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Visual Queries for Neurobiology Research", "accessDate": "2011-10-20T14:13:48Z", "url": "http://www.computer.org/portal/web/csdl/doi/10.1109/TVCG.2009.121", "note": "", "contentType": "text/html", "charset": "utf-8", "filename": "TVCG.2009.html", "md5": "2eb2bbc7b5cc412bdd0a5c087150eb5f", "mtime": 1319120029000, "tags": [], "relations": {}, "dateAdded": "2011-12-06T21:05:45Z", "dateModified": "2011-12-06T21:05:45Z" } }, { "key": "A7D5TGSV", "version": 1, "library": { "type": "group", "id": 57793, "name": "MBVAnatomy", "links": { "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/57793/items/A7D5TGSV", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy/items/A7D5TGSV", "type": "text/html" } }, "meta": { "createdByUser": { "id": 783777, "username": "Noeska", "name": "Noeska Smit", "links": { "alternate": { "href": "https://www.zotero.org/noeska", "type": "text/html" } } }, "creatorSummary": "Bruckner et al.", "parsedDate": "2009", "numChildren": 2 }, "data": { "key": "A7D5TGSV", "version": 1, "itemType": "journalArticle", "title": "BrainGazer - Visual Queries for Neurobiology Research", "creators": [ { "creatorType": "author", "firstName": "Stefan", "lastName": "Bruckner" }, { "creatorType": "author", "firstName": "Veronika", "lastName": "Šoltészová" }, { "creatorType": "author", "firstName": "Eduard", "lastName": "Gröller" }, { "creatorType": "author", "firstName": "Jiří", "lastName": "Hladůvka" }, { "creatorType": "author", "firstName": "Katja", "lastName": "Bühler" }, { "creatorType": "author", "firstName": "Jai Y.", "lastName": "Yu" }, { "creatorType": "author", "firstName": "Barry J.", "lastName": "Dickson" } ], "abstractNote": "Neurobiology investigates how anatomical and physiological relationships in the nervous system mediate behavior. Molecular genetic techniques, applied to species such as the common fruit fly Drosophila melanogaster, have proven to be an important tool in this research. Large databases of transgenic specimens are being built and need to be analyzed to establish models of neural information processing. In this paper we present an approach for the exploration and analysis of neural circuits based on such a database. We have designed and implemented \\emph{BrainGazer}, a system which integrates visualization techniques for volume data acquired through confocal microscopy as well as annotated anatomical structures with an intuitive approach for accessing the available information. We focus on the ability to visually query the data based on semantic as well as spatial relationships. Additionally, we present visualization techniques for the concurrent depiction of neurobiological volume data and geometric objects which aim to reduce visual clutter. The described system is the result of an ongoing interdisciplinary collaboration between neurobiologists and visualization researchers.", "publicationTitle": "IEEE Transactions on Visualization and Computer Graphics", "publisher": "", "place": "", "date": "2009", "volume": "15", "issue": "6", "section": "", "partNumber": "", "partTitle": "", "pages": "1497-1504", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "http://doi.ieeecomputersociety.org/10.1109/TVCG.2009.121", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1077-2626", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "IEEE Computer Society", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "biomedical visualization", "type": 1 }, { "tag": "neurobiology", "type": 1 }, { "tag": "visual queries", "type": 1 }, { "tag": "volume visualization", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2011-12-06T21:05:45Z", "dateModified": "2011-12-06T21:05:45Z" } }, { "key": "FGV383XC", "version": 2, "library": { "type": "group", "id": 57793, "name": "MBVAnatomy", "links": { "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/57793/items/FGV383XC", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy/items/FGV383XC", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/57793/items/PITPXAUW", "type": "application/json" } }, "meta": { "createdByUser": { "id": 783777, "username": "Noeska", "name": "Noeska Smit", "links": { "alternate": { "href": "https://www.zotero.org/noeska", "type": "text/html" } } } }, "data": { "key": "FGV383XC", "version": 2, "parentItem": "PITPXAUW", "itemType": "attachment", "linkMode": "imported_url", "title": "Snapshot", "accessDate": "2011-12-06T18:45:53Z", "url": "http://www.ajnr.org/content/14/3/551.short", "note": "", "contentType": "text/html", "charset": "utf-8", "filename": "551.html", "md5": "136e65c29e0c046ac8e706aca9ab65e2", "mtime": 1323197154380, "tags": [], "relations": {}, "dateAdded": "2011-12-06T18:46:22Z", "dateModified": "2011-12-06T18:46:22Z" } }, { "key": "PITPXAUW", "version": 1, "library": { "type": "group", "id": 57793, "name": "MBVAnatomy", "links": { "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/57793/items/PITPXAUW", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy/items/PITPXAUW", "type": "text/html" } }, "meta": { "createdByUser": { "id": 783777, "username": "Noeska", "name": "Noeska Smit", "links": { "alternate": { "href": "https://www.zotero.org/noeska", "type": "text/html" } } }, "creatorSummary": "Tiede et al.", "parsedDate": "1993-05-01", "numChildren": 1 }, "data": { "key": "PITPXAUW", "version": 1, "itemType": "journalArticle", "title": "A computerized three-dimensional atlas of the human skull and brain.", "creators": [ { "creatorType": "author", "firstName": "U", "lastName": "Tiede" }, { "creatorType": "author", "firstName": "M", "lastName": "Bomans" }, { "creatorType": "author", "firstName": "K H", "lastName": "H√∂hne" }, { "creatorType": "author", "firstName": "A", "lastName": "Pommert" }, { "creatorType": "author", "firstName": "M", "lastName": "Riemer" }, { "creatorType": "author", "firstName": "T", "lastName": "Schiemann" }, { "creatorType": "author", "firstName": "R", "lastName": "Schubert" }, { "creatorType": "author", "firstName": "W", "lastName": "Lierse" } ], "abstractNote": "PURPOSE To develop an anatomic atlas of the human head based on a volume model derived from MR and CT.METHODS Every voxel of this model was labeled by a neuroanatomist concerning its membership to a structural and/or functional region. A computer program was written that, instead of displaying precomputed images, allows the user to choose and compose arbitrary views.RESULTS The user can subtract parts and ask for annotations just by using the mouse. Conversely, one can compose images by choosing objects from the list of anatomical constituents which is displayed on the screen. A set of dissection tools allows a \"look and feel\" that comes near to a true dissection. Operations that are not possible in a real dissection, such as reassembly or filling cavities, can be performed.CONCLUSION The authors have developed a computerized model that can be used for anatomy teaching and also as a reference for radiologists or surgeons. To replace classical atlases, the spatial resolution must be improved and speed must approach real time. Functional imaging data (position emission tomography and single photon emission CT) can be added to the system. The system is mobile and can be situated in classrooms, operating rooms, reading rooms, and libraries.", "publicationTitle": "American Journal of Neuroradiology", "publisher": "", "place": "", "date": "May 01 , 1993", "volume": "14", "issue": "3", "section": "", "partNumber": "", "partTitle": "", "pages": "551 -559", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "http://www.ajnr.org/content/14/3/551.abstract", "accessDate": "2011-12-06T18:45:50Z", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "Highwire 2.0", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2011-12-06T18:46:22Z", "dateModified": "2011-12-06T18:46:22Z" } }, { "key": "5JM65SSU", "version": 1, "library": { "type": "group", "id": 57793, "name": "MBVAnatomy", "links": { "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/57793/items/5JM65SSU", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy/items/5JM65SSU", "type": "text/html" } }, "meta": { "createdByUser": { "id": 783777, "username": "Noeska", "name": "Noeska Smit", "links": { "alternate": { "href": "https://www.zotero.org/noeska", "type": "text/html" } } }, "creatorSummary": "Botha and Post", "numChildren": 0 }, "data": { "key": "5JM65SSU", "version": 1, "itemType": "journalArticle", "title": "Hybrid Scheduling in the DeVIDE Dataflow Visualisation Environment", "creators": [ { "creatorType": "author", "firstName": "Charl P", "lastName": "Botha" }, { "creatorType": "author", "firstName": "Frits H", "lastName": "Post" } ], "abstractNote": "", "publicationTitle": "", "publisher": "", "place": "", "date": "", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.111.8346", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2011-11-30T18:33:55Z", "dateModified": "2011-11-30T18:33:55Z" } }, { "key": "Q7QAGTS3", "version": 2, "library": { "type": "group", "id": 57793, "name": "MBVAnatomy", "links": { "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/57793/items/Q7QAGTS3", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy/items/Q7QAGTS3", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/57793/items/KPXI5NRP", "type": "application/json" } }, "meta": { "createdByUser": { "id": 783777, "username": "Noeska", "name": "Noeska Smit", "links": { "alternate": { "href": "https://www.zotero.org/noeska", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "Q7QAGTS3", "version": 2, "parentItem": "KPXI5NRP", "itemType": "attachment", "linkMode": "imported_url", "title": "ScienceDirect Full Text PDF", "accessDate": "2011-11-29T23:44:07Z", "url": "http://www.sciencedirect.com/science?_ob=MiamiImageURL&_cid=272422&_user=499885&_pii=S0748798300909983&_check=y&_origin=&_coverDate=31-Dec-2000&view=c&wchp=dGLbVlS-zSkWb&md5=e81fcd3cac9466fd82a0f0626007bdfd/1-s2.0-S0748798300909983-main.pdf", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Maas et al. - 2000 - A prospective study on radical and nerve-preservin.pdf", "md5": "016be934812d5d4fd5f8cbdd8def5440", "mtime": 1322610249994, "tags": [], "relations": {}, "dateAdded": "2011-11-29T23:48:10Z", "dateModified": "2011-11-29T23:48:10Z" } }, { "key": "8T9UWWSU", "version": 2, "library": { "type": "group", "id": 57793, "name": "MBVAnatomy", "links": { "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/57793/items/8T9UWWSU", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy/items/8T9UWWSU", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/57793/items/KPXI5NRP", "type": "application/json" } }, "meta": { "createdByUser": { "id": 783777, "username": "Noeska", "name": "Noeska Smit", "links": { "alternate": { "href": "https://www.zotero.org/noeska", "type": "text/html" } } } }, "data": { "key": "8T9UWWSU", "version": 2, "parentItem": "KPXI5NRP", "itemType": "attachment", "linkMode": "imported_url", "title": "ScienceDirect Snapshot", "accessDate": "2011-11-29T23:44:11Z", "url": "http://www.sciencedirect.com/science/article/pii/S0748798300909983", "note": "", "contentType": "text/html", "charset": "utf-8", "filename": "S0748798300909983.html", "md5": "3954c3aa86bd9b3c762195575ff71c55", "mtime": 1322610251756, "tags": [], "relations": {}, "dateAdded": "2011-11-29T23:48:10Z", "dateModified": "2011-11-29T23:48:10Z" } }, { "key": "KPXI5NRP", "version": 1, "library": { "type": "group", "id": 57793, "name": "MBVAnatomy", "links": { "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/57793/items/KPXI5NRP", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy/items/KPXI5NRP", "type": "text/html" } }, "meta": { "createdByUser": { "id": 783777, "username": "Noeska", "name": "Noeska Smit", "links": { "alternate": { "href": "https://www.zotero.org/noeska", "type": "text/html" } } }, "creatorSummary": "Maas et al.", "parsedDate": "2000-12", "numChildren": 2 }, "data": { "key": "KPXI5NRP", "version": 1, "itemType": "journalArticle", "title": "A prospective study on radical and nerve-preserving surgery for rectal cancer in The Netherlands", "creators": [ { "creatorType": "author", "firstName": "C.P.", "lastName": "Maas" }, { "creatorType": "author", "firstName": "Y.", "lastName": "Moriya" }, { "creatorType": "author", "firstName": "W.H.", "lastName": "Steup" }, { "creatorType": "author", "firstName": "E.", "lastName": "Klein Kranenbarg" }, { "creatorType": "author", "firstName": "C.J.H.", "lastName": "van de Velde" } ], "abstractNote": "Introduction: Preservation of the pelvic autonomic nerves is thought to lower bladder and sexual dysfunction after rectal cancer surgery. A prospective study was undertaken in a Dutch population to evaluate functional outcome, local recurrence and survival of a Japanese operative technique combining nerve preservation with radical tumour resection. Methods: Forty-seven patients were operated upon by a Japanese surgeon. Voiding and sexual function were prospectively analysed using questionnaires. Two-year follow-up on urinary function was complete in 73%, and 2-year follow-up of male sexual function was complete in 77%. Median follow-up for survival and recurrence was 42 months and was complete in all patients. Results: Five patients (19%) developed minor urinary incontinence in the period between 1 and 2 years of follow-up. Six patients (22%) had a persistently elevated frequency of voiding. There was no statistically significant correlation between the extent of nerve preservation and the reported minor voiding dysfunctions. None of the patients reported major incontinence of urine. Impotence was related to sacrifice of the inferior hypogastric plexus and ejaculatory dysfunction was related to sacrifice of the superior hypogastric plexus. Sexual function did not change during follow-up. Of 42 curatively-operated patients, three (7.1%) developed local recurrence. Sixty-seven per cent were overall free of recurrence. Disease-free survival was 57%. Conclusions: Preservation of the pelvic autonomic nerves minimizes bladder dysfunction after rectal cancer surgery. The preservation of the total autonomic nerve system is essential for normal sexual function in male patients. Nerve preservation does not compromise radicality in mesorectal excision. Mesorectal excision should involve identification and preservation of the pelvic autonomic nerves.", "publicationTitle": "European Journal of Surgical Oncology (EJSO)", "publisher": "", "place": "", "date": "December 2000", "volume": "26", "issue": "8", "section": "", "partNumber": "", "partTitle": "", "pages": "751-757", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1053/ejso.2000.0998", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/S0748798300909983", "accessDate": "2011-11-29T23:44:05Z", "PMID": "", "PMCID": "", "ISSN": "0748-7983", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "colorectal surgery", "type": 1 }, { "tag": "impotence", "type": 1 }, { "tag": "rectal neoplasms", "type": 1 }, { "tag": "urination.", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2011-11-29T23:48:10Z", "dateModified": "2011-11-29T23:48:10Z" } }, { "key": "PZF55QMM", "version": 2, "library": { "type": "group", "id": 57793, "name": "MBVAnatomy", "links": { "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/57793/items/PZF55QMM", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy/items/PZF55QMM", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/57793/items/Q4ME35Q9", "type": "application/json" } }, "meta": { "createdByUser": { "id": 783777, "username": "Noeska", "name": "Noeska Smit", "links": { "alternate": { "href": "https://www.zotero.org/noeska", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "PZF55QMM", "version": 2, "parentItem": "Q4ME35Q9", "itemType": "attachment", "linkMode": "imported_url", "title": "Wiley Full Text PDF", "accessDate": "2011-11-29T21:17:46Z", "url": "http://onlinelibrary.wiley.com/store/10.1002/bjs.5540/asset/5540_ftp.pdf?v=1&t=gvkvhvpi&s=6c99f004cd11190a14f9a367a3794f6792ffdd3d", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Kinugasa et al. - 2007 - Histological identification of fascial structures .pdf", "md5": "8df4141397b62222caa68d0a9491b0a0", "mtime": 1322601467837, "tags": [], "relations": {}, "dateAdded": "2011-11-29T21:20:21Z", "dateModified": "2011-11-29T21:20:21Z" } }, { "key": "Q4ME35Q9", "version": 1, "library": { "type": "group", "id": 57793, "name": "MBVAnatomy", "links": { "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/57793/items/Q4ME35Q9", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy/items/Q4ME35Q9", "type": "text/html" } }, "meta": { "createdByUser": { "id": 783777, "username": "Noeska", "name": "Noeska Smit", "links": { "alternate": { "href": "https://www.zotero.org/noeska", "type": "text/html" } } }, "creatorSummary": "Kinugasa et al.", "parsedDate": "2007-05-01", "numChildren": 1 }, "data": { "key": "Q4ME35Q9", "version": 1, "itemType": "journalArticle", "title": "Histological identification of fascial structures posterolateral to the rectum", "creators": [ { "creatorType": "author", "firstName": "Y.", "lastName": "Kinugasa" }, { "creatorType": "author", "firstName": "G.", "lastName": "Murakami" }, { "creatorType": "author", "firstName": "D.", "lastName": "Suzuki" }, { "creatorType": "author", "firstName": "K.", "lastName": "Sugihara" } ], "abstractNote": "", "publicationTitle": "British Journal of Surgery", "publisher": "", "place": "", "date": "2007/05/01", "volume": "94", "issue": "5", "section": "", "partNumber": "", "partTitle": "", "pages": "620-626", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1002/bjs.5540", "citationKey": "", "url": "http://onlinelibrary.wiley.com/doi/10.1002/bjs.5540/abstract", "accessDate": "2011-11-29T21:17:44Z", "PMID": "", "PMCID": "", "ISSN": "1365-2168", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "Wiley Online Library", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2011-11-29T21:20:21Z", "dateModified": "2011-11-29T21:20:21Z" } }, { "key": "8UJ6V3DP", "version": 2, "library": { "type": "group", "id": 57793, "name": "MBVAnatomy", "links": { "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/57793/items/8UJ6V3DP", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy/items/8UJ6V3DP", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/57793/items/QFNS32P8", "type": "application/json" } }, "meta": { "createdByUser": { "id": 783777, "username": "Noeska", "name": "Noeska Smit", "links": { "alternate": { "href": "https://www.zotero.org/noeska", "type": "text/html" } } } }, "data": { "key": "8UJ6V3DP", "version": 2, "parentItem": "QFNS32P8", "itemType": "attachment", "linkMode": "imported_url", "title": "ScienceDirect Snapshot", "accessDate": "2011-11-29T21:02:59Z", "url": "http://www.sciencedirect.com/science/article/pii/S0959804908010290", "note": "", "contentType": "text/html", "charset": "utf-8", "filename": "S0959804908010290.html", "md5": "e96feaa284856fab6c4eb49972ecaf04", "mtime": 1322600579320, "tags": [], "relations": {}, "dateAdded": "2011-11-29T21:03:12Z", "dateModified": "2011-11-29T21:03:12Z" } }, { "key": "8UPZKIV7", "version": 2, "library": { "type": "group", "id": 57793, "name": "MBVAnatomy", "links": { "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/57793/items/8UPZKIV7", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy/items/8UPZKIV7", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/57793/items/QFNS32P8", "type": "application/json" } }, "meta": { "createdByUser": { "id": 783777, "username": "Noeska", "name": "Noeska Smit", "links": { "alternate": { "href": "https://www.zotero.org/noeska", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "8UPZKIV7", "version": 2, "parentItem": "QFNS32P8", "itemType": "attachment", "linkMode": "imported_url", "title": "ScienceDirect Full Text PDF", "accessDate": "2011-11-29T21:02:54Z", "url": "http://www.sciencedirect.com/science?_ob=MiamiImageURL&_cid=271325&_user=499885&_pii=S0959804908010290&_check=y&_origin=&_coverDate=30-Jun-2009&view=c&wchp=dGLbVBA-zSkzk&md5=3ebef832740d9fa10b17acbf9d542152/1-s2.0-S0959804908010290-main.pdf", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Lange et al. - 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2008 - Causes of Fecal and Urinary Incontinence After Tot.pdf", "md5": "af8f61308a57abb14058f8a436d39e18", "mtime": 1322600340217, "tags": [], "relations": {}, "dateAdded": "2011-11-29T21:03:12Z", "dateModified": "2011-11-29T21:03:12Z" } }, { "key": "QFNS32P8", "version": 1, "library": { "type": "group", "id": 57793, "name": "MBVAnatomy", "links": { "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/57793/items/QFNS32P8", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy/items/QFNS32P8", "type": "text/html" } }, "meta": { "createdByUser": { "id": 783777, "username": "Noeska", "name": "Noeska Smit", "links": { "alternate": { "href": "https://www.zotero.org/noeska", "type": "text/html" } } }, "creatorSummary": "Lange et al.", "parsedDate": "2009-06", "numChildren": 2 }, "data": { "key": "QFNS32P8", "version": 1, "itemType": "journalArticle", "title": "Risk factors for sexual dysfunction after rectal cancer treatment", "creators": [ { "creatorType": "author", "firstName": "M.M.", "lastName": "Lange" }, { "creatorType": "author", "firstName": "C.A.M.", "lastName": "Marijnen" }, { "creatorType": "author", "firstName": "C.P.", "lastName": "Maas" }, { "creatorType": "author", "firstName": "H.", "lastName": "Putter" }, { "creatorType": "author", "firstName": "H.J.", "lastName": "Rutten" }, { "creatorType": "author", "firstName": "A.M.", "lastName": "Stiggelbout" }, { "creatorType": "author", "firstName": "E. Meershoek-Klein", "lastName": "Kranenbarg" }, { "creatorType": "author", "firstName": "C.J.H.", "lastName": "van de Velde" } ], "abstractNote": "This study aimed to identify risk factors for long-term sexual dysfunction (SD) after rectal cancer treatment.\n\nPatients with resectable rectal cancer were randomised to total mesorectal excision with or without preoperative radiotherapy (PRT). Preoperatively and at 3, 6, 12, 18 and 24 months postoperatively, SD scores were filled out in questionnaires. Possible risk factors for postoperative deterioration of sexual functioning, including patients’ demographics, tumour-specific factors and treatment-related variables, were investigated with univariate and multivariable regression analyses.\n\nIncrease in general SD, erectile dysfunction and ejaculatory problems were reported by 76.4, 79.8 and 72.2 percent of the male patients, respectively. Risk factors were nerve damage, blood loss, anastomotic leakage, PRT and the presence of a stoma. In female patients, increase in general SD, dyspareunia and vaginal dryness were reported by 61.5, 59.1 and 56.6 percent, respectively. This was associated with PRT and the presence of a stoma.\n\nSD occurs frequently after rectal cancer treatment and is caused by surgical (nerve) damage with an additional effect of PRT. Patients should be informed preoperatively, and education of surgeons in neuroanatomy may provide the key to the improvement of functional outcome.", "publicationTitle": "European Journal of Cancer", "publisher": "", "place": "", "date": "June 2009", "volume": "45", "issue": "9", "section": "", "partNumber": "", "partTitle": "", "pages": "1578-1588", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1016/j.ejca.2008.12.014", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/S0959804908010290", "accessDate": "2011-11-29T21:02:52Z", "PMID": "", "PMCID": "", "ISSN": "0959-8049", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Autonomic nerve damage", "type": 1 }, { "tag": "Dyspareunia", "type": 1 }, { "tag": "Ejaculation", "type": 1 }, { "tag": "Erection", "type": 1 }, { "tag": "Radiotherapy", "type": 1 }, { "tag": "Rectal cancer", "type": 1 }, { "tag": "Risk factors", "type": 1 }, { "tag": "Sexual dysfunction", "type": 1 }, { "tag": "Total mesorectal excision", "type": 1 }, { "tag": "Vaginal dryness", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2011-11-29T21:03:12Z", "dateModified": "2011-11-29T21:03:12Z" } }, { "key": "9XZRMS3W", "version": 1, "library": { "type": "group", "id": 57793, "name": "MBVAnatomy", "links": { "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/57793/items/9XZRMS3W", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy/items/9XZRMS3W", "type": "text/html" } }, "meta": { "createdByUser": { "id": 783777, "username": "Noeska", "name": "Noeska Smit", "links": { "alternate": { "href": "https://www.zotero.org/noeska", "type": "text/html" } } }, "creatorSummary": "Wallner et al.", "parsedDate": "2008-09-20", "numChildren": 2 }, "data": { "key": "9XZRMS3W", "version": 1, "itemType": "journalArticle", "title": "Causes of Fecal and Urinary Incontinence After Total Mesorectal Excision for Rectal Cancer Based on Cadaveric Surgery: A Study From the Cooperative Clinical Investigators of the Dutch Total Mesorectal Excision Trial", "creators": [ { "creatorType": "author", "firstName": "Christian", "lastName": "Wallner" }, { "creatorType": "author", "firstName": "Marilyne M.", "lastName": "Lange" }, { "creatorType": "author", "firstName": "Bert A.", "lastName": "Bonsing" }, { "creatorType": "author", "firstName": "Cornelis P.", "lastName": "Maas" }, { "creatorType": "author", "firstName": "Charles N.", "lastName": "Wallace" }, { "creatorType": "author", "firstName": "Noshir F.", "lastName": "Dabhoiwala" }, { "creatorType": "author", "firstName": "Harm J.", "lastName": "Rutten" }, { "creatorType": "author", "firstName": "Wouter H.", "lastName": "Lamers" }, { "creatorType": "author", "firstName": "Marco C.", "lastName": "DeRuiter" }, { "creatorType": "author", "firstName": "Cornelis J.H.", "lastName": "van de Velde" } ], "abstractNote": "Purpose Total mesorectal excision (TME) for rectal cancer may result in anorectal and urogenital dysfunction. We aimed to study possible nerve disruption during TME and its consequences for functional outcome. Because the levator ani muscle plays an important role in both urinary and fecal continence, an explanation could be peroperative damage of the nerve supply to the levator ani muscle.Methods TME was performed on cadaver pelves. Subsequently, the anatomy of the pelvic floor innervation and its relation to the pelvic autonomic innervation and the mesorectum were studied. Additionally, data from the Dutch TME trial were analyzed to relate anorectal and urinary dysfunction to possible nerve damage during TME procedure.Results Cadaver TME surgery demonstrated that, especially in low tumors, the pelvic floor innervation can be damaged. Furthermore, the origin of the levator ani nerve was located in close proximity of the origin of the pelvic splanchnic nerves. Analysis of the TME trial data showed that newly developed urinary and fecal incontinence was present in 33.7% and 38.8% of patients, respectively. Both types of incontinence were significantly associated with each other (P = .027). Low anastomosis was significantly associated with urinary incontinence (P = .049). One third of the patients with newly developed urinary and fecal incontinence also reported difficulty in bladder emptying, for which excessive perioperative blood loss was a significant risk factor.Conclusion Perioperative damage to the pelvic floor innervation could contribute to fecal and urinary incontinence after TME, especially in case of a low anastomosis or damage to the pelvic splanchnic nerves.", "publicationTitle": "Journal of Clinical Oncology", "publisher": "", "place": "", "date": "September 20, 2008", "volume": "26", "issue": "27", "section": "", "partNumber": "", "partTitle": "", "pages": "4466 -4472", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1200/JCO.2008.17.3062", "citationKey": "", "url": "http://jco.ascopubs.org/content/26/27/4466.abstract", "accessDate": "2011-11-29T20:58:50Z", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "Causes of Fecal and Urinary Incontinence After Total Mesorectal Excision for Rectal Cancer Based on Cadaveric Surgery", "language": "", "libraryCatalog": "Highwire 2.0", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2011-11-29T21:03:12Z", "dateModified": "2011-11-29T21:03:12Z" } }, { "key": "PBT9QV4G", "version": 1, "library": { "type": "group", "id": 57793, "name": "MBVAnatomy", "links": { "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/57793/items/PBT9QV4G", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy/items/PBT9QV4G", "type": "text/html" } }, "meta": { "createdByUser": { "id": 783777, "username": "Noeska", "name": "Noeska Smit", "links": { "alternate": { "href": "https://www.zotero.org/noeska", "type": "text/html" } } }, "creatorSummary": "Heald et al.", "parsedDate": "1982-10", "numChildren": 0 }, "data": { "key": "PBT9QV4G", "version": 1, "itemType": "journalArticle", "title": "The mesorectum in rectal cancer surgery—the clue to pelvic recurrence?", "creators": [ { "creatorType": "author", "firstName": "R. J", "lastName": "Heald" }, { "creatorType": "author", "firstName": "E. M", "lastName": "Husband" }, { "creatorType": "author", "firstName": "R. D. H", "lastName": "Ryall" } ], "abstractNote": "Five cases are described where minute foci of adenocarcinoma have been demonstrated in the mesorectum several centimetres distal to the apparent lower edge of a rectal cancer. In 2 of these there was no other evidence of lymphatic spread of the tumour. In orthodox anterior resection much of this tissue remains in the pelvis, and it is suggested that these foci might lead to suture-line or pelvic recurrence. Total excision of the mesorectum has, therefore, been carried out as a part of over 100 consecutive anterior resections. Fifty of these, which were classified as ‘curative’ or ‘conceivably curative’ operations, have now been followed for over 2 years with no pelvic or staple-line recurrence.", "publicationTitle": "British Journal of Surgery", "publisher": "", "place": "", "date": "October 1982", "volume": "69", "issue": "10", "section": "", "partNumber": "", "partTitle": "", "pages": "613–616", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1002/bjs.1800691019", "citationKey": "", "url": "http://onlinelibrary.wiley.com/doi/10.1002/bjs.1800691019/abstract", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1365-2168", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2011-11-29T19:03:27Z", "dateModified": "2011-11-29T19:03:27Z" } }, { "key": "WF5BTDPK", "version": 4, "library": { "type": "group", "id": 57793, "name": "MBVAnatomy", "links": { "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/57793/items/WF5BTDPK", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/mbvanatomy/items/WF5BTDPK", "type": "text/html" } }, "meta": { "createdByUser": { "id": 783777, "username": "Noeska", "name": "Noeska Smit", "links": { "alternate": { "href": "https://www.zotero.org/noeska", "type": "text/html" } } }, "lastModifiedByUser": { "id": 17660, "username": "cpbotha", "name": "Charl P. Botha", "links": { "alternate": { "href": "https://www.zotero.org/cpbotha", "type": "text/html" } } }, "creatorSummary": "Höhne et al.", "parsedDate": "2001-05", "numChildren": 1 }, "data": { "key": "WF5BTDPK", "version": 4, "itemType": "journalArticle", "title": "A realistic model of human structure from the visible human data", "creators": [ { "creatorType": "author", "firstName": "K H", "lastName": "Höhne" }, { "creatorType": "author", "firstName": "B", "lastName": "Pflesser" }, { "creatorType": "author", "firstName": "A", "lastName": "Pommert" }, { "creatorType": "author", "firstName": "M", "lastName": "Riemer" }, { "creatorType": "author", "firstName": "R", "lastName": "Schubert" }, { "creatorType": "author", "firstName": "T", "lastName": "Schiemann" }, { "creatorType": "author", "firstName": "U", "lastName": "Tiede" }, { "creatorType": "author", "firstName": "U", "lastName": "Schumacher" } ], "abstractNote": "The computer-based 3D models of the human body reported to date suffer from poor spatial resolution. The Visible Human project has delivered high resolution cross-sectional images that are suited for generation of high-quality models. Yet none of the 3D models described to date reflect the quality of the original images. We present a method of segmentation and visualization which provides a new quality of realism and detail. 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