateModified": "2016-10-05T21:12:03Z" } }, { "key": "GWP6C2N8", "version": 67, "library": { "type": "group", "id": 646550, "name": "Grupo2-6", "links": { "alternate": { "href": "https://www.zotero.org/groups/grupo2-6", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/646550/items/GWP6C2N8", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/grupo2-6/items/GWP6C2N8", "type": "text/html" } }, "meta": { "createdByUser": { "id": 3269900, "username": "yanci mendoza30", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/yanci_mendoza30", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "GWP6C2N8", "version": 67, "itemType": "webpage", "title": "coccion de los alimentos - Buscar con Google", "creators": [], "abstractNote": "", "websiteTitle": "", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "https://www.google.com/search?q=coccion+de+los+alimentos&ie=utf-8&oe=utf-8&client=firefox-b-ab", "accessDate": "2016-10-03T16:18:46Z", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [ "FCXXPMRH" ], "relations": {}, "dateAdded": "2016-10-03T16:18:46Z", "dateModified": "2016-10-03T16:18:46Z" } }, { "key": "54P69DNS", "version": 66, "library": { "type": "group", "id": 646550, "name": "Grupo2-6", "links": { "alternate": { "href": "https://www.zotero.org/groups/grupo2-6", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/646550/items/54P69DNS", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/grupo2-6/items/54P69DNS", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/646550/items/PEEJ5EDT", "type": "application/json" } }, "meta": { "createdByUser": { "id": 3269900, "username": "yanci mendoza30", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/yanci_mendoza30", "type": "text/html" } } } }, "data": { "key": "54P69DNS", "version": 66, "parentItem": "PEEJ5EDT", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2016-09-30T05:33:47Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/15024131", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2016-09-30T05:34:02Z", "dateModified": "2016-09-30T05:34:02Z" } }, { "key": "PEEJ5EDT", "version": 66, "library": { "type": "group", "id": 646550, "name": "Grupo2-6", "links": { "alternate": { "href": "https://www.zotero.org/groups/grupo2-6", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/646550/items/PEEJ5EDT", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/grupo2-6/items/PEEJ5EDT", "type": "text/html" } }, "meta": { "createdByUser": { "id": 3269900, "username": "yanci mendoza30", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/yanci_mendoza30", "type": "text/html" } } }, "creatorSummary": "Martin et al.", "parsedDate": "2004-03-23", "numChildren": 1 }, "data": { "key": "PEEJ5EDT", "version": 66, "itemType": "journalArticle", "title": "Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant", "creators": [ { "creatorType": "author", "firstName": "Annalise M.", "lastName": "Martin" }, { "creatorType": "author", "firstName": "David", "lastName": "Nolan" }, { "creatorType": "author", "firstName": "Silvana", "lastName": "Gaudieri" }, { "creatorType": "author", "firstName": "Coral Ann", "lastName": "Almeida" }, { "creatorType": "author", "firstName": "Richard", "lastName": "Nolan" }, { "creatorType": "author", "firstName": "Ian", "lastName": "James" }, { "creatorType": "author", "firstName": "Filipa", "lastName": "Carvalho" }, { "creatorType": "author", "firstName": "Elizabeth", "lastName": "Phillips" }, { "creatorType": "author", "firstName": "Frank T.", "lastName": "Christiansen" }, { "creatorType": "author", "firstName": "Anthony W.", "lastName": "Purcell" }, { "creatorType": "author", "firstName": "James", "lastName": "McCluskey" }, { "creatorType": "author", "firstName": "Simon", "lastName": "Mallal" } ], "abstractNote": "Susceptibility to a clinically significant drug hypersensitivity syndrome associated with abacavir use seems to have a strong genetic component. We have previously shown that the presence of HLA-B*5701 strongly predicts abacavir hypersensitivity and have identified a potential susceptibility locus within a 300-kb region between the MEGT1 and C4A6 loci in the central MHC. We now report the results of fine recombinant genetic mapping in an expanded patient population of 248 consecutive, fully ascertained, abacavir-exposed individuals in the Western Australian HIV Cohort Study, in which 18 cases of definite abacavir hypersensitivity (7.3%) and 230 tolerant controls were identified. Haplotype mapping within patients with allelic markers of the 57.1 ancestral haplotype suggests a susceptibility locus within the 14-kb Hsp70 gene cluster. HLA-B*5701 was present in 94.4% of hypersensitive cases compared with 1.7% of controls (odds ratio, 960; P < 0.00001). A haplotypic nonsynonymous polymorphism of Hsp70-Hom (HspA1L, resulting from the substitution of residue M493T in the peptide-binding subunit) was found in combination with HLA-B*5701 in 94.4% of hypersensitive cases and 0.4% of controls (odds ratio, 3,893; P < 0.00001). Individuals with abacavir hypersensitivity demonstrated increased monocyte tumor necrosis factor expression in response to ex vivo abacavir stimulation, which was abrogated with CD8+ T cell depletion. These data indicate that the concurrence of HLA-B*5701 and Hsp70-Hom M493T alleles is necessary for the development of abacavir hypersensitivity, which is likely to be mediated by an HLA-B*5701-restricted immune response to abacavir.", "publicationTitle": "Proceedings of the National Academy of Sciences", "publisher": "", "place": "", "date": "03/23/2004", "volume": "101", "issue": "12", "section": "", "partNumber": "", "partTitle": "", "pages": "4180-4185", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "PNAS", "DOI": "10.1073/pnas.0307067101", "citationKey": "", "url": "http://www.pnas.org/content/101/12/4180", "accessDate": "2016-09-30T05:33:47Z", "PMID": "", "PMCID": "", "ISSN": "0027-8424, 1091-6490", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "www.pnas.org", "callNumber": "", "rights": "", "extra": "PMID: 15024131", "tags": [ { "tag": "ancestral haplotype", "type": 1 }, { "tag": "human leukocyte antigen", "type": 1 }, { "tag": "microsatellite", "type": 1 }, { "tag": "single-nucleotide polymorphism", "type": 1 } ], "collections": [ "FCXXPMRH" ], "relations": {}, "dateAdded": "2016-09-30T05:34:02Z", "dateModified": "2016-09-30T05:34:02Z" } }, { "key": "DJ8Q5R3C", "version": 65, "library": { "type": "group", "id": 646550, "name": "Grupo2-6", "links": { "alternate": { "href": "https://www.zotero.org/groups/grupo2-6", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/646550/items/DJ8Q5R3C", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/grupo2-6/items/DJ8Q5R3C", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/646550/items/RJQVR7AK", "type": "application/json" } }, "meta": { "createdByUser": { "id": 3269900, "username": "yanci mendoza30", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/yanci_mendoza30", "type": "text/html" } } } }, "data": { "key": "DJ8Q5R3C", "version": 65, "parentItem": "RJQVR7AK", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Central Link", "accessDate": "2016-09-30T05:24:58Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751420/", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2016-09-30T05:24:58Z", "dateModified": "2016-09-30T05:24:58Z" } }, { "key": "RJQVR7AK", "version": 65, "library": { "type": "group", "id": 646550, "name": "Grupo2-6", "links": { "alternate": { "href": "https://www.zotero.org/groups/grupo2-6", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/646550/items/RJQVR7AK", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/grupo2-6/items/RJQVR7AK", "type": "text/html" } }, "meta": { "createdByUser": { "id": 3269900, "username": "yanci mendoza30", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/yanci_mendoza30", "type": "text/html" } } }, "creatorSummary": "Pirmohamed", "parsedDate": "2006-03", "numChildren": 1 }, "data": { "key": "RJQVR7AK", "version": 65, "itemType": "journalArticle", "title": "Genetic factors in the predisposition to drug-induced hypersensitivity reactions", "creators": [ { "creatorType": "author", "firstName": "Munir", "lastName": "Pirmohamed" } ], "abstractNote": "Drug hypersensitivity reactions can occur with most drugs, although the frequency, severity, and clinical manifestations vary. Case reports have suggested that there may be familial clustering of drug hypersensitivity suggesting a genetiv predisposition. As with most other forms of drug response, predisposition to drug hypersensitivity reactions is likely to be multifactorial and multigenic. Given the immune pathogenesis of these reactions, it is perhaps not surprising that the most significant genetic associations have been identified in the major histocompatibility complex for drugs such as abacavir, carbamazepine, and allopurinol. For abacavir, it has been suggested that preprescription genotyping for HLA-B*5701 in whites may reduce the incidence of hypersensitivity. It is likely that as our knowledge of variation in the human genome improves, coupled with improvements in technology, many more significant genetic predisposing factors for drug hypersensitivity are likely to be identified in the next decade. However, as we search for these genetic factors, it is important that we do not forget environmental predisposition, and to bear in mind that a genetic marker for drug hypersensitivity in one population may not necessarily be relevant for another population. Notwithstanding the advances in genetic technologies, the ultimate determinant of success in this area of research will be the identification and careful phenotyping of patients with drug hypersensitivity reactions. As we progress to whole genome scanning, in order to satisfy the requirements for adequate statistical power, the identification of large numbers of carefully phenotyped patients will be feasible only through international collaborations.", "publicationTitle": "The AAPS Journal", "publisher": "", "place": "", "date": "2006-3", "volume": "8", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "E20-E26", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "AAPS J", "DOI": "10.1208/aapsj080103", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751420/", "accessDate": "2016-09-30T05:24:58Z", "PMID": "", "PMCID": "", "ISSN": "1550-7416", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "PubMed Central", "callNumber": "", "rights": "", "extra": "PMID: 16584129\nPMCID: PMC2751420", "tags": [], "collections": [ "FCXXPMRH" ], "relations": {}, "dateAdded": "2016-09-30T05:24:58Z", "dateModified": "2016-09-30T05:24:58Z" } }, { "key": "ZJBHG773", "version": 64, "library": { "type": "group", "id": 646550, "name": "Grupo2-6", "links": { "alternate": { "href": "https://www.zotero.org/groups/grupo2-6", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/646550/items/ZJBHG773", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/grupo2-6/items/ZJBHG773", "type": "text/html" } }, "meta": { "createdByUser": { "id": 3269900, "username": "yanci mendoza30", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/yanci_mendoza30", "type": "text/html" } } }, "creatorSummary": "Pérez Prior et al.", "parsedDate": "2009", "numChildren": 0 }, "data": { "key": "ZJBHG773", "version": 64, "itemType": "journalArticle", "title": "Correlación, en pacientes infectados por el VIH-1 y previamente tratados, entre la reacción de hipersensibilidad a abacavir y el alelo HLA-B*5701", "creators": [ { "creatorType": "author", "firstName": "Noemí", "lastName": "Pérez Prior" }, { "creatorType": "author", "firstName": "Amparo", "lastName": "Rocher Milla" }, { "creatorType": "author", "firstName": "Enrique", "lastName": "Soler Company" }, { "creatorType": "author", "firstName": "Juan", "lastName": "Flores Cid" }, { "creatorType": "author", "firstName": "Benjamín", "lastName": "Sarria Chust" } ], "abstractNote": "", "publicationTitle": "Farmacia Hospitalaria", "publisher": "", "place": "", "date": "6/2009", "volume": "33", "issue": "3", "section": "", "partNumber": "", "partTitle": "", "pages": "155-160", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1016/S1130-6343(09)71157-2", "citationKey": "", "url": "http://linkinghub.elsevier.com/retrieve/pii/S1130634309711572", "accessDate": "2016-09-30T03:45:53Z", "PMID": "", "PMCID": "", "ISSN": "11306343", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "es", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "FCXXPMRH" ], "relations": {}, "dateAdded": "2016-09-30T03:45:53Z", "dateModified": "2016-09-30T03:45:53Z" } }, { "key": "AFPEE9QQ", "version": 60, "library": { "type": "group", "id": 646550, "name": "Grupo2-6", "links": { "alternate": { "href": "https://www.zotero.org/groups/grupo2-6", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/646550/items/AFPEE9QQ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/grupo2-6/items/AFPEE9QQ", "type": "text/html" } }, "meta": { "createdByUser": { "id": 3274239, "username": "Fátima Castro", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/ftima_castro", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "AFPEE9QQ", "version": 60, "itemType": "webpage", "title": "12-19ENDO1-Gangoiti.pdf", "creators": [], "abstractNote": "", "websiteTitle": "", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://www.raem.org.ar/numeros/2012-vol49/numero-01/12-19ENDO1-Gangoiti.pdf", "accessDate": "2016-09-01T13:29:29Z", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [ "VXA499JE" ], "relations": {}, "dateAdded": "2016-09-01T13:29:29Z", "dateModified": "2016-09-01T13:29:29Z" } }, { "key": "3XUX98P7", "version": 59, "library": { "type": "group", "id": 646550, "name": "Grupo2-6", "links": { "alternate": { "href": "https://www.zotero.org/groups/grupo2-6", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/646550/items/3XUX98P7", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/grupo2-6/items/3XUX98P7", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/646550/items/3FXXDEWS", "type": "application/json" } }, "meta": { "createdByUser": { "id": 3274239, "username": "Fátima Castro", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/ftima_castro", "type": "text/html" } } } }, "data": { "key": "3XUX98P7", "version": 59, "parentItem": "3FXXDEWS", "itemType": "attachment", "linkMode": "linked_url", "title": "ScienceDirect Full Text PDF", "accessDate": "2016-09-01T13:04:51Z", "url": "http://www.sciencedirect.com/science/article/pii/S2212877813001245/pdfft?md5=1f5e570a78fad5dc71cc4e97013bc693&pid=1-s2.0-S2212877813001245-main.pdf", "note": "", "contentType": "application/pdf", "charset": "", "tags": [], "relations": {}, "dateAdded": "2016-09-01T13:04:51Z", "dateModified": "2016-09-01T13:04:51Z" } }, { "key": "3FXXDEWS", "version": 59, "library": { "type": "group", "id": 646550, "name": "Grupo2-6", "links": { "alternate": { "href": "https://www.zotero.org/groups/grupo2-6", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/646550/items/3FXXDEWS", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/grupo2-6/items/3FXXDEWS", "type": "text/html" } }, "meta": { "createdByUser": { "id": 3274239, "username": "Fátima Castro", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/ftima_castro", "type": "text/html" } } }, "creatorSummary": "Stirban et al.", "parsedDate": "2014", "numChildren": 2 }, "data": { "key": "3FXXDEWS", "version": 59, "itemType": "journalArticle", "title": "Vascular effects of advanced glycation endproducts: Clinical effects and molecular mechanisms", "creators": [ { "creatorType": "author", "firstName": "Alin", "lastName": "Stirban" }, { "creatorType": "author", "firstName": "Thomas", "lastName": "Gawlowski" }, { "creatorType": "author", "firstName": "Michael", "lastName": "Roden" } ], "abstractNote": "The enhanced generation and accumulation of advanced glycation endproducts (AGEs) have been linked to increased risk for macrovascular and microvascular complications associated with diabetes mellitus. AGEs result from the nonenzymatic reaction of reducing sugars with proteins, lipids, and nucleic acids, potentially altering their function by disrupting molecular conformation, promoting cross-linking, altering enzyme activity, reducing their clearance, and impairing receptor recognition. AGEs may also activate specific receptors, like the receptor for AGEs (RAGE), which is present on the surface of all cells relevant to atherosclerotic processes, triggering oxidative stress, inflammation and apoptosis. Understanding the pathogenic mechanisms of AGEs is paramount to develop strategies against diabetic and cardiovascular complications.", "publicationTitle": "Molecular Metabolism", "publisher": "", "place": "", "date": "Abril 2014", "volume": "3", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "94-108", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Molecular Metabolism", "DOI": "10.1016/j.molmet.2013.11.006", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/S2212877813001245", "accessDate": "2016-09-01T13:04:51Z", "PMID": "", "PMCID": "", "ISSN": "2212-8778", "archive": "", "archiveLocation": "", "shortTitle": "Vascular effects of advanced glycation endproducts", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Advanced glycation endproducts", "type": 1 }, { "tag": "Endothelium", "type": 1 }, { "tag": "Vascular", "type": 1 } ], "collections": [ "VXA499JE" ], "relations": {}, "dateAdded": "2016-09-01T13:04:51Z", "dateModified": "2016-09-01T13:04:51Z" } }, { "key": "MG8SX92C", "version": 59, "library": { "type": "group", "id": 646550, "name": "Grupo2-6", "links": { "alternate": { "href": "https://www.zotero.org/groups/grupo2-6", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/646550/items/MG8SX92C", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/grupo2-6/items/MG8SX92C", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/646550/items/3FXXDEWS", "type": "application/json" } }, "meta": { "createdByUser": { "id": 3274239, "username": "Fátima Castro", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/ftima_castro", "type": "text/html" } } } }, "data": { "key": "MG8SX92C", "version": 59, "parentItem": "3FXXDEWS", "itemType": "attachment", "linkMode": "linked_url", "title": "ScienceDirect Snapshot", "accessDate": "2016-09-01T13:04:51Z", "url": "http://www.sciencedirect.com/science/article/pii/S2212877813001245", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2016-09-01T13:04:51Z", "dateModified": "2016-09-01T13:04:51Z" } }, { "key": "MTV5CMTH", "version": 58, "library": { "type": "group", "id": 646550, "name": "Grupo2-6", "links": { "alternate": { "href": "https://www.zotero.org/groups/grupo2-6", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/646550/items/MTV5CMTH", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/grupo2-6/items/MTV5CMTH", "type": "text/html" } }, "meta": { "createdByUser": { "id": 3274239, "username": "Fátima Castro", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/ftima_castro", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "MTV5CMTH", "version": 58, "itemType": "webpage", "title": "", "creators": [], "abstractNote": "", "websiteTitle": "", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://repositorio.uchile.cl/handle/2250/116527", "accessDate": "2016-09-01T13:01:51Z", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [ "VXA499JE" ], "relations": {}, "dateAdded": "2016-09-01T13:01:51Z", "dateModified": "2016-09-01T13:01:51Z" } }, { "key": "Q4E4P4VU", "version": 57, "library": { "type": "group", "id": 646550, "name": "Grupo2-6", "links": { "alternate": { "href": "https://www.zotero.org/groups/grupo2-6", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/646550/items/Q4E4P4VU", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/grupo2-6/items/Q4E4P4VU", "type": "text/html" } }, "meta": { "createdByUser": { "id": 3272880, "username": "Gabriela.06", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/gabriela.06", "type": "text/html" } } }, "creatorSummary": "Rubenstein et al.", "parsedDate": "2011-05", "numChildren": 1 }, "data": { "key": "Q4E4P4VU", "version": 57, "itemType": "journalArticle", "title": "Glycated albumin modulates endothelial cell thrombogenic and inflammatory responses", "creators": [ { "creatorType": "author", "firstName": "David A.", "lastName": "Rubenstein" }, { "creatorType": "author", "firstName": "Zahra", "lastName": "Maria" }, { "creatorType": "author", "firstName": "Wei", "lastName": "Yin" } ], "abstractNote": "BACKGROUND: It has become established that a diabetic vasculature promotes cardiovascular disease progression via changes to endothelial cells, platelets, and the interactions of these cells. It is believed that the majority of these changes are induced by the presence of advanced glycation end products (AGEs), which permanently alter various functions. Studies have shown that platelets perpetuate endothelial cell responses under these conditions. However, the role of changes in endothelial cell thrombogenicity and inflammatory responses, after subjected to AGEs, has not been characterized. Our objective was to evaluate the effects of AGEs on these functions.\nMETHODS: To accomplish this, albumin was chemically modified by exposure to glucose for up to 8 weeks, and endothelial cells were subjected to glycated albumin for up to 5 days in a cell culture system. A time course for changes in endothelial cell viability, density, morphology, and metabolic activity were investigated, along with the surface expression of intercellular adhesion molecule-1, thrombomodulin, tissue factor, connexin-43, and caveolin-1.\nRESULTS: Endothelial cells exposed to irreversibly glycated albumin were less viable, proliferated slower, and had a lower metabolic activity as compared to cells exposed to nonglycated albumin. Endothelial cells that were exposed to any glycated albumin were procoagulant and proinflammatory as compared with all other conditions. There were no overall trends in the expression of connexin-43 or caveolin-1.\nCONCLUSIONS: Our data suggest that the presence of irreversible glycated albumin is deleterious to endothelial cells, makes endothelial cells more procoagulant, and promotes inflammatory responses. It is therefore possible that endothelial cell activation may precede and promote platelet activation during diabetic conditions.", "publicationTitle": "Journal of Diabetes Science and Technology", "publisher": "", "place": "", "date": "May 2011", "volume": "5", "issue": "3", "section": "", "partNumber": "", "partTitle": "", "pages": "703-713", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Diabetes Sci Technol", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1932-2968", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "PMID: 21722586\nPMCID: PMC3192637", "tags": [ { "tag": "Albumins", "type": 1 }, { "tag": "Animals", "type": 1 }, { "tag": "Blood Glucose", "type": 1 }, { "tag": "Cardiovascular Diseases", "type": 1 }, { "tag": "Cattle", "type": 1 }, { "tag": "Caveolin 1", "type": 1 }, { "tag": "Connexin 43", "type": 1 }, { "tag": "Diabetes Complications", "type": 1 }, { "tag": "Disease Progression", "type": 1 }, { "tag": "Endothelial Cells", "type": 1 }, { "tag": "Glycosylation End Products, Advanced", "type": 1 }, { "tag": "Human Umbilical Vein Endothelial Cells", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Inflammation", "type": 1 }, { "tag": "Intercellular Adhesion Molecule-1", "type": 1 }, { "tag": "Serum Albumin", "type": 1 }, { "tag": "Thrombin", "type": 1 }, { "tag": "Thrombomodulin", "type": 1 }, { "tag": "Time Factors", "type": 1 } ], "collections": [ "VXA499JE" ], "relations": {}, "dateAdded": "2016-09-01T02:33:34Z", "dateModified": "2016-09-01T02:33:34Z" } }, { "key": "EDITCQUR", "version": 57, "library": { "type": "group", "id": 646550, "name": "Grupo2-6", "links": { "alternate": { "href": "https://www.zotero.org/groups/grupo2-6", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/646550/items/EDITCQUR", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/grupo2-6/items/EDITCQUR", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/646550/items/Q4E4P4VU", "type": "application/json" } }, "meta": { "createdByUser": { "id": 3272880, "username": "Gabriela.06", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/gabriela.06", "type": "text/html" } } } }, "data": { "key": "EDITCQUR", "version": 57, "parentItem": "Q4E4P4VU", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2016-09-01T01:59:51Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/21722586", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2016-09-01T02:33:34Z", "dateModified": "2016-09-01T02:33:34Z" } }, { "key": "Q84NFQJ2", "version": 57, "library": { "type": "group", "id": 646550, "name": "Grupo2-6", "links": { "alternate": { "href": "https://www.zotero.org/groups/grupo2-6", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/646550/items/Q84NFQJ2", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/grupo2-6/items/Q84NFQJ2", "type": "text/html" } }, "meta": { "createdByUser": { "id": 3272880, "username": "Gabriela.06", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/gabriela.06", "type": "text/html" } } }, "creatorSummary": "Rubenstein et al.", "parsedDate": "2010", "numChildren": 0 }, "data": { "key": "Q84NFQJ2", "version": 57, "itemType": "journalArticle", "title": "The combined effects of sidestream smoke extracts and glycated serum albumin on endothelial cells and platelets", "creators": [ { "creatorType": "author", "firstName": "David A", "lastName": "Rubenstein" }, { "creatorType": "author", "firstName": "Blake E", "lastName": "Morton" }, { "creatorType": "author", "firstName": "Wei", "lastName": "Yin" } ], "abstractNote": "", "publicationTitle": "Cardiovascular Diabetology", "publisher": "", "place": "", "date": "2010", "volume": "9", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "28", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1186/1475-2840-9-28", "citationKey": "", "url": "http://cardiab.biomedcentral.com/articles/10.1186/1475-2840-9-28", "accessDate": "2016-09-01T02:11:19Z", "PMID": "", "PMCID": "", "ISSN": "1475-2840", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "VXA499JE" ], "relations": {}, "dateAdded": "2016-09-01T02:33:22Z", "dateModified": "2016-09-01T02:33:22Z" } }, { "key": "655B5XSA", "version": 56, "library": { "type": "group", "id": 646550, "name": "Grupo2-6", "links": { "alternate": { "href": "https://www.zotero.org/groups/grupo2-6", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/646550/items/655B5XSA", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/grupo2-6/items/655B5XSA", "type": "text/html" } }, "meta": { "createdByUser": { "id": 3272880, "username": "Gabriela.06", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/gabriela.06", "type": "text/html" } } }, "creatorSummary": "Guillemot-Legris et al.", "parsedDate": "2016", "numChildren": 0 }, "data": { "key": "655B5XSA", "version": 56, "itemType": "journalArticle", "title": "High-fat diet feeding differentially affects the development of inflammation in the central nervous system", "creators": [ { "creatorType": "author", "firstName": "Owein", "lastName": "Guillemot-Legris" }, { "creatorType": "author", "firstName": "Julien", "lastName": "Masquelier" }, { "creatorType": "author", "firstName": "Amandine", "lastName": "Everard" }, { "creatorType": "author", "firstName": "Patrice D.", "lastName": "Cani" }, { "creatorType": "author", "firstName": "Mireille", "lastName": "Alhouayek" }, { "creatorType": "author", "firstName": "Giulio G.", "lastName": "Muccioli" } ], "abstractNote": "", "publicationTitle": "Journal of Neuroinflammation", "publisher": "", "place": "", "date": "12/2016", "volume": "13", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1186/s12974-016-0666-8", "citationKey": "", "url": "http://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-016-0666-8", "accessDate": "2016-09-01T02:30:11Z", "PMID": "", "PMCID": "", "ISSN": "1742-2094", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "VXA499JE" ], "relations": {}, "dateAdded": "2016-09-01T02:32:57Z", "dateModified": "2016-09-01T02:32:57Z" } }, { "key": "G4TFFNEM", "version": 55, "library": { "type": "group", "id": 646550, "name": "Grupo2-6", "links": { "alternate": { "href": "https://www.zotero.org/groups/grupo2-6", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/646550/items/G4TFFNEM", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/grupo2-6/items/G4TFFNEM", "type": "text/html" } }, "meta": { "createdByUser": { "id": 3269900, "username": "yanci mendoza30", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/yanci_mendoza30", "type": "text/html" } } }, "creatorSummary": "Smith et al.", "parsedDate": "2016-07-15", "numChildren": 1 }, "data": { "key": "G4TFFNEM", "version": 55, "itemType": "journalArticle", "title": "The false alarm hypothesis: Food allergy is associated with high dietary advanced glycation end-products and proglycating dietary sugars that mimic alarmins", "creators": [ { "creatorType": "author", "firstName": "Peter K.", "lastName": "Smith" }, { "creatorType": "author", "firstName": "Madhan", "lastName": "Masilamani" }, { "creatorType": "author", "firstName": "Xiu-Min", "lastName": "Li" }, { "creatorType": "author", "firstName": "Hugh A.", "lastName": "Sampson" } ], "abstractNote": "The incidence of food allergy has increased dramatically in the last few decades in westernized developed countries. We propose that the Western lifestyle and diet promote innate danger signals and immune responses through production of \"alarmins.\" Alarmins are endogenous molecules secreted from cells undergoing nonprogrammed cell death that signal tissue and cell damage. High molecular group S (HMGB1) is a major alarmin that binds to the receptor for advanced glycation end-products (RAGE). Advanced glycation end-products (AGEs) are also present in foods. We propose the \"false alarm\" hypothesis, in which AGEs that are present in or formed from the food in our diet are predisposing to food allergy. The Western diet is high in AGEs, which are derived from cooked meat, oils, and cheese. AGEs are also formed in the presence of a high concentration of sugars. We propose that a diet high in AGEs and AGE-forming sugars results in misinterpretation of a threat from dietary allergens, promoting the development of food allergy. AGEs and other alarmins inadvertently prime innate signaling through multiple mechanisms, resulting in the development of allergic phenotypes. Current hypotheses and models of food allergy do not adequately explain the dramatic increase in food allergy in Western countries. Dietary AGEs and AGE-forming sugars might be the missing link, a hypothesis supported by a number of convincing epidemiologic and experimental observations, as discussed in this article.", "publicationTitle": "The Journal of Allergy and Clinical Immunology", "publisher": "", "place": "", "date": "Jul 15, 2016", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J. Allergy Clin. Immunol.", "DOI": "10.1016/j.jaci.2016.05.040", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1097-6825", "archive": "", "archiveLocation": "", "shortTitle": "The false alarm hypothesis", "language": "ENG", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "PMID: 27544741", "tags": [ { "tag": "Food allergy", "type": 1 }, { "tag": "advanced glycated end-products", "type": 1 }, { "tag": "alarmins", "type": 1 }, { "tag": "glycation", "type": 1 }, { "tag": "receptor for advanced glycated end-products", "type": 1 } ], "collections": [ "VXA499JE" ], "relations": {}, "dateAdded": "2016-08-28T00:12:04Z", "dateModified": "2016-08-28T00:12:04Z" } }, { "key": "SNW54MRQ", "version": 55, "library": { "type": "group", "id": 646550, "name": "Grupo2-6", "links": { "alternate": { "href": "https://www.zotero.org/groups/grupo2-6", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/646550/items/SNW54MRQ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/grupo2-6/items/SNW54MRQ", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/646550/items/G4TFFNEM", "type": "application/json" } }, "meta": { "createdByUser": { "id": 3269900, "username": "yanci mendoza30", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/yanci_mendoza30", "type": "text/html" } } } }, "data": { "key": "SNW54MRQ", "version": 55, "parentItem": "G4TFFNEM", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2016-08-28T00:12:04Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/27544741", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2016-08-28T00:12:04Z", "dateModified": "2016-08-28T00:12:04Z" } }, { "key": "7I33JR3G", "version": 54, "library": { "type": "group", "id": 646550, "name": "Grupo2-6", "links": { "alternate": { "href": "https://www.zotero.org/groups/grupo2-6", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/646550/items/7I33JR3G", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/grupo2-6/items/7I33JR3G", "type": "text/html" } }, "meta": { "createdByUser": { "id": 3269900, "username": "yanci mendoza30", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/yanci_mendoza30", "type": "text/html" } } }, "creatorSummary": "González-Gil et al.", "parsedDate": "2015-09-29", "numChildren": 1 }, "data": { "key": "7I33JR3G", "version": 54, "itemType": "journalArticle", "title": "Food intake and inflammation in European children: the IDEFICS study", "creators": [ { "creatorType": "author", "firstName": "Esther M.", "lastName": "González-Gil" }, { "creatorType": "author", "firstName": "Javier", "lastName": "Santabárbara" }, { "creatorType": "author", "firstName": "Paola", "lastName": "Russo" }, { "creatorType": "author", "firstName": "Wolfgang", "lastName": "Ahrens" }, { "creatorType": "author", "firstName": "Mandy", "lastName": "Claessens" }, { "creatorType": "author", "firstName": "Lauren", "lastName": "Lissner" }, { "creatorType": "author", "firstName": "Claudia", "lastName": "Börnhorst" }, { "creatorType": "author", "firstName": "Vittorio", "lastName": "Krogh" }, { "creatorType": "author", "firstName": "Licia", "lastName": "Iacoviello" }, { "creatorType": "author", "firstName": "Denes", "lastName": "Molnar" }, { "creatorType": "author", "firstName": "Alfonso", "lastName": "Siani" }, { "creatorType": "author", "firstName": "Michael", "lastName": "Tornaritis" }, { "creatorType": "author", "firstName": "Toomas", "lastName": "Veidebaum" }, { "creatorType": "author", "firstName": "Luis A.", "lastName": "Moreno" } ], "abstractNote": "PURPOSE: This cross-sectional study assesses the relationship between consumption frequencies of food items and high-sensitivity C-reactive protein (hs-CRP) in European children.\nMETHODS: Out of the baseline sample (N = 16.228) of the IDEFICS study, 6.403 children (1.315 boys aged 2 to <6, 1.908 boys aged 6 to <10, 1.204 girls aged 2 to <6 and 1.976 girls aged 6 to <10 years) had hs-CRP measured and the Children's Eating Habits Questionnaire filled, including a food frequency questionnaire. Logistic regression adjusted for body mass index z-score, education of the mother, breast-feeding and self-reported hours of physical activity in a sport club per week was conducted.\nRESULTS: Mean frequency intake of raw vegetable was lower in boys (p = 0.022 in young and p = 0.020 in old) and older girls (p = 0.026) with high hs-CRP concentration, while in younger girls (p = 0.008) the same occurred with the cooked vegetables. The probability of having higher hs-CRP concentration was significantly associated with having low consumption frequency of vegetables (p = 0.004 in older boys, raw vegetables; and p = 0.0032 in younger girls, cooked vegetables). Also, honey/jam intake decreased the probability of having higher concentration of hs-CRP, whereas soft drinks with sugar, mayonnaise and cereals milled increased this probability.\nCONCLUSIONS: Out of all food items associated with hs-CRP, frequency intake of vegetables presented more associations across all the analysis. Findings suggest that a high-frequency intake of vegetables is inversely related to an inflammatory status in children. More studies are needed to assess the association between diet and inflammation.", "publicationTitle": "European Journal of Nutrition", "publisher": "", "place": "", "date": "Sep 29, 2015", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Eur J Nutr", "DOI": "10.1007/s00394-015-1054-3", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1436-6215", "archive": "", "archiveLocation": "", "shortTitle": "Food intake and inflammation in European children", "language": "ENG", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "PMID: 26419585", "tags": [ { "tag": "European", "type": 1 }, { "tag": "Food intake", "type": 1 }, { "tag": "IDEFICS", "type": 1 }, { "tag": "Inflammation", "type": 1 }, { "tag": "children", "type": 1 } ], "collections": [ "VXA499JE" ], "relations": {}, "dateAdded": "2016-08-28T00:08:55Z", "dateModified": "2016-08-28T00:08:55Z" } }, { "key": "HK2NWFHZ", "version": 54, "library": { "type": "group", "id": 646550, "name": "Grupo2-6", "links": { "alternate": { "href": "https://www.zotero.org/groups/grupo2-6", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/646550/items/HK2NWFHZ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/grupo2-6/items/HK2NWFHZ", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/646550/items/7I33JR3G", "type": "application/json" } }, "meta": { "createdByUser": { "id": 3269900, "username": "yanci mendoza30", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/yanci_mendoza30", "type": "text/html" } } } }, "data": { "key": "HK2NWFHZ", "version": 54, "parentItem": "7I33JR3G", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2016-08-28T00:08:55Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/26419585", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2016-08-28T00:08:55Z", "dateModified": "2016-08-28T00:08:55Z" } }, { "key": "4KCEK8RF", "version": 54, "library": { "type": "group", "id": 646550, "name": "Grupo2-6", "links": { "alternate": { "href": "https://www.zotero.org/groups/grupo2-6", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/646550/items/4KCEK8RF", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/grupo2-6/items/4KCEK8RF", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/646550/items/RWIKTVZH", "type": "application/json" } }, "meta": { "createdByUser": { "id": 3269900, "username": "yanci mendoza30", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/yanci_mendoza30", "type": "text/html" } } } }, "data": { "key": "4KCEK8RF", "version": 54, "parentItem": "RWIKTVZH", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2016-08-28T00:08:53Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/26419585", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2016-08-28T00:08:53Z", "dateModified": "2016-08-28T00:08:53Z" } } ]