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                    "firstName": "G",
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                    "lastName": "Folstein"
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                    "lastName": "Katzman"
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                    "firstName": "D",
                    "lastName": "Price"
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                    "creatorType": "author",
                    "firstName": "E M",
                    "lastName": "Stadlan"
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            "abstractNote": "Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information become available.",
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            "publisher": "",
            "place": "",
            "date": "Jul 1984",
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                    "firstName": "Jacquelin",
                    "lastName": "Perry"
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                {
                    "creatorType": "author",
                    "firstName": "Mary",
                    "lastName": "Garrett"
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                {
                    "creatorType": "author",
                    "firstName": "JoAnne K.",
                    "lastName": "Gronley"
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                {
                    "creatorType": "author",
                    "firstName": "Sara J.",
                    "lastName": "Mulroy"
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            "abstractNote": "Background and Purpose The limited walking ability that follows a stroke restricts the patient's independent mobility about the home and community, a significant social handicap. To improve the in-hospital prediction of functional outcome, the relationships between impairment, disability, and handicap were assessed with clinical measures in 147 stroke patients. Methods The patients' level of functional walking ability at home and in the community was assigned by expert clinicians to one of the six categories of a modified Hoffer Functional Ambulation scale at least 3 months after discharge. A 19-item questionnaire was further used to assess current customary mobility of the subjects. Functional muscle strength and proprioception were tested, and walking velocity was measured. Results The significant indicators of impairment, upright motor control knee flexion and extension strength, differentiated household from community ambulators. The addition of velocity improved the functional prediction. Proprioception was clinically normal in all walkers. The validity of the criteria for the six levels of walking handicap was confirmed statistically. Stepwise discriminant analysis reduced the ambulation activities on the questionnaire from 19 to 7. Redefinition of the criteria for patient classification using the coefficients and constants of the seven critical functions improved the prediction of patient walking ability to 84%. Conclusions The results of this study offer a quantitative method of relating the social disadvantage of stroke patients to the impairment and disability sustained. The measurement of therapeutic outcome in relation to the social advantage for the patient would allow more efficient standardization of treatment and services.",
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            "creatorSummary": "Yakura et al.",
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                    "firstName": "J S",
                    "lastName": "Yakura"
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                {
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                    "firstName": "R L",
                    "lastName": "Waters"
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                {
                    "creatorType": "author",
                    "firstName": "R H",
                    "lastName": "Adkins"
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            "abstractNote": "The energy cost and gait parameters of 10 spinal cord injury patients (mean age = 21.7 +/- 2.3 years) were measured at discharge from initial rehabilitation and at 1 year follow-up. At follow-up testing patients walked faster (59.5 m/minute vs 40.4 m/minutes; p less than 0.001), more efficiently (0.26 ml O2/kg.m vs 0.40 ml O2/kg.m; p less than 0.05) had slower heart rates (115 beats/minute vs 133 beats/minute; p less than 0.01), and required decreased axial load on upper extremity assistive devices (18% body weight vs 26% body weight; p less than 0.03). At follow-up testing, those patients with remaining weakness in the lower limbs had greater conditioning effects (increased rate of oxygen consumption and oxygen pulse) than those patients with relatively stronger limbs. These findings indicate that clinicians can expect significant improvements in functional ambulation performance in the first year following initial rehabilitation due to improved strength and conditioning.",
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            "date": "Jul 1990",
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            "pages": "364-370",
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            "extra": "PMID: 2235047",
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                    "tag": "Adult",
                    "type": 1
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                    "tag": "Heart Rate",
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            "creatorSummary": "Vasudevan et al.",
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            "version": 1,
            "itemType": "journalArticle",
            "title": "Can Trendelenburg's sign be positive if the hip is normal?",
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                    "firstName": "P N",
                    "lastName": "Vasudevan"
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                    "firstName": "P B",
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            "abstractNote": "In 1895 Trendelenburg described his sign to determine the integrity of hip function. We found the sign to be positive in a patient whose hip was clinically and radiologically normal, and therefore investigated this in other patients. We confirmed that a medial shift of the mechanical axis of the leg below the hip may cause a positive Trendelenburg sign. This has not been previously described.",
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            "date": "May 1997",
            "volume": "79",
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            "creatorSummary": "Winter et al.",
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        "data": {
            "key": "IMVVAQQE",
            "version": 1,
            "itemType": "journalArticle",
            "title": "Biomechanical Walking Pattern Changes in the Fit and Healthy Elderly",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "David A",
                    "lastName": "Winter"
                },
                {
                    "creatorType": "author",
                    "firstName": "Aftab E",
                    "lastName": "Patla"
                },
                {
                    "creatorType": "author",
                    "firstName": "James S",
                    "lastName": "Frank"
                },
                {
                    "creatorType": "author",
                    "firstName": "Sharon E",
                    "lastName": "Walt"
                }
            ],
            "abstractNote": "A descriptive study of the biomechanical variables of the walking patterns of the fit and healthy elderly compared with those of young adults revealed several significant differences. The walking patterns of 15 elderly subjects, selected for their active life style and screened for any gait- or balance-related pathological conditions, were analyzed. Kinematic and kinetic data for a minimum of 10 repeat walking trials were collected using a video digitizing system and a force platform. Basic kinematic analyses and an inverse dynamics model yielded data based on the following variables: temporal and cadence measures, heal and toe trajectories, joint kinematics, joint moments of force, and joint mechanical power generation and absorption. Significant differences between these elderly subjects and a database of young adults revealed the following: the same cadence but a shorter step length, an increased double-support stance period, decreased push-off power, a more flat-footed landing, and a reduction in their “index of dynamic balance.” All of these differences, except reduction in index of dynamic balance, indicate adaptation by the elderly toward a safer, more stable gait pattern. The reduction in index of dynamic balance suggests deterioration in the efficiency of the balance control system during gait. Because of these significant differences attributable to age alone, it is apparent that a separate gait database is needed in order to pinpoint falling disorders of the elderly.",
            "publicationTitle": "Physical Therapy",
            "publisher": "",
            "place": "",
            "date": "Juni 01 , 1990",
            "volume": "70",
            "issue": "6",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "340 -347",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "",
            "DOI": "",
            "citationKey": "",
            "url": "http://ptjournal.apta.org/content/70/6/340.abstract",
            "accessDate": "2012-01-15T20:19:56Z",
            "PMID": "",
            "PMCID": "",
            "ISSN": "",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "",
            "language": "",
            "libraryCatalog": "Highwire 2.0",
            "callNumber": "",
            "rights": "",
            "extra": "",
            "tags": [],
            "collections": [
                "CIGB3A79"
            ],
            "relations": {},
            "dateAdded": "2012-01-23T14:51:14Z",
            "dateModified": "2012-01-23T14:51:14Z"
        }
    },
    {
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            "creatorSummary": "Verghese et al.",
            "parsedDate": "2002-11-28",
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        "data": {
            "key": "Z83SSGEH",
            "version": 1,
            "itemType": "journalArticle",
            "title": "Abnormality of gait as a predictor of non-Alzheimer's dementia",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Joe",
                    "lastName": "Verghese"
                },
                {
                    "creatorType": "author",
                    "firstName": "Richard B",
                    "lastName": "Lipton"
                },
                {
                    "creatorType": "author",
                    "firstName": "Charles B",
                    "lastName": "Hall"
                },
                {
                    "creatorType": "author",
                    "firstName": "Gail",
                    "lastName": "Kuslansky"
                },
                {
                    "creatorType": "author",
                    "firstName": "Mindy J",
                    "lastName": "Katz"
                },
                {
                    "creatorType": "author",
                    "firstName": "Herman",
                    "lastName": "Buschke"
                }
            ],
            "abstractNote": "BACKGROUND\n\nNeurologic abnormalities affecting gait occur early in several types of non-Alzheimer's dementias, but their value in predicting the development of dementia is uncertain.\n\n\nMETHODS\n\nWe analyzed the relation between neurologic gait status at base line and the development of dementia in a prospective study involving 422 subjects older than 75 years of age who lived in the community and did not have dementia at base line. Cox proportional-hazards regression analysis was used to calculate hazard ratios with adjustment for potential confounding demographic, medical, and cognitive variables.\n\n\nRESULTS\n\nAt enrollment, 85 subjects had neurologic gait abnormalities of the following types: unsteady gait (in 31 subjects), frontal gait (in 12 subjects), hemiparetic gait (in 11 subjects), neuropathic gait (in 11 subjects), ataxic gait (in 10 subjects), parkinsonian gait (in 8 subjects), and spastic gait (in 2 subjects). During follow-up (median duration, 6.6 years), there were 125 newly diagnosed cases of dementia, 70 of them cases of Alzheimer's disease and 55 cases of non-Alzheimer's dementia (47 of which involved vascular dementia and 8 of which involved other types of dementia). Subjects with neurologic gait abnormalities had a greater risk of development of dementia (hazard ratio, 1.96 [95 percent confidence interval, 1.30 to 2.96]). These subjects had an increased risk of non-Alzheimer's dementia (hazard ratio, 3.51 [95 percent confidence interval, 1.98 to 6.24]), but not of Alzheimer's dementia (hazard ratio, 1.07 [95 percent confidence interval, 0.57 to 2.02]). Of non-Alzheimer's dementias, abnormal gait predicted the development of vascular dementia (hazard ratio, 3.46 [95 percent confidence interval, 1.86 to 6.42]). Among the types of abnormal gait, unsteady gait predicted vascular dementia (hazard ratio, 2.61), as did frontal gait (hazard ratio, 4.32) and hemiparetic gait (hazard ratio, 13.13).\n\n\nCONCLUSIONS\n\nThe presence of neurologic gait abnormalities in elderly persons without dementia at base line is a significant predictor of the risk of development of dementia, especially non-Alzheimer's dementia.",
            "publicationTitle": "The New England Journal of Medicine",
            "publisher": "",
            "place": "",
            "date": "Nov 28, 2002",
            "volume": "347",
            "issue": "22",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "1761-1768",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "N. Engl. J. Med.",
            "DOI": "10.1056/NEJMoa020441",
            "citationKey": "",
            "url": "http://www.ncbi.nlm.nih.gov/pubmed/12456852",
            "accessDate": "2012-01-15T21:33:00Z",
            "PMID": "",
            "PMCID": "",
            "ISSN": "1533-4406",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "",
            "language": "",
            "libraryCatalog": "NCBI PubMed",
            "callNumber": "",
            "rights": "",
            "extra": "PMID: 12456852",
            "tags": [
                {
                    "tag": "Aged",
                    "type": 1
                },
                {
                    "tag": "Aged, 80 and over",
                    "type": 1
                },
                {
                    "tag": "Alzheimer Disease",
                    "type": 1
                },
                {
                    "tag": "Autopsy",
                    "type": 1
                },
                {
                    "tag": "Cohort Studies",
                    "type": 1
                },
                {
                    "tag": "Dementia",
                    "type": 1
                },
                {
                    "tag": "Female",
                    "type": 1
                },
                {
                    "tag": "Gait Disorders, Neurologic",
                    "type": 1
                },
                {
                    "tag": "Humans",
                    "type": 1
                },
                {
                    "tag": "Incidence",
                    "type": 1
                },
                {
                    "tag": "Male",
                    "type": 1
                },
                {
                    "tag": "Neuropsychological Tests",
                    "type": 1
                },
                {
                    "tag": "Prognosis",
                    "type": 1
                },
                {
                    "tag": "Risk",
                    "type": 1
                }
            ],
            "collections": [
                "CIGB3A79"
            ],
            "relations": {},
            "dateAdded": "2012-01-23T14:50:27Z",
            "dateModified": "2012-01-23T14:50:27Z"
        }
    }
]