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Cited By :4

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To better clarify the role of drug therapy in AG, the authors summarized and discussed recent evidence on pharmacological treatments, based on clinical trials available from 2000, with the aim of highlighting pharmacotherapies that may improve this complex syndrome. Methods: A systematic review of the literature regarding the pharmacological treatment of AG was carried out using MEDLINE, EBSCO, and Cochrane databases, with keywords individuated by MeSH research. Only randomized, placebo-controlled studies or comparative clinical trials were included. Results: After selection, 25 studies were included. All the selected studies included patients with AG associated with panic disorder. Effective compounds included selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, tricyclic antidepressants, selective noradrenergic reuptake inhibitors, and benzodiazepines. Paroxetine, sertraline, citalopram, escitalopram, and clomipramine showed the most consistent results, while fluvoxamine, fluoxetine, and imipramine showed limited efficacy. Preliminary results suggested the potential efficacy of inositol; D-cycloserine showed mixed results for its ability to improve the outcome of exposure-based cognitive behavioral therapy. More studies with the latter compounds are needed before drawing definitive conclusions. Conclusion: No studies have been specifically oriented toward evaluating the effect of drugs on AG; in the available studies, the improvement of AG might have been the consequence of the reduction of panic attacks. Before developing a \"true\" psychopharmacology of AG it is crucial to clarify its definition. There may be several potential mechanisms involved, including fearlearning processes, balance system dysfunction, high light sensitivity, and impaired visuospatial abilities, but further studies are warranted. © 2011 Perna et al, publisher and licensee Dove Medical Press Ltd.", "publicationTitle": "Neuropsychiatric Disease and Treatment", "publisher": "", "place": "", "date": "2011", "volume": "7", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "621-637", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1176-6328", "archive": "Scopus", "archiveLocation": "", "shortTitle": "Antianxiety medications for the treatment of complex agoraphobia", "language": "English", "libraryCatalog": "Scopus", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Anxiety", "type": 1 }, { "tag": "Avoidance", "type": 1 }, { "tag": "Drug therapy", "type": 1 }, { "tag": "Panic", "type": 1 }, { "tag": "Pharmacological treatment", "type": 1 } ], "collections": [ "CTVVPCKS" ], "relations": {}, "dateAdded": "2016-01-30T19:02:58Z", "dateModified": "2016-01-30T19:02:58Z" } }, { "key": "TJGIC25S", "version": 2, "library": { "type": "group", "id": 471626, "name": "daria skvortsova latorre", "links": { "alternate": { "href": "https://www.zotero.org/groups/daria_skvortsova_latorre", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/471626/items/TJGIC25S", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/daria_skvortsova_latorre/items/TJGIC25S", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2697572, "username": "Fre Engl", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/fre_engl", "type": "text/html" } } }, "creatorSummary": "Perna", "parsedDate": "2012", "numChildren": 1 }, "data": { "key": "TJGIC25S", "version": 2, "itemType": "journalArticle", "title": "Panic disorder: From psychopathology to treatment", "creators": [ { "creatorType": "author", "firstName": "G.", "lastName": "Perna" } ], "abstractNote": "Panic disorder (PD) is a clinical entity which complexity can be organized in a \"march of panic\" whose organizing psychopathological principle is represented by the unexpected panic attacks. Panic phenomenology is defined not only by full blown and limited symptoms panic attacks but also by aborted panic attacks and shadows of panic. All together these phenomena are the expression of the psychobiological mechanisms abnormally activated in PD. The target of psychopharmacological treatment should be focused on panic phenomenology while the only effective psychotherapeutic intervention, cognitive behavioral therapy, should correct the cognitive distortions and the avoidant and protective behaviors that limit panic patient's freedom. A complete therapeutic approach should include also regular aerobic exercise and evidence based breathing therapy. Often the chronicization of PD is the results of mistakes in the diagnostic and therapeutic processes rather than a true treatment resistance.", "publicationTitle": "Journal of Psychopathology", "publisher": "", "place": "", "date": "2012", "volume": "18", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "82-91", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1592-1107", "archive": "Scopus", "archiveLocation": "", "shortTitle": "Panic disorder", "language": "English", "libraryCatalog": "Scopus", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "CBT", "type": 1 }, { "tag": "Drug treatment", "type": 1 }, { "tag": "Panic attacks", "type": 1 }, { "tag": "Panic disorder", "type": 1 }, { "tag": "Psychopathology", "type": 1 }, { "tag": "SSRI", "type": 1 } ], "collections": [ "CTVVPCKS" ], "relations": {}, "dateAdded": "2016-01-30T19:02:58Z", "dateModified": "2016-01-30T19:02:58Z" } } ]