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State of art", "creators": [ { "creatorType": "author", "firstName": "Marianno", "lastName": "Franzini" }, { "creatorType": "author", "firstName": "Umberto", "lastName": "Tirelli" }, { "creatorType": "author", "firstName": "Luigi", "lastName": "Valdenassi" }, { "creatorType": "author", "firstName": "Francesco", "lastName": "Vaiano" }, { "creatorType": "author", "firstName": "Antonio Carlo", "lastName": "Galoforo" }, { "creatorType": "author", "firstName": "Giovanni", "lastName": "Ricevuti" }, { "creatorType": "author", "firstName": "Salvatore", "lastName": "Chirumbolo" } ], "abstractNote": "", "publicationTitle": "International Immunopharmacology", "publisher": "", "place": "", "date": "2024-08-20", "volume": "137", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "112489", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Int Immunopharmacol", "DOI": "10.1016/j.intimp.2024.112489", "citationKey": "", "url": "", "accessDate": "", "PMID": "38910083", "PMCID": "", "ISSN": "1878-1705", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Animals", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Oxygen", "type": 1 }, { "tag": "Oxygen Inhalation Therapy", "type": 1 }, { "tag": "Ozone", "type": 1 } ], "collections": [ "87STQD3Z" ], "relations": {}, "dateAdded": "2026-04-12T14:02:54Z", "dateModified": "2026-04-12T14:02:54Z" } }, { "key": "MUPUHWM9", "version": 9155, "library": { "type": "group", "id": 46074, "name": "Ozone Health Care", "links": { "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/46074/items/MUPUHWM9", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care/items/MUPUHWM9", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/46074/items/L2PA83HT", "type": "application/json" } }, "meta": { "createdByUser": { "id": 474198, "username": "gregorcuba", "name": "Data Base Manager", "links": { "alternate": { "href": "https://www.zotero.org/gregorcuba", "type": "text/html" } } } }, "data": { "key": "MUPUHWM9", "version": 9155, "parentItem": "L2PA83HT", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2026-04-12T14:01:02Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/40408806", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2026-04-12T14:01:02Z", "dateModified": "2026-04-12T14:01:02Z" } }, { "key": "L2PA83HT", "version": 9154, "library": { "type": "group", "id": 46074, "name": "Ozone Health Care", "links": { "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/46074/items/L2PA83HT", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care/items/L2PA83HT", "type": "text/html" } }, "meta": { "createdByUser": { "id": 474198, "username": "gregorcuba", "name": "Data Base Manager", "links": { "alternate": { "href": "https://www.zotero.org/gregorcuba", "type": "text/html" } } }, "creatorSummary": "Chirumbolo et al.", "parsedDate": "2025-07", "numChildren": 1 }, "data": { "key": "L2PA83HT", "version": 9154, "itemType": "journalArticle", "title": "Intravenous glutathione should not be mismatched with ozone as an antioxidant therapy", "creators": [ { "creatorType": "author", "firstName": "Salvatore", "lastName": "Chirumbolo" }, { "creatorType": "author", "firstName": "Marianno", "lastName": "Franzini" }, { "creatorType": "author", "firstName": "Giovanni", "lastName": "Ricevuti" }, { "creatorType": "author", "firstName": "Luigi", "lastName": "Valdenassi" } ], "abstractNote": "Intravenous (IV) glutathione (GSH) therapy is increasingly used as an antioxidant intervention, often perceived as interchangeable with ozone therapy. However, this article challenges that notion, highlighting significant biochemical differences and uses dynamic modelling, via Ordinary Differential Equations, the authors compare pharmacokinetics of IV-GSH versus endogenous GSH production stimulated by ozone. Findings indicate that IV-GSH induces non-physiological plasma concentrations, causing reductive stress and impairing mitochondrial and immune functions. In contrast, ozone elicits a controlled oxidative stimulus via the Nrf2 pathway, promoting adaptive, physiological GSH synthesis. Despite patient reports of symptom relief with high-dose IV antioxidants, these effects may reflect transient metabolic modulation or placebo influence, not sustainable therapeutic benefit. The study calls for a paradigm shift in redox-based therapies, emphasizing dose-dependent effects and advocating for physiological mimicry over pharmacological excess. Clinicians are urged to critically assess antioxidant interventions, recognizing the potential harms of reductive extremes alongside oxidative ones.", "publicationTitle": "Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie", "publisher": "", "place": "", "date": "2025-07", "volume": "188", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "118197", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Biomed Pharmacother", "DOI": "10.1016/j.biopha.2025.118197", "citationKey": "", "url": "", "accessDate": "", "PMID": "40408806", "PMCID": "", "ISSN": "1950-6007", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Administration, Intravenous", "type": 1 }, { "tag": "Animals", "type": 1 }, { "tag": "Antioxidants", "type": 1 }, { "tag": "Clinics", "type": 1 }, { "tag": "Glutathione", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "NADH", "type": 1 }, { "tag": "Oxidation-Reduction", "type": 1 }, { "tag": "Oxidative Stress", "type": 1 }, { "tag": "Ozone", "type": 1 }, { "tag": "Reductiive stress", "type": 1 } ], "collections": [ "77T6DF38" ], "relations": {}, "dateAdded": "2026-04-12T14:01:01Z", "dateModified": "2026-04-12T14:01:01Z" } }, { "key": "QVYYQ6MK", "version": 9153, "library": { "type": "group", "id": 46074, "name": "Ozone Health Care", "links": { "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/46074/items/QVYYQ6MK", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care/items/QVYYQ6MK", "type": "text/html" } }, "meta": { "createdByUser": { "id": 474198, "username": "gregorcuba", "name": "Data Base Manager", "links": { "alternate": { "href": "https://www.zotero.org/gregorcuba", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "QVYYQ6MK", "version": 9153, "itemType": "webpage", "title": "Ozone Therapy for Interstitial Cystitis and Bladder Pain Syndrome How can ozone help?", "creators": [], "abstractNote": "How ozone therapy can help with Interstitial Cystitis and Bladder Pain Syndrome", "websiteTitle": "", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "https://www.mediskill.com/ozone-therapy/ozone-therapy-for-interstitial-cystitis-and-bladder-pain-syndrome", "accessDate": "2026-04-12T13:58:01Z", "shortTitle": "", "language": "en", "rights": "", "extra": "", "tags": [], "collections": [ "3JRHBVUQ" ], "relations": {}, "dateAdded": "2026-04-12T13:58:01Z", "dateModified": "2026-04-12T13:58:01Z" } }, { "key": "MST543HV", "version": 9150, "library": { "type": "group", "id": 46074, "name": "Ozone Health Care", "links": { "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/46074/items/MST543HV", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care/items/MST543HV", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/46074/items/YT7TWX4X", "type": "application/json" } }, "meta": { "createdByUser": { "id": 474198, "username": "gregorcuba", "name": "Data Base Manager", "links": { "alternate": { "href": "https://www.zotero.org/gregorcuba", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "MST543HV", "version": 9150, "parentItem": "YT7TWX4X", "itemType": "attachment", "linkMode": "imported_file", "title": "PDF", "accessDate": "", "url": "", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Farina et al. - 2026 - Consensus Conference Use of Ozone in the Context of Regenerative Medicine. Recommendations from the.pdf", "md5": null, "mtime": null, "tags": [], "relations": {}, "dateAdded": "2026-04-09T15:59:19Z", "dateModified": "2026-04-09T15:59:19Z" } }, { "key": "YT7TWX4X", "version": 9149, "library": { "type": "group", "id": 46074, "name": "Ozone Health Care", "links": { "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/46074/items/YT7TWX4X", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care/items/YT7TWX4X", "type": "text/html" } }, "meta": { "createdByUser": { "id": 474198, "username": "gregorcuba", "name": "Data Base Manager", "links": { "alternate": { "href": "https://www.zotero.org/gregorcuba", "type": "text/html" } } }, "creatorSummary": "Farina et al.", "parsedDate": "2026", "numChildren": 1 }, "data": { "key": "YT7TWX4X", "version": 9149, "itemType": "journalArticle", "title": "Consensus Conference: Use of Ozone in the Context of Regenerative Medicine. Recommendations from the Italian Society of Multi-Specialist Regenerative Medicine and Surgery (SIMCRI)", "creators": [ { "creatorType": "author", "firstName": "Michele Angelo", "lastName": "Farina" }, { "creatorType": "author", "firstName": "Gregorio", "lastName": "Martínez-Sanchez" }, { "creatorType": "author", "firstName": "M", "lastName": "Danese" }, { "creatorType": "author", "firstName": "A.", "lastName": "Alexandre" }, { "creatorType": "author", "firstName": "G", "lastName": "Caloprisco" }, { "creatorType": "author", "firstName": "R", "lastName": "Miranda" } ], "abstractNote": "", "publicationTitle": "European Journal of Musculoskeletal Diseases", "publisher": "", "place": "", "date": "2026", "volume": "15", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "G6HU5DKE" ], "relations": {}, "dateAdded": "2026-04-09T15:56:41Z", "dateModified": "2026-04-09T15:59:10Z" } }, { "key": "57NCN7CG", "version": 9135, "library": { "type": "group", "id": 46074, "name": "Ozone Health Care", "links": { "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/46074/items/57NCN7CG", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care/items/57NCN7CG", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/46074/items/27SVSRP2", "type": "application/json" } }, "meta": { "createdByUser": { "id": 474198, "username": "gregorcuba", "name": "Data Base Manager", "links": { "alternate": { "href": "https://www.zotero.org/gregorcuba", "type": "text/html" } } } }, "data": { "key": "57NCN7CG", "version": 9135, "parentItem": "27SVSRP2", "itemType": "attachment", "linkMode": "imported_url", "title": "Snapshot", "accessDate": "2026-04-09T15:51:07Z", "url": "https://www.labpublishers.com/ejmd/consensus-conference-use-of-ozone-in-the-context-of-regenerative-medicine-recommendations-from-the-italian-society-of-multi-specialist-regenerative-medicine-and-surgery-simcri/", "note": "", "contentType": "text/html", "charset": "utf-8", "filename": "consensus-conference-use-of-ozone-in-the-context-of-regenerative-medicine-recommendations-from-.html", "md5": null, "mtime": null, "tags": [], "relations": {}, "dateAdded": "2026-04-09T15:51:07Z", "dateModified": "2026-04-09T15:51:07Z" } }, { "key": "NYRBN24L", "version": 9131, "library": { "type": "group", "id": 46074, "name": "Ozone Health Care", "links": { "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/46074/items/NYRBN24L", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care/items/NYRBN24L", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/46074/items/LFVB7CBK", "type": "application/json" } }, "meta": { "createdByUser": { "id": 474198, "username": "gregorcuba", "name": "Data Base Manager", "links": { "alternate": { "href": "https://www.zotero.org/gregorcuba", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "NYRBN24L", "version": 9131, "parentItem": "LFVB7CBK", "itemType": "attachment", "linkMode": "imported_file", "title": "PDF", "accessDate": "", "url": "", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Saxena et al. - 2026 - Evaluating the Efficacy of Ozone Therapy in Fibromyalgia.pdf", "md5": null, "mtime": null, "tags": [], "relations": {}, "dateAdded": "2026-04-09T14:14:12Z", "dateModified": "2026-04-09T14:14:12Z" } }, { "key": "ZPYDYX7M", "version": 9130, "library": { "type": "group", "id": 46074, "name": "Ozone Health Care", "links": { "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/46074/items/ZPYDYX7M", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care/items/ZPYDYX7M", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/46074/items/LFVB7CBK", "type": "application/json" } }, "meta": { "createdByUser": { "id": 474198, "username": "gregorcuba", "name": "Data Base Manager", "links": { "alternate": { "href": "https://www.zotero.org/gregorcuba", "type": "text/html" } } } }, "data": { "key": "ZPYDYX7M", "version": 9130, "parentItem": "LFVB7CBK", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2026-04-09T14:11:04Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/41943556", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2026-04-09T14:11:04Z", "dateModified": "2026-04-09T14:11:04Z" } }, { "key": "LFVB7CBK", "version": 9129, "library": { "type": "group", "id": 46074, "name": "Ozone Health Care", "links": { "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/46074/items/LFVB7CBK", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care/items/LFVB7CBK", "type": "text/html" } }, "meta": { "createdByUser": { "id": 474198, "username": "gregorcuba", "name": "Data Base Manager", "links": { "alternate": { "href": "https://www.zotero.org/gregorcuba", "type": "text/html" } } }, "creatorSummary": "Saxena et al.", "parsedDate": "2026-04-07", "numChildren": 2 }, "data": { "key": "LFVB7CBK", "version": 9129, "itemType": "journalArticle", "title": "Evaluating the Efficacy of Ozone Therapy in Fibromyalgia", "creators": [ { "creatorType": "author", "firstName": "Prakhar", "lastName": "Saxena" }, { "creatorType": "author", "firstName": "Satyalakshmi", "lastName": "Komarraju" }, { "creatorType": "author", "firstName": "D.", "lastName": "Sathyanath" }, { "creatorType": "author", "firstName": "Shrikanth", "lastName": "Muralidharan" } ], "abstractNote": "Fibromyalgia is a chronic disorder, characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and psychological distress, with limited efficacy from conventional treatments. Ozone therapy, a medical approach that induces controlled oxidative stress to enhance antioxidant defences and modulate immune responses, has emerged as a potential complementary intervention. Evidence suggests that ozone therapy improves pain, fatigue, and sleep quality by correcting oxidative imbalances, enhancing oxygen utilization, and regulating inflammatory pathways. Clinical studies, report significant symptom relief in up to 70% of patients, with minimal adverse effects when administered according to standardized protocols. Despite promising outcomes, the current literature is constrained by small sample sizes, heterogeneity in study designs, and limited long-term follow-up data. Future research should focus on large-scale, well-designed trials, standardized treatment protocols, and mechanistic studies to establish ozone therapy's role in fibromyalgia management.", "publicationTitle": "Annals of African Medicine", "publisher": "", "place": "", "date": "2026-04-07", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Ann Afr Med", "DOI": "10.4103/aam.aam_682_25", "citationKey": "", "url": "", "accessDate": "", "PMID": "41943556", "PMCID": "", "ISSN": "0975-5764", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "fre, eng", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Antioxidant defence", "type": 1 }, { "tag": "Défense antioxydante", "type": 1 }, { "tag": "chronic pain", "type": 1 }, { "tag": "douleur chronique", "type": 1 }, { "tag": "du sommeil", "type": 1 }, { "tag": "fibromyalgia", "type": 1 }, { "tag": "fibromyalgie", "type": 1 }, { "tag": "immune modulation", "type": 1 }, { "tag": "modulation immunitaire", "type": 1 }, { "tag": "médecine complémentaire", "type": 1 }, { "tag": "oxidative stress", "type": 1 }, { "tag": "ozone therapy", "type": 1 }, { "tag": "ozonothérapie", "type": 1 }, { "tag": "qualité", "type": 1 }, { "tag": "stress oxydatif", "type": 1 } ], "collections": [ "7FIHMJKH" ], "relations": {}, "dateAdded": "2026-04-09T14:11:03Z", "dateModified": "2026-04-09T14:11:03Z" } }, { "key": "R3VT53AJ", "version": 9126, "library": { "type": "group", "id": 46074, "name": "Ozone Health Care", "links": { "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/46074/items/R3VT53AJ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care/items/R3VT53AJ", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/46074/items/567A2PB5", "type": "application/json" } }, "meta": { "createdByUser": { "id": 474198, "username": "gregorcuba", "name": "Data Base Manager", "links": { "alternate": { "href": "https://www.zotero.org/gregorcuba", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "R3VT53AJ", "version": 9126, "parentItem": "567A2PB5", "itemType": "attachment", "linkMode": "imported_url", "title": "Full Text", "accessDate": "2026-04-05T15:12:32Z", "url": "https://public-pages-files-2025.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1780893/pdf", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Zhang et al. - 2026 - Ozone therapy in femoral head necrosis a perspective on biomarker-guided treatment rationalization.pdf", "md5": null, "mtime": null, "tags": [], "relations": {}, "dateAdded": "2026-04-05T15:12:32Z", "dateModified": "2026-04-05T15:12:32Z" } }, { "key": "JTVNCK7U", "version": 9127, "library": { "type": "group", "id": 46074, "name": "Ozone Health Care", "links": { "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/46074/items/JTVNCK7U", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care/items/JTVNCK7U", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/46074/items/567A2PB5", "type": "application/json" } }, "meta": { "createdByUser": { "id": 474198, "username": "gregorcuba", "name": "Data Base Manager", "links": { "alternate": { "href": "https://www.zotero.org/gregorcuba", "type": "text/html" } } } }, "data": { "key": "JTVNCK7U", "version": 9127, "parentItem": "567A2PB5", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2026-04-05T15:12:30Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/41924738", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2026-04-05T15:12:30Z", "dateModified": "2026-04-05T15:12:30Z" } }, { "key": "567A2PB5", "version": 9125, "library": { "type": "group", "id": 46074, "name": "Ozone Health Care", "links": { "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/46074/items/567A2PB5", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care/items/567A2PB5", "type": "text/html" } }, "meta": { "createdByUser": { "id": 474198, "username": "gregorcuba", "name": "Data Base Manager", "links": { "alternate": { "href": "https://www.zotero.org/gregorcuba", "type": "text/html" } } }, "creatorSummary": "Zhang et al.", "parsedDate": "2026", "numChildren": 2 }, "data": { "key": "567A2PB5", "version": 9125, "itemType": "journalArticle", "title": "Ozone therapy in femoral head necrosis: a perspective on biomarker-guided treatment rationalization and mechanistic exploration", "creators": [ { "creatorType": "author", "firstName": "Liang", "lastName": "Zhang" }, { "creatorType": "author", "firstName": "Qing-Hua", "lastName": "Wang" }, { "creatorType": "author", "firstName": "Xu-Ting", "lastName": "Zhao" }, { "creatorType": "author", "firstName": "Yu-Mei", "lastName": "Ding" }, { "creatorType": "author", "firstName": "Xiao-Dong", "lastName": "Wang" }, { "creatorType": "author", "firstName": "Zhi-Feng", "lastName": "Zhang" }, { "creatorType": "author", "firstName": "Mu-Han", "lastName": "Na" }, { "creatorType": "author", "firstName": "Yi-Fan", "lastName": "Zhao" }, { "creatorType": "author", "firstName": "Yi", "lastName": "Qiu" }, { "creatorType": "author", "firstName": "Liang-Liang", "lastName": "He" } ], "abstractNote": "Femoral head necrosis (FHN) is a progressive and disabling disorder caused by compromised blood supply to the femoral head. Current treatments primarily aim to slow progression. However, they often fail to reverse early-stage necrosis or reliably prevent disease advancement. Importantly, most approaches lack precise molecular targets for early intervention. Ozone therapy has emerged as a potential option because of its pleiotropic biological effects, such as modulating oxidative stress, improving microcirculation, and exerting anti-inflammatory activity. However, its mechanisms remain poorly understood. Clinical evidence is limited and inconsistent, and the absence of standardized protocols hinders evidence-based implementation. To address these gaps, this perspective proposes biomarkers as a translational bridge linking ozone-induced biological responses to FHN pathology. We further outline a dynamic, biomarker-guided framework through which ozone therapy can evolve from an empirical intervention into a mechanism-informed, personalized, and more standardized precision strategy. This approach offers a scientifically grounded pathway for advancing the clinical management of FHN.", "publicationTitle": "Frontiers in Medicine", "publisher": "", "place": "", "date": "2026", "volume": "13", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "1780893", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Front Med (Lausanne)", "DOI": "10.3389/fmed.2026.1780893", "citationKey": "", "url": "", "accessDate": "", "PMID": "41924738", "PMCID": "PMC13036745", "ISSN": "2296-858X", "archive": "", "archiveLocation": "", "shortTitle": "Ozone therapy in femoral head necrosis", "language": "eng", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "biomarkers", "type": 1 }, { "tag": "bone remodeling", "type": 1 }, { "tag": "femoral head necrosis", "type": 1 }, { "tag": "oxidative stress", "type": 1 }, { "tag": "ozone therapy", "type": 1 }, { "tag": "personalized medicine", "type": 1 }, { "tag": "precision medicine", "type": 1 }, { "tag": "translational research", "type": 1 } ], "collections": [ "5QCR6U5P" ], "relations": {}, "dateAdded": "2026-04-05T15:12:29Z", "dateModified": "2026-04-05T15:12:29Z" } }, { "key": "L85JJZSX", "version": 9123, "library": { "type": "group", "id": 46074, "name": "Ozone Health Care", "links": { "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/46074/items/L85JJZSX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care/items/L85JJZSX", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/46074/items/F44EBUMG", "type": "application/json" } }, "meta": { "createdByUser": { "id": 474198, "username": "gregorcuba", "name": "Data Base Manager", "links": { "alternate": { "href": "https://www.zotero.org/gregorcuba", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "L85JJZSX", "version": 9123, "parentItem": "F44EBUMG", "itemType": "attachment", "linkMode": "imported_url", "title": "Full Text PDF", "accessDate": "2026-04-05T13:08:57Z", "url": "https://ojs.brazilianjournals.com.br/ojs/index.php/BJAER/article/download/86415/58808", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Carranza et al. - 2026 - Ozonoterapia como tratamiento de heridas y lesiones dermatológicas en perros.pdf", "md5": null, "mtime": null, "tags": [], "relations": {}, "dateAdded": "2026-04-05T13:08:57Z", "dateModified": "2026-04-05T13:08:57Z" } }, { "key": "F44EBUMG", "version": 9122, "library": { "type": "group", "id": 46074, "name": "Ozone Health Care", "links": { "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/46074/items/F44EBUMG", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care/items/F44EBUMG", "type": "text/html" } }, "meta": { "createdByUser": { "id": 474198, "username": "gregorcuba", "name": "Data Base Manager", "links": { "alternate": { "href": "https://www.zotero.org/gregorcuba", "type": "text/html" } } }, "creatorSummary": "Carranza et al.", "parsedDate": "2026-03-30", "numChildren": 1 }, "data": { "key": "F44EBUMG", "version": 9122, "itemType": "journalArticle", "title": "Ozonoterapia como tratamiento de heridas y lesiones dermatológicas en perros", "creators": [ { "creatorType": "author", "firstName": "Benjamín Valladares", "lastName": "Carranza" }, { "creatorType": "author", "firstName": "Yesica Itzhel", "lastName": "Vázquez-Romero" }, { "creatorType": "author", "firstName": "Lucia", "lastName": "Delgadillo-Ruiz" }, { "creatorType": "author", "firstName": "Nallely", "lastName": "Rivero-Pérez" }, { "creatorType": "author", "firstName": "Adrián Zaragoza", "lastName": "Bastida" }, { "creatorType": "author", "firstName": "Rómulo", "lastName": "Bañuelos-Valenzuela" }, { "creatorType": "author", "firstName": "Alejandro", "lastName": "Córdova-Izquierdo" }, { "creatorType": "author", "firstName": "José Luis Carlos Bedolla", "lastName": "Cedeño" } ], "abstractNote": "", "publicationTitle": "Brazilian Journal of Animal and Environmental Research", "publisher": "", "place": "", "date": "2026-03-30", "volume": "9", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "e86415-e86415", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.34188/bjaerv9n1-216", "citationKey": "", "url": "https://ojs.brazilianjournals.com.br/ojs/index.php/BJAER/article/view/86415", "accessDate": "2026-04-05T13:08:54Z", "PMID": "", "PMCID": "", "ISSN": "2595-573X", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "pt", "libraryCatalog": "ojs.brazilianjournals.com.br", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "heridas", "type": 1 }, { "tag": "ozonoterapia", "type": 1 }, { "tag": "perro", "type": 1 }, { "tag": "piel", "type": 1 } ], "collections": [ "J3WAS2VG" ], "relations": {}, "dateAdded": "2026-04-05T13:08:54Z", "dateModified": "2026-04-05T13:08:54Z" } }, { "key": "P8NVBVAG", "version": 9121, "library": { "type": "group", "id": 46074, "name": "Ozone Health Care", "links": { "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/46074/items/P8NVBVAG", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care/items/P8NVBVAG", "type": "text/html" } }, "meta": { "createdByUser": { "id": 474198, "username": "gregorcuba", "name": "Data Base Manager", "links": { "alternate": { "href": "https://www.zotero.org/gregorcuba", "type": "text/html" } } }, "creatorSummary": "Kuculmez", "parsedDate": "2026-02-13", "numChildren": 1 }, "data": { "key": "P8NVBVAG", "version": 9121, "itemType": "journalArticle", "title": "Efficacy of major ozone autohemotherapy in patients with post-COVID syndrome", "creators": [ { "creatorType": "author", "firstName": "Ozlem", "lastName": "Kuculmez" } ], "abstractNote": "Background and objectivesIt has been suggested that medical ozone treatment may be used for post-COVID syndrome, but there is still a lack of evidence. The aim of the study is to investigate the efficacy of medical ozone treatment in fatigue, anxiety, depression, quality of life, and quality of sleep in patients diagnosed with post-COVID syndrome.Materials and methodsThe study was designed as a retrospective medical records review study. It was conducted at Baskent University in patients who had been diagnosed with post-COVID syndrome and accepted 10 sessions of major ozone autohemotherapy. Demographic data, FACIT Fatigue Scale, Beck Depression Inventory, Beck Anxiety Inventory, Pittsburgh Sleep Quality Index, and Short Form−36 scores were obtained from the hospital database. The scores before and after treatment were compared statistically. p < 0.05 was revealed as statistically significant.ResultsA total of 40 patients were analyzed. Thirty two of them were female, and eight of them were male. It was determined that both Beck Anxiety Inventory and Beck Depression Inventory scores were decreased after ozone application (p < 0.05). Statistically significant decreases in FACIT scores were obtained after 10 sessions of major blood ozonation (p < 0.05). Additionally, improvement in all subscores of Short Form-36 was determined after the medical ozone treatment (p < 0.05).ConclusionThe patients suffering from post-COVID syndrome may benefit from major blood ozonation. The treatment may be one of the complementary treatments after COVID-19 infection.", "publicationTitle": "Frontiers in Medicine", "publisher": "Frontiers", "place": "", "date": "2026-02-13", "volume": "13", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Front. Med.", "DOI": "10.3389/fmed.2026.1720578", "citationKey": "", "url": "https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1720578/full", "accessDate": "2026-02-14T16:21:15Z", "PMID": "41767530", "PMCID": "", "ISSN": "2296-858X", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "English", "libraryCatalog": "Frontiers", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "complementary therapies", "type": 1 }, { "tag": "coronavirus", "type": 1 }, { "tag": "fatigue", "type": 1 }, { "tag": "musculoskeletal diseases", "type": 1 }, { "tag": "ozone", "type": 1 }, { "tag": "pain", "type": 1 } ], "collections": [ "DDCVFBPP" ], "relations": {}, "dateAdded": "2026-02-14T16:21:15Z", "dateModified": "2026-04-04T16:05:01Z" } }, { "key": "BY4KNIKH", "version": 9119, "library": { "type": "group", "id": 46074, "name": "Ozone Health Care", "links": { "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/46074/items/BY4KNIKH", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care/items/BY4KNIKH", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/46074/items/5YRLIT6X", "type": "application/json" } }, "meta": { "createdByUser": { "id": 474198, "username": "gregorcuba", "name": "Data Base Manager", "links": { "alternate": { "href": "https://www.zotero.org/gregorcuba", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "BY4KNIKH", "version": 9119, "parentItem": "5YRLIT6X", "itemType": "attachment", "linkMode": "imported_url", "title": "Full Text", "accessDate": "2026-04-04T15:57:40Z", "url": "https://www.epain.org/journal/download_pdf.php?doi=10.3344/kjp.22221", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Atar et al. - 2023 - Comparison of ultrasound-guided subacromial corticosteroid and ozone (O2-O3) injections in the treat.pdf", "md5": null, "mtime": null, "tags": [], "relations": {}, "dateAdded": "2026-04-04T15:57:40Z", "dateModified": "2026-04-04T15:57:40Z" } }, { "key": "B2M766AV", "version": 9118, "library": { "type": "group", "id": 46074, "name": "Ozone Health Care", "links": { "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/46074/items/B2M766AV", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care/items/B2M766AV", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/46074/items/5YRLIT6X", "type": "application/json" } }, "meta": { "createdByUser": { "id": 474198, "username": "gregorcuba", "name": "Data Base Manager", "links": { "alternate": { "href": "https://www.zotero.org/gregorcuba", "type": "text/html" } } } }, "data": { "key": "B2M766AV", "version": 9118, "parentItem": "5YRLIT6X", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2026-04-04T15:57:27Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/36533317", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2026-04-04T15:57:27Z", "dateModified": "2026-04-04T15:57:27Z" } }, { "key": "5YRLIT6X", "version": 9117, "library": { "type": "group", "id": 46074, "name": "Ozone Health Care", "links": { "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/46074/items/5YRLIT6X", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care/items/5YRLIT6X", "type": "text/html" } }, "meta": { "createdByUser": { "id": 474198, "username": "gregorcuba", "name": "Data Base Manager", "links": { "alternate": { "href": "https://www.zotero.org/gregorcuba", "type": "text/html" } } }, "creatorSummary": "Atar et al.", "parsedDate": "2023-01-01", "numChildren": 2 }, "data": { "key": "5YRLIT6X", "version": 9117, "itemType": "journalArticle", "title": "Comparison of ultrasound-guided subacromial corticosteroid and ozone (O2-O3) injections in the treatment of chronic rotator cuff tendinopathy: a randomized clinical trial", "creators": [ { "creatorType": "author", "firstName": "Merve Örücü", "lastName": "Atar" }, { "creatorType": "author", "firstName": "Nurdan", "lastName": "Korkmaz" }, { "creatorType": "author", "firstName": "Sefa Gümrük", "lastName": "Aslan" }, { "creatorType": "author", "firstName": "Özge", "lastName": "Tezen" }, { "creatorType": "author", "firstName": "Sinem Uyar", "lastName": "Köylü" }, { "creatorType": "author", "firstName": "Yasin", "lastName": "Demir" }, { "creatorType": "author", "firstName": "Serdar", "lastName": "Kesikburun" } ], "abstractNote": "BACKGROUND: : The authors aimed to compare the effects of a one-time ultrasound (US)-guided subacromial corticosteroid injection and three-time ozone (O2-O3) injection in patients with chronic supraspinatus tendinopathy.\nMETHODS: : Participants were randomly assigned to the corticosteroid group (n = 22) or ozone group (n = 22). Injections in both groups were administered into subacromial bursa with an US-guided in-plane posterolateral approach. Primary outcome measure was the change in the Western Ontario Rotator Cuff Index (WORC) score between baseline and 12-weeks post-injection. Secondary outcome measures included visual analog scale and Shoulder Pain and Disability Index scores. Assessments were recorded at baseline, and 4-weeks and 12-weeks post-injection.\nRESULTS: : Forty participants completed this study. Based on repeated measurement analysis of variance, a significant effect of time was found for all outcome measures in both groups. Both the groups showed clinically significant improvements in shoulder pain, quality of life, and function. Baseline, 4-week post-injection, and 12-week post-injection WORC scores (mean ± standard deviation) were 57.91 ± 18.97, 39.10 ± 20.50 and 37.22 ± 27.31 in the corticosteroid group, respectively and 69.03 ± 15.89, 39.11 ± 24.36, and 32.26 ± 24.58 in the ozone group, respectively. However, no significant group × time interaction was identified regarding all outcome measures.\nCONCLUSIONS: : Three-time ozone injection was not superior to a one-time corticosteroid injection in patients with chronic supraspinatus tendinopathy. It might be as effective as corticosteroid injection at 4-weeks and 12-weeks post-injection in terms of relieving pain and improving quality of life and function.", "publicationTitle": "The Korean Journal of Pain", "publisher": "", "place": "", "date": "2023-01-01", "volume": "36", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "128-136", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Korean J Pain", "DOI": "10.3344/kjp.22221", "citationKey": "", "url": "", "accessDate": "", "PMID": "36533317", "PMCID": "PMC9812695", "ISSN": "2005-9159", "archive": "", "archiveLocation": "", "shortTitle": "Comparison of ultrasound-guided subacromial corticosteroid and ozone (O2-O3) injections in the treatment of chronic rotator cuff tendinopathy", "language": "eng", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Adrenal Cortex Hormones", "type": 1 }, { "tag": "Bursa", "type": 1 }, { "tag": "Interventional.", "type": 1 }, { "tag": "Ozone", "type": 1 }, { "tag": "Pain Management", "type": 1 }, { "tag": "Rotator Cuff", "type": 1 }, { "tag": "Shoulder Pain", "type": 1 }, { "tag": "Steroids", "type": 1 }, { "tag": "Synovial", "type": 1 }, { "tag": "Tendinopathy", "type": 1 }, { "tag": "Ultrasonography", "type": 1 } ], "collections": [ "5QCR6U5P" ], "relations": {}, "dateAdded": "2026-04-04T15:57:25Z", "dateModified": "2026-04-04T15:57:25Z" } }, { "key": "DDRRUL3A", "version": 9116, "library": { "type": "group", "id": 46074, "name": "Ozone Health Care", "links": { "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/46074/items/DDRRUL3A", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care/items/DDRRUL3A", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/46074/items/J9KXPPLX", "type": "application/json" } }, "meta": { "createdByUser": { "id": 474198, "username": "gregorcuba", "name": "Data Base Manager", "links": { "alternate": { "href": "https://www.zotero.org/gregorcuba", "type": "text/html" } } } }, "data": { "key": "DDRRUL3A", "version": 9116, "parentItem": "J9KXPPLX", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2026-04-04T15:54:24Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/39014873", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2026-04-04T15:54:24Z", "dateModified": "2026-04-04T15:54:24Z" } }, { "key": "J9KXPPLX", "version": 9115, "library": { "type": "group", "id": 46074, "name": "Ozone Health Care", "links": { "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/46074/items/J9KXPPLX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care/items/J9KXPPLX", "type": "text/html" } }, "meta": { "createdByUser": { "id": 474198, "username": "gregorcuba", "name": "Data Base Manager", "links": { "alternate": { "href": "https://www.zotero.org/gregorcuba", "type": "text/html" } } }, "creatorSummary": "Atcı et al.", "parsedDate": "2024-07-17", "numChildren": 1 }, "data": { "key": "J9KXPPLX", "version": 9115, "itemType": "journalArticle", "title": "Effects of Ozone Disc Nucleolysis in Management of Herniated Lumbar Intervertebral Disc: A Retrospective Single-Center Study of 149 Patients", "creators": [ { "creatorType": "author", "firstName": "Ibrahim Burak", "lastName": "Atcı" }, { "creatorType": "author", "firstName": "Okan", "lastName": "Turk" }, { "creatorType": "author", "firstName": "Nail", "lastName": "Demirel" }, { "creatorType": "author", "firstName": "Huseyin", "lastName": "Demir" }, { "creatorType": "author", "firstName": "Aysel", "lastName": "Gurcan Atci" }, { "creatorType": "author", "firstName": "Adil Can", "lastName": "Karaoglu" }, { "creatorType": "author", "firstName": "Yesim", "lastName": "Abut" }, { "creatorType": "author", "firstName": "Hakan", "lastName": "Yilmaz" } ], "abstractNote": "BACKGROUND Lower back pain is a common problem in the general population. Medical treatment is the first choice for patients without severe pain and major motor weakness. If patients do not benefit from conservative treatment, minimally invasive treatment is recommended. Ozone nucleolysis has recently been used to reduce pain and inflammation in herniated discs and other spinal conditions. This retrospective study from a single center aimed to evaluate the effects of ozone disc nucleolysis in the management of 149 patients with herniated lumbar intervertebral discs from 2022 to 2024. MATERIAL AND METHODS Between 2022 and 2024, intradiscal ozone nucleolysis was performed under operating room C-arm scopy in 149 patients who received medical treatment and physical therapy without surgical indication but did not benefit, and the results were evaluated retrospectively. Visual Analog Scale (VAS) scores and Oswestry Disability Index (ODI) scores were recorded before the procedure, and at 1 month, 3 months, 6 months, and 1 year. RESULTS The study enrolled 149 patients, comprising 61 males and 88 females, with an overall mean age of 43.9±4.7 years. The procedure was performed as 1 level in 138 patients and 2 levels in 11 patients. Among patients who underwent procedures based on lumbar MRI findings, 15 involved the L3-L4 intervertebral disc, 3 involved both the L3-L4 and L4-L5 discs, 90 involved the L4-L5 disc, and 31 involved the L5-S1 disc. Post-procedure VAS scores were significantly different at 1 month and 6 months (P<0.05). Post-procedure ODI scores were also significantly different at 1 month and 6 months. CONCLUSIONS Due to its low complication rate and effectiveness in treating lumbar disc herniation, ozone chemonucleolysis should be considered for use in patients who do not have a surgical indication or do not accept surgical intervention and did not benefit from medical treatment and physical therapy.", "publicationTitle": "Medical Science Monitor: International Medical Journal of Experimental and Clinical Research", "publisher": "", "place": "", "date": "2024-07-17", "volume": "30", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "e944645", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Med Sci Monit", "DOI": "10.12659/MSM.944645", "citationKey": "", "url": "", "accessDate": "", "PMID": "39014873", "PMCID": "PMC11302184", "ISSN": "1643-3750", "archive": "", "archiveLocation": "", "shortTitle": "Effects of Ozone Disc Nucleolysis in Management of Herniated Lumbar Intervertebral Disc", "language": "eng", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Adult", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Intervertebral Disc", "type": 1 }, { "tag": "Intervertebral Disc Displacement", "type": 1 }, { "tag": "Low Back Pain", "type": 1 }, { "tag": "Lumbar Vertebrae", "type": 1 }, { "tag": "Magnetic Resonance Imaging", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Middle Aged", "type": 1 }, { "tag": "Ozone", "type": 1 }, { "tag": "Pain Measurement", "type": 1 }, { "tag": "Retrospective Studies", "type": 1 }, { "tag": "Treatment Outcome", "type": 1 } ], "collections": [ "5QCR6U5P" ], "relations": {}, "dateAdded": "2026-04-04T15:54:23Z", "dateModified": "2026-04-04T15:54:23Z" } }, { "key": "CYG5X822", "version": 9112, "library": { "type": "group", "id": 46074, "name": "Ozone Health Care", "links": { "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/46074/items/CYG5X822", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care/items/CYG5X822", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/46074/items/TZY33RXQ", "type": "application/json" } }, "meta": { "createdByUser": { "id": 474198, "username": "gregorcuba", "name": "Data Base Manager", "links": { "alternate": { "href": "https://www.zotero.org/gregorcuba", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "CYG5X822", "version": 9112, "parentItem": "TZY33RXQ", "itemType": "attachment", "linkMode": "imported_url", "title": "Full Text", "accessDate": "2026-04-04T15:38:21Z", "url": "https://doi.org/10.4317/medoral.26974", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Almeida et al. - 2025 - Effects of ozone therapy on postoperative pain, swelling, and trismus caused by surgical extraction.pdf", "md5": null, "mtime": null, "tags": [], "relations": {}, "dateAdded": "2026-04-04T15:38:21Z", "dateModified": "2026-04-04T15:38:21Z" } }, { "key": "2TX2EU8Z", "version": 9113, "library": { "type": "group", "id": 46074, "name": "Ozone Health Care", "links": { "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/46074/items/2TX2EU8Z", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care/items/2TX2EU8Z", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/46074/items/TZY33RXQ", "type": "application/json" } }, "meta": { "createdByUser": { "id": 474198, "username": "gregorcuba", "name": "Data Base Manager", "links": { "alternate": { "href": "https://www.zotero.org/gregorcuba", "type": "text/html" } } } }, "data": { "key": "2TX2EU8Z", "version": 9113, "parentItem": "TZY33RXQ", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2026-04-04T15:38:18Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/39954273", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2026-04-04T15:38:18Z", "dateModified": "2026-04-04T15:38:18Z" } }, { "key": "TZY33RXQ", "version": 9111, "library": { "type": "group", "id": 46074, "name": "Ozone Health Care", "links": { "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/46074/items/TZY33RXQ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ozone_health_care/items/TZY33RXQ", "type": "text/html" } }, "meta": { "createdByUser": { "id": 474198, "username": "gregorcuba", "name": "Data Base Manager", "links": { "alternate": { "href": "https://www.zotero.org/gregorcuba", "type": "text/html" } } }, "creatorSummary": "Almeida et al.", "parsedDate": "2025-05-01", "numChildren": 2 }, "data": { "key": "TZY33RXQ", "version": 9111, "itemType": "journalArticle", "title": "Effects of ozone therapy on postoperative pain, swelling, and trismus caused by surgical extraction of unerupted lower third molars: a double-blinded split-mouth randomized controlled trial", "creators": [ { "creatorType": "author", "firstName": "R.-B.", "lastName": "Almeida" }, { "creatorType": "author", "firstName": "F.-U.", "lastName": "Campos" }, { "creatorType": "author", "firstName": "J.-C.", "lastName": "Ramacciato" }, { "creatorType": "author", "firstName": "D.-C.", "lastName": "Peruzzo" }, { "creatorType": "author", "firstName": "G.-V.", "lastName": "Fernandes" }, { "creatorType": "author", "firstName": "J.-C.", "lastName": "Joly" }, { "creatorType": "author", "firstName": "M.", "lastName": "Sperandio" } ], "abstractNote": "BACKGROUND: Third molar extraction surgery is a common procedure, but it results in pain, swelling, and trismus. Ozone therapy (Oz) has emerged as a viable option for pain control and as an option to limit bacterial growth, improving the wound healing. Then, this randomized controlled trial aimed to evaluate the effectiveness of adjunctive use of ozone therapy (OzT) in managing pain, swelling, and trismus after lower third molar removal.\nMATERIAL AND METHODS: A split-mouth design was selected, enrolling 60 patients. There were 2 groups (Sham and OzT). The same surgeon performed all procedures. The pain was evaluated using the VAS scale and the number of paracetamol tablets taken. The quality of life was assessed using the OHIP-14 questionnaire. The data were statistically evaluated.\nRESULTS: 120 surgical procedures were performed on 60 participants (34 males [56%] and 26 females [44%]). Regarding the number of paracetamol tablets taken, the test group had a significantly lower consumption (p<0.002). In addition, the test group presented a significantly lower pain score on days 1, 3, and 5 postoperatively, with no difference between groups on the 7th day (p<0.0145). Both sides presented postoperative edema, which regressed from day 5 (no significant difference). A similar case scenario was observed for mouth opening. OzT impacted the patient's quality of life (OHIP-14, p<0.05), favoring ozone therapy.\nCONCLUSIONS: The results demonstrated that OzT is an effective adjunctive strategy for reducing postoperative pain following the extraction of lower third molar teeth.", "publicationTitle": "Medicina Oral, Patologia Oral Y Cirugia Bucal", "publisher": "", "place": "", "date": "2025-05-01", "volume": "30", "issue": "3", "section": "", "partNumber": "", "partTitle": "", "pages": "e431-e439", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Med Oral Patol Oral Cir Bucal", "DOI": "10.4317/medoral.26974", "citationKey": "", "url": "", "accessDate": "", "PMID": "39954273", "PMCID": "PMC12019658", "ISSN": "1698-6946", "archive": "", "archiveLocation": "", "shortTitle": "Effects of ozone therapy on postoperative pain, swelling, and trismus caused by surgical extraction of unerupted lower third molars", "language": "eng", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Adult", "type": 1 }, { "tag": "Double-Blind Method", "type": 1 }, { "tag": "Edema", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Mandible", "type": 1 }, { "tag": "Molar, Third", "type": 1 }, { "tag": "Ozone", "type": 1 }, { "tag": "Postoperative Complications", "type": 1 }, { "tag": "Postoperative Pain", "type": 1 }, { "tag": "Tooth Extraction", "type": 1 }, { "tag": "Trismus", "type": 1 }, { "tag": "Young Adult", "type": 1 } ], "collections": [ "CXZBF5CE" ], "relations": {}, "dateAdded": "2026-04-04T15:38:18Z", "dateModified": "2026-04-04T15:38:18Z" } } ]