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2012.pdf", "md5": "145af0522e1886bb6917cc2dd274480e", "mtime": 1459348960435, "tags": [], "relations": {}, "dateAdded": "2016-03-30T17:59:25Z", "dateModified": "2016-03-30T17:59:25Z" } }, { "key": "CIVBD2K7", "version": 3, "library": { "type": "group", "id": 505438, "name": "Hair Cortisol", "links": { "alternate": { "href": "https://www.zotero.org/groups/hair_cortisol", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/505438/items/CIVBD2K7", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/hair_cortisol/items/CIVBD2K7", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/505438/items/DM627UEJ", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1995943, "username": "bbhpennstate", "name": "Biobehavioral Health", "links": { "alternate": { "href": "https://www.zotero.org/bbhpennstate", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "CIVBD2K7", "version": 3, "parentItem": "DM627UEJ", "itemType": "attachment", "linkMode": "imported_file", "title": "Attachment", "accessDate": "", "url": "", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Detection of physiological concentrations of cortisol and cortisone in human hair - 2004.pdf", "md5": "3189a5f79a8a4e98769d5241c57953bf", "mtime": 1459347811235, "tags": [], "relations": {}, "dateAdded": "2016-03-30T17:59:25Z", "dateModified": "2016-03-30T17:59:25Z" } }, { "key": "V7IZVDQI", "version": 3, "library": { "type": "group", "id": 505438, "name": "Hair Cortisol", "links": { "alternate": { "href": "https://www.zotero.org/groups/hair_cortisol", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/505438/items/V7IZVDQI", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/hair_cortisol/items/V7IZVDQI", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/505438/items/CMHNBMVA", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1995943, "username": "bbhpennstate", "name": "Biobehavioral Health", "links": { "alternate": { "href": "https://www.zotero.org/bbhpennstate", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "V7IZVDQI", "version": 3, "parentItem": "CMHNBMVA", "itemType": "attachment", "linkMode": "imported_file", "title": "Attachment", "accessDate": "", "url": "", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Analysis of endogenous cortisol concentrations in the hair of rhesus macaques - 2006.pdf", "md5": "eba369b279c848c44e51ecc74dce28ba", "mtime": 1459347556325, "tags": [], "relations": {}, "dateAdded": "2016-03-30T17:59:25Z", "dateModified": "2016-03-30T17:59:25Z" } }, { "key": "ZE7BVHVE", "version": 3, "library": { "type": "group", "id": 505438, "name": "Hair Cortisol", "links": { "alternate": { "href": "https://www.zotero.org/groups/hair_cortisol", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/505438/items/ZE7BVHVE", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/hair_cortisol/items/ZE7BVHVE", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/505438/items/MMI3JT4N", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1995943, "username": "bbhpennstate", "name": "Biobehavioral Health", "links": { "alternate": { "href": "https://www.zotero.org/bbhpennstate", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "ZE7BVHVE", "version": 3, "parentItem": "MMI3JT4N", "itemType": "attachment", "linkMode": "imported_file", "title": "Attachment", "accessDate": "", "url": "", "note": "", "contentType": "application/pdf", "charset": "", "filename": "A novel method using hair for determining hormonal levels in wildlife - 2002.pdf", "md5": "723da1d3b50ad19a385694f16bdff1b3", "mtime": 1455808804563, "tags": [], "relations": {}, "dateAdded": "2016-03-30T17:59:25Z", "dateModified": "2016-03-30T17:59:25Z" } }, { "key": "FETJUU8P", "version": 2, "library": { "type": "group", "id": 505438, "name": "Hair Cortisol", "links": { "alternate": { "href": "https://www.zotero.org/groups/hair_cortisol", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/505438/items/FETJUU8P", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/hair_cortisol/items/FETJUU8P", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1995943, "username": "bbhpennstate", "name": "Biobehavioral Health", "links": { "alternate": { "href": "https://www.zotero.org/bbhpennstate", "type": "text/html" } } }, "creatorSummary": "Yang et al.", "parsedDate": "2014-01", "numChildren": 1 }, "data": { "key": "FETJUU8P", "version": 2, "itemType": "journalArticle", "title": "The structure of people's hair.", "creators": [ { "creatorType": "author", "firstName": "Fei-Chi", "lastName": "Yang" }, { "creatorType": "author", "firstName": "Yuchen", "lastName": "Zhang" }, { "creatorType": "author", "firstName": "Maikel C", "lastName": "Rheinstädter" } ], "abstractNote": "Hair is a filamentous biomaterial consisting mainly of proteins in particular keratin. The structure of human hair is well known: the medulla is a loosely packed, disordered region near the centre of the hair surrounded by the cortex, which contains the major part of the fibre mass, mainly consisting of keratin proteins and structural lipids. The cortex is surrounded by the cuticle, a layer of dead, overlapping cells forming a protective layer around the hair. The corresponding structures have been studied extensively using a variety of different techniques, such as light, electron and atomic force microscopes, and also X-ray diffraction. We were interested in the question how much the molecular hair structure differs from person to person, between male and female hair, hair of different appearances such as colour and waviness. We included hair from parent and child, identical and fraternal twins in the study to see if genetically similar hair would show similar structural features. The molecular structure of the hair samples was studied using high-resolution X-ray diffraction, which covers length scales from molecules up to the organization of secondary structures. Signals due to the coiled-coil phase of α-helical keratin proteins, intermediate keratin filaments in the cortex and from the lipid layers in the cell membrane complex were observed in the specimen of all individuals, with very small deviations. Despite the relatively small number of individuals (12) included in this study, some conclusions can be drawn. While the general features were observed in all individuals and the corresponding molecular structures were almost identical, additional signals were observed in some specimen and assigned to different types of lipids in the cell membrane complex. Genetics seem to play a role in this composition as identical patterns were observed in hair from father and daughter and identical twins, however, not for fraternal twins. Identification and characterization of these features is an important step towards the detection of abnormalities in the molecular structure of hair as a potential diagnostic tool for certain diseases.", "publicationTitle": "PeerJ", "publisher": "", "place": "", "date": "January 2014", "volume": "2", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "e619", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.7717/peerj.619", "citationKey": "", "url": "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4201279&tool=pmcentrez&rendertype=abstract", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "2167-8359", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "PMID: 25332846", "tags": [], "collections": [], "relations": {}, "dateAdded": "2016-03-30T17:59:25Z", "dateModified": "2016-03-30T17:59:25Z" } }, { "key": "BJ7TM4CN", "version": 2, "library": { "type": "group", "id": 505438, "name": "Hair Cortisol", "links": { "alternate": { "href": "https://www.zotero.org/groups/hair_cortisol", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/505438/items/BJ7TM4CN", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/hair_cortisol/items/BJ7TM4CN", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1995943, "username": "bbhpennstate", "name": "Biobehavioral Health", "links": { "alternate": { "href": "https://www.zotero.org/bbhpennstate", "type": "text/html" } } }, "creatorSummary": "Lunn and Evans", "parsedDate": "1977", "numChildren": 1 }, "data": { "key": "BJ7TM4CN", "version": 2, "itemType": "journalArticle", "title": "The Electrostatic Properties of Human Hair", "creators": [ { "creatorType": "author", "firstName": "Anthony C.", "lastName": "Lunn" }, { "creatorType": "author", "firstName": "Robert E.", "lastName": "Evans" } ], "abstractNote": "Three factors have been studied which are significant in the development of ELECTROSTATIC CHARGE on HAIR FIBERS: (1) the charge generated by separation between hair fibers and brush or comb; (2) the mobility of charge on the fibers; and (3) the distribution of charge along the fiber length. Instrumentation has been developed to measure each of these parameters, and the effect upon them of quaternary ammonium compounds and other fiber treatments. Quaternary antistatic agents are found to reduce substantially the charge generated on the fibers; the half-life of charge mobility varies with the quantity of agent on the hair. The density of charge is greatest near the fiber tips, corresponding to the region of a peak in the combing force. It is concluded that the mechanism of action of these antistatic agents is primarily one of lubrication: a reduction in combing force leads to a reduction of static charge generated on the hair.", "publicationTitle": "Journal of the Society of Cosmetic Chemists", "publisher": "", "place": "", "date": "1977", "volume": "28", "issue": "9", "section": "", "partNumber": "", "partTitle": "", "pages": "549–569", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2016-03-30T17:59:25Z", "dateModified": "2016-03-30T17:59:25Z" } }, { "key": "WC9C2P2R", "version": 2, "library": { "type": "group", "id": 505438, "name": "Hair Cortisol", "links": { "alternate": { "href": "https://www.zotero.org/groups/hair_cortisol", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/505438/items/WC9C2P2R", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/hair_cortisol/items/WC9C2P2R", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1995943, "username": "bbhpennstate", "name": "Biobehavioral Health", "links": { "alternate": { "href": "https://www.zotero.org/bbhpennstate", "type": "text/html" } } }, "creatorSummary": "Gao et al.", "parsedDate": "2013-06", "numChildren": 1 }, "data": { "key": "WC9C2P2R", "version": 2, "itemType": "journalArticle", "title": "Quantitative analysis of steroid hormones in human hair using a column-switching LC-APCI-MS/MS assay.", "creators": [ { "creatorType": "author", "firstName": "Wei", "lastName": "Gao" }, { "creatorType": "author", "firstName": "Tobias", "lastName": "Stalder" }, { "creatorType": "author", "firstName": "Paul", "lastName": "Foley" }, { "creatorType": "author", "firstName": "Manfred", "lastName": "Rauh" }, { "creatorType": "author", "firstName": "Huihua", "lastName": "Deng" }, { "creatorType": "author", "firstName": "Clemens", "lastName": "Kirschbaum" } ], "abstractNote": "The analysis of steroid hormones in hair is increasingly used in the field of stress-related research to obtain a retrospective index of integrated long-term hormone secretion. Here, most laboratories have so far relied on immunochemical assays originally developed for salivary analyses. Although these assays are fast and easy to perform, they have a reduced reliability and specificity due to cross-reactivity with other substances and are limited to the detection of one hormone at a time. Here, we report the development of a LC-MS/MS-based method for simultaneous identification of endogenous concentrations of seven steroid hormones (cortisol, cortisone, testosterone, progesterone, corticosterone, dehydroepiandrosterone (DHEA) and androstenedione) in human hair. Hair samples were washed with isopropanol and steroid hormones were extracted from 10mg whole, nonpulverized hair by methanol incubation. A column switching strategy for on-line solid phase extraction (SPE) was applied, followed by analyte detection on an AB Sciex API 5000 QTrap mass spectrometer. Results indicated linearity of the method for all steroids over ranges of 0.09-90pg/mg (0.9-900pg/mg for DHEA) with correlation coefficients ranging between 0.9995 and 0.9999. Intra- and inter-assay coefficients of variation were between 3.7 and 9.1%. The limits of quantification (LOQ) were below (or equal to) 0.1pg/mg for all steroids, except of DHEA for which the LOQ was 0.9pg/mg. An analysis of 30 natural hair samples (15 men/15 women) using this method confirmed that all steroid hormones could be quantified at endogenous levels in each individual. In addition, the use of whole hair samples and on-line SPE resulted in a significant reduction in sample throughput times, increasing the applicability of this method for research questions where a larger number of samples needs to be processed.", "publicationTitle": "Journal of chromatography. B, Analytical technologies in the biomedical and life sciences", "publisher": "", "place": "", "date": "June 2013", "volume": "928", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "1–8", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1016/j.jchromb.2013.03.008", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/23584040", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1873-376X", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "PMID: 23584040", "tags": [ { "tag": "Chromatography" }, { "tag": "Equipment Design" }, { "tag": "Female" }, { "tag": "Hair: chemistry" }, { "tag": "Hormones" }, { "tag": "Hormones: analysis" }, { "tag": "Humans" }, { "tag": "Limit of Detection" }, { "tag": "Liquid" }, { "tag": "Liquid: instrumentation" }, { "tag": "Liquid: methods" }, { "tag": "Male" }, { "tag": "Reproducibility of Results" }, { "tag": "Solid Phase Extraction" }, { "tag": "Solid Phase Extraction: instrumentation" }, { "tag": "Solid Phase Extraction: methods" }, { "tag": "Steroids" }, { "tag": "Steroids: analysis" }, { "tag": "Tandem Mass Spectrometry" }, { "tag": "Tandem Mass Spectrometry: instrumentation" }, { "tag": "Tandem Mass Spectrometry: methods" }, { "tag": "hair" } ], "collections": [], "relations": {}, "dateAdded": "2016-03-30T17:59:25Z", "dateModified": "2016-03-30T17:59:25Z" } }, { "key": "CFZ4R45S", "version": 2, "library": { "type": "group", "id": 505438, "name": "Hair Cortisol", "links": { "alternate": { "href": "https://www.zotero.org/groups/hair_cortisol", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/505438/items/CFZ4R45S", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/hair_cortisol/items/CFZ4R45S", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1995943, "username": "bbhpennstate", "name": "Biobehavioral Health", "links": { "alternate": { "href": "https://www.zotero.org/bbhpennstate", "type": "text/html" } } }, "creatorSummary": "Pragst", "parsedDate": "2004", "numChildren": 1 }, "data": { "key": "CFZ4R45S", "version": 2, "itemType": "conferencePaper", "title": "Pitfalls in hair analysis - GTFCh", "creators": [ { "creatorType": "author", "firstName": "Fritz", "lastName": "Pragst" } ], "abstractNote": "Hair analysis has become a routine technique for the retrospective detection of exposure to illegal drugs in driving ability examination, criminal liability cases and several other forensic cases. It was shown in many papers that in the same way also therapeutic drugs, doping agents and alcohol metabolites can be determined in hair as a prove of previous or chronic intake. Based on the steady growth, segmental hair analysis can give information about the time course of the substance use. Even a previous single drug application, e. g. in drug facilitated sexual assault cases, could be detected by the increased sensitivity of up-to-date MS-MS techniques. However, the physiological basics as well as the analytical performance of hair analysis are very complicated and there are several sources of error and misinterpretation which should be known and handled with responsibility. In this presentation reasons of such pitfalls and ways of its avoidance are considered from the collection of the hair sample to the interpretation of the analytical outcome.", "proceedingsTitle": "Analytica Conference, Joint GTFCh/TIAFT Symposium “Analytical Pitfalls and Trends in Clinical and Forensic Toxiclolgy”", "conferenceName": "", "publisher": "", "place": "Munich", "date": "2004", "eventPlace": "", "volume": "", "issue": "", "numberOfVolumes": "", "pages": "", "series": "", "seriesNumber": "", "DOI": "", "ISBN": "", "citationKey": "", "url": "", "accessDate": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2016-03-30T17:59:25Z", "dateModified": "2016-03-30T17:59:25Z" } }, { "key": "8P8DFKFX", "version": 2, "library": { "type": "group", "id": 505438, "name": "Hair Cortisol", "links": { "alternate": { "href": "https://www.zotero.org/groups/hair_cortisol", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/505438/items/8P8DFKFX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/hair_cortisol/items/8P8DFKFX", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1995943, "username": "bbhpennstate", "name": "Biobehavioral Health", "links": { "alternate": { "href": "https://www.zotero.org/bbhpennstate", "type": "text/html" } } }, "creatorSummary": "Sauvé et al.", "parsedDate": "2007-01", "numChildren": 1 }, "data": { "key": "8P8DFKFX", "version": 2, "itemType": "journalArticle", "title": "Measurement of cortisol in human hair as a biomarker of systemic exposure.", "creators": [ { "creatorType": "author", "firstName": "Brittany", "lastName": "Sauvé" }, { "creatorType": "author", "firstName": "Gideon", "lastName": "Koren" }, { "creatorType": "author", "firstName": "Grace", "lastName": "Walsh" }, { "creatorType": "author", "firstName": "Sonya", "lastName": "Tokmakejian" }, { "creatorType": "author", "firstName": "Stan H M", "lastName": "Van Uum" } ], "abstractNote": "PURPOSE: Current methods for measuring long-term endogenous production of cortisol can be challenging due to the need to take multiple urine, saliva or serum samples. Hair grows approximately 1 centimeter per month, and hair analysis accurately reflects exposure to drug abuse and environmental toxins. Here we describe a new assay for measurement of cortisol in hair, and determined a reference range for non-obese subjects. METHODS: For measurement of cortisol in hair we modified an immunoassay originally developed for measuring cortisol in saliva. We compared hair samples obtained from various parts of the head, and assessed the effect of hair dying. We analyzed hair samples from non-obese subjects, in whom we also obtained urine, saliva and blood samples for cortisol measurements. RESULTS: The mean extraction recovery for hair cortisol standards of 100 ng/ml, 50 ng/ml and 2 ng/ml (n=6) was 87.9%, 88.9% and 87.4%, respectively. Hair cortisol levels were not affected by hair color or by dying hair samples after they were obtained. Cortisol levels were decreased in hair that was artificially colored before taking the sample. The coefficient of variation was high for cortisol levels in hair from different sections of the head (30.5 %), but was smaller when comparing between hair samples obtained from the vertex posterior (15.6%). The reference range for cortisol in hair was 17.7-153.2 pg/mg of hair (median 46.1 pg/mg). Hair cortisol levels correlated significantly with cortisol in 24-hour urine (r=0.33; P=0.041). CONCLUSION: The correlation of hair cortisol with 24-hour urine cortisol supports its relevance as biomarker for long-term exposure.", "publicationTitle": "Clinical and investigative medicine. Médecine clinique et experimentale", "publisher": "", "place": "", "date": "January 2007", "volume": "30", "issue": "5", "section": "", "partNumber": "", "partTitle": "", "pages": "E183–91", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/17892760", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1488-2353", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "PMID: 17892760", "tags": [ { "tag": "Adult" }, { "tag": "Aged" }, { "tag": "Biomarkers" }, { "tag": "Biomarkers: analysis" }, { "tag": "Biomarkers: urine" }, { "tag": "Environmental Exposure" }, { "tag": "Female" }, { "tag": "Humans" }, { "tag": "Hydrocortisone" }, { "tag": "Hydrocortisone: analysis" }, { "tag": "Hydrocortisone: urine" }, { "tag": "Male" }, { "tag": "Middle Aged" }, { "tag": "Saliva" }, { "tag": "Saliva: chemistry" }, { "tag": "Saliva: metabolism" }, { "tag": "Sensitivity and Specificity" }, { "tag": "Time Factors" }, { "tag": "hair" } ], "collections": [], "relations": {}, "dateAdded": "2016-03-30T17:59:25Z", "dateModified": "2016-03-30T17:59:25Z" } } ]