[ { "key": "MSZA7N68", "version": 14, "library": { "type": "group", "id": 511301, "name": "ALS 439 Group", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_439_group", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/511301/items/MSZA7N68", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_439_group/items/MSZA7N68", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2041743, "username": "wtamav14", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/wtamav14", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "MSZA7N68", "version": 14, "itemType": "webpage", "title": "Paper: Effect of IEPA, a Novel Orally Bioavailable Small Molecule, on Chemotherapy-Induced Myelosuppression", "creators": [], "abstractNote": "", "websiteTitle": "", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "https://ash.confex.com/ash/2014/webprogram/Paper76791.html", "accessDate": "2016-05-03T00:16:33Z", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2016-05-03T00:16:33Z", "dateModified": "2016-05-03T00:16:33Z" } }, { "key": "UXH5ITH8", "version": 13, "library": { "type": "group", "id": 511301, "name": "ALS 439 Group", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_439_group", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/511301/items/UXH5ITH8", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_439_group/items/UXH5ITH8", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/511301/items/76ZRCRJR", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2041743, "username": "wtamav14", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/wtamav14", "type": "text/html" } } } }, "data": { "key": "UXH5ITH8", "version": 13, "parentItem": "76ZRCRJR", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2016-05-03T00:12:25Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/24432596", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2016-05-03T00:12:25Z", "dateModified": "2016-05-03T00:12:25Z" } }, { "key": "N2BNEGPA", "version": 12, "library": { "type": "group", "id": 511301, "name": "ALS 439 Group", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_439_group", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/511301/items/N2BNEGPA", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_439_group/items/N2BNEGPA", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2041743, "username": "wtamav14", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/wtamav14", "type": "text/html" } } }, "creatorSummary": "Kolobukhina et al.", "parsedDate": "2009", "numChildren": 1 }, "data": { "key": "N2BNEGPA", "version": 12, "itemType": "journalArticle", "title": "Efficacy of ingavirin in adults with influenza", "creators": [ { "creatorType": "author", "firstName": "L. V.", "lastName": "Kolobukhina" }, { "creatorType": "author", "firstName": "L. N.", "lastName": "Merkulova" }, { "creatorType": "author", "firstName": "M. Iu", "lastName": "Shchelkanov" }, { "creatorType": "author", "firstName": "E. I.", "lastName": "Burtseva" }, { "creatorType": "author", "firstName": "E. I.", "lastName": "Isaeva" }, { "creatorType": "author", "firstName": "N. A.", "lastName": "Malyshev" }, { "creatorType": "author", "firstName": "D. K.", "lastName": "L'vov" } ], "abstractNote": "AIM: To compare therapeutic efficacy and safety of ingavirin and arbidol in patients with influenza.\nMATERIAL AND METHODS: The trial included 105 patients with a verified diagnosis of influenza, definite clinical symptoms, body temperature at least 38 degrees C and duration of the disease 36 hours maximum. Ingavirin efficacy was analysed basing on the evidence for 100 patients with uncomplicated influenza. The patients were randomized into three groups: taking ingavirin in a single daily dose 90 mg (n = 33), placebo (n = 36) or arbidol (200 mg 4 times a day). The duration of the treatment was 5 days.\nRESULTS: Intake of ingavirin in initial 24-36 hours of the disease significantly reduced fever compared to placebo and arbidol (34.5, 72.0 and 48.4 hours, respectively). Ingavirin was less toxic and had no side effects.\nCONCLUSION: Ingavirin is safe and effective in the treatment of influenza. By some criteria it is more effective than arbidol.", "publicationTitle": "Terapevticheskiĭ Arkhiv", "publisher": "", "place": "", "date": "2009", "volume": "81", "issue": "3", "section": "", "partNumber": "", "partTitle": "", "pages": "51-54", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Ter. 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A.", "lastName": "Shul'diakov" }, { "creatorType": "author", "firstName": "E. P.", "lastName": "Liapina" }, { "creatorType": "author", "firstName": "V. I.", "lastName": "Kuznetsov" } ], "abstractNote": "AIM: To evaluate the preventive efficacy of the Russian antiviral drug ingavirin (vitaglutam) in the epidemiological foci with the peak incidence of acute respiratory viral infections (ARVI).\nSUBJECTS AND METHODS: Four hundred men and women aged 18 to 65 years from the epidemic foci of ARVI who had been in close daily contact with the patients whose diagnosis was verified by laboratory tests were examined. Two hundred persons received prophylaxis with ingavirin (a 90-mg oral capsule once daily for 7 days) and 200 took placebo according to the same scheme. The efficiency index and coefficient were calculated and the relative risk of the disease was estimated to evaluate the efficiency of ARVI prevention. A pharmacoeconomic analysis was made.\nRESULTS: There is evidence that the administration of 90-mg ingavirin capsules (OAO \"Valenta Farm\", Russia) caused a reduction in morbidity rates among those who had been in contact by 63% and in the risk of ARVI by 2.7 times. There was a reduction in the duration of fever by one day and a milder course of respiratory disease in the ingavirin-treated contact persons who developed ARVI.\nCONCLUSION: Ingavirin meets all requirements for current drugs for the nonspecific prevention of ARVI at the peak of its incidence. It has a pronounced protective effect and broad-spectrum activity, low toxicity and high safety, which allows it to be recommended for the emergency intrafocal prevention at the peak of the incidence of influenza and ARVI in adults.", "publicationTitle": "Terapevticheskiĭ Arkhiv", "publisher": "", "place": "", "date": "2013", "volume": "85", "issue": "11", "section": "", "partNumber": "", "partTitle": "", "pages": "27-33", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Ter. 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They can be associated with a wide range of clinical manifestations ranging from self-limited upper respiratory tract infections to more devastating conditions such as pneumonia. In particular, in serious cases influenza A leads to pneumonia, which is particularly fatal in patients with cardiopulmonary diseases, obesity, young children and the elderly. In the present study, we show a protective effect of the low-molecular weight compound Ingavirin (6-[2-(1H-imidazol-4-yl)ethylamino]-5-oxohexanoic acid) against influenza A (H1N1) virus, human parainfluenza virus and human adenovirus infections in animals. Mortality, weight loss, infectious titer of the virus in tissues and tissue morphology were monitored in the experimental groups of animals. The protective action of Ingavirin was observed as a reduction of infectious titer of the virus in the lung tissue, prolongation of the life of the infected animals, normalization of weight dynamics throughout the course of the disease, lowering of mortality of treated animals compared to a placebo control and normalization of tissue structure. In case of influenza virus infection, the protective activity of Ingavirin was similar to that of the reference compound Tamiflu. Based on the results obtained, Ingavirin should be considered as an important part of anti-viral prophylaxis and therapy.", "publicationTitle": "Pharmaceuticals", "publisher": "", "place": "", "date": "2011-11-25", "volume": "4", "issue": "12", "section": "", "partNumber": "", "partTitle": "", "pages": "1518-1534", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.3390/ph4121518", "citationKey": "", "url": "http://www.mdpi.com/1424-8247/4/12/1518", "accessDate": "2016-04-06T15:02:49Z", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "www.mdpi.com", "callNumber": "", "rights": "http://creativecommons.org/licenses/by/3.0/", "extra": "", "tags": [ { "tag": "Ingavirin", "type": 1 }, { "tag": "adenovirus", "type": 1 }, { "tag": "animal model", "type": 1 }, { "tag": "antiviral", "type": 1 }, { "tag": "influenza", "type": 1 }, { "tag": "pandemic", "type": 1 }, { "tag": "parainfluenza virus", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2016-04-12T00:06:04Z", "dateModified": "2016-04-12T00:06:04Z" } } ]