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"Raichle et al.", "parsedDate": "1976-08", "numChildren": 0 }, "data": { "key": "4SHSCUFV", "version": 1, "itemType": "journalArticle", "title": "Correlation between regional cerebral blood flow and oxidative metabolism. In vivo studies in man", "creators": [ { "creatorType": "author", "firstName": "M E", "lastName": "Raichle" }, { "creatorType": "author", "firstName": "R L, Jr", "lastName": "Grubb" }, { "creatorType": "author", "firstName": "M H", "lastName": "Gado" }, { "creatorType": "author", "firstName": "J O", "lastName": "Eichling" }, { "creatorType": "author", "firstName": "M M", "lastName": "Ter-Pogossian" } ], "abstractNote": "To test the hypothesis that regional cerebral blood flow (rCBF) is normally regulated by regional metabolic activity, rCBF and the regional cerebral metabolic rate for oxygen (rCMRO2) were compared in selected human subjects. In normal subjects and patients with chronic, stable diseases of brain, rCBF correlated well with rCMRO2. In one individual with mild dementia, rCBF and rCMRO2 were measured before and during exercise of the hand and forearm contralateral to the hemisphere studied. Appropriate parallel changes occurred in both rCBF and rCMRO2 during hand exercise. In patients with acute diseases affecting the hemisphere studied, however, the correlation between rCBF and rCMRO2 was unpredictable.", "publicationTitle": "Archives of Neurology", "publisher": "", "place": "", "date": "Aug 1976", "volume": "33", "issue": "8", "section": "", "partNumber": "", "partTitle": "", "pages": "523-526", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Arch. 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It is required that the pH be known, along with appropriate sets of ligand-hydrogen and ligand-divalent cation concentration binding constants. It is assumed that these sets of constants are chosen to be consistent with the ionic strength of the complete solution which contains the divalent cations and ligands. The technique is an iterative one which provides upper and lower bounds for the values of the unknowns. The method does not require initial guesses at the values of the unknowns, and it gives correct answers even when the concentrations involved are many orders of magnitude apart. The present formulation of the problem is restricted to the case where only one cation can bind to a given ligand at any one time. The method is applicable to large molecules with multiple \"sub-ligands\" provided these sub-ligands are independent in their function as ion-binding sites. These sub-ligands need not all have the same properties. It is also shown that a simple modification of the method permits the determination of the subset of total ion concentrations that are required in order to produce a specified subset of free ion concentrations. The modifications required to include monovalent cation binding are presented in outline form.", "publicationTitle": "Biophysical Journal", "publisher": "", "place": "", "date": "May 1979", "volume": "26", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "235-242", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Biophys. 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