[ { "key": "49PPJHEP", "version": 73, "library": { "type": "group", "id": 468664, "name": "BioRealm", "links": { "alternate": { "href": "https://www.zotero.org/groups/biorealm", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/468664/items/49PPJHEP", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biorealm/items/49PPJHEP", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2811919, "username": "m_gaddis", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/m_gaddis", "type": "text/html" } } }, "creatorSummary": "Saccone et al.", "parsedDate": "2009-04-21", "numChildren": 0 }, "data": { "key": "49PPJHEP", "version": 73, "itemType": "journalArticle", "title": "Supplementing High-Density SNP Microarrays for Additional Coverage of Disease-Related Genes: Addiction as a Paradigm", "creators": [ { "creatorType": "author", "firstName": "Scott F.", "lastName": "Saccone" }, { "creatorType": "author", "firstName": "Laura J.", "lastName": "Bierut" }, { "creatorType": "author", "firstName": "Elissa J.", "lastName": "Chesler" }, { "creatorType": "author", "firstName": "Peter W.", "lastName": "Kalivas" }, { "creatorType": "author", "firstName": "Caryn", "lastName": "Lerman" }, { "creatorType": "author", "firstName": "Nancy L.", "lastName": "Saccone" }, { "creatorType": "author", "firstName": "George R.", "lastName": "Uhl" }, { "creatorType": "author", "firstName": "Chuan-Yun", "lastName": "Li" }, { "creatorType": "author", "firstName": "Vivek M.", "lastName": "Philip" }, { "creatorType": "author", "firstName": "Howard J.", "lastName": "Edenberg" }, { "creatorType": "author", "firstName": "Stephen T.", "lastName": "Sherry" }, { "creatorType": "author", "firstName": "Michael", "lastName": "Feolo" }, { "creatorType": "author", "firstName": "Robert K.", "lastName": "Moyzis" }, { "creatorType": "author", "firstName": "Joni L.", "lastName": "Rutter" } ], "abstractNote": "Commercial SNP microarrays now provide comprehensive and affordable coverage of the human genome. However, some diseases have biologically relevant genomic regions that may require additional coverage. Addiction, for example, is thought to be influenced by complex interactions among many relevant genes and pathways. We have assembled a list of 486 biologically relevant genes nominated by a panel of experts on addiction. We then added 424 genes that showed evidence of association with addiction phenotypes through mouse QTL mappings and gene co-expression analysis. We demonstrate that there are a substantial number of SNPs in these genes that are not well represented by commercial SNP platforms. We address this problem by introducing a publicly available SNP database for addiction. The database is annotated using numeric prioritization scores indicating the extent of biological relevance. The scores incorporate a number of factors such as SNP/gene functional properties (including synonymy and promoter regions), data from mouse systems genetics and measures of human/mouse evolutionary conservation. We then used HapMap genotyping data to determine if a SNP is tagged by a commercial microarray through linkage disequilibrium. This combination of biological prioritization scores and LD tagging annotation will enable addiction researchers to supplement commercial SNP microarrays to ensure comprehensive coverage of biologically relevant regions.", "publicationTitle": "PLOS ONE", "publisher": "", "place": "", "date": "Apr 21, 2009", "volume": "4", "issue": "4", "section": "", "partNumber": "", "partTitle": "", "pages": "e5225", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "PLOS ONE", "DOI": "10.1371/journal.pone.0005225", "citationKey": "", "url": "http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005225", "accessDate": "2016-04-19T05:27:12Z", "PMID": "", "PMCID": "", "ISSN": "1932-6203", "archive": "", "archiveLocation": "", "shortTitle": "Supplementing High-Density SNP Microarrays for Additional Coverage of Disease-Related Genes", "language": "", "libraryCatalog": "PLoS Journals", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Addiction", "type": 1 }, { "tag": "Alcoholism", "type": 1 }, { "tag": "Genetics", "type": 1 }, { "tag": "Genome-wide association studies", "type": 1 }, { "tag": "Genomic databases", "type": 1 }, { "tag": "Mammalian genomics", "type": 1 }, { "tag": "Microarrays", "type": 1 }, { "tag": "NICOTINE addiction", "type": 1 } ], "collections": [ "HEDCUSSC" ], "relations": { "owl:sameAs": "http://zotero.org/groups/481369/items/9PB2U8FR" }, "dateAdded": "2016-04-19T05:27:40Z", "dateModified": "2016-04-19T05:27:40Z" } }, { "key": "CMEXWE7S", "version": 72, "library": { "type": "group", "id": 468664, "name": "BioRealm", "links": { "alternate": { "href": "https://www.zotero.org/groups/biorealm", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/468664/items/CMEXWE7S", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biorealm/items/CMEXWE7S", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2075492, "username": "knozaw14", "name": "", 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"4RHPKJGH", "itemType": "attachment", "linkMode": "linked_url", "title": "Full Text PDF", "accessDate": "2016-04-06T17:37:58Z", "url": "http://tobaccocontrol.bmj.com/content/early/2011/09/23/tc.2011.042739.full.pdf", "note": "", "contentType": "application/pdf", "charset": "", "tags": [], "relations": {}, "dateAdded": "2016-04-06T17:37:58Z", "dateModified": "2016-04-06T17:37:58Z" } }, { "key": "4RHPKJGH", "version": 70, "library": { "type": "group", "id": 468664, "name": "BioRealm", "links": { "alternate": { "href": "https://www.zotero.org/groups/biorealm", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/468664/items/4RHPKJGH", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biorealm/items/4RHPKJGH", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2811919, "username": "m_gaddis", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/m_gaddis", "type": "text/html" } } }, "creatorSummary": "Smerecnik et al.", "parsedDate": "2011-09-26", "numChildren": 3 }, "data": { "key": "4RHPKJGH", "version": 70, "itemType": "journalArticle", "title": "Effectiveness of testing for genetic susceptibility to smoking-related diseases on smoking cessation outcomes: a systematic review and meta-analysis", "creators": [ { "creatorType": "author", "firstName": "Chris", "lastName": "Smerecnik" }, { "creatorType": "author", "firstName": "Janaica E. J.", "lastName": "Grispen" }, { "creatorType": "author", "firstName": "Marieke", "lastName": "Quaak" } ], "abstractNote": "Objective To examine whether genetic testing for smoking-related diseases benefits smoking cessation.\nData sources PubMed, EMBASE, ERIC, PsycINFO, PsychArticles, CiNAHL and socINDEX databases, the search engine Google Scholar, and key-author and reference list searches.\nStudy selection Randomised controlled smoking cessation interventions using genetic testing for smoking-related diseases.\nData extraction Consistent with the Cochrane guidelines, two reviewers completed the review process (initial n=139) in three phases, title selection (n=56), abstract selection (n=28) and whole paper selection (n=9). From these nine studies, each reviewer extracted information about outcome measures and statistical and methodological quality.\nData synthesis Relevant data were abstracted from included papers and were subsequently subjected to meta-analysis.\nResults Interest in genetic testing was relatively high with 60-80% of smokers reporting to be interested. The authors observed positive short-term effects on risk perception, motivation to quit smoking and smoking cessation, but these effects fade at longer follow-ups. Importantly, the authors did not find any evidence of adverse effect of testing negative on the risk-predisposing gene.\nConclusions This systematic review does not provide solid evidence for the proposed beneficial effects of genetic testing for smoking-related diseases on smoking cessation, but does suggest the presence of an immediate motivational effect, such that genetic testing resulted in higher risk perception and more motivation to quit smoking.", "publicationTitle": "Tobacco Control", "publisher": "", "place": "", "date": "2011-09-26", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "tc.2011.042739", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Tob Control", "DOI": "10.1136/tc.2011.042739", "citationKey": "", "url": "http://tobaccocontrol.bmj.com/content/early/2011/09/23/tc.2011.042739", "accessDate": "2016-04-06T17:37:58Z", "PMID": "", "PMCID": "", "ISSN": ", 1468-3318", "archive": "", "archiveLocation": "", "shortTitle": "Effectiveness of testing for genetic susceptibility to smoking-related diseases on smoking cessation outcomes", "language": "en", "libraryCatalog": "tobaccocontrol.bmj.com", "callNumber": "", "rights": "", "extra": "PMID: 21948804", "tags": [ { "tag": "Genetic Testing", "type": 1 }, { "tag": "Smoking addiction", "type": 1 }, { "tag": "cessation", "type": 1 }, { "tag": "health services", "type": 1 }, { "tag": "meta-analysis", "type": 1 }, { "tag": "smoking caused disease", "type": 1 }, { "tag": "smoking cessation", "type": 1 }, { "tag": "systematic review", "type": 1 } ], "collections": [ "KERRWDJG" ], "relations": {}, "dateAdded": "2016-04-06T17:37:58Z", "dateModified": "2016-04-06T17:37:58Z" } }, { "key": "AEJ5UAGB", "version": 69, "library": { "type": "group", "id": 468664, "name": "BioRealm", "links": { "alternate": { "href": "https://www.zotero.org/groups/biorealm", "type": "text/html" } } }, "links": { "self": { "href": 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"2016-04-03T16:31:52Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/21678175", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2016-04-03T16:31:52Z", "dateModified": "2016-04-03T16:31:52Z" } }, { "key": "TDBJZWCG", "version": 67, "library": { "type": "group", "id": 468664, "name": "BioRealm", "links": { "alternate": { "href": "https://www.zotero.org/groups/biorealm", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/468664/items/TDBJZWCG", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biorealm/items/TDBJZWCG", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2042968, "username": "dwibow14", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/dwibow14", "type": "text/html" } } }, "creatorSummary": "Smerecnik et al.", "parsedDate": "2011-08", "numChildren": 1 }, "data": { "key": "TDBJZWCG", "version": 67, "itemType": "journalArticle", "title": "Are smokers interested in genetic testing for smoking addiction? A socio-cognitive approach", "creators": [ { "creatorType": "author", "firstName": "Chris", "lastName": "Smerecnik" }, { "creatorType": "author", "firstName": "Marieke", "lastName": "Quaak" }, { "creatorType": "author", "firstName": "Constant P.", "lastName": "van Schayck" }, { "creatorType": "author", "firstName": "Frederik-Jan", "lastName": "van Schooten" }, { "creatorType": "author", "firstName": "Hein", "lastName": "de Vries" } ], "abstractNote": "Genetic advances have made genetically tailored smoking cessation treatments possible. In this study, we examined whether smokers are interested in undergoing a genetic test to identify their genetic susceptibility to nicotine addiction. In addition, we aimed to identify socio-cognitive determinants of smokers' intention to undergo genetic testing. Following the protection motivation theory (PMT), we assessed the following constructs using an online survey among 587 smokers: threat appraisal (i.e. susceptibility and severity), fear, coping appraisal (i.e. response efficacy and self-efficacy), response costs and intention. In addition, knowledge, social norms and information-seeking behaviour were measured. Mean intention rates were 2.57 on a 5-point scale. Intention was significantly associated with threat appraisal and coping appraisal, as predicted by the PMT. Fear of the outcome was negatively associated with the intention to undergo genetic testing, but response costs, knowledge and social influence were not. Intention to undergo genetic testing in turn was positively related to seeking information about genetic testing and genetically tailored smoking cessation treatments. Smokers seem ambivalent or 'on the fence' with regard to undergoing a genetic test for smoking addiction. Socio-cognitive concepts such as susceptibility, severity, response efficacy and self-efficacy may be used to inform or educate smokers about the value of genetically tailored smoking cessation treatments.", "publicationTitle": "Psychology & Health", "publisher": "", "place": "", "date": "Aug 2011", "volume": "26", "issue": "8", "section": "", "partNumber": "", "partTitle": "", "pages": "1099-1112", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Psychol Health", "DOI": "10.1080/08870446.2010.541909", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1476-8321", "archive": "", "archiveLocation": "", "shortTitle": "Are smokers interested in genetic testing for smoking addiction?", "language": "eng", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "PMID: 21678175", "tags": [ { "tag": "Adult", "type": 1 }, { "tag": "Aged", "type": 1 }, { "tag": "Cognition", "type": 1 }, { "tag": "Data Collection", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Genetic Testing", "type": 1 }, { "tag": "Health Knowledge, Attitudes, Practice", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Intention", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Middle Aged", "type": 1 }, { "tag": "Netherlands", "type": 1 }, { "tag": "Psychological Theory", "type": 1 }, { "tag": "SMOKING", "type": 1 }, { "tag": "Social Control, Informal", "type": 1 }, { "tag": "Tobacco Use Disorder", "type": 1 }, { "tag": "Young Adult", "type": 1 } ], "collections": [ "KERRWDJG" ], "relations": {}, "dateAdded": "2016-04-03T16:31:52Z", "dateModified": "2016-04-03T16:31:52Z" } }, { "key": "GHAW9N8D", "version": 67, "library": { "type": "group", "id": 468664, "name": "BioRealm", "links": { "alternate": { "href": "https://www.zotero.org/groups/biorealm", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/468664/items/GHAW9N8D", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biorealm/items/GHAW9N8D", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2042968, "username": "dwibow14", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/dwibow14", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "GHAW9N8D", "version": 67, "itemType": "webpage", "title": "", "creators": [], "abstractNote": "", "websiteTitle": "", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://www-tandfonline-com.ccl.idm.oclc.org/doi/pdf/10.1080/08870446.2010.541909", "accessDate": "2016-04-03T16:31:38Z", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [ "KERRWDJG" ], "relations": {}, "dateAdded": "2016-04-03T16:31:38Z", "dateModified": "2016-04-03T16:31:38Z" } }, { "key": "QAACIZ5R", "version": 66, "library": { "type": "group", "id": 468664, "name": "BioRealm", "links": { "alternate": { "href": "https://www.zotero.org/groups/biorealm", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/468664/items/QAACIZ5R", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biorealm/items/QAACIZ5R", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/468664/items/8A7N5MV5", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2075492, "username": "knozaw14", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/knozaw14", "type": "text/html" } } } }, "data": { "key": "QAACIZ5R", "version": 66, "parentItem": "8A7N5MV5", "itemType": "attachment", "linkMode": "linked_url", "title": "Snapshot", "accessDate": "2016-04-02T22:35:09Z", "url": "http://papers.ssrn.com/sol3/papers.cfm?abstract_id=1418687", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2016-04-02T22:35:09Z", "dateModified": "2016-04-02T22:35:09Z" } }, { "key": "8A7N5MV5", "version": 66, "library": { "type": "group", "id": 468664, "name": "BioRealm", "links": { "alternate": { "href": "https://www.zotero.org/groups/biorealm", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/468664/items/8A7N5MV5", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biorealm/items/8A7N5MV5", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2075492, "username": "knozaw14", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/knozaw14", "type": "text/html" } } }, "creatorSummary": "Damodaran", "parsedDate": "2009-06-12", "numChildren": 2 }, "data": { "key": "8A7N5MV5", "version": 66, "itemType": "report", "title": "Valuing Young, Start-Up and Growth Companies: Estimation Issues and Valuation Challenges", "creators": [ { "creatorType": "author", "firstName": "Aswath", "lastName": "Damodaran" } ], "abstractNote": "Young companies are difficult to value for a number of reasons. 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