[ { "key": "RSQTKGWH", "version": 83, "library": { "type": "group", "id": 508454, "name": "JAKBAM301", "links": { "alternate": { "href": "https://www.zotero.org/groups/jakbam301", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/508454/items/RSQTKGWH", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/jakbam301/items/RSQTKGWH", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/508454/items/U57BUZXT", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2642588, "username": "jeffreyxwu", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jeffreyxwu", "type": "text/html" } } } }, "data": { "key": "RSQTKGWH", "version": 83, "parentItem": "U57BUZXT", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2016-05-07T00:23:35Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/24358223", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2016-05-07T00:23:35Z", "dateModified": "2016-05-07T00:23:35Z" } }, { "key": "U57BUZXT", "version": 83, "library": { "type": "group", "id": 508454, "name": "JAKBAM301", "links": { "alternate": { "href": "https://www.zotero.org/groups/jakbam301", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/508454/items/U57BUZXT", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/jakbam301/items/U57BUZXT", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2642588, "username": "jeffreyxwu", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jeffreyxwu", "type": "text/html" } } }, "creatorSummary": "Budde et al.", "parsedDate": "2013", "numChildren": 1 }, "data": { "key": "U57BUZXT", "version": 83, "itemType": "journalArticle", "title": "Combining a CD20 chimeric antigen receptor and an inducible caspase 9 suicide switch to improve the efficacy and safety of T cell adoptive immunotherapy for lymphoma", "creators": [ { "creatorType": "author", "firstName": "Lihua E.", "lastName": "Budde" }, { "creatorType": "author", "firstName": "Carolina", "lastName": "Berger" }, { "creatorType": "author", "firstName": "Yukang", "lastName": "Lin" }, { "creatorType": "author", "firstName": "Jinjuan", "lastName": "Wang" }, { "creatorType": "author", "firstName": "Xubin", "lastName": "Lin" }, { "creatorType": "author", "firstName": "Shani E.", "lastName": "Frayo" }, { "creatorType": "author", "firstName": "Shaunda A.", "lastName": "Brouns" }, { "creatorType": "author", "firstName": "David M.", "lastName": "Spencer" }, { "creatorType": "author", "firstName": "Brian G.", "lastName": "Till" }, { "creatorType": "author", "firstName": "Michael C.", "lastName": "Jensen" }, { "creatorType": "author", "firstName": "Stanley R.", "lastName": "Riddell" }, { "creatorType": "author", "firstName": "Oliver W.", "lastName": "Press" } ], "abstractNote": "Modification of T cells with chimeric antigen receptors (CAR) has emerged as a promising treatment modality for human malignancies. Integration of co-stimulatory domains into CARs can augment the activation and function of genetically targeted T cells against tumors. However, the potential for insertional mutagenesis and toxicities due to the infused cells have made development of safe methods for removing transferred cells an important consideration. We have genetically modified human T cells with a lentiviral vector to express a CD20-CAR containing both CD28 and CD137 co-stimulatory domains, a \"suicide gene\" relying on inducible activation of caspase 9 (iC9), and a truncated CD19 selectable marker. Rapid expansion (2000 fold) of the transduced T cells was achieved in 28 days after stimulation with artificial antigen presenting cells. Transduced T cells exhibited effective CD20-specific cytotoxic activity in vitro and in a mouse xenograft tumor model. Activation of the iC9 suicide switch resulted in efficient removal of transduced T cells both in vitro and in vivo. Our work demonstrates the feasibility and promise of this approach for treating CD20(+) malignancies in a safe and more efficient manner. A phase I clinical trial using this approach in patients with relapsed indolent B-NHL is planned.", "publicationTitle": "PloS One", "publisher": "", "place": "", "date": "2013", "volume": "8", "issue": "12", "section": "", "partNumber": "", "partTitle": "", "pages": "e82742", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "PLoS ONE", "DOI": "10.1371/journal.pone.0082742", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1932-6203", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "PMID: 24358223\nPMCID: PMC3866194", "tags": [ { "tag": "Animals", "type": 1 }, { "tag": "Antigens, CD20", "type": 1 }, { "tag": "Caspase 9", "type": 1 }, { "tag": "Cells, Cultured", "type": 1 }, { "tag": "Genes, Transgenic, Suicide", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Immunotherapy, Adoptive", "type": 1 }, { "tag": "Jurkat Cells", "type": 1 }, { "tag": "Lymphoma", "type": 1 }, { "tag": "Mice", "type": 1 }, { "tag": "Mice, Inbred NOD", "type": 1 }, { "tag": "Mice, Knockout", "type": 1 }, { "tag": "Mice, SCID", "type": 1 }, { "tag": "NIH 3T3 Cells", "type": 1 }, { "tag": "Receptors, Antigen, T-Cell", "type": 1 }, { "tag": "Recombinant Fusion Proteins", "type": 1 }, { "tag": "T-Lymphocytes", "type": 1 }, { "tag": "Treatment Outcome", "type": 1 }, { "tag": "Xenograft Model Antitumor Assays", "type": 1 } ], "collections": [ "8D68KX62" ], "relations": {}, "dateAdded": "2016-05-07T00:23:35Z", "dateModified": "2016-05-07T00:23:35Z" } }, { "key": "347X28E6", "version": 83, "library": { "type": "group", "id": 508454, "name": "JAKBAM301", "links": { "alternate": { "href": "https://www.zotero.org/groups/jakbam301", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/508454/items/347X28E6", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/jakbam301/items/347X28E6", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/508454/items/2HFT56IT", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2642588, "username": "jeffreyxwu", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jeffreyxwu", "type": "text/html" } } } }, "data": { "key": "347X28E6", "version": 83, "parentItem": "2HFT56IT", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2016-05-07T00:23:27Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/22047558", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2016-05-07T00:23:27Z", "dateModified": "2016-05-07T00:23:27Z" } }, { "key": "2HFT56IT", "version": 83, "library": { "type": "group", "id": 508454, "name": "JAKBAM301", "links": { "alternate": { "href": "https://www.zotero.org/groups/jakbam301", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/508454/items/2HFT56IT", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/jakbam301/items/2HFT56IT", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2642588, "username": "jeffreyxwu", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jeffreyxwu", "type": "text/html" } } }, "creatorSummary": "Di Stasi et al.", "parsedDate": "2011-11-03", "numChildren": 1 }, "data": { "key": "2HFT56IT", "version": 83, "itemType": "journalArticle", "title": "Inducible apoptosis as a safety switch for adoptive cell therapy", "creators": [ { "creatorType": "author", "firstName": "Antonio", "lastName": "Di Stasi" }, { "creatorType": "author", "firstName": "Siok-Keen", "lastName": "Tey" }, { "creatorType": "author", "firstName": "Gianpietro", "lastName": "Dotti" }, { "creatorType": "author", "firstName": "Yuriko", "lastName": "Fujita" }, { "creatorType": "author", "firstName": "Alana", "lastName": "Kennedy-Nasser" }, { "creatorType": "author", "firstName": "Caridad", "lastName": "Martinez" }, { "creatorType": "author", "firstName": "Karin", "lastName": "Straathof" }, { "creatorType": "author", "firstName": "Enli", "lastName": "Liu" }, { "creatorType": "author", "firstName": "April G.", "lastName": "Durett" }, { "creatorType": "author", "firstName": "Bambi", "lastName": "Grilley" }, { "creatorType": "author", "firstName": "Hao", "lastName": "Liu" }, { "creatorType": "author", "firstName": "Conrad R.", "lastName": "Cruz" }, { "creatorType": "author", "firstName": "Barbara", "lastName": "Savoldo" }, { "creatorType": "author", "firstName": "Adrian P.", "lastName": "Gee" }, { "creatorType": "author", "firstName": "John", "lastName": "Schindler" }, { "creatorType": "author", "firstName": "Robert A.", "lastName": "Krance" }, { "creatorType": "author", "firstName": "Helen E.", "lastName": "Heslop" }, { "creatorType": "author", "firstName": "David M.", "lastName": "Spencer" }, { "creatorType": "author", "firstName": "Cliona M.", "lastName": "Rooney" }, { "creatorType": "author", "firstName": "Malcolm K.", "lastName": "Brenner" } ], "abstractNote": "BACKGROUND: Cellular therapies could play a role in cancer treatment and regenerative medicine if it were possible to quickly eliminate the infused cells in case of adverse events. We devised an inducible T-cell safety switch that is based on the fusion of human caspase 9 to a modified human FK-binding protein, allowing conditional dimerization. When exposed to a synthetic dimerizing drug, the inducible caspase 9 (iCasp9) becomes activated and leads to the rapid death of cells expressing this construct.\nMETHODS: We tested the activity of our safety switch by introducing the gene into donor T cells given to enhance immune reconstitution in recipients of haploidentical stem-cell transplants. Patients received AP1903, an otherwise bioinert small-molecule dimerizing drug, if graft-versus-host disease (GVHD) developed. We measured the effects of AP1903 on GVHD and on the function and persistence of the cells containing the iCasp9 safety switch.\nRESULTS: Five patients between the ages of 3 and 17 years who had undergone stem-cell transplantation for relapsed acute leukemia were treated with the genetically modified T cells. The cells were detected in peripheral blood from all five patients and increased in number over time, despite their constitutive transgene expression. A single dose of dimerizing drug, given to four patients in whom GVHD developed, eliminated more than 90% of the modified T cells within 30 minutes after administration and ended the GVHD without recurrence.\nCONCLUSIONS: The iCasp9 cell-suicide system may increase the safety of cellular therapies and expand their clinical applications. (Funded by the National Heart, Lung, and Blood Institute and the National Cancer Institute; ClinicalTrials.gov number, NCT00710892.).", "publicationTitle": "The New England Journal of Medicine", "publisher": "", "place": "", "date": "Nov 3, 2011", "volume": "365", "issue": "18", "section": "", "partNumber": "", "partTitle": "", "pages": "1673-1683", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "N. Engl. J. Med.", "DOI": "10.1056/NEJMoa1106152", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1533-4406", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "PMID: 22047558\nPMCID: PMC3236370", "tags": [ { "tag": "Adolescent", "type": 1 }, { "tag": "Apoptosis", "type": 1 }, { "tag": "Caspase 9", "type": 1 }, { "tag": "Child", "type": 1 }, { "tag": "Child, Preschool", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Gene Transfer Techniques", "type": 1 }, { "tag": "Genes, Transgenic, Suicide", "type": 1 }, { "tag": "Graft vs Host Disease", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Immunotherapy, Adoptive", "type": 1 }, { "tag": "Leukemia", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Organic Chemicals", "type": 1 }, { "tag": "Recurrence", "type": 1 }, { "tag": "Stem Cell Transplantation", "type": 1 }, { "tag": "T-Lymphocytes", "type": 1 }, { "tag": "Tacrolimus Binding Proteins", "type": 1 } ], "collections": [ "8D68KX62" ], "relations": {}, "dateAdded": "2016-05-07T00:23:27Z", "dateModified": "2016-05-07T00:23:27Z" } }, { "key": "26T83BXT", "version": 83, "library": { "type": "group", "id": 508454, "name": "JAKBAM301", "links": { "alternate": { "href": "https://www.zotero.org/groups/jakbam301", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/508454/items/26T83BXT", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/jakbam301/items/26T83BXT", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/508454/items/ESESV64E", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2642588, "username": "jeffreyxwu", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jeffreyxwu", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "26T83BXT", "version": 83, "parentItem": "ESESV64E", "itemType": "attachment", "linkMode": "imported_url", "title": "PubMed Central Full Text PDF", "accessDate": "2016-05-07T00:01:49Z", "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979594/pdf/nihms561820.pdf", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Ramos et al. - 2014 - CD19-CAR Trials.pdf", "md5": "e9b08747bcbf0571ca1a3f7e6f2d8377", "mtime": 1462579310000, "tags": [], "relations": {}, "dateAdded": "2016-05-07T00:01:49Z", "dateModified": "2016-05-07T00:01:51Z" } }, { "key": "2I7URJVW", "version": 82, "library": { "type": "group", "id": 508454, "name": "JAKBAM301", "links": { "alternate": { "href": "https://www.zotero.org/groups/jakbam301", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/508454/items/2I7URJVW", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/jakbam301/items/2I7URJVW", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/508454/items/ESESV64E", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2642588, "username": "jeffreyxwu", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jeffreyxwu", "type": "text/html" } } } }, "data": { "key": "2I7URJVW", "version": 82, "parentItem": "ESESV64E", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Central Link", "accessDate": "2016-05-07T00:01:49Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979594/", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2016-05-07T00:01:49Z", "dateModified": "2016-05-07T00:01:49Z" } }, { "key": "ESESV64E", "version": 82, "library": { "type": "group", "id": 508454, "name": "JAKBAM301", "links": { "alternate": { "href": "https://www.zotero.org/groups/jakbam301", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/508454/items/ESESV64E", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/jakbam301/items/ESESV64E", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2642588, "username": "jeffreyxwu", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jeffreyxwu", "type": "text/html" } } }, "creatorSummary": "Ramos et al.", "parsedDate": "2014", "numChildren": 2 }, "data": { "key": "ESESV64E", "version": 82, "itemType": "journalArticle", "title": "CD19-CAR Trials", "creators": [ { "creatorType": "author", "firstName": "Carlos A.", "lastName": "Ramos" }, { "creatorType": "author", "firstName": "Barbara", "lastName": "Savoldo" }, { "creatorType": "author", "firstName": "Gianpietro", "lastName": "Dotti" } ], "abstractNote": "CD19 is a B-lineage specific transmembrane glycoprotein, the expression of which is maintained on more than 95% B-cell malignancies. This strict lineage restriction makes CD19 an ideal target for immune therapies using chimeric antigen receptors (CARs). Here we review published phase I trials of T cells expressing CARs targeting CD19 and describe briefly the biological questions that they addressed. All patients treated in these trials had relapsed B-cell malignancies, which in many cases were chemorefractory. Nonetheless, major responses have been observed, especially in patients with CLL and ALL. Many of these responses were accompanied by a systemic inflammatory reaction syndrome that could be life-threatening but was almost always reversible with adequate medical management. Given their remarkable activity, CD19-CAR T cells are likely to be quickly incorporated into the management of B-cell neoplasms and have become the paradigm for similar strategies targeting other cancers.", "publicationTitle": "Cancer journal (Sudbury, Mass.)", "publisher": "", "place": "", "date": "2014", "volume": "20", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "112-118", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Cancer J", "DOI": "10.1097/PPO.0000000000000031", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979594/", "accessDate": "2016-05-07T00:01:49Z", "PMID": "", "PMCID": "", "ISSN": "1528-9117", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "PubMed Central", "callNumber": "", "rights": "", "extra": "PMID: 24667955\nPMCID: PMC3979594", "tags": [], "collections": [ "8D68KX62" ], "relations": {}, "dateAdded": "2016-05-07T00:01:49Z", "dateModified": "2016-05-07T00:01:49Z" } }, { "key": "3JDVB2D9", "version": 82, "library": { "type": "group", "id": 508454, "name": "JAKBAM301", "links": { "alternate": { "href": "https://www.zotero.org/groups/jakbam301", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/508454/items/3JDVB2D9", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/jakbam301/items/3JDVB2D9", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/508454/items/IZ4J5EMS", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2642588, "username": "jeffreyxwu", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jeffreyxwu", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "3JDVB2D9", "version": 82, "parentItem": "IZ4J5EMS", "itemType": "attachment", "linkMode": "imported_url", "title": "PubMed Central Full Text PDF", "accessDate": "2016-05-06T23:58:53Z", "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979594/pdf/nihms561820.pdf", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Ramos et al. - 2014 - CD19-CAR Trials.pdf", "md5": "e9b08747bcbf0571ca1a3f7e6f2d8377", "mtime": 1462579134000, "tags": [], "relations": {}, "dateAdded": "2016-05-06T23:58:53Z", "dateModified": "2016-05-06T23:58:55Z" } }, { "key": "IZ4J5EMS", "version": 81, "library": { "type": "group", "id": 508454, "name": "JAKBAM301", "links": { "alternate": { "href": "https://www.zotero.org/groups/jakbam301", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/508454/items/IZ4J5EMS", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/jakbam301/items/IZ4J5EMS", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2642588, "username": "jeffreyxwu", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jeffreyxwu", "type": "text/html" } } }, "creatorSummary": "Ramos et al.", "parsedDate": "2014", "numChildren": 2 }, "data": { "key": "IZ4J5EMS", "version": 81, "itemType": "journalArticle", "title": "CD19-CAR Trials", "creators": [ { "creatorType": "author", "firstName": "Carlos A.", "lastName": "Ramos" }, { "creatorType": "author", "firstName": "Barbara", "lastName": "Savoldo" }, { "creatorType": "author", "firstName": "Gianpietro", "lastName": "Dotti" } ], "abstractNote": "CD19 is a B-lineage specific transmembrane glycoprotein, the expression of which is maintained on more than 95% B-cell malignancies. This strict lineage restriction makes CD19 an ideal target for immune therapies using chimeric antigen receptors (CARs). Here we review published phase I trials of T cells expressing CARs targeting CD19 and describe briefly the biological questions that they addressed. All patients treated in these trials had relapsed B-cell malignancies, which in many cases were chemorefractory. Nonetheless, major responses have been observed, especially in patients with CLL and ALL. Many of these responses were accompanied by a systemic inflammatory reaction syndrome that could be life-threatening but was almost always reversible with adequate medical management. 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An optimized CAR vector containing CD28, 4-1BB, and CD3ζ signaling moieties was assembled in a γ-retroviral vector and used to transduce autologous peripheral blood lymphocytes (PBLs) from a patient with colon cancer metastatic to the lungs and liver, refractory to multiple standard treatments. The gene transfer efficiency into autologous T cells was 79% CAR+ in CD3+ cells and these cells demonstrated high-specific reactivity in in vitro coculture assays. Following completion of nonmyeloablative conditioning, the patient received 1010 cells intravenously. Within 15 minutes after cell infusion the patient experienced respiratory distress, and displayed a dramatic pulmonary infiltrate on chest X-ray. She was intubated and despite intensive medical intervention the patient died 5 days after treatment. Serum samples after cell infusion showed marked increases in interferon-γ (IFN-γ), granulocyte macrophage-colony stimulating factor (GM-CSF), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and IL-10, consistent with a cytokine storm. 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cancer (aGC), not amenable to curative surgery, is still a burdensome illness tormenting afflicted patients and their healthcare providers. Whereas combination chemotherapy has been shown to improve survival and tumor related symptoms in the frontline setting, second-line therapy (SLT) is subject to much debate in the scientific community, mainly because of the debilitating effects of GC, which would impede the administration of cytotoxic therapy. Recent data has provided sufficient evidence for the safe use of SLT in patients with an adequate performance status. Taxanes, Irinotecan and even some Fluoropyrimidine analogs were found to provide a survival advantage in this subset of patients. Most importantly, quality of life measures were also improved through the use of adequate therapy. Even more pertinent were the findings involving antiangiogenic agents, which would add measurable improvements without significantly jeopardizing the patients’ well-being. Further lines of therapy are cause for much more debate nowadays, but specific targeted agents have shown considerable promise in this context. We herein review noteworthy published data involving the use of additional lines of the therapy after failure of standard frontline therapies in patients with aGC.", "publicationTitle": "World Journal of Gastroenterology", "publisher": "", "place": "", "date": "2016-3-21", "volume": "22", "issue": "11", "section": "", "partNumber": "", "partTitle": "", "pages": "3069-3077", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "World J Gastroenterol", "DOI": "10.3748/wjg.v22.i11.3069", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789984/", "accessDate": "2016-05-06T20:19:04Z", "PMID": "", "PMCID": "", "ISSN": "1007-9327", "archive": "", "archiveLocation": "", "shortTitle": "Metastatic gastric cancer treatment", "language": "", "libraryCatalog": "PubMed Central", "callNumber": "", "rights": "", "extra": "PMID: 27003986\nPMCID: PMC4789984", "tags": [], "collections": [], "relations": {}, "dateAdded": "2016-05-06T20:19:04Z", "dateModified": "2016-05-06T20:19:04Z" } }, { "key": "EPPDIBNT", "version": 72, "library": { "type": "group", "id": 508454, "name": "JAKBAM301", "links": { "alternate": { "href": "https://www.zotero.org/groups/jakbam301", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/508454/items/EPPDIBNT", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/jakbam301/items/EPPDIBNT", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/508454/items/B2ZBQ5KV", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2642588, "username": "jeffreyxwu", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jeffreyxwu", "type": "text/html" } } } }, "data": { "key": "EPPDIBNT", "version": 72, "parentItem": "B2ZBQ5KV", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2016-05-06T20:18:18Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/9863013", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2016-05-06T20:18:18Z", "dateModified": "2016-05-06T20:18:18Z" } } ]