[ { "key": "XTXJEUQ6", "version": 220, "library": { "type": "group", "id": 62016, "name": "xavier.robin", "links": { "alternate": { "href": "https://www.zotero.org/groups/xavier.robin", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/62016/items/XTXJEUQ6", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/xavier.robin/items/XTXJEUQ6", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/62016/items/6P5KEJPZ", "type": "application/json" } }, "meta": { "createdByUser": { "id": 12953, "username": "Calimo", "name": "Xavier Robin", "links": { "alternate": { "href": "https://www.zotero.org/calimo", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "XTXJEUQ6", "version": 220, "parentItem": "6P5KEJPZ", "itemType": "note", "note": "

Supplementary information available for this article at http://www.nature.com/ncomms/2014/140910/ncomms5846/suppinfo/ncomms5846_S1.html

", "tags": [], "relations": {}, "dateAdded": "2016-01-25T15:27:46Z", "dateModified": "2016-01-25T15:27:46Z" } }, { "key": "6P5KEJPZ", "version": 220, "library": { "type": "group", "id": 62016, "name": "xavier.robin", "links": { "alternate": { "href": "https://www.zotero.org/groups/xavier.robin", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/62016/items/6P5KEJPZ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/xavier.robin/items/6P5KEJPZ", "type": "text/html" } }, "meta": { "createdByUser": { "id": 12953, "username": "Calimo", "name": "Xavier Robin", "links": { "alternate": { "href": "https://www.zotero.org/calimo", "type": "text/html" } } }, "creatorSummary": "Stransky et al.", "parsedDate": "2014-09-10", "numChildren": 1 }, "data": { "key": "6P5KEJPZ", "version": 220, "itemType": "journalArticle", "title": "The landscape of kinase fusions in cancer", "creators": [ { "creatorType": "author", "firstName": "Nicolas", "lastName": "Stransky" }, { "creatorType": "author", "firstName": "Ethan", "lastName": "Cerami" }, { "creatorType": "author", "firstName": "Stefanie", "lastName": "Schalm" }, { "creatorType": "author", "firstName": "Joseph L.", "lastName": "Kim" }, { "creatorType": "author", "firstName": "Christoph", "lastName": "Lengauer" } ], "abstractNote": "Human cancer genomes harbour a variety of alterations leading to the deregulation of key pathways in tumour cells. The genomic characterization of tumours has uncovered numerous genes recurrently mutated, deleted or amplified, but gene fusions have not been characterized as extensively. Here we develop heuristics for reliably detecting gene fusion events in RNA-seq data and apply them to nearly 7,000 samples from The Cancer Genome Atlas. We thereby are able to discover several novel and recurrent fusions involving kinases. These findings have immediate clinical implications and expand the therapeutic options for cancer patients, as approved or exploratory drugs exist for many of these kinases.", "publicationTitle": "Nat Commun", "publisher": "", "place": "", "date": "September 10, 2014", "volume": "5", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Nat Commun", "DOI": "", "citationKey": "", "url": "http://dx.doi.org/10.1038/ncomms5846", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "75VPBAXC" ], "relations": {}, "dateAdded": "2016-01-25T15:27:46Z", "dateModified": "2016-01-25T15:27:46Z" } }, { "key": "3AFEKVQ9", "version": 219, "library": { "type": "group", "id": 62016, "name": "xavier.robin", "links": { "alternate": { "href": "https://www.zotero.org/groups/xavier.robin", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/62016/items/3AFEKVQ9", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/xavier.robin/items/3AFEKVQ9", "type": "text/html" } }, "meta": { "createdByUser": { "id": 12953, "username": "Calimo", "name": "Xavier Robin", "links": { "alternate": { "href": "https://www.zotero.org/calimo", "type": "text/html" } } }, "creatorSummary": "Calderón-Santiago et al.", "parsedDate": "2015-05-03", "numChildren": 0 }, "data": { "key": "3AFEKVQ9", "version": 219, "itemType": "journalArticle", "title": "Human sweat metabolomics for lung cancer screening", "creators": [ { "creatorType": "author", "firstName": "Mónica", "lastName": "Calderón-Santiago" }, { "creatorType": "author", "firstName": "Feliciano", "lastName": "Priego-Capote" }, { "creatorType": "author", "firstName": "Natacha", "lastName": "Turck" }, { "creatorType": "author", "firstName": "Xavier", "lastName": "Robin" }, { "creatorType": "author", "firstName": "Bernabé", "lastName": "Jurado-Gámez" }, { "creatorType": "author", "firstName": "Jean C.", "lastName": "Sanchez" }, { "creatorType": "author", "firstName": "María D. Luque de", "lastName": "Castro" } ], "abstractNote": "Sweat is one of the less employed biofluids for discovery of markers in spite of its increased application in medicine for detection of drugs or for diagnostic of cystic fibrosis. In this research, human sweat was used as clinical sample to develop a screening tool for lung cancer, which is the carcinogenic disease with the highest mortality rate owing to the advanced stage at which it is usually detected. In this context, a method based on the metabolite analysis of sweat to discriminate between patients with lung cancer versus smokers as control individuals is proposed. The capability of the metabolites identified in sweat to discriminate between both groups of individuals was studied and, among them, a trisaccharide phosphate presented the best independent performance in terms of the specificity/sensitivity pair (80 and 72.7 %, respectively). Additionally, two panels of metabolites were configured using the PanelomiX tool as an attempt to reduce false negatives (at least 80 % specificity) and false positives (at least 80 % sensitivity). The first panel (80 % specificity and 69 % sensitivity) was composed by suberic acid, a tetrahexose, and a trihexose, while the second panel (69 % specificity and 80 % sensitivity) included nonanedioic acid, a trihexose, and the monoglyceride MG(22:2). Thus, the combination of the five metabolites led to a single panel providing 80 % specificity and 79 % sensitivity, reducing the false positive and negative rates to almost 20 %. The method was validated by estimation of within-day and between-days variability of the quantitative analysis of the five metabolites. Graphical Abstract Sweat analysis for screening of lung cancer", "publicationTitle": "Analytical and Bioanalytical Chemistry", "publisher": "", "place": "", "date": "2015/05/03", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "1-12", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Anal Bioanal Chem", "DOI": "10.1007/s00216-015-8700-8", "citationKey": "", "url": "http://link.springer.com/article/10.1007/s00216-015-8700-8", "accessDate": "2015-05-11T07:53:50Z", "PMID": "", "PMCID": "", "ISSN": "1618-2642, 1618-2650", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "link.springer.com", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Analytical Chemistry", "type": 1 }, { "tag": "Biochemistry, general", "type": 1 }, { "tag": "Biomarker panel", "type": 1 }, { "tag": "Characterization and Evaluation of Materials", "type": 1 }, { "tag": "Environmental Monitoring/Analysis", "type": 1 }, { "tag": "Food Science", "type": 1 }, { "tag": "Human sweat", "type": 1 }, { "tag": "LC–QTOF", "type": 1 }, { "tag": "Laboratory Medicine", "type": 1 }, { "tag": "Mass Spectrometry", "type": 1 }, { "tag": "lung cancer", "type": 1 }, { "tag": "metabolomics", "type": 1 } ], "collections": [ "75VPBAXC" ], "relations": {}, "dateAdded": "2015-05-11T07:54:36Z", "dateModified": "2015-05-11T07:54:36Z" } }, { "key": "CHEMGIMV", "version": 218, "library": { "type": "group", "id": 62016, "name": "xavier.robin", "links": { "alternate": { "href": "https://www.zotero.org/groups/xavier.robin", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/62016/items/CHEMGIMV", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/xavier.robin/items/CHEMGIMV", "type": "text/html" } }, "meta": { "createdByUser": { "id": 12953, "username": "Calimo", "name": "Xavier Robin", "links": { "alternate": { "href": "https://www.zotero.org/calimo", "type": "text/html" } } }, "creatorSummary": "Nyariki et al.", "parsedDate": "2014", "numChildren": 0 }, "data": { "key": "CHEMGIMV", "version": 218, "itemType": "journalArticle", "title": "Coenzyme Q10 prevented full blown splenomegaly and decreased melarsoprol-induced reactive encephalopathy in mice infected with Trypanosoma brucei rhodesiense", "creators": [ { "creatorType": "author", "firstName": "James Nyabuga", "lastName": "Nyariki" }, { "creatorType": "author", "firstName": "John Kibuthu", "lastName": "Thuita" }, { "creatorType": "author", "firstName": "Grace Kemunto", "lastName": "Nyambati" }, { "creatorType": "author", "firstName": "Alfred Orina", "lastName": "Isaac" } ], "abstractNote": "", "publicationTitle": "Journal of Coastal Life Medicine", "publisher": "", "place": "", "date": "2014", "volume": "2", "issue": "3", "section": "", "partNumber": "", "partTitle": "", "pages": "230–238", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "http://www.jclmm.com/qk/20143/11.pdf", "accessDate": "2014-06-09T08:34:44Z", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "Google Scholar", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "XRTS6Q6R" ], "relations": {}, "dateAdded": "2014-06-09T08:40:05Z", "dateModified": "2014-06-09T08:40:05Z" } }, { "key": "RMB868G2", "version": 218, "library": { "type": "group", "id": 62016, "name": "xavier.robin", "links": { "alternate": { "href": "https://www.zotero.org/groups/xavier.robin", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/62016/items/RMB868G2", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/xavier.robin/items/RMB868G2", "type": "text/html" } }, "meta": { "createdByUser": { "id": 12953, "username": "Calimo", "name": "Xavier Robin", "links": { "alternate": { "href": "https://www.zotero.org/calimo", "type": "text/html" } } }, "creatorSummary": "Hansen et al.", "parsedDate": "2013", "numChildren": 0 }, "data": { "key": "RMB868G2", "version": 218, "itemType": "bookSection", "title": "Diagnostik und Prognostik von Bewusstseinsstörungen und Enzephalopathien", "creators": [ { "creatorType": "author", "firstName": "H.-C.", "lastName": "Hansen" }, { "creatorType": "author", "firstName": "O.", "lastName": "Jansen" }, { "creatorType": "author", "firstName": "C.", "lastName": "Cnyrim" }, { "creatorType": "author", "firstName": "G.", "lastName": "Hamann" }, { "creatorType": "author", "firstName": "K.", "lastName": "Helmke" }, { "creatorType": "author", "firstName": "T.", "lastName": "Weber" }, { "creatorType": "author", "firstName": "S.", "lastName": "Zschocke" } ], "abstractNote": "", "bookTitle": "Bewusstseinsstörungen und Enzephalopathien", "series": "", "seriesNumber": "", "volume": "", "numberOfVolumes": "", "edition": "", "date": "2013", "publisher": "Springer", "place": "", "originalDate": "", "originalPublisher": "", "originalPlace": "", "format": "", "pages": "175–201", "ISBN": "", "DOI": "", "citationKey": "", "url": "http://link.springer.com/chapter/10.1007/978-3-642-36915-5_11", "accessDate": "2014-06-09T08:36:33Z", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "Google Scholar", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "XRTS6Q6R" ], "relations": {}, "dateAdded": "2014-06-09T08:40:05Z", "dateModified": "2014-06-09T08:40:05Z" } }, { "key": "SDFPF7CJ", "version": 218, "library": { "type": "group", "id": 62016, "name": "xavier.robin", "links": { "alternate": { "href": "https://www.zotero.org/groups/xavier.robin", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/62016/items/SDFPF7CJ", "type": "application/json" }, "alternate": { "href": 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"originalPublisher": "", "originalPlace": "", "format": "", "pages": "183–200", "ISBN": "", "DOI": "", "citationKey": "", "url": "http://link.springer.com/chapter/10.1007/978-1-4614-8100-3_10", "accessDate": "2014-06-09T08:36:11Z", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "Google Scholar", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "8QFQVCUA", "XRTS6Q6R" ], "relations": {}, "dateAdded": "2014-06-09T08:39:31Z", "dateModified": "2014-06-09T08:39:31Z" } }, { "key": "PPRB9Q29", "version": 216, "library": { "type": "group", "id": 62016, "name": "xavier.robin", "links": { "alternate": { "href": "https://www.zotero.org/groups/xavier.robin", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/62016/items/PPRB9Q29", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/xavier.robin/items/PPRB9Q29", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/62016/items/EZGUJX4Q", "type": "application/json" } }, "meta": { "createdByUser": { "id": 12953, "username": "Calimo", "name": "Xavier Robin", "links": { "alternate": { "href": "https://www.zotero.org/calimo", "type": "text/html" } } } }, "data": { "key": "PPRB9Q29", "version": 216, "parentItem": "EZGUJX4Q", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Central Link", "accessDate": "2014-06-09T08:29:28Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031975/", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-06-09T08:29:36Z", "dateModified": "2014-06-09T08:29:36Z" } }, { "key": "EZGUJX4Q", "version": 216, "library": { "type": "group", "id": 62016, "name": "xavier.robin", "links": { "alternate": { "href": "https://www.zotero.org/groups/xavier.robin", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/62016/items/EZGUJX4Q", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/xavier.robin/items/EZGUJX4Q", "type": "text/html" } }, "meta": { "createdByUser": { "id": 12953, "username": "Calimo", "name": "Xavier Robin", "links": { "alternate": { "href": "https://www.zotero.org/calimo", "type": "text/html" } } }, "creatorSummary": "Chikezie and Uwakwe", "parsedDate": "2014-04-22", "numChildren": 1 }, "data": { "key": "EZGUJX4Q", "version": 216, "itemType": "journalArticle", "title": "Activities of three erythrocyte enzymes of hyperglycemic rats (Rattus norvegicus) treated with Allium sativa extract", "creators": [ { "creatorType": "author", "firstName": "Paul C", "lastName": "Chikezie" }, { "creatorType": "author", "firstName": "Augustine A", "lastName": "Uwakwe" } ], "abstractNote": "Background\nThe present study sought to investigate erythrocyte glutathione S-transferases (GST), NADH-Methaemoglobin reductase (NADH-MR) and Na+/K+-ATPase activities of hypoglycemic rats treated with ethanol/water (1:2 v/v) extract of A. sativa as agent of glycemic control.\n\nMethods\nHyperglycemia was induced by a single intra-peritoneal injection of 0.1 mol/L alloxan monohydrate in phosphate buffer saline (PBS) solution (pH = 7.4); dosage = 140 mg/kg. At the end of the experimental time (t = 76 h), erythrocyte GST, NADH-MR and Na+/K+-ATPase activities as well as serum fasting blood sugar (FBS) levels were measured by spectrophotometric methods.\n\nResults\nSerum FBS levels of control/normal (C/N) rats ranged between 72.93 ± 0.82–95.12 ± 0.92 mg/dL, whereas experimental rats without glycemic control gave: 249.41 ± 1.03–256.11 ± 1.23 mg/dL. Hyperglycemic rats treated with ethanol/water (1:2 v/v) extract of A. sativa exhibited comparative reduced serum levels of FBS alongside with erythrocyte GST, NADH-MR and Na+/K+-ATPase activities. The average relative activities of the three enzymes and corresponding order of enzyme activity in hyperglycemic rats treated with ethanol/water (1:2 v/v) extract of A. sativa was: NADH-MR = 60.99% > GST = 47.81% > Na+/K+-ATPase = 46.81%. In the same order, relative activities of the three enzymes in rats without glycemic control were: NADH-MR = 49.65% > GST = 23.69% > Na+/K+-ATPase = 17.02%.\n\nConclusion\nErythrocyte GST, NADH-MR and Na+/K+-ATPase activities gave insights into the pathophysiology of diabetic state and served as biomarkers for ascertaining therapeutic control in Type 1 diabetes mellitus.", "publicationTitle": "Journal of Diabetes and Metabolic Disorders", "publisher": "", "place": "", "date": "2014-4-22", "volume": "13", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "50", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Diabetes Metab Disord", "DOI": "10.1186/2251-6581-13-50", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031975/", "accessDate": "2014-06-09T08:29:28Z", "PMID": "", "PMCID": "", "ISSN": "2251-6581", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "PubMed Central", "callNumber": "", "rights": "", "extra": "PMID: null\nPMCID: PMC4031975", "tags": [], "collections": [ "HM7ZK83T" ], "relations": {}, "dateAdded": "2014-06-09T08:29:36Z", "dateModified": "2014-06-09T08:29:36Z" } }, { "key": "PUASKUH6", "version": 216, "library": { "type": "group", "id": 62016, "name": "xavier.robin", "links": { "alternate": { "href": "https://www.zotero.org/groups/xavier.robin", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/62016/items/PUASKUH6", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/xavier.robin/items/PUASKUH6", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/62016/items/BF6Q3E6D", "type": "application/json" } }, "meta": { "createdByUser": { "id": 12953, "username": "Calimo", "name": "Xavier Robin", "links": { "alternate": { "href": "https://www.zotero.org/calimo", "type": "text/html" } } } }, "data": { "key": "PUASKUH6", "version": 216, "parentItem": "BF6Q3E6D", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Central Full Text PDF", "accessDate": "2014-06-09T08:29:20Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031975/pdf/2251-6581-13-50.pdf", "note": "", "contentType": "application/pdf", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-06-09T08:29:20Z", "dateModified": "2014-06-09T08:29:20Z" } }, { "key": "652X4Q22", "version": 216, "library": { "type": "group", "id": 62016, "name": "xavier.robin", "links": { "alternate": { "href": "https://www.zotero.org/groups/xavier.robin", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/62016/items/652X4Q22", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/xavier.robin/items/652X4Q22", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/62016/items/BF6Q3E6D", "type": "application/json" } }, "meta": { "createdByUser": { "id": 12953, "username": "Calimo", "name": "Xavier Robin", "links": { "alternate": { "href": "https://www.zotero.org/calimo", "type": "text/html" } } } }, "data": { "key": "652X4Q22", "version": 216, "parentItem": "BF6Q3E6D", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Central Link", "accessDate": "2014-06-09T08:29:20Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031975/", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-06-09T08:29:20Z", "dateModified": "2014-06-09T08:29:20Z" } }, { "key": "ZIH2E6X5", "version": 218, "library": { "type": "group", "id": 62016, "name": "xavier.robin", "links": { "alternate": { "href": "https://www.zotero.org/groups/xavier.robin", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/62016/items/ZIH2E6X5", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/xavier.robin/items/ZIH2E6X5", "type": "text/html" } }, "meta": { "createdByUser": { "id": 12953, "username": "Calimo", "name": "Xavier Robin", "links": { "alternate": { "href": "https://www.zotero.org/calimo", "type": "text/html" } } }, "creatorSummary": "Bentivoglio and Kristensson", "parsedDate": "2014", "numChildren": 0 }, "data": { "key": "ZIH2E6X5", "version": 218, "itemType": "journalArticle", "title": "Tryps and trips: cell trafficking across the 100-year-old blood–brain barrier", "creators": [ { "creatorType": "author", "firstName": "Marina", "lastName": "Bentivoglio" }, { "creatorType": "author", "firstName": "Krister", "lastName": "Kristensson" } ], "abstractNote": "One hundred years ago, Edwin E. Goldmann discovered the blood–brain barrier (BBB) using trypan dyes. These dyes were developed and named by Paul Ehrlich during his search for drugs to kill African trypanosomes (extracellular parasites that cause sleeping sickness) while sparing host cells. For Ehrlich, this was the first strategy based on the ‘chemotherapy’ concept he had introduced. The discovery of the BBB revealed, however, the difficulties in drug delivery to the brain. Mechanisms by which parasites enter, dwell, and exit the brain currently provide novel views on cell trafficking across the BBB. These mechanisms also highlight the role of pericytes and endocytosis regulation in BBB functioning and in disrupted BBB gating, which may be involved in the pathogenesis of neurodegeneration.", "publicationTitle": "Trends in Neurosciences", "publisher": "", "place": "", "date": "juin 2014", "volume": "37", "issue": "6", "section": "", "partNumber": "", "partTitle": "", "pages": "325-333", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Trends in Neurosciences", "DOI": "10.1016/j.tins.2014.03.007", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/S0166223614000599", "accessDate": "2014-06-09T08:24:06Z", "PMID": "", "PMCID": "", "ISSN": "0166-2236", "archive": "", "archiveLocation": "", "shortTitle": "Tryps and trips", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Neurodegeneration", "type": 1 }, { "tag": "Neuroinflammation", "type": 1 }, { "tag": "Sleeping sickness", "type": 1 }, { "tag": "endocytosis", "type": 1 }, { "tag": "neurovascular unit", "type": 1 }, { "tag": "pericytes", "type": 1 } ], "collections": [ "8QFQVCUA", "K2HIHR6Q", "XRTS6Q6R" ], "relations": {}, "dateAdded": "2014-06-09T08:27:31Z", "dateModified": "2014-06-09T08:27:31Z" } }, { "key": "VAH2GRSR", "version": 215, "library": { "type": "group", "id": 62016, "name": "xavier.robin", "links": { "alternate": { "href": "https://www.zotero.org/groups/xavier.robin", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/62016/items/VAH2GRSR", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/xavier.robin/items/VAH2GRSR", "type": "text/html" } }, "meta": { "createdByUser": { "id": 12953, "username": "Calimo", "name": "Xavier Robin", "links": { "alternate": { "href": "https://www.zotero.org/calimo", "type": "text/html" } } }, "creatorSummary": "Lejon et al.", "parsedDate": "2013", "numChildren": 0 }, "data": { "key": "VAH2GRSR", "version": 215, "itemType": "journalArticle", "title": "Human African trypanosomiasis", "creators": [ { "creatorType": "author", "firstName": "VEERLE", "lastName": "Lejon" }, { "creatorType": "author", "firstName": "M.", "lastName": "Bentivoglio" }, { "creatorType": "author", "firstName": "JOSE RAMON", "lastName": "Franco" } ], "abstractNote": "", "publicationTitle": "Neuroparasitology and Tropical Neurology: Handbook of Clinical Neurology Series (Editors: Aminoff, Boller, Swaab)", "publisher": "", "place": "", "date": "2013", "volume": "114", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "169", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "http://www.google.com/books?hl=en&lr=&id=bJx3g30aDhIC&oi=fnd&pg=PA169&ots=T6gAerw2ZB&sig=0rIqSVG3eX5xHCEyOMOJVRV8snY", "accessDate": "2014-06-09T08:26:52Z", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "Google Scholar", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "K2HIHR6Q" ], "relations": {}, "dateAdded": "2014-06-09T08:27:31Z", "dateModified": "2014-06-09T08:27:31Z" } }, { "key": "B3JW6AIP", "version": 215, "library": { "type": "group", "id": 62016, "name": "xavier.robin", "links": { "alternate": { "href": "https://www.zotero.org/groups/xavier.robin", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/62016/items/B3JW6AIP", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/xavier.robin/items/B3JW6AIP", "type": "text/html" } }, "meta": { "createdByUser": { "id": 12953, "username": "Calimo", "name": "Xavier Robin", "links": { "alternate": { "href": "https://www.zotero.org/calimo", "type": "text/html" } } }, "creatorSummary": "Tiberti et al.", "parsedDate": "2013", "numChildren": 0 }, "data": { "key": "B3JW6AIP", "version": 215, "itemType": "journalArticle", "title": "Translation of human African trypanosomiasis biomarkers towards field application", "creators": [ { "creatorType": "author", "firstName": "Natalia", "lastName": "Tiberti" }, { "creatorType": "author", "firstName": "Alexandre", "lastName": "Hainard" }, { "creatorType": "author", "firstName": "Jean-Charles", "lastName": "Sanchez" } ], "abstractNote": "Sleeping sickness is a neglected tropical disease affecting rural communities in sub-Saharan Africa. The reduction in the number of reported cases in recent years indicates that disease transmission is under control. However, many aspects of patient management still need to be improved. Undiagnosed patients or inappropriate treatment due to an incorrect determination of the disease stage could in fact lead to its re-emergence. There is thus a strong need for new diagnostic and staging tools to keep the disease under control and to improve the clinical care of patients. This review describes the most promising biomarkers proposed so far for the diagnosis and stage determination of patients suffering from sleeping sickness, with a particular emphasis on their translation into diagnostic tools for field applications.", "publicationTitle": "Translational Proteomics", "publisher": "", "place": "", "date": "2013", "volume": "1", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "12-24", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Translational Proteomics", "DOI": "10.1016/j.trprot.2013.04.001", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/S2212963413000041", "accessDate": "2014-06-09T08:26:25Z", "PMID": "", "PMCID": "", "ISSN": "2212-9634", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Biomarkers", "type": 1 }, { "tag": "Diagnosis", "type": 1 }, { "tag": "Diagnostic tools", "type": 1 }, { "tag": "Human African trypanosomiasis", "type": 1 }, { "tag": "Stage determination", "type": 1 } ], "collections": [ "K2HIHR6Q" ], "relations": {}, "dateAdded": "2014-06-09T08:27:31Z", "dateModified": "2014-06-09T08:27:31Z" } }, { "key": "XKNVB85R", "version": 215, "library": { "type": "group", "id": 62016, "name": "xavier.robin", "links": { "alternate": { "href": "https://www.zotero.org/groups/xavier.robin", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/62016/items/XKNVB85R", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/xavier.robin/items/XKNVB85R", "type": "text/html" } }, "meta": { "createdByUser": { "id": 12953, "username": "Calimo", "name": "Xavier Robin", "links": { "alternate": { "href": "https://www.zotero.org/calimo", "type": "text/html" } } }, "creatorSummary": "Masocha et al.", "parsedDate": "2014-01-01", "numChildren": 0 }, "data": { "key": "XKNVB85R", "version": 215, "itemType": "bookSection", "title": "Neurobiology of African Trypanosomiasis", "creators": [ { "creatorType": "author", "firstName": "Willias", "lastName": "Masocha" }, { "creatorType": "author", "firstName": "Krister", "lastName": "Kristensson" }, { "creatorType": "author", "firstName": "Martin E.", "lastName": "Rottenberg" }, { "creatorType": "editor", "firstName": "Marina", "lastName": "Bentivoglio" }, { "creatorType": "editor", "firstName": "Esper A.", "lastName": "Cavalheiro" }, { "creatorType": "editor", "firstName": "Krister", "lastName": "Kristensson" }, { "creatorType": "editor", "firstName": "Nilesh B.", "lastName": "Patel" } ], "abstractNote": "Invasion of the central nervous system (CNS) by the extracellular parasite Trypanosoma brucei is a major pathogenic event, causing a number of neurological dysfunctions, which makes African trypanosomiasis (sleeping sickness) almost always fatal if untreated. We here present our current understanding on the complex cellular and molecular host-parasite interactions, which underlie the neurobiology of African trypanosomiasis. Such interactions involve parasite- and host-derived molecules that play a role in the parasite invasion of the CNS. This invasion occurs in two phases: first through fenestrated vessels in the choroid plexus, circumventricular organs and peripheral nerve root ganglia, and then as a multistep process across post-capillary venules in the brain parenchyma. Potential mechanisms mediating the control of parasite accumulation within the brain parenchyma and the nervous system dysfunctions that include pain and sleep pattern disruptions are discussed. The need for better understanding of the neurobiology of the pathogenesis of these interactions in order to improve the diagnosis and management of sleeping sickness is also highlighted.", "bookTitle": "Neglected Tropical Diseases and Conditions of the Nervous System", "series": "", "seriesNumber": "", "volume": "", "numberOfVolumes": "", "edition": "", "date": "2014/01/01", "publisher": "Springer New York", "place": "", "originalDate": "", "originalPublisher": "", "originalPlace": "", "format": "", "pages": "183-200", "ISBN": "978-1-4614-8099-0, 978-1-4614-8100-3", "DOI": "", "citationKey": "", "url": "http://link.springer.com/chapter/10.1007/978-1-4614-8100-3_10", "accessDate": "2014-06-09T08:25:07Z", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "link.springer.com", "callNumber": "", "rights": "©2014 Springer Science+Business Media New York", "extra": "", "tags": [ { "tag": "Blood-brain barrier", "type": 1 }, { "tag": "Immune responses", "type": 1 }, { "tag": "Inflammation", "type": 1 }, { "tag": "Nervous system", "type": 1 }, { "tag": "Neurology", "type": 1 }, { "tag": "Neurosciences", "type": 1 }, { "tag": "Pain", "type": 1 }, { "tag": "Parasites", "type": 1 }, { "tag": "Public Health", "type": 1 }, { "tag": "Sleep", "type": 1 }, { "tag": "Sleeping sickness", "type": 1 }, { "tag": "Trypanosoma brucei", "type": 1 }, { "tag": "Virology", "type": 1 } ], "collections": [ "K2HIHR6Q" ], "relations": {}, "dateAdded": "2014-06-09T08:27:31Z", "dateModified": "2014-06-09T08:27:31Z" } }, { "key": "QQZG7W4I", "version": 213, "library": { "type": "group", "id": 62016, "name": "xavier.robin", "links": { "alternate": { "href": "https://www.zotero.org/groups/xavier.robin", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/62016/items/QQZG7W4I", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/xavier.robin/items/QQZG7W4I", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/62016/items/BSP9T78B", "type": "application/json" } }, "meta": { "createdByUser": { "id": 12953, "username": "Calimo", "name": "Xavier Robin", "links": { "alternate": { "href": "https://www.zotero.org/calimo", "type": "text/html" } } } }, "data": { "key": "QQZG7W4I", "version": 213, "parentItem": "BSP9T78B", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-06-09T08:15:53Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/24789741", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-06-09T08:16:10Z", "dateModified": "2014-06-09T08:16:10Z" } }, { "key": "BSP9T78B", "version": 213, "library": { "type": "group", "id": 62016, "name": "xavier.robin", "links": { "alternate": { "href": "https://www.zotero.org/groups/xavier.robin", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/62016/items/BSP9T78B", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/xavier.robin/items/BSP9T78B", "type": "text/html" } }, "meta": { "createdByUser": { "id": 12953, "username": "Calimo", "name": "Xavier Robin", "links": { "alternate": { "href": "https://www.zotero.org/calimo", "type": "text/html" } } }, "creatorSummary": "Sternberg and Mitchell", "parsedDate": "2014-04-30", "numChildren": 1 }, "data": { "key": "BSP9T78B", "version": 213, "itemType": "journalArticle", "title": "Plasma neuronal specific enolase: a potential stage diagnostic marker in human African trypanosomiasis", "creators": [ { "creatorType": "author", "firstName": "Jeremy M.", "lastName": "Sternberg" }, { "creatorType": "author", "firstName": "Julia A.", "lastName": "Mitchell" } ], "abstractNote": "Background This study was carried out to determine the potential of neuronal specific enolase (NSE) as a stage diagnostic marker in human African trypanosomiasis.\nMethods Plasma and cerebrospinal fluid were obtained from a cohort of Trypanosoma brucei rhodesiense infected patients and non-infected controls. Neuronal specific enolase concentrations were measured by ELISA and analysed in relation to diagnosis and disease-stage data.\nResults Plasma NSE concentration was significantly increased in late-stage patients (median 21 ng/ml), compared to the control (median 11 ng/ml), but not in early-stage patients (median 5.3 ng/ml). Cerebrospinal fluid NSE concentration did not vary between stages.\nConclusion Plasma NSE is a potential stage diagnostic in this cohort and merits further investigation.", "publicationTitle": "Transactions of The Royal Society of Tropical Medicine and Hygiene", "publisher": "", "place": "", "date": "2014-04-30", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "tru065", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Trans R Soc Trop Med Hyg", "DOI": "10.1093/trstmh/tru065", "citationKey": "", "url": "http://trstmh.oxfordjournals.org/content/early/2014/04/29/trstmh.tru065", "accessDate": "2014-06-09T08:15:53Z", "PMID": "", "PMCID": "", "ISSN": "0035-9203, 1878-3503", "archive": "", "archiveLocation": "", "shortTitle": "Plasma neuronal specific enolase", "language": "en", "libraryCatalog": "trstmh.oxfordjournals.org", "callNumber": "", "rights": "", "extra": "PMID: 24789741", "tags": [ { "tag": "African trypanosomiasis", "type": 1 }, { "tag": "Neuronal specific enolase", "type": 1 }, { "tag": "Stage", "type": 1 } ], "collections": [ "E6BR434W" ], "relations": {}, "dateAdded": "2014-06-09T08:16:10Z", "dateModified": "2014-06-09T08:16:10Z" } }, { "key": "CK7HC358", "version": 212, "library": { "type": "group", "id": 62016, "name": "xavier.robin", "links": { "alternate": { "href": "https://www.zotero.org/groups/xavier.robin", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/62016/items/CK7HC358", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/xavier.robin/items/CK7HC358", "type": "text/html" } }, "meta": { "createdByUser": { "id": 12953, "username": "Calimo", "name": "Xavier Robin", "links": { "alternate": { "href": "https://www.zotero.org/calimo", "type": "text/html" } } }, "creatorSummary": "Phillips et al.", "parsedDate": "2014", "numChildren": 0 }, "data": { "key": "CK7HC358", "version": 212, "itemType": "journalArticle", "title": "Time dependent integration of matrix metalloproteinases and their targeted substrates directs axonal sprouting and synaptogenesis following central nervous system injury", "creators": [ { "creatorType": "author", "firstName": "LindaL", "lastName": "Phillips" }, { "creatorType": "author", "firstName": "ThomasM", "lastName": "Reeves" }, { "creatorType": "author", "firstName": "JulieL", "lastName": "Chan" }, { "creatorType": "author", "firstName": "AdeleE", "lastName": "Doperalski" } ], "abstractNote": "", "publicationTitle": "Neural Regeneration Research", "publisher": "", "place": "", "date": "2014", "volume": "9", "issue": "4", "section": "", "partNumber": "", "partTitle": "", "pages": "362", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.4103/1673-5374.128237", "citationKey": "", "url": "http://www.nrronline.org/article.asp?issn=1673-5374;year=2014;volume=9;issue=4;spage=362;epage=376;aulast=Phillips", "accessDate": "2014-06-09T08:07:26Z", "PMID": "", "PMCID": "", "ISSN": "1673-5374", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "5G6V7ABZ" ], "relations": {}, "dateAdded": "2014-06-09T08:11:23Z", "dateModified": "2014-06-09T08:11:23Z" } }, { "key": "4HD9KHCU", "version": 214, "library": { "type": "group", "id": 62016, "name": "xavier.robin", "links": { "alternate": { "href": "https://www.zotero.org/groups/xavier.robin", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/62016/items/4HD9KHCU", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/xavier.robin/items/4HD9KHCU", "type": "text/html" } }, "meta": { "createdByUser": { "id": 12953, "username": "Calimo", "name": "Xavier Robin", "links": { "alternate": { "href": "https://www.zotero.org/calimo", "type": "text/html" } } }, "creatorSummary": "von Tobel et al.", "numChildren": 0 }, "data": { "key": "4HD9KHCU", "version": 214, "itemType": "journalArticle", "title": "Repeated exposure to Ochratoxin A generates a neuroinflammatory response, characterized by neurodegenerative M1 microglial phenotype", "creators": [ { "creatorType": "author", "firstName": "Jenny Sandström", "lastName": "von Tobel" }, { "creatorType": "author", "firstName": "Paola", "lastName": "Antinori" }, { "creatorType": "author", "firstName": "Marie-Gabrielle", "lastName": "Zurich" }, { "creatorType": "author", "firstName": "Robin", "lastName": "Rosset" }, { "creatorType": "author", "firstName": "Michael", "lastName": "Aschner" }, { "creatorType": "author", "firstName": "Florent", "lastName": "Glück" }, { "creatorType": "author", "firstName": "Alexander", "lastName": "Scherl" }, { "creatorType": "author", "firstName": "Florianne", "lastName": "Monnet-Tschudi" } ], "abstractNote": "Neurotoxic effects of the environmentally abundant mycotoxin Ochratoxin A (OTA) were studied in histotypic 3D rat brain cell cultures, comprising all brain cell types. Cultures were exposed to nanomolar OTA concentrations and samples were collected 48 h after a single exposure, or after 10 days of repeated administration. OTA-induced changes in gene- and protein expression, as well as alterations in cell morphology were assessed.\n\nForty-eight-hour OTA exposure resulted in a disruption of the neuronal cytoskeleton and reduced expression of several oligodendrocyte-specific markers indicative of demyelination. Astrocyte disturbances were revealed by a decrease in two astrocytic proteins involved in regulation of inflammatory responses, metallothioneins I and II. Repeated OTA administration induced a neuroinflammatory response, as visualized by an increase of isolectin B4 labelled cells, increased expression of pro-inflammatory cytokines, and detection of macrophagic ED1/CD68 positive cells, as well as an upregulation of neurodegenerative M1 microglial phenotype markers.\n\nPartial recovery from OTA-induced deleterious effects on oligodendrocytes and astrocytes was achieved by co-treatment with sonic hedgehog (SHH). In addition, metallothionein I and II co-treatment partially restored OTA-induced effects on oligodendrocytes after 48 h, and modulated microglial reactivity after 10 days. These results suggest that OTA-exposure affects Shh-signalling, which in turn may influence both oligodendrocytes and astrocytes. Furthermore, the primarily astrocytic proteins MTI/MTII may affect microglial activation. Thus the neuroinflammatory response appears to be downstream of OTA-induced effects on demyelination, axonal instabilities and astrocytes disturbances. In conclusion, repeated OTA-exposure induced a secondary neuroinflammatory response characterized by neurodegenerative M1 microglial activation and pro-inflammatory response that could exacerbate the neurodegenerative process.", "publicationTitle": "NeuroToxicology", "publisher": "", "place": "", "date": "", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "NeuroToxicology", "DOI": "10.1016/j.neuro.2014.04.005", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/S0161813X14000643", "accessDate": "2014-06-09T08:03:51Z", "PMID": "", "PMCID": "", "ISSN": "0161-813X", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "3D brain cell cultures", "type": 1 }, { "tag": "Demyelination", "type": 1 }, { "tag": "M1/M2 microglial phenotypes", "type": 1 }, { "tag": "Metallothionein I and II", "type": 1 }, { "tag": "Neuroinflammation", "type": 1 }, { "tag": "Ochratoxin A", "type": 1 }, { "tag": "Sonic hedgehog", "type": 1 } ], "collections": [ "PUMUZUWE", "TZNGZ92U" ], "relations": {}, "dateAdded": "2014-06-09T08:05:01Z", "dateModified": "2014-06-09T08:05:01Z" } }, { "key": "JQ2X6UT4", "version": 211, "library": { "type": "group", "id": 62016, "name": "xavier.robin", "links": { "alternate": { "href": "https://www.zotero.org/groups/xavier.robin", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/62016/items/JQ2X6UT4", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/xavier.robin/items/JQ2X6UT4", "type": "text/html" } }, "meta": { "createdByUser": { "id": 12953, "username": "Calimo", "name": "Xavier Robin", "links": { "alternate": { "href": "https://www.zotero.org/calimo", "type": "text/html" } } }, "creatorSummary": "Zufferey et al.", "parsedDate": "2014", "numChildren": 0 }, "data": { "key": "JQ2X6UT4", "version": 211, "itemType": "journalArticle", "title": "Characterization of the platelet granule proteome: Evidence of the presence of MHC1 in alpha-granules", "creators": [ { "creatorType": "author", "firstName": "Anne", "lastName": "Zufferey" }, { "creatorType": "author", "firstName": "Domitille", "lastName": "Schvartz" }, { "creatorType": "author", "firstName": "Séverine", "lastName": "Nolli" }, { "creatorType": "author", "firstName": "Jean-Luc", "lastName": "Reny" }, { "creatorType": "author", "firstName": "Jean-Charles", "lastName": "Sanchez" }, { "creatorType": "author", "firstName": "Pierre", "lastName": "Fontana" } ], "abstractNote": "In the present study, we performed an extensive qualitative characterization of the platelet granule proteome using subcellular fractionation followed by mass spectrometry analysis and functional annotation. Eight-hundred-and-twenty-seven proteins were identified, most of them being associated to granules and to the granule's secretory machinery. Functional pathway analysis revealed 30 pathways, including the major histocompatibility complex class 1 (MHC I) presenting antigen pathway. This pathway was of particular interest for its potential interrelation between platelets and the immune system. Key proteins belonging to this metabolic route such as β-2-microglobulin, 26S protease regulatory subunit 10B from the proteasome and proteins 1 and 2 of the transporter associated with antigen processing were shown to co-localize with von Willebrand factor in resting platelets and to be located on the plasma membrane when platelets were activated. Key proteins of the MHC1 antigen-presenting pathway are located in platelet alpha-granules. These results suggest a possible functional role of platelet granules in platelet-related immune modulation.\nBiological significance\nIn this study, we described the largest dataset related to platelet granule proteins. We performed a functional pathway analysis that evidenced several expected granule-related pathways. We also highlighted the “Antigen processing and presentation” pathway that has drawn our attention. Using immunofluorescence technique, we confirmed the presence of several key proteins for antigen presentation in platelet granules. This study suggests a putative functional role of MHC1 and platelet granules in the immune modulation.", "publicationTitle": "Journal of Proteomics", "publisher": "", "place": "", "date": "avril 14, 2014", "volume": "101", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "130-140", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Journal of Proteomics", "DOI": "10.1016/j.jprot.2014.02.008", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/S1874391914000578", "accessDate": "2014-06-09T08:02:38Z", "PMID": "", "PMCID": "", "ISSN": "1874-3919", "archive": "", "archiveLocation": "", "shortTitle": "Characterization of the platelet granule proteome", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "MHC I", "type": 1 }, { "tag": "Platelet", "type": 1 }, { "tag": "Proteomics", "type": 1 }, { "tag": "granules", "type": 1 }, { "tag": "β-2-microglobulin", "type": 1 } ], "collections": [ "PUMUZUWE" ], "relations": {}, "dateAdded": "2014-06-09T08:05:01Z", "dateModified": "2014-06-09T08:05:01Z" } }, { "key": "XI6GMQFP", "version": 211, "library": { "type": "group", "id": 62016, "name": "xavier.robin", "links": { "alternate": { "href": "https://www.zotero.org/groups/xavier.robin", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/62016/items/XI6GMQFP", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/xavier.robin/items/XI6GMQFP", "type": "text/html" } }, "meta": { "createdByUser": { "id": 12953, "username": "Calimo", "name": "Xavier Robin", "links": { "alternate": { "href": "https://www.zotero.org/calimo", "type": "text/html" } } }, "creatorSummary": "Parker et al.", "parsedDate": "2014", "numChildren": 0 }, "data": { "key": "XI6GMQFP", "version": 211, "itemType": "journalArticle", "title": "Maf-dependent bacterial flagellin glycosylation occurs before chaperone binding and flagellar T3SS export", "creators": [ { "creatorType": "author", "firstName": "Jennifer L.", "lastName": "Parker" }, { "creatorType": "author", "firstName": "Rebecca C.", "lastName": "Lowry" }, { "creatorType": "author", "firstName": "Narciso A. S.", "lastName": "Couto" }, { "creatorType": "author", "firstName": "Phillip C.", "lastName": "Wright" }, { "creatorType": "author", "firstName": "Graham P.", "lastName": "Stafford" }, { "creatorType": "author", "firstName": "Jonathan G.", "lastName": "Shaw" } ], "abstractNote": "Bacterial swimming is mediated by rotation of a filament that is assembled via polymerization of flagellin monomers after secretion via a dedicated flagellar Type III secretion system. Several bacteria decorate their flagellin with sialic acid related sugars that is essential for motility. Aeromonas caviae is a model organism for this process as it contains a genetically simple glycosylation system and decorates its flagellin with pseudaminic acid (Pse). The link between flagellin glycosylation and export has yet to be fully determined. We examined the role of glycosylation in the export and assembly process in a strain lacking Maf1, a protein involved in the transfer of Pse onto flagellin at the later stages of the glycosylation pathway. Immunoblotting, established that glycosylation is not required for flagellin export but is essential for filament assembly since non-glycosylated flagellin is still secreted. Maf1 interacts directly with its flagellin substrate in vivo, even in the absence of pseudaminic acid. Flagellin glycosylation in a flagellin chaperone mutant (flaJ) indicated that glycosylation occurs in the cytoplasm before chaperone binding and protein secretion. Preferential chaperone binding to glycosylated flagellin revealed its crucial role, indicating that this system has evolved to favour secretion of the polymerization competent glycosylated form.", "publicationTitle": "Molecular Microbiology", "publisher": "", "place": "", "date": "avril 1, 2014", "volume": "92", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "258-272", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Molecular Microbiology", "DOI": "10.1111/mmi.12549", "citationKey": "", "url": "http://onlinelibrary.wiley.com/doi/10.1111/mmi.12549/abstract", "accessDate": "2014-06-09T08:03:25Z", "PMID": "", "PMCID": "", "ISSN": "1365-2958", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "Wiley Online Library", "callNumber": "", "rights": "© 2014 The Authors. Molecular Microbiology published by John Wiley & Sons Ltd., This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.", "extra": "", "tags": [], "collections": [ "PUMUZUWE" ], "relations": {}, "dateAdded": "2014-06-09T08:05:01Z", "dateModified": "2014-06-09T08:05:01Z" } }, { "key": "X5Q8U88C", "version": 211, "library": { "type": "group", "id": 62016, "name": "xavier.robin", "links": { "alternate": { "href": "https://www.zotero.org/groups/xavier.robin", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/62016/items/X5Q8U88C", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/xavier.robin/items/X5Q8U88C", "type": "text/html" } }, "meta": { "createdByUser": { "id": 12953, "username": "Calimo", "name": "Xavier Robin", "links": { "alternate": { "href": "https://www.zotero.org/calimo", "type": "text/html" } } }, "creatorSummary": "Jacot et al.", "parsedDate": "2014", "numChildren": 0 }, "data": { "key": "X5Q8U88C", "version": 211, "itemType": "journalArticle", "title": "Assessment of phosphorylation in Toxoplasma glideosome assembly and function", "creators": [ { "creatorType": "author", "firstName": "Damien", "lastName": "Jacot" }, { "creatorType": "author", "firstName": "Karine", "lastName": "Frénal" }, { "creatorType": "author", "firstName": "Jean-Baptiste", "lastName": "Marq" }, { "creatorType": "author", "firstName": "Pushkar", "lastName": "Sharma" }, { "creatorType": "author", "firstName": "Dominique", "lastName": "Soldati-Favre" } ], "abstractNote": "Members of the phylum Apicomplexa possess a highly conserved molecular motor complex anchored in the parasite pellicle and associated with gliding motility, invasion and egress from infected cells. This machinery, called the glideosome, is structured around the acylated gliding-associated protein GAP45 that recruits the motor complex composed of myosin A and two associated myosin light chains (TgMLC1 and TgELC1). This motor is presumably firmly anchored to the inner membrane complex underneath the plasma membrane via an interaction with two integral membrane proteins, GAP50 and GAP40. To determine if the previously mapped phosphorylation sites on TgGAP45 and TgMLC1 have a direct significance for glideosome assembly and function, a series of phospho-mimetic and phospho-null mutants were generated. Neither the overexpression nor the allelic replacement of TgMLC1 with phospho-mutants impacted on glideosome assembly and parasite motility. TgGAP45 phosphorylation mutants were functionally investigated using a complementation strategy in a TgGAP45 inducible knockout background. The loss of interaction with TgGAP50 by one previously reported GAP45-mutant appeared to depend only on the presence of a remaining competing wild type copy of TgGAP45. Accordingly, this mutant displayed no phenotype in complementation experiments. Unexpectedly, GAP45 lacking the region encompassing the cluster of twelve phosphorylation sites did not impact on its dual function in motor recruitment and pellicle integrity. Despite the extensive phosphorylation of TgMLC1 and TgGAP45, this post-translational modification does not appear to be critical for the assembly and function of the glideosome.", "publicationTitle": "Cellular Microbiology", "publisher": "", "place": "", "date": "juin 1, 2014", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "n/a-n/a", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Cell Microbiol", "DOI": "10.1111/cmi.12307", "citationKey": "", "url": "http://onlinelibrary.wiley.com/doi/10.1111/cmi.12307/abstract", "accessDate": "2014-06-09T08:04:27Z", "PMID": "", "PMCID": "", "ISSN": "1462-5822", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "Wiley Online Library", "callNumber": "", "rights": "© 2014 John Wiley & Sons Ltd", "extra": "", "tags": [], "collections": [ "PUMUZUWE" ], "relations": {}, "dateAdded": "2014-06-09T08:05:01Z", "dateModified": "2014-06-09T08:05:01Z" } }, { "key": "R3NUAKSK", "version": 208, "library": { "type": "group", "id": 62016, "name": "xavier.robin", "links": { "alternate": { "href": "https://www.zotero.org/groups/xavier.robin", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/62016/items/R3NUAKSK", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/xavier.robin/items/R3NUAKSK", "type": "text/html" } }, "meta": { "createdByUser": { "id": 12953, "username": "Calimo", "name": "Xavier Robin", "links": { "alternate": { "href": "https://www.zotero.org/calimo", "type": "text/html" } } }, "creatorSummary": "Liu et al.", "parsedDate": "2013", "numChildren": 0 }, "data": { "key": "R3NUAKSK", "version": 208, "itemType": "journalArticle", "title": "Early diagnosis of complex diseases by molecular biomarkers, network biomarkers, and dynamical network biomarkers", "creators": [ { "creatorType": "author", "firstName": "Rui", "lastName": "Liu" }, { "creatorType": "author", "firstName": "Xiangdong", "lastName": "Wang" }, { "creatorType": "author", "firstName": "Kazuyuki", "lastName": "Aihara" }, { "creatorType": "author", "firstName": "Luonan", "lastName": "Chen" } ], "abstractNote": "", "publicationTitle": "Medicinal research reviews", "publisher": "", "place": "", "date": "2013", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "http://onlinelibrary.wiley.com/doi/10.1002/med.21293/full", "accessDate": "2014-04-18T14:34:38Z", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "Google Scholar", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "CNN5THP7" ], "relations": {}, "dateAdded": "2014-06-09T07:57:14Z", "dateModified": "2014-06-09T07:57:14Z" } }, { "key": "92CDETTR", "version": 209, "library": { "type": "group", "id": 62016, "name": "xavier.robin", "links": { "alternate": { "href": "https://www.zotero.org/groups/xavier.robin", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/62016/items/92CDETTR", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/xavier.robin/items/92CDETTR", "type": "text/html" } }, "meta": { "createdByUser": { "id": 12953, "username": "Calimo", "name": "Xavier Robin", "links": { "alternate": { "href": "https://www.zotero.org/calimo", "type": "text/html" } } }, "creatorSummary": "Ottens et al.", "parsedDate": "2013", "numChildren": 0 }, "data": { "key": "92CDETTR", "version": 209, "itemType": "journalArticle", "title": "Post-Acute Brain Injury Urinary Signature: A New Resource for Molecular Diagnostics", "creators": [ { "creatorType": "author", "firstName": "Andrew K.", "lastName": "Ottens" }, { "creatorType": "author", "firstName": "Jillian E.", "lastName": "Stafflinger" }, { "creatorType": "author", "firstName": "Hailey E.", "lastName": "Griffin" }, { "creatorType": "author", "firstName": "Richard D.", "lastName": "Kunz" }, { "creatorType": "author", "firstName": "David X.", "lastName": "Cifu" }, { "creatorType": "author", "firstName": "Janet P.", "lastName": "Niemeier" } ], "abstractNote": "Heterogeneity within brain injury presents a challenge to the development of informative molecular diagnostics. Recent studies show progress, particularly in cerebrospinal fluid, with biomarker assays targeting one or a few structural proteins. Protein-based assays in peripheral fluids, however, have been more challenging to develop, in part because of restricted and intermittent barrier access. Further, a greater number of molecular variables may be required to inform on patient status given the multi-factorial nature of brain injury. Presented is an alternative approach profiling peripheral fluid for a class of small metabolic by-products rendered by ongoing brain pathobiology. Urine specimens were collected for head trauma subjects upon admission to acute brain injury rehabilitation and non-traumatized matched controls. An innovative data-independent mass spectrometry approach was employed for reproducible molecular quantification across osmolarity-normalized samples. The postacute human traumatic brain injury urinary signature encompassed 2476 discriminant variables reproducibly measured in specimens for subject classification. Multiple subprofiles were then discerned in correlation with injury severity per the Glasgow Comma Scale and behavioral and neurocognitive function per the Patient Competency Rating Scale and Frontal Systems Behavioral Scale. Identified peptide constituents were enriched for outgrowth and guidance, extracellular matrix, and post-synaptic density proteins, which were reflective of ongoing post-acute neuroplastic processes demonstrating pathobiological relevance. Taken together, these findings support further development of diagnostics based on brain injury urinary signatures using either combinatorial quantitative models or pattern-recognition methods. Particularly, these findings espouse assay development to address unmet diagnostic and theragnostic needs in brain injury rehabilitative medicine.", "publicationTitle": "Journal of Neurotrauma", "publisher": "", "place": "", "date": "décembre 29, 2013", "volume": "31", "issue": "8", "section": "", "partNumber": "", "partTitle": "", "pages": "782-788", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Journal of Neurotrauma", "DOI": "10.1089/neu.2013.3116", "citationKey": "", "url": "http://online.liebertpub.com/doi/abs/10.1089/neu.2013.3116", "accessDate": "2014-06-09T07:56:41Z", "PMID": "", "PMCID": "", "ISSN": "0897-7151", "archive": "", "archiveLocation": "", "shortTitle": "Post-Acute Brain Injury Urinary Signature", "language": "", "libraryCatalog": "online.liebertpub.com (Atypon)", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "CJ7W9HFJ", "CNN5THP7" ], "relations": {}, "dateAdded": "2014-06-09T07:57:07Z", "dateModified": "2014-06-09T07:57:07Z" } }, { "key": "ICF6Q97U", "version": 207, "library": { "type": "group", "id": 62016, "name": "xavier.robin", "links": { "alternate": { "href": "https://www.zotero.org/groups/xavier.robin", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/62016/items/ICF6Q97U", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/xavier.robin/items/ICF6Q97U", "type": "text/html" } }, "meta": { "createdByUser": { "id": 12953, "username": "Calimo", "name": "Xavier Robin", "links": { "alternate": { "href": "https://www.zotero.org/calimo", "type": "text/html" } } }, "creatorSummary": "Gu et al.", "parsedDate": "2014-02-04", "numChildren": 0 }, "data": { "key": "ICF6Q97U", "version": 207, "itemType": "journalArticle", "title": "A systematic study of chemogenomics of carbohydrates", "creators": [ { "creatorType": "author", "firstName": "Jiangyong", "lastName": "Gu" }, { "creatorType": "author", "firstName": "Fang", "lastName": "Luo" }, { "creatorType": "author", "firstName": "Lirong", "lastName": "Chen" }, { "creatorType": "author", "firstName": "Gu", "lastName": "Yuan" }, { "creatorType": "author", "firstName": "Xiaojie", "lastName": "Xu" } ], "abstractNote": "Chemogenomics focuses on the interactions between biologically active molecules and protein targets for drug discovery. Carbohydrates are the most abundant compounds in natural products. Compared with other drugs, the carbohydrate drugs show weaker side effects. Searching for multi-target carbohydrate drugs can be regarded as a solution to improve therapeutic efficacy and safety. In this work, we collected 60344 carbohydrates from the Universal Natural Products Database (UNPD) and explored the chemical space of carbohydrates by principal component analysis. We found that there is a large quantity of potential lead compounds among carbohydrates. Then we explored the potential of carbohydrates in drug discovery by using a network-based multi-target computational approach. All carbohydrates were docked to 2389 target proteins. The most potential carbohydrates for drug discovery and their indications were predicted based on a docking score-weighted prediction model. We also explored the interactions between carbohydrates and target proteins to find the pathological networks, potential drug candidates and new indications.", "publicationTitle": "Molecular BioSystems", "publisher": "", "place": "", "date": "2014-02-04", "volume": "10", "issue": "3", "section": "", "partNumber": "", "partTitle": "", "pages": "391-397", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Mol. BioSyst.", "DOI": "10.1039/C3MB70534J", "citationKey": "", "url": "http://pubs.rsc.org/en/content/articlelanding/2014/mb/c3mb70534j", "accessDate": "2014-03-13T18:07:58Z", "PMID": "", "PMCID": "", "ISSN": "1742-2051", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "pubs.rsc.org", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-06-09T07:55:42Z", "dateModified": "2014-06-09T07:55:42Z" } }, { "key": "7ZVK649R", "version": 207, "library": { "type": "group", "id": 62016, "name": "xavier.robin", "links": { "alternate": { "href": "https://www.zotero.org/groups/xavier.robin", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/62016/items/7ZVK649R", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/xavier.robin/items/7ZVK649R", "type": "text/html" } }, "meta": { "createdByUser": { "id": 12953, "username": "Calimo", "name": "Xavier Robin", "links": { "alternate": { "href": "https://www.zotero.org/calimo", "type": "text/html" } } }, "creatorSummary": "Schena", "parsedDate": "2014", "numChildren": 0 }, "data": { "key": "7ZVK649R", "version": 207, "itemType": "journalArticle", "title": "Biomarkers and personalized therapy in chronic kidney diseases", "creators": [ { "creatorType": "author", "firstName": "Francesco Paolo", "lastName": "Schena" } ], "abstractNote": "Numerous clinical trials are currently evaluating new strategies to halt the progression of renal damage in patients with chronic kidney diseases (CKDs). Unfortunately, none of them have considered that the lack of response to new therapies may be due to the pharmacogenetics/pharmacogenomics profile of the patient. The recent impact of high-throughput technologies used in genomics, proteomics and metabolomics may open a new way for discovering biomarkers that can provide us information about the mechanisms on the progression of renal damage. However, they can also be used for diagnosis and for selecting drugs, leading to personalized tailored therapy. The uses of classifiers formed by a list of genes, proteins and metabolites have been introduced into oncology and organ transplantation. These new approaches have recently also been used in the care of human glomerulonephritis. Integrating the large omic data sets with drug and disease databases could give the prediction of drug efficacy and side effects in CKDs.", "publicationTitle": "Expert Opinion on Investigational Drugs", "publisher": "", "place": "", "date": "mai 26, 2014", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "1-4", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Expert Opin. Investig. Drugs", "DOI": "10.1517/13543784.2014.922953", "citationKey": "", "url": "http://informahealthcare.com/doi/abs/10.1517/13543784.2014.922953", "accessDate": "2014-06-09T07:55:19Z", "PMID": "", "PMCID": "", "ISSN": "1354-3784", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "informahealthcare.com (Atypon)", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "PE6ZC9XW" ], "relations": {}, "dateAdded": "2014-06-09T07:55:39Z", "dateModified": "2014-06-09T07:55:39Z" } } ]