[
    {
        "key": "9AWU35PD",
        "version": 98,
        "library": {
            "type": "group",
            "id": 504425,
            "name": "ALS 301 Paper",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/als_301_paper",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/504425/items/9AWU35PD",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/als_301_paper/items/9AWU35PD",
                "type": "text/html"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 2635034,
                "username": "vsadykov15",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/vsadykov15",
                        "type": "text/html"
                    }
                }
            },
            "numChildren": 0
        },
        "data": {
            "key": "9AWU35PD",
            "version": 98,
            "itemType": "document",
            "title": "",
            "creators": [],
            "abstractNote": "",
            "type": "",
            "date": "",
            "publisher": "",
            "place": "",
            "DOI": "",
            "citationKey": "",
            "url": "",
            "accessDate": "",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "",
            "language": "",
            "libraryCatalog": "",
            "callNumber": "",
            "rights": "",
            "extra": "",
            "tags": [],
            "collections": [
                "EZECI5TS"
            ],
            "relations": {},
            "dateAdded": "2018-05-15T05:10:12Z",
            "dateModified": "2018-05-15T05:10:12Z"
        }
    },
    {
        "key": "HADRIR4N",
        "version": 97,
        "library": {
            "type": "group",
            "id": 504425,
            "name": "ALS 301 Paper",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/als_301_paper",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/504425/items/HADRIR4N",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/als_301_paper/items/HADRIR4N",
                "type": "text/html"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 2635034,
                "username": "vsadykov15",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/vsadykov15",
                        "type": "text/html"
                    }
                }
            },
            "numChildren": 0
        },
        "data": {
            "key": "HADRIR4N",
            "version": 97,
            "itemType": "report",
            "title": "",
            "creators": [],
            "abstractNote": "",
            "reportNumber": "",
            "reportType": "",
            "institution": "",
            "place": "",
            "date": "",
            "seriesTitle": "",
            "seriesNumber": "",
            "pages": "",
            "DOI": "",
            "ISBN": "",
            "citationKey": "",
            "url": "",
            "accessDate": "",
            "ISSN": "",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "",
            "language": "",
            "libraryCatalog": "",
            "callNumber": "",
            "rights": "",
            "extra": "",
            "tags": [],
            "collections": [],
            "relations": {},
            "dateAdded": "2018-05-15T05:09:00Z",
            "dateModified": "2018-05-15T05:09:00Z"
        }
    },
    {
        "key": "RGF5WF4V",
        "version": 96,
        "library": {
            "type": "group",
            "id": 504425,
            "name": "ALS 301 Paper",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/als_301_paper",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/504425/items/RGF5WF4V",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/als_301_paper/items/RGF5WF4V",
                "type": "text/html"
            },
            "up": {
                "href": "https://api.zotero.org/groups/504425/items/WTTGEF2S",
                "type": "application/json"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 3020675,
                "username": "dpak13",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/dpak13",
                        "type": "text/html"
                    }
                }
            },
            "numChildren": 0
        },
        "data": {
            "key": "RGF5WF4V",
            "version": 96,
            "parentItem": "WTTGEF2S",
            "itemType": "attachment",
            "linkMode": "imported_url",
            "title": "PubMed Central Full Text PDF",
            "accessDate": "2016-05-06T10:12:22Z",
            "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721227/pdf/nihms68385.pdf",
            "note": "",
            "contentType": "application/pdf",
            "charset": "",
            "filename": "Ma et al. - 2008 - The challenge of selecting protein kinase assays f.pdf",
            "md5": "8c94a7c20a5bf1a030e555fc9bb67e59",
            "mtime": 1462529550000,
            "tags": [],
            "relations": {},
            "dateAdded": "2016-05-06T10:12:22Z",
            "dateModified": "2016-05-06T10:12:30Z"
        }
    },
    {
        "key": "I3XBNARS",
        "version": 95,
        "library": {
            "type": "group",
            "id": 504425,
            "name": "ALS 301 Paper",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/als_301_paper",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/504425/items/I3XBNARS",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/als_301_paper/items/I3XBNARS",
                "type": "text/html"
            },
            "up": {
                "href": "https://api.zotero.org/groups/504425/items/WTTGEF2S",
                "type": "application/json"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 3020675,
                "username": "dpak13",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/dpak13",
                        "type": "text/html"
                    }
                }
            }
        },
        "data": {
            "key": "I3XBNARS",
            "version": 95,
            "parentItem": "WTTGEF2S",
            "itemType": "attachment",
            "linkMode": "linked_url",
            "title": "PubMed Central Link",
            "accessDate": "2016-05-06T10:12:22Z",
            "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721227/",
            "note": "",
            "contentType": "text/html",
            "charset": "",
            "tags": [],
            "relations": {},
            "dateAdded": "2016-05-06T10:12:22Z",
            "dateModified": "2016-05-06T10:12:22Z"
        }
    },
    {
        "key": "WTTGEF2S",
        "version": 95,
        "library": {
            "type": "group",
            "id": 504425,
            "name": "ALS 301 Paper",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/als_301_paper",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/504425/items/WTTGEF2S",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/als_301_paper/items/WTTGEF2S",
                "type": "text/html"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 3020675,
                "username": "dpak13",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/dpak13",
                        "type": "text/html"
                    }
                }
            },
            "creatorSummary": "Ma et al.",
            "parsedDate": "2008-06",
            "numChildren": 2
        },
        "data": {
            "key": "WTTGEF2S",
            "version": 95,
            "itemType": "journalArticle",
            "title": "The challenge of selecting protein kinase assays for lead discovery optimization",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Haiching",
                    "lastName": "Ma"
                },
                {
                    "creatorType": "author",
                    "firstName": "Sean",
                    "lastName": "Deacon"
                },
                {
                    "creatorType": "author",
                    "firstName": "Kurumi",
                    "lastName": "Horiuchi"
                }
            ],
            "abstractNote": "Background\nProtein kinases represent one of the most promising groups of drug targets owing to their involvement in such pathological conditions as cancer, inflammatory diseases, neural disorders, and metabolism problems. In the last few years, numerous pharmaceutical and biotech companies have established kinase high-throughput screening (HTS) programs, and the reagent and service industries for kinase assay platforms, kits, and profiling services have begun to thrive.\n\nObjective\nThe plethora of different assay formats available today poses a great challenge to scientists who want to select a technology that will be cost efficient, convenient to use, and have low false positive and false negative rates.\n\nMethods\nIn the current review, we summarize the most commonly used kinase assay methods in the drug discovery process, present the advantages and disadvantages of each of these methods, and discuss the challenges of discovering kinase inhibitors by using these technologies.\n\nConclusions\nThe decision of selecting the assay formats for HTS or service platform for profiling should take into account not only the final goals of the screens but also the limitation of resources.",
            "publicationTitle": "Expert opinion on drug discovery",
            "publisher": "",
            "place": "",
            "date": "2008-6",
            "volume": "3",
            "issue": "6",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "607-621",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "Expert Opin Drug Discov",
            "DOI": "10.1517/17460441.3.6.607",
            "citationKey": "",
            "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721227/",
            "accessDate": "2016-05-06T10:12:22Z",
            "PMID": "",
            "PMCID": "",
            "ISSN": "1746-0441",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "",
            "language": "",
            "libraryCatalog": "PubMed Central",
            "callNumber": "",
            "rights": "",
            "extra": "PMID: 19662101\nPMCID: PMC2721227",
            "tags": [],
            "collections": [],
            "relations": {},
            "dateAdded": "2016-05-06T10:12:22Z",
            "dateModified": "2016-05-06T10:12:22Z"
        }
    },
    {
        "key": "FHIJ64N4",
        "version": 95,
        "library": {
            "type": "group",
            "id": 504425,
            "name": "ALS 301 Paper",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/als_301_paper",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/504425/items/FHIJ64N4",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/als_301_paper/items/FHIJ64N4",
                "type": "text/html"
            },
            "up": {
                "href": "https://api.zotero.org/groups/504425/items/HFMTRJH6",
                "type": "application/json"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 3020675,
                "username": "dpak13",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/dpak13",
                        "type": "text/html"
                    }
                }
            }
        },
        "data": {
            "key": "FHIJ64N4",
            "version": 95,
            "parentItem": "HFMTRJH6",
            "itemType": "attachment",
            "linkMode": "imported_url",
            "title": "Kinase Inhibitor Library for Screening | 96-Well",
            "accessDate": "2016-05-06T09:46:51Z",
            "url": "http://www.selleckchem.com/screening/kinase-inhibitor-library.html",
            "note": "",
            "contentType": "text/html",
            "charset": "utf-8",
            "filename": "kinase-inhibitor-library.html",
            "md5": "3e7d4214a2b8b786597b748f2946cd58",
            "mtime": 1462528010000,
            "tags": [],
            "relations": {},
            "dateAdded": "2016-05-06T09:46:51Z",
            "dateModified": "2016-05-06T09:46:51Z"
        }
    },
    {
        "key": "HFMTRJH6",
        "version": 94,
        "library": {
            "type": "group",
            "id": 504425,
            "name": "ALS 301 Paper",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/als_301_paper",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/504425/items/HFMTRJH6",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/als_301_paper/items/HFMTRJH6",
                "type": "text/html"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 3020675,
                "username": "dpak13",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/dpak13",
                        "type": "text/html"
                    }
                }
            },
            "numChildren": 1
        },
        "data": {
            "key": "HFMTRJH6",
            "version": 94,
            "itemType": "webpage",
            "title": "Kinase Inhibitor Library for Screening | 96-Well",
            "creators": [],
            "abstractNote": "",
            "websiteTitle": "",
            "websiteType": "",
            "date": "",
            "publisher": "",
            "place": "",
            "DOI": "",
            "citationKey": "",
            "url": "http://www.selleckchem.com/screening/kinase-inhibitor-library.html",
            "accessDate": "2016-05-06T09:46:50Z",
            "shortTitle": "",
            "language": "",
            "rights": "",
            "extra": "",
            "tags": [],
            "collections": [],
            "relations": {},
            "dateAdded": "2016-05-06T09:46:50Z",
            "dateModified": "2016-05-06T09:46:50Z"
        }
    },
    {
        "key": "9SPMVE5P",
        "version": 93,
        "library": {
            "type": "group",
            "id": 504425,
            "name": "ALS 301 Paper",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/als_301_paper",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/504425/items/9SPMVE5P",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/als_301_paper/items/9SPMVE5P",
                "type": "text/html"
            },
            "up": {
                "href": "https://api.zotero.org/groups/504425/items/JX9HGZH6",
                "type": "application/json"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 2635034,
                "username": "vsadykov15",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/vsadykov15",
                        "type": "text/html"
                    }
                }
            }
        },
        "data": {
            "key": "9SPMVE5P",
            "version": 93,
            "parentItem": "JX9HGZH6",
            "itemType": "attachment",
            "linkMode": "imported_url",
            "title": "European Medicines Agency - News and Events - EMA reviews cancer medicine Zydelig",
            "accessDate": "2016-05-06T06:49:23Z",
            "url": "http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2016/03/news_detail_002487.jsp&mid=WC0b01ac058004d5c1",
            "note": "",
            "contentType": "text/html",
            "charset": "utf-8",
            "filename": "index.html",
            "md5": "d46eac7960db85616733973a3822b48b",
            "mtime": 1462517362669,
            "tags": [],
            "relations": {},
            "dateAdded": "2016-05-06T06:49:23Z",
            "dateModified": "2016-05-06T06:49:23Z"
        }
    },
    {
        "key": "JX9HGZH6",
        "version": 92,
        "library": {
            "type": "group",
            "id": 504425,
            "name": "ALS 301 Paper",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/als_301_paper",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/504425/items/JX9HGZH6",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/als_301_paper/items/JX9HGZH6",
                "type": "text/html"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 2635034,
                "username": "vsadykov15",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/vsadykov15",
                        "type": "text/html"
                    }
                }
            },
            "numChildren": 1
        },
        "data": {
            "key": "JX9HGZH6",
            "version": 92,
            "itemType": "webpage",
            "title": "European Medicines Agency - News and Events - EMA reviews cancer medicine Zydelig",
            "creators": [],
            "abstractNote": "",
            "websiteTitle": "",
            "websiteType": "",
            "date": "",
            "publisher": "",
            "place": "",
            "DOI": "",
            "citationKey": "",
            "url": "http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2016/03/news_detail_002487.jsp&mid=WC0b01ac058004d5c1",
            "accessDate": "2016-05-06T06:49:22Z",
            "shortTitle": "",
            "language": "",
            "rights": "",
            "extra": "",
            "tags": [],
            "collections": [],
            "relations": {},
            "dateAdded": "2016-05-06T06:49:22Z",
            "dateModified": "2016-05-06T06:49:22Z"
        }
    },
    {
        "key": "K7JT2AXQ",
        "version": 91,
        "library": {
            "type": "group",
            "id": 504425,
            "name": "ALS 301 Paper",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/als_301_paper",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/504425/items/K7JT2AXQ",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/als_301_paper/items/K7JT2AXQ",
                "type": "text/html"
            },
            "up": {
                "href": "https://api.zotero.org/groups/504425/items/9AT3II4I",
                "type": "application/json"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 2635034,
                "username": "vsadykov15",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/vsadykov15",
                        "type": "text/html"
                    }
                }
            }
        },
        "data": {
            "key": "K7JT2AXQ",
            "version": 91,
            "parentItem": "9AT3II4I",
            "itemType": "attachment",
            "linkMode": "imported_url",
            "title": "Snapshot",
            "accessDate": "2016-05-06T06:48:29Z",
            "url": "http://www.taconic.com/design-your-model/gems-design/crispr-gene-editing/",
            "note": "",
            "contentType": "text/html",
            "charset": "utf-8",
            "filename": "crispr-gene-editing.html",
            "md5": "febb7314bb54eea507459c6c4ea31d9c",
            "mtime": 1462517309757,
            "tags": [],
            "relations": {},
            "dateAdded": "2016-05-06T06:48:29Z",
            "dateModified": "2016-05-06T06:48:29Z"
        }
    },
    {
        "key": "9AT3II4I",
        "version": 90,
        "library": {
            "type": "group",
            "id": 504425,
            "name": "ALS 301 Paper",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/als_301_paper",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/504425/items/9AT3II4I",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/als_301_paper/items/9AT3II4I",
                "type": "text/html"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 2635034,
                "username": "vsadykov15",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/vsadykov15",
                        "type": "text/html"
                    }
                }
            },
            "creatorSummary": "Biosciences",
            "numChildren": 1
        },
        "data": {
            "key": "9AT3II4I",
            "version": 90,
            "itemType": "webpage",
            "title": "CRISPR Gene Editing | Precision Editing of Native Genes",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Taconic",
                    "lastName": "Biosciences"
                }
            ],
            "abstractNote": "CRISPR Gene Editing of Mouse Models After thorough evaluation of the technology through a number of pilot projects, Taconic Biosciences now offers CRISPR (Clustered Regularly Interspersed Palindromic Repeats) gene editing to provide clients with an efficient way to generate...",
            "websiteTitle": "",
            "websiteType": "",
            "date": "",
            "publisher": "",
            "place": "",
            "DOI": "",
            "citationKey": "",
            "url": "http://www.taconic.com/design-your-model/gems-design/crispr-gene-editing/",
            "accessDate": "2016-05-06T06:48:28Z",
            "shortTitle": "",
            "language": "",
            "rights": "",
            "extra": "",
            "tags": [],
            "collections": [],
            "relations": {},
            "dateAdded": "2016-05-06T06:48:28Z",
            "dateModified": "2016-05-06T06:48:28Z"
        }
    },
    {
        "key": "W5UJ89PV",
        "version": 89,
        "library": {
            "type": "group",
            "id": 504425,
            "name": "ALS 301 Paper",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/als_301_paper",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/504425/items/W5UJ89PV",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/als_301_paper/items/W5UJ89PV",
                "type": "text/html"
            },
            "up": {
                "href": "https://api.zotero.org/groups/504425/items/Z9C3WXI4",
                "type": "application/json"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 2635034,
                "username": "vsadykov15",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/vsadykov15",
                        "type": "text/html"
                    }
                }
            }
        },
        "data": {
            "key": "W5UJ89PV",
            "version": 89,
            "parentItem": "Z9C3WXI4",
            "itemType": "attachment",
            "linkMode": "imported_url",
            "title": "CRISPR mammalian cell line gene editing service - GenScript",
            "accessDate": "2016-05-06T06:47:37Z",
            "url": "http://www.genscript.com/CRISPR-genome-edited-mammalian-cell-lines.html",
            "note": "",
            "contentType": "text/html",
            "charset": "utf-8",
            "filename": "CRISPR-genome-edited-mammalian-cell-lines.html",
            "md5": "ec1ba3c8457a56a266566e7fbf2de03d",
            "mtime": 1462517256283,
            "tags": [],
            "relations": {},
            "dateAdded": "2016-05-06T06:47:37Z",
            "dateModified": "2016-05-06T06:47:37Z"
        }
    },
    {
        "key": "Z9C3WXI4",
        "version": 88,
        "library": {
            "type": "group",
            "id": 504425,
            "name": "ALS 301 Paper",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/als_301_paper",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/504425/items/Z9C3WXI4",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/als_301_paper/items/Z9C3WXI4",
                "type": "text/html"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 2635034,
                "username": "vsadykov15",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/vsadykov15",
                        "type": "text/html"
                    }
                }
            },
            "numChildren": 1
        },
        "data": {
            "key": "Z9C3WXI4",
            "version": 88,
            "itemType": "webpage",
            "title": "CRISPR mammalian cell line gene editing service - GenScript",
            "creators": [],
            "abstractNote": "",
            "websiteTitle": "",
            "websiteType": "",
            "date": "",
            "publisher": "",
            "place": "",
            "DOI": "",
            "citationKey": "",
            "url": "http://www.genscript.com/CRISPR-genome-edited-mammalian-cell-lines.html",
            "accessDate": "2016-05-06T06:47:36Z",
            "shortTitle": "",
            "language": "",
            "rights": "",
            "extra": "",
            "tags": [],
            "collections": [],
            "relations": {},
            "dateAdded": "2016-05-06T06:47:36Z",
            "dateModified": "2016-05-06T06:47:36Z"
        }
    },
    {
        "key": "35CAM9BD",
        "version": 87,
        "library": {
            "type": "group",
            "id": 504425,
            "name": "ALS 301 Paper",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/als_301_paper",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/504425/items/35CAM9BD",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/als_301_paper/items/35CAM9BD",
                "type": "text/html"
            },
            "up": {
                "href": "https://api.zotero.org/groups/504425/items/I5VASTQU",
                "type": "application/json"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 2635034,
                "username": "vsadykov15",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/vsadykov15",
                        "type": "text/html"
                    }
                }
            }
        },
        "data": {
            "key": "35CAM9BD",
            "version": 87,
            "parentItem": "I5VASTQU",
            "itemType": "attachment",
            "linkMode": "imported_url",
            "title": "ScienceDirect Snapshot",
            "accessDate": "2016-05-06T06:04:46Z",
            "url": "http://www.sciencedirect.com/science/article/pii/S0968000414002205",
            "note": "",
            "contentType": "text/html",
            "charset": "utf-8",
            "filename": "S0968000414002205.html",
            "md5": "2b8d1b4291f5d5715fd0d802c1855837",
            "mtime": 1462514686372,
            "tags": [],
            "relations": {},
            "dateAdded": "2016-05-06T06:04:46Z",
            "dateModified": "2016-05-06T06:04:46Z"
        }
    },
    {
        "key": "I5VASTQU",
        "version": 86,
        "library": {
            "type": "group",
            "id": 504425,
            "name": "ALS 301 Paper",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/als_301_paper",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/504425/items/I5VASTQU",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/als_301_paper/items/I5VASTQU",
                "type": "text/html"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 2635034,
                "username": "vsadykov15",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/vsadykov15",
                        "type": "text/html"
                    }
                }
            },
            "creatorSummary": "Burke and Williams",
            "parsedDate": "2015-02",
            "numChildren": 1
        },
        "data": {
            "key": "I5VASTQU",
            "version": 86,
            "itemType": "journalArticle",
            "title": "Synergy in activating class I PI3Ks",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "John E.",
                    "lastName": "Burke"
                },
                {
                    "creatorType": "author",
                    "firstName": "Roger L.",
                    "lastName": "Williams"
                }
            ],
            "abstractNote": "The class I phosphoinositide 3-kinases (PI3Ks) are lipid kinases that transduce a host of cellular signals and regulate a broad range of essential functions including growth, proliferation, and migration. As such, PI3Ks have pivotal roles in diseases such as cancer, diabetes, primary immune disorders, and inflammation. These enzymes are activated downstream of numerous activating stimuli including receptor tyrosine kinases, G protein-coupled receptors (GPCRs), and the Ras superfamily of small G proteins. A major challenge is to decipher how each PI3K isoform is able to successfully synergize these inputs into their intended signaling function. This article highlights recent progress in characterizing the molecular mechanisms of PI3K isoform-specific activation pathways, as well as novel roles for PI3Ks in human diseases, specifically cancer and immune diseases.",
            "publicationTitle": "Trends in Biochemical Sciences",
            "publisher": "",
            "place": "",
            "date": "February 2015",
            "volume": "40",
            "issue": "2",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "88-100",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "Trends in Biochemical Sciences",
            "DOI": "10.1016/j.tibs.2014.12.003",
            "citationKey": "",
            "url": "http://www.sciencedirect.com/science/article/pii/S0968000414002205",
            "accessDate": "2016-05-06T06:04:44Z",
            "PMID": "",
            "PMCID": "",
            "ISSN": "0968-0004",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "",
            "language": "",
            "libraryCatalog": "ScienceDirect",
            "callNumber": "",
            "rights": "",
            "extra": "",
            "tags": [
                {
                    "tag": "cancer",
                    "type": 1
                },
                {
                    "tag": "lipid kinases",
                    "type": 1
                },
                {
                    "tag": "lipid signaling",
                    "type": 1
                },
                {
                    "tag": "phosphoinositide 3 kinases",
                    "type": 1
                },
                {
                    "tag": "phosphoinositides",
                    "type": 1
                },
                {
                    "tag": "primary immunodeficiencies",
                    "type": 1
                }
            ],
            "collections": [],
            "relations": {},
            "dateAdded": "2016-05-06T06:04:44Z",
            "dateModified": "2016-05-06T06:04:44Z"
        }
    },
    {
        "key": "G68WBF8C",
        "version": 85,
        "library": {
            "type": "group",
            "id": 504425,
            "name": "ALS 301 Paper",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/als_301_paper",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/504425/items/G68WBF8C",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/als_301_paper/items/G68WBF8C",
                "type": "text/html"
            },
            "up": {
                "href": "https://api.zotero.org/groups/504425/items/7B2T4NM3",
                "type": "application/json"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 2635034,
                "username": "vsadykov15",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/vsadykov15",
                        "type": "text/html"
                    }
                }
            }
        },
        "data": {
            "key": "G68WBF8C",
            "version": 85,
            "parentItem": "7B2T4NM3",
            "itemType": "attachment",
            "linkMode": "imported_url",
            "title": "Snapshot",
            "accessDate": "2016-05-06T06:03:53Z",
            "url": "http://www.apdsyndrome.org/index.php/for-scientists/overview",
            "note": "",
            "contentType": "text/html",
            "charset": "utf-8",
            "filename": "overview.html",
            "md5": "29a2755dcee13d46254e42704996c3ec",
            "mtime": 1462514634055,
            "tags": [],
            "relations": {},
            "dateAdded": "2016-05-06T06:03:53Z",
            "dateModified": "2016-05-06T06:03:53Z"
        }
    },
    {
        "key": "DNAMDFV9",
        "version": 85,
        "library": {
            "type": "group",
            "id": 504425,
            "name": "ALS 301 Paper",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/als_301_paper",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/504425/items/DNAMDFV9",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/als_301_paper/items/DNAMDFV9",
                "type": "text/html"
            },
            "up": {
                "href": "https://api.zotero.org/groups/504425/items/7DCN769D",
                "type": "application/json"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 2635034,
                "username": "vsadykov15",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/vsadykov15",
                        "type": "text/html"
                    }
                }
            }
        },
        "data": {
            "key": "DNAMDFV9",
            "version": 85,
            "parentItem": "7DCN769D",
            "itemType": "attachment",
            "linkMode": "imported_url",
            "title": "Snapshot",
            "accessDate": "2016-05-06T06:03:52Z",
            "url": "http://www.apdsyndrome.org/index.php/for-scientists/overview",
            "note": "",
            "contentType": "text/html",
            "charset": "utf-8",
            "filename": "overview.html",
            "md5": "026489522e43a09d4ec0e221a231e0fd",
            "mtime": 1462514631386,
            "tags": [],
            "relations": {},
            "dateAdded": "2016-05-06T06:03:52Z",
            "dateModified": "2016-05-06T06:03:52Z"
        }
    },
    {
        "key": "Z5XGTH7W",
        "version": 83,
        "library": {
            "type": "group",
            "id": 504425,
            "name": "ALS 301 Paper",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/als_301_paper",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/504425/items/Z5XGTH7W",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/als_301_paper/items/Z5XGTH7W",
                "type": "text/html"
            },
            "up": {
                "href": "https://api.zotero.org/groups/504425/items/2PJIGATZ",
                "type": "application/json"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 2635034,
                "username": "vsadykov15",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/vsadykov15",
                        "type": "text/html"
                    }
                }
            }
        },
        "data": {
            "key": "Z5XGTH7W",
            "version": 83,
            "parentItem": "2PJIGATZ",
            "itemType": "attachment",
            "linkMode": "imported_url",
            "title": "Snapshot",
            "accessDate": "2016-05-06T06:01:58Z",
            "url": "http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm406410.htm",
            "note": "",
            "contentType": "text/html",
            "charset": "utf-8",
            "filename": "ucm406410.html",
            "md5": "799cd94c79243ed0730df68735f78679",
            "mtime": 1462514518093,
            "tags": [],
            "relations": {},
            "dateAdded": "2016-05-06T06:01:58Z",
            "dateModified": "2016-05-06T06:01:58Z"
        }
    },
    {
        "key": "ITETZ762",
        "version": 79,
        "library": {
            "type": "group",
            "id": 504425,
            "name": "ALS 301 Paper",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/als_301_paper",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/504425/items/ITETZ762",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/als_301_paper/items/ITETZ762",
                "type": "text/html"
            },
            "up": {
                "href": "https://api.zotero.org/groups/504425/items/VUTHTIZP",
                "type": "application/json"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 2635034,
                "username": "vsadykov15",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/vsadykov15",
                        "type": "text/html"
                    }
                }
            }
        },
        "data": {
            "key": "ITETZ762",
            "version": 79,
            "parentItem": "VUTHTIZP",
            "itemType": "attachment",
            "linkMode": "imported_url",
            "title": "Selleck IC-87114",
            "accessDate": "2016-05-06T05:54:36Z",
            "url": "http://www.selleckchem.com/search.html?searchDTO.searchParam=IC-87114+&sp=IC-87114%252520",
            "note": "",
            "contentType": "text/html",
            "charset": "utf-8",
            "filename": "search.html",
            "md5": "ee316894fdc2d2626c04fcf758ddd431",
            "mtime": 1462514075217,
            "tags": [],
            "relations": {},
            "dateAdded": "2016-05-06T05:54:36Z",
            "dateModified": "2016-05-06T05:54:36Z"
        }
    },
    {
        "key": "K9ZTBHD5",
        "version": 79,
        "library": {
            "type": "group",
            "id": 504425,
            "name": "ALS 301 Paper",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/als_301_paper",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/504425/items/K9ZTBHD5",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/als_301_paper/items/K9ZTBHD5",
                "type": "text/html"
            },
            "up": {
                "href": "https://api.zotero.org/groups/504425/items/RKQM5REW",
                "type": "application/json"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 2635034,
                "username": "vsadykov15",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/vsadykov15",
                        "type": "text/html"
                    }
                }
            }
        },
        "data": {
            "key": "K9ZTBHD5",
            "version": 79,
            "parentItem": "RKQM5REW",
            "itemType": "attachment",
            "linkMode": "imported_url",
            "title": "Selleck IC-87114",
            "accessDate": "2016-05-06T05:54:34Z",
            "url": "http://www.selleckchem.com/search.html?searchDTO.searchParam=IC-87114+&sp=IC-87114%252520",
            "note": "",
            "contentType": "text/html",
            "charset": "utf-8",
            "filename": "search.html",
            "md5": "d5784b7b843cbc48d977e78e7b42ea3b",
            "mtime": 1462514074022,
            "tags": [],
            "relations": {},
            "dateAdded": "2016-05-06T05:54:34Z",
            "dateModified": "2016-05-06T05:54:34Z"
        }
    },
    {
        "key": "RKQM5REW",
        "version": 78,
        "library": {
            "type": "group",
            "id": 504425,
            "name": "ALS 301 Paper",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/als_301_paper",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/504425/items/RKQM5REW",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/als_301_paper/items/RKQM5REW",
                "type": "text/html"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 2635034,
                "username": "vsadykov15",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/vsadykov15",
                        "type": "text/html"
                    }
                }
            },
            "numChildren": 1
        },
        "data": {
            "key": "RKQM5REW",
            "version": 78,
            "itemType": "webpage",
            "title": "Selleck IC-87114",
            "creators": [],
            "abstractNote": "",
            "websiteTitle": "",
            "websiteType": "",
            "date": "",
            "publisher": "",
            "place": "",
            "DOI": "",
            "citationKey": "",
            "url": "http://www.selleckchem.com/search.html?searchDTO.searchParam=IC-87114+&sp=IC-87114%252520",
            "accessDate": "2016-05-06T05:54:33Z",
            "shortTitle": "",
            "language": "",
            "rights": "",
            "extra": "",
            "tags": [],
            "collections": [],
            "relations": {},
            "dateAdded": "2016-05-06T05:54:33Z",
            "dateModified": "2016-05-06T05:54:33Z"
        }
    },
    {
        "key": "GK9DA8RH",
        "version": 77,
        "library": {
            "type": "group",
            "id": 504425,
            "name": "ALS 301 Paper",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/als_301_paper",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/504425/items/GK9DA8RH",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/als_301_paper/items/GK9DA8RH",
                "type": "text/html"
            },
            "up": {
                "href": "https://api.zotero.org/groups/504425/items/U5ABFP3F",
                "type": "application/json"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 2635034,
                "username": "vsadykov15",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/vsadykov15",
                        "type": "text/html"
                    }
                }
            }
        },
        "data": {
            "key": "GK9DA8RH",
            "version": 77,
            "parentItem": "U5ABFP3F",
            "itemType": "attachment",
            "linkMode": "imported_url",
            "title": "Selleck cal-101",
            "accessDate": "2016-05-06T05:52:30Z",
            "url": "http://www.selleckchem.com/search.html?searchDTO.searchParam=cal-101&sp=cal-101",
            "note": "",
            "contentType": "text/html",
            "charset": "utf-8",
            "filename": "search.html",
            "md5": "c38739f34b4a946f4c3ca5e5df0218a5",
            "mtime": 1462513949934,
            "tags": [],
            "relations": {},
            "dateAdded": "2016-05-06T05:52:30Z",
            "dateModified": "2016-05-06T05:52:30Z"
        }
    },
    {
        "key": "U5ABFP3F",
        "version": 76,
        "library": {
            "type": "group",
            "id": 504425,
            "name": "ALS 301 Paper",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/als_301_paper",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/504425/items/U5ABFP3F",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/als_301_paper/items/U5ABFP3F",
                "type": "text/html"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 2635034,
                "username": "vsadykov15",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/vsadykov15",
                        "type": "text/html"
                    }
                }
            },
            "numChildren": 1
        },
        "data": {
            "key": "U5ABFP3F",
            "version": 76,
            "itemType": "webpage",
            "title": "Selleck cal-101",
            "creators": [],
            "abstractNote": "",
            "websiteTitle": "",
            "websiteType": "",
            "date": "",
            "publisher": "",
            "place": "",
            "DOI": "",
            "citationKey": "",
            "url": "http://www.selleckchem.com/search.html?searchDTO.searchParam=cal-101&sp=cal-101",
            "accessDate": "2016-05-06T05:52:29Z",
            "shortTitle": "",
            "language": "",
            "rights": "",
            "extra": "",
            "tags": [],
            "collections": [],
            "relations": {},
            "dateAdded": "2016-05-06T05:52:29Z",
            "dateModified": "2016-05-06T05:52:29Z"
        }
    },
    {
        "key": "DZ7FU29A",
        "version": 75,
        "library": {
            "type": "group",
            "id": 504425,
            "name": "ALS 301 Paper",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/als_301_paper",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/504425/items/DZ7FU29A",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/als_301_paper/items/DZ7FU29A",
                "type": "text/html"
            },
            "up": {
                "href": "https://api.zotero.org/groups/504425/items/BIFV8W8U",
                "type": "application/json"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 2635034,
                "username": "vsadykov15",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/vsadykov15",
                        "type": "text/html"
                    }
                }
            }
        },
        "data": {
            "key": "DZ7FU29A",
            "version": 75,
            "parentItem": "BIFV8W8U",
            "itemType": "attachment",
            "linkMode": "imported_url",
            "title": "Snapshot",
            "accessDate": "2016-05-06T03:39:01Z",
            "url": "http://www.fda.gov/drugs/informationondrugs/approveddrugs/ucm406410.htm",
            "note": "",
            "contentType": "text/html",
            "charset": "utf-8",
            "filename": "ucm406410.html",
            "md5": "3111b15a4e1ea97badf528e66972dbbd",
            "mtime": 1462505941295,
            "tags": [],
            "relations": {},
            "dateAdded": "2016-05-06T03:39:01Z",
            "dateModified": "2016-05-06T03:39:01Z"
        }
    },
    {
        "key": "BIFV8W8U",
        "version": 74,
        "library": {
            "type": "group",
            "id": 504425,
            "name": "ALS 301 Paper",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/als_301_paper",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/504425/items/BIFV8W8U",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/als_301_paper/items/BIFV8W8U",
                "type": "text/html"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 2635034,
                "username": "vsadykov15",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/vsadykov15",
                        "type": "text/html"
                    }
                }
            },
            "creatorSummary": "Research",
            "numChildren": 1
        },
        "data": {
            "key": "BIFV8W8U",
            "version": 74,
            "itemType": "webpage",
            "title": "Approved Drugs - Idelalisib",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Center for Drug Evaluation and",
                    "lastName": "Research"
                }
            ],
            "abstractNote": "News Burst",
            "websiteTitle": "",
            "websiteType": "WebContent",
            "date": "",
            "publisher": "",
            "place": "",
            "DOI": "",
            "citationKey": "",
            "url": "http://www.fda.gov/drugs/informationondrugs/approveddrugs/ucm406410.htm",
            "accessDate": "2016-05-06T03:38:59Z",
            "shortTitle": "",
            "language": "en",
            "rights": "",
            "extra": "",
            "tags": [],
            "collections": [],
            "relations": {},
            "dateAdded": "2016-05-06T03:38:59Z",
            "dateModified": "2016-05-06T03:38:59Z"
        }
    }
]