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It is encouraging that majority of patients do recover from the acute infection, however, those that progress to chronic disease state is at great risk of developing complications such as hepatocellular carcinoma, cirrhosis and liver failure. Hepatitis B virus infection can be influenced by many factors such as host immune status, age at infection, and level of viral replication. The discovery about the existence of various genotypes and its association with different geographic distribution as well as the knowledge regarding mutant species has aid us in better understanding the nature of HBV infection and in delivering better care for patients. It is especially important to recognize those individuals with HBeAg-negative chronic HBV as they have a poorer prognosis compare with their counterparts, HBeAg-positive. 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Although universal vaccination may be required for total eradication, several countries, including Japan, have not yet adopted universal vaccination programs. Some individuals are non-responders to HBV vaccine and several mechanisms responsible for their poor response have been proposed. To overcome non-response, third generation vaccines with pre-S proteins have been developed. These vaccines have shown better anti-HBs responses and may also be effective in preventing infection by HBV with S mutant. Improvement of vaccine efficacy by intradermal administration, or co-administration with cytokines or adjuvants, may also be effective in non-responders. 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"href": "https://api.zotero.org/groups/482022/items/GEX2UHJZ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/bioprocessing_als420/items/GEX2UHJZ", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2640379, "username": "KseniyaP", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kseniyap", "type": "text/html" } } }, "creatorSummary": "Ulmer et al.", "parsedDate": "2006-11", "numChildren": 1 }, "data": { "key": "GEX2UHJZ", "version": 24, "itemType": "journalArticle", "title": "Vaccine manufacturing: challenges and solutions", "creators": [ { "creatorType": "author", "firstName": "Jeffrey B", "lastName": "Ulmer" }, { "creatorType": "author", "firstName": "Ulrich", "lastName": "Valley" }, { "creatorType": "author", "firstName": "Rino", "lastName": "Rappuoli" } ], "abstractNote": "The recent influenza vaccine shortages have provided a timely reminder of the tenuous nature of the world's vaccine supply and the potential for 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J. M.", "lastName": "Vingerhoets" }, { "creatorType": "author", "firstName": "Frank G.", "lastName": "Oostveen" }, { "creatorType": "author", "firstName": "Hugo J.", "lastName": "Duivenvoorden" }, { "creatorType": "author", "firstName": "Rudy E.", "lastName": "Ballieux" } ], "abstractNote": "In a previous study it was shown that antibody formation after vaccination with a low-dose recombinant DNA (rDNA) hepatitis B vaccine was negatively influenced by psychological stress. The present study was designed to assess whether the same inverse relation between HBs-antibody levels and psychological stress could be observed, while administering the standard, and thus higher, dose of vaccine. Volunteers (n = 68) scoring extremely low or high on a combination of questionnaires measuring daily problems and psychoneurotic symptoms were selected for participation. Antibody levels were determined 2, 6, and 7 months after the first vaccination. Questionnaires were completed before entering the study and at month 6. In contrast to the previous study, psychological stress was not found to be related to the antibody levels at any timepoint. These results suggest that, under certain conditions, stress-induced immunomodulation in vivo might be dependent on antigen dose.", "publicationTitle": "Journal of Psychosomatic Research", "publisher": "", "place": "", "date": "August 1996", "volume": "41", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "129-137", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Journal of Psychosomatic Research", "DOI": "10.1016/0022-3999(96)00123-7", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/0022399996001237", "accessDate": "2016-02-29T18:57:28Z", "PMID": "", "PMCID": "", "ISSN": "0022-3999", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Hepatitis B", "type": 1 }, { "tag": "Psychological stress", "type": 1 }, { "tag": "Psychoneuroimmunology", "type": 1 }, { "tag": "Vaccination", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2016-02-29T18:57:28Z", "dateModified": "2016-02-29T18:57:28Z" } }, { "key": "CQ2WRBIV", "version": 8, "library": { "type": "group", "id": 482022, "name": "Bioprocessing ALS420", "links": { "alternate": { "href": "https://www.zotero.org/groups/bioprocessing_als420", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/482022/items/CQ2WRBIV", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/bioprocessing_als420/items/CQ2WRBIV", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/482022/items/I4NWJ34I", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2640379, "username": "KseniyaP", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kseniyap", "type": "text/html" } } } }, "data": { "key": "CQ2WRBIV", "version": 8, "parentItem": "I4NWJ34I", "itemType": "attachment", "linkMode": "linked_url", "title": "ScienceDirect Snapshot", "accessDate": "2016-02-29T18:57:28Z", "url": "http://www.sciencedirect.com/science/article/pii/0022399996001237", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2016-02-29T18:57:28Z", "dateModified": "2016-02-29T18:57:28Z" } }, { "key": "K6297ZNJ", "version": 7, "library": { "type": "group", "id": 482022, "name": "Bioprocessing ALS420", "links": { "alternate": { "href": "https://www.zotero.org/groups/bioprocessing_als420", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/482022/items/K6297ZNJ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/bioprocessing_als420/items/K6297ZNJ", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/482022/items/6R5352H7", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2640379, "username": "KseniyaP", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kseniyap", "type": "text/html" } } } }, "data": { "key": "K6297ZNJ", "version": 7, "parentItem": "6R5352H7", "itemType": "attachment", "linkMode": "linked_url", "title": "ScienceDirect Snapshot", "accessDate": "2016-02-29T18:55:25Z", "url": "http://www.sciencedirect.com/science/article/pii/0264410X90902095", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2016-02-29T18:55:25Z", "dateModified": "2016-02-29T18:55:25Z" } } ]