[ { "key": "B645K8EG", "version": 46, "library": { "type": "group", "id": 455961, "name": "Groupe 33 HAKKAKIAN Kevin, PUSSIEUX Chloé, GASC Lorian, LAVACQUERY Pierre", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/455961/items/B645K8EG", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre/items/B645K8EG", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/455961/items/V4P95IH3", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2843144, "username": "Lavacquery Pierre", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lavacquery_pierre", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "B645K8EG", "version": 46, "parentItem": "V4P95IH3", "itemType": "note", "note": "

Google \"radiothérapie cérébrale innovation\"

", "tags": [], "relations": {}, "dateAdded": "2016-01-04T10:30:53Z", "dateModified": "2016-01-04T10:30:53Z" } }, { "key": "35BERVKK", "version": 44, "library": { "type": "group", "id": 455961, "name": "Groupe 33 HAKKAKIAN Kevin, PUSSIEUX Chloé, GASC Lorian, LAVACQUERY Pierre", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/455961/items/35BERVKK", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre/items/35BERVKK", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/455961/items/CVTHG9UB", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2843144, "username": "Lavacquery Pierre", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lavacquery_pierre", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "35BERVKK", "version": 44, "parentItem": "CVTHG9UB", "itemType": "note", "note": "

Google: \"Radiothérapie cérébrale thèse\"

", "tags": [], "relations": {}, "dateAdded": "2016-01-04T10:30:02Z", "dateModified": "2016-01-04T10:30:02Z" } }, { "key": "7GUDXRMD", "version": 42, "library": { "type": "group", "id": 455961, "name": "Groupe 33 HAKKAKIAN Kevin, PUSSIEUX Chloé, GASC Lorian, LAVACQUERY Pierre", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/455961/items/7GUDXRMD", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre/items/7GUDXRMD", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/455961/items/F869VVCP", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2843144, "username": "Lavacquery Pierre", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lavacquery_pierre", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "7GUDXRMD", "version": 42, "parentItem": "F869VVCP", "itemType": "note", "note": "

Utilisation de Google, sans filtre avec les mots clef \"radiothérapie cérébrale\"

", "tags": [], "relations": {}, "dateAdded": "2016-01-04T10:28:24Z", "dateModified": "2016-01-04T10:28:24Z" } }, { "key": "H9KXFTIG", "version": 42, "library": { "type": "group", "id": 455961, "name": "Groupe 33 HAKKAKIAN Kevin, PUSSIEUX Chloé, GASC Lorian, LAVACQUERY Pierre", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/455961/items/H9KXFTIG", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre/items/H9KXFTIG", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/455961/items/F869VVCP", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2843144, "username": "Lavacquery Pierre", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lavacquery_pierre", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "H9KXFTIG", "version": 42, "parentItem": "F869VVCP", "itemType": "note", "note": "", "tags": [], "relations": {}, "dateAdded": "2016-01-04T10:28:24Z", "dateModified": "2016-01-04T10:28:24Z" } }, { "key": "59MWKKHZ", "version": 38, "library": { "type": "group", "id": 455961, "name": "Groupe 33 HAKKAKIAN Kevin, PUSSIEUX Chloé, GASC Lorian, LAVACQUERY Pierre", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/455961/items/59MWKKHZ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre/items/59MWKKHZ", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/455961/items/UDHK36R4", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2843060, "username": "Chloé Pussieux", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/chlo_pussieux", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "59MWKKHZ", "version": 38, "parentItem": "UDHK36R4", "itemType": "note", "note": "

Article trouvé par recherche sur le moteur de recherche \"Google\", avec les mots clés \" institut national du cancer\". Puis navigation sur le site dans l'onglet \"patients et proches\", puis dans le menu déroulant \"tumeurs du cerveau\", puis dans l'onglet \"radiothérapie\". 

\n

 

\n

Article accessible au grand public, reprenant les bases de la radiothérapie cérébrale, et les modalités du traitement. Article fiable, l'Institut National du Cancer étant un organisme reconnu. 

", "tags": [], "relations": {}, "dateAdded": "2016-01-04T09:12:44Z", "dateModified": "2016-01-04T09:12:44Z" } }, { "key": "3UWXZMG4", "version": 34, "library": { "type": "group", "id": 455961, "name": "Groupe 33 HAKKAKIAN Kevin, PUSSIEUX Chloé, GASC Lorian, LAVACQUERY Pierre", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/455961/items/3UWXZMG4", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre/items/3UWXZMG4", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/455961/items/K5V7257T", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2843060, "username": "Chloé Pussieux", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/chlo_pussieux", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "3UWXZMG4", "version": 34, "parentItem": "K5V7257T", "itemType": "note", "note": "", "tags": [], "relations": {}, "dateAdded": "2016-01-04T09:01:36Z", "dateModified": "2016-01-04T09:01:36Z" } }, { "key": "MAB88TBM", "version": 34, "library": { "type": "group", "id": 455961, "name": "Groupe 33 HAKKAKIAN Kevin, PUSSIEUX Chloé, GASC Lorian, LAVACQUERY Pierre", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/455961/items/MAB88TBM", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre/items/MAB88TBM", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/455961/items/K5V7257T", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2843060, "username": "Chloé Pussieux", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/chlo_pussieux", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "MAB88TBM", "version": 34, "parentItem": "K5V7257T", "itemType": "note", "note": "

Page web trouvée après une recherche sur le site du campus de neurochirurgie avec comme mot clé \"radiothérapie cérébrale chez l'enfant\"

\n

Référence fiable, site médical reconnu.

\n

 

\n

Article traitant de l'impact de la radiothérapie cérébrale chez l'enfant et des modalités d'application de ce traitement chez l'enfant, comparativement à l'adulte.

", "tags": [], "relations": {}, "dateAdded": "2016-01-04T09:01:36Z", "dateModified": "2016-01-04T09:01:36Z" } }, { "key": "TR6SSPTC", "version": 32, "library": { "type": "group", "id": 455961, "name": "Groupe 33 HAKKAKIAN Kevin, PUSSIEUX Chloé, GASC Lorian, LAVACQUERY Pierre", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/455961/items/TR6SSPTC", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre/items/TR6SSPTC", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/455961/items/UPD7E84K", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2741518, "username": "KevinHakkakian", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kevinhakkakian", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "TR6SSPTC", "version": 32, "parentItem": "UPD7E84K", "itemType": "note", "note": "

Lien vers un article sur les effets secondaires de la radiothérapie cérébrale.

\n

Trouvé à l'aide de Google avec les mots-clés \"radiothérapie cérébrale effets secondaires\".

", "tags": [], "relations": {}, "dateAdded": "2016-01-04T08:48:04Z", "dateModified": "2016-01-04T08:48:46Z" } }, { "key": "XP2A7AR4", "version": 29, "library": { "type": "group", "id": 455961, "name": "Groupe 33 HAKKAKIAN Kevin, PUSSIEUX Chloé, GASC Lorian, LAVACQUERY Pierre", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/455961/items/XP2A7AR4", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre/items/XP2A7AR4", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/455961/items/F869VVCP", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2741518, "username": "KevinHakkakian", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kevinhakkakian", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "XP2A7AR4", "version": 29, "parentItem": "F869VVCP", "itemType": "note", "note": "

Trouvé à l'aide de Google avec les mots-clés \"radiothérapie cérébrale tumeur\".

\n

Lien vers un article de neurologie précisant les bases de la radiothérapie cérébrale.

", "tags": [], "relations": {}, "dateAdded": "2016-01-04T08:46:28Z", "dateModified": "2016-01-04T08:47:38Z" } }, { "key": "J3JNKCXQ", "version": 27, "library": { "type": "group", "id": 455961, "name": "Groupe 33 HAKKAKIAN Kevin, PUSSIEUX Chloé, GASC Lorian, LAVACQUERY Pierre", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/455961/items/J3JNKCXQ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre/items/J3JNKCXQ", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/455961/items/UDHK36R4", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2741518, "username": "KevinHakkakian", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kevinhakkakian", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "J3JNKCXQ", "version": 27, "parentItem": "UDHK36R4", "itemType": "note", "note": "

Lien vers un article sur internet précisant les bases de l'utilisation de la radiothérapie.

\n

Trouvé à l'aide de Google, avec les mots-clés \"radiothérapie cérébrale\".

", "tags": [], "relations": {}, "dateAdded": "2016-01-04T08:45:11Z", "dateModified": "2016-01-04T08:46:10Z" } }, { "key": "XNAZ8JVT", "version": 24, "library": { "type": "group", "id": 455961, "name": "Groupe 33 HAKKAKIAN Kevin, PUSSIEUX Chloé, GASC Lorian, LAVACQUERY Pierre", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/455961/items/XNAZ8JVT", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre/items/XNAZ8JVT", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/455961/items/539HN2CI", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2741518, "username": "KevinHakkakian", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kevinhakkakian", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "XNAZ8JVT", "version": 24, "parentItem": "539HN2CI", "itemType": "note", "note": "

Trouvé sur la bibliothèque en ligne de Paris Sud avec les mots-clés \"radiothérapie cérébrale\".

\n

Article montrant des effets secondaire aux radiothérapies et leurs conséquences.

", "tags": [], "relations": {}, "dateAdded": "2016-01-04T08:43:16Z", "dateModified": "2016-01-04T08:44:20Z" } }, { "key": "VQW7N39X", "version": 21, "library": { "type": "group", "id": 455961, "name": "Groupe 33 HAKKAKIAN Kevin, PUSSIEUX Chloé, GASC Lorian, LAVACQUERY Pierre", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/455961/items/VQW7N39X", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre/items/VQW7N39X", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/455961/items/CEVCE5ZB", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2741518, "username": "KevinHakkakian", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kevinhakkakian", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "VQW7N39X", "version": 21, "parentItem": "CEVCE5ZB", "itemType": "note", "note": "

Trouvé sur la bibliothèque en ligne de Paris Sud avec les mots-clés \"Radiothérapie cérébrale\".

\n

Article poussé montrant une nouvelle façon d'utiliser la radiothérapie, en association avec d'autres techniques.

", "tags": [], "relations": {}, "dateAdded": "2016-01-04T08:40:52Z", "dateModified": "2016-01-04T08:42:49Z" } }, { "key": "UDHK36R4", "version": 35, "library": { "type": "group", "id": 455961, "name": "Groupe 33 HAKKAKIAN Kevin, PUSSIEUX Chloé, GASC Lorian, LAVACQUERY Pierre", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/455961/items/UDHK36R4", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre/items/UDHK36R4", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2843060, "username": "Chloé Pussieux", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/chlo_pussieux", "type": "text/html" } } }, "numChildren": 3 }, "data": { "key": "UDHK36R4", "version": 35, "itemType": "webpage", "title": "Radiothérapie et tumeurs du cerveau", "creators": [], "abstractNote": "", "websiteTitle": "e-cancer", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://www.e-cancer.fr/Patients-et-proches/Les-cancers/Tumeurs-du-cerveau/Radiotherapie", "accessDate": "", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [ "KM2NHMAF" ], "relations": {}, "dateAdded": "2016-01-03T23:00:01Z", "dateModified": "2016-01-03T23:00:01Z" } }, { "key": "K5V7257T", "version": 35, "library": { "type": "group", "id": 455961, "name": "Groupe 33 HAKKAKIAN Kevin, PUSSIEUX Chloé, GASC Lorian, LAVACQUERY Pierre", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/455961/items/K5V7257T", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre/items/K5V7257T", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2843060, "username": "Chloé Pussieux", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/chlo_pussieux", "type": "text/html" } } }, "creatorSummary": "JL HABRAND, S HELFRE, H BOUHNIK", "numChildren": 2 }, "data": { "key": "K5V7257T", "version": 35, "itemType": "webpage", "title": "La radiothérapie des tumeurs cérébrales chez l'enfant", "creators": [ { "creatorType": "author", "firstName": "", "lastName": "JL HABRAND, S HELFRE, H BOUHNIK" } ], "abstractNote": "", "websiteTitle": "campus.neurochirurgie.fr", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://campus.neurochirurgie.fr/spip.php?article364", "accessDate": "", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [ "KM2NHMAF" ], "relations": {}, "dateAdded": "2016-01-03T22:56:01Z", "dateModified": "2016-01-03T22:56:01Z" } }, { "key": "F869VVCP", "version": 35, "library": { "type": "group", "id": 455961, "name": "Groupe 33 HAKKAKIAN Kevin, PUSSIEUX Chloé, GASC Lorian, LAVACQUERY Pierre", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/455961/items/F869VVCP", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre/items/F869VVCP", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2843144, "username": "Lavacquery Pierre", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lavacquery_pierre", "type": "text/html" } } }, "creatorSummary": "D. PONTVERT and C. ALAPETITE", "numChildren": 3 }, "data": { "key": "F869VVCP", "version": 35, "itemType": "journalArticle", "title": "Radiothérapie des tumeurs cérébrales chez l’adulte", "creators": [ { "creatorType": "author", "firstName": "G. GABORIAUD", "lastName": "D. PONTVERT" }, { "creatorType": "author", "firstName": "", "lastName": "C. ALAPETITE" } ], "abstractNote": "La tolérance du tissu sain, inévitablement concerné lors de l’irradiation, est le facteur limitant commun à toute radiothérapie. Depuis Sheline (1980), l’accent est mis sur la toxicité particulière des radiations ionisantes sur le système nerveux central. La physiopathologie de ces troubles a fait l’objet de nombreux travaux expérimentaux chez l’animal ; différentes théories, gliale et vasculaire, ont été proposées pour expliquer la diversité des lésions et leur chronologie (VAN DER KOGEL, 1991). Chez l’homme, cette toxicité est à l’origine de deux complications principales, qui apparaissent dans les mois ou années qui suivent l’irradiation. La radionécrose a été la plus étudiée. Elle est rarement observée, aujourd’hui, aprés une radiothérapie fractionnée standard utilisant des rayons X de haute énergie. Elle reste toutefois d’actualité avec la pratique récente de hautes doses d’irradiation dans les gliomes malins et le nouvel essor pris par la curiethérapie et la radiochirurgie. Les détériorations intellectuelles représentent une pathologie moins bien connue chez l’adulte que chez l’enfant. Elles concernent principalement la mémoire et sont de gravités variables. Elles sont fréquemment observées depuis qu’elles sont recherchées lors de bilans neuro-psychologiques réalisés avant le traitement puis répètés à distance de la radiothérapie.", "publicationTitle": "", "publisher": "", "place": "", "date": "", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "http://campus.neurochirurgie.fr/spip.php?article363", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "Campus de nuerochimie", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "KM2NHMAF" ], "relations": {}, "dateAdded": "2016-01-03T20:57:09Z", "dateModified": "2016-01-03T20:57:55Z" } }, { "key": "CVTHG9UB", "version": 35, "library": { "type": "group", "id": 455961, "name": "Groupe 33 HAKKAKIAN Kevin, PUSSIEUX Chloé, GASC Lorian, LAVACQUERY Pierre", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/455961/items/CVTHG9UB", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre/items/CVTHG9UB", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2843144, "username": "Lavacquery Pierre", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lavacquery_pierre", "type": "text/html" } } }, "creatorSummary": "Julia Rousseau", "parsedDate": "2007", "numChildren": 1 }, "data": { "key": "CVTHG9UB", "version": 35, "itemType": "thesis", "title": "Chimio-radiothérapie des tumeurs cérébrales : intérêt de\nl’injection intra-tumorale de drogues antinéoplasiques.", "creators": [ { "creatorType": "author", "firstName": "", "lastName": "Julia Rousseau" }, { "creatorType": "contributor", "firstName": "", "lastName": "Hélène ELLEAUME" } ], "abstractNote": "L’objectif est donc d’incorporer un élément (platine ou iode dans notre cas) au sein des cellules tumorales, au plus près de l’ADN et de l’irradier par une source externe de rayonnement X. Les ionisations en couche L sont largement plus favorables qu’en couche K pour engendrer une désexcitation non radiative, et cet effet s’accentue pour les éléments de numéro atomique élevé (Z>50)", "thesisType": "Biophysique", "university": "Université Joseph Fourier", "place": "Grenoble", "date": "2007", "series": "", "seriesNumber": "", "numPages": "53", "DOI": "", "ISBN": "", "citationKey": "", "url": "https://hal.archives-ouvertes.fr/tel-00274902/document", "accessDate": "", "ISSN": "", "archive": "HAL archives-ouvertes.fr", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "KM2NHMAF" ], "relations": {}, "dateAdded": "2016-01-03T20:52:43Z", "dateModified": "2016-01-03T20:52:43Z" } }, { "key": "V4P95IH3", "version": 35, "library": { "type": "group", "id": 455961, "name": "Groupe 33 HAKKAKIAN Kevin, PUSSIEUX Chloé, GASC Lorian, LAVACQUERY Pierre", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/455961/items/V4P95IH3", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre/items/V4P95IH3", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2843144, "username": "Lavacquery Pierre", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lavacquery_pierre", "type": "text/html" } } }, "creatorSummary": "Zacher J and Engert A", "parsedDate": "2014", "numChildren": 1 }, "data": { "key": "V4P95IH3", "version": 35, "itemType": "newspaperArticle", "title": "Le rôle de la radiothérapie du cerveau (rayons X) dans le traitement du lymphome cérébral", "creators": [ { "creatorType": "author", "firstName": "Kasenda B", "lastName": "Zacher J" }, { "creatorType": "author", "firstName": "Skoetz N", "lastName": "Engert A" } ], "abstractNote": "Les principaux résultats : Lorsque nous avons analysé les données concernant l'effet de la chimiothérapie plus RCE par rapport à la chimiothérapie seule sur la survie globale, les résultats étaient imprécis et n'importe lequel des deux traitements pouvait s'avérer supérieur à l'autre. Outre la survie globale, nous avons pris en compte un autre critère de jugement, la survie sans progression (SSP), un état dans lequel la maladie ne s'aggrave pas. L'ajout de la radiothérapie à la chimiothérapie a eu un effet positif sur la SSP, allongeant légèrement la période durant laquelle la maladie n'a pas progressé par rapport à celle obtenue avec la chimiothérapie seule. Les auteurs n'ont pas analysé la mortalité liée au traitement. \nNous avons également cherché à déterminer si le traitement a causé des lésions des tissus cérébraux sains pendant le traitement. Nous n'avons trouvé aucune preuve indiquant que les symptômes d'une détérioration de la fonction cérébrale liés au traitement aient été plus fréquents dans le groupe des participants recevant une chimiothérapie plus une radiothérapie que chez ceux recevant une chimiothérapie seule.\n\nLa qualité des preuves : Nous considérons la qualité des preuves comme modérée à faible, car nous n'avons inclus qu'un seul essai portant sur un petit nombre de participants. Comme l'étude incluse n'a pas analysé les événements indésirables chez tous les participants, nous considérons la qualité des données, pour le critère de jugement de la neurotoxicité, comme très faible.\n\nConclusion : En résumé, les preuves actuellement disponibles (un essai contrôlé randomisé) ne sont pas suffisantes pour conclure qu'une RCE plus une chimiothérapie et une chimiothérapie seule ont des effets similaires sur la survie globale chez les patients atteints de LPSNC. L'ajout de la RCE à la chimiothérapie pourrait augmenter la survie sans progression, mais pourrait également accroître les niveaux d'effets toxiques sur le cerveau. D'autres essais randomisés prospectifs sont nécessaires avant de pouvoir tirer des conclusions définitives concernant le rôle de l'ajout de la radiothérapie à la chimiothérapie dans le traitement du LPSNC.", "publicationTitle": "", "publisher": "", "place": "", "date": "16 juin 2014", "volume": "", "issue": "", "edition": "", "section": "", "pages": "", "ISSN": "", "DOI": "", "citationKey": "", "url": "http://www.cochrane.org/fr/CD009211/le-role-de-la-radiotherapie-du-cerveau-rayons-x-dans-le-traitement-du-lymphome-cerebral", "accessDate": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "Traduit en Français", "libraryCatalog": "Cochrane", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "KM2NHMAF" ], "relations": {}, "dateAdded": "2016-01-03T20:36:33Z", "dateModified": "2016-01-03T20:36:33Z" } }, { "key": "FHSD94JR", "version": 11, "library": { "type": "group", "id": 455961, "name": "Groupe 33 HAKKAKIAN Kevin, PUSSIEUX Chloé, GASC Lorian, LAVACQUERY Pierre", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/455961/items/FHSD94JR", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre/items/FHSD94JR", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/455961/items/539HN2CI", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2741518, "username": "KevinHakkakian", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kevinhakkakian", "type": "text/html" } } } }, "data": { "key": "FHSD94JR", "version": 11, "parentItem": "539HN2CI", "itemType": "attachment", "linkMode": "linked_url", "title": "opac-detail.pl", "accessDate": "2016-01-03T19:20:35Z", "url": 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"username": "KevinHakkakian", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kevinhakkakian", "type": "text/html" } } } }, "data": { "key": "GD4S335X", "version": 10, "parentItem": "CEVCE5ZB", "itemType": "attachment", "linkMode": "linked_url", "title": "opac-detail.pl", "accessDate": "2016-01-03T19:20:23Z", "url": "http://catalogue.scd.u-psud.fr/cgi-bin/koha/opac-detail.pl?biblionumber=233368", "note": "", "contentType": "", "charset": "", "tags": [], "relations": {}, "dateAdded": "2016-01-03T19:20:23Z", "dateModified": "2016-01-03T19:20:23Z" } }, { "key": "CEVCE5ZB", "version": 35, "library": { "type": "group", "id": 455961, "name": "Groupe 33 HAKKAKIAN Kevin, PUSSIEUX Chloé, GASC Lorian, LAVACQUERY Pierre", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/455961/items/CEVCE5ZB", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre/items/CEVCE5ZB", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2741518, "username": "KevinHakkakian", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kevinhakkakian", "type": "text/html" } } }, "creatorSummary": "Delorme et al.", "parsedDate": "2013", "numChildren": 2 }, "data": { "key": "CEVCE5ZB", "version": 35, "itemType": "thesis", "title": "Radiothérapie par Photoactivation de Nanoparticules: modélisation à l'Échelle Sub-Micrométrique et Comparaison Expérimentale", "creators": [ { "creatorType": "author", "firstName": "Rachel", "lastName": "Delorme" }, { "creatorType": "author", "firstName": "Christophe", "lastName": "Champion" }, { "creatorType": "author", "firstName": "Pierre", "lastName": "Désesquelles" }, { "creatorType": "author", "firstName": "Sébastien", "lastName": "Incerti" }, { "creatorType": "author", "firstName": "Jacques", "lastName": "Balosso" }, { "creatorType": "author", "firstName": "Albert", "lastName": "Lisbona" }, { "creatorType": "author", "firstName": "Cécile", "lastName": "Sicard-Roselli" }, { "creatorType": "contributor", "name": "Laboratoire d'Intégration des Systèmes et des Technologies" }, { "creatorType": "contributor", "name": "Université de Paris-Sud" }, { "creatorType": "contributor", "name": "Ecole doctorale Modélisation et Instrumentation en Physique, Energie, Géosciences et Environnement" } ], "abstractNote": "Une approche thérapeutique innovante utilisant l'adjonction d'éléments de numéro atomique élevé à une radiothérapie de basse énergie semble offrir une voie prometteuse pour le traitement des tumeurs cérébrales résistantes. Une telle technique est notamment développée sur la ligne médicale de l'ESRF (European Synchrotron Radiation Facility) utilisant un rayonnement monochromatique allant de 25 à 90 keV [Adam 2003, Adam 2006]. Des résultats encourageants ont été obtenus en traitant des souris cancéreuses après injection de nanoparticules d'or (AuNP) [Hainfeld 2004]. Cependant, les processus physiques et l'impact biologique issus de la photoactivation de nanoparticules sont encore aujourd'hui mal compris et ne peuvent être expliqués par des calculs de doses macroscopiques [Cho 2005, Zhang 2009]. Le but de ce travail est d'évaluer par simulation Monte Carlo l'augmentation locale de dose en présence de nanoparticules ainsi que les caractéristiques des électrons secondaires produits. Dans un premier temps, des simulations ont été réalisées en utilisant une géométrie cellulaire, de manière à comparer les données simulées aux expérimentations menées à l'ESRF. Des tests de clonogénicité ont été réalisés pour mesurer le taux de radiosensibilité des cellules pour une irradiation de 4 Gy (SER4Gy) en présence de gadolinium, pour différentes énergies d'irradiation (25 keV à 1250 keV). Ces études, expérimentales et numériques, ont permis l'évaluation de l'influence de la localisation du gadolinium au sein de la cellule et la forme de ce dernier (nanoparticules ou agent de contraste). D'autre part, une étude comparative a été menée pour caractériser le comportement d'une nanoparticule sous irradiation à une échelle nanométrique, en fonction de l'énergie de faisceau, du rayon de la nanoparticule et de l'élément lourd (or et gadolinium)", "thesisType": "", "university": "s.n.", "place": "S.l.", "date": "2013", "series": "", "seriesNumber": "", "numPages": "", "DOI": "", "ISBN": "", "citationKey": "", "url": "", "accessDate": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "Radiothérapie par Photoactivation de Nanoparticules", "language": "fre", "libraryCatalog": "Library Catalog (Koha)", "callNumber": "530", "rights": "", "extra": "", "tags": [ { "tag": "Basse énergie", "type": 1 }, { "tag": "Modélisation", "type": 1 }, { "tag": "Monte Carlo", "type": 1 }, { "tag": "Photoactivation", "type": 1 }, { "tag": "RX", "type": 1 }, { "tag": "Radiobiologie", "type": 1 }, { "tag": "Radiosensibilité", "type": 1 }, { "tag": "Simulation", "type": 1 }, { "tag": "Électrons", "type": 1 } ], "collections": [ "KM2NHMAF" ], "relations": {}, "dateAdded": "2016-01-03T19:20:08Z", "dateModified": "2016-01-03T19:20:08Z" } }, { "key": "539HN2CI", "version": 35, "library": { "type": "group", "id": 455961, "name": "Groupe 33 HAKKAKIAN Kevin, PUSSIEUX Chloé, GASC Lorian, LAVACQUERY Pierre", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/455961/items/539HN2CI", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_33_hakkakian_kevin_pussieux_chlo_gasc_lorian_lavacquery_pierre/items/539HN2CI", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2741518, "username": "KevinHakkakian", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kevinhakkakian", "type": "text/html" } } }, "creatorSummary": "Soussain et al.", "parsedDate": "2014", "numChildren": 2 }, "data": { "key": "539HN2CI", "version": 35, "itemType": "thesis", "title": "Etude du rôle des péricytes dans le développement des lésions du système nerveux central induites par la radiothérapie. Développement d'un modèle animal de lymphome cérébral appliqué aux essais thérapeutiques précliniques", "creators": [ { "creatorType": "author", "firstName": "Carole", "lastName": "Soussain" }, { "creatorType": "author", "firstName": "Jean-Yves", "lastName": "Delattre" }, { "creatorType": "author", "firstName": "François", "lastName": "Dautry" }, { "creatorType": "author", "firstName": "Fabrice", "lastName": "Jardin" }, { "creatorType": "author", "firstName": "Jérôme", "lastName": "Honnorat" }, { "creatorType": "author", "firstName": "Sergio", "lastName": "Roman-Roman" }, { "creatorType": "author", "firstName": "Franck", "lastName": "Lebrin" }, { "creatorType": "contributor", "name": "Centre de Recherche de l'Institut du Cerveau et de la Moëlle épinière" }, { "creatorType": "contributor", "name": "Centre Interdisciplinaire de Recherche en Biologie" }, { "creatorType": "contributor", "name": "Université de Paris-Sud" }, { "creatorType": "contributor", "name": "Ecole doctorale Cancérologie : Biologie, Médecine, Santé" } ], "abstractNote": "L’irradiation cérébrale thérapeutique comporte un risque de neurotoxicité tardive irréversible en partie lié à l’effet de l’irradiation sur le compartiment vasculaire cérébrale. Les péricytes et les communications entre les péricytes et les cellules endothéliales jouent un rôle majeur dans la stabilisation des vaisseaux, dans la formation et la régulation de la barrière hématoencéphalique et dans le contrôle du flux sanguin cérébral. Nous montrons, dans un modèle murin d’irradiation cérébrale, que les péricytes sont une cible précoce de l’irradiation cérébrale. Après irradiation, la morphologie des péricytes est modifiée et des marqueurs d’activations du péricytes sont surexprimés. En conséquence, la communication entre péricyte et cellule endothéliale est rompue, ce qui se traduit par une diminution de la capacité du péricyte à induire une constriction vasculaire après stimulation électrique. De façon concomitante, la perméabilité de la barrière hémato-encéphalique est anormalement augmentée après irradiation. Un traitement par thalidomide, administré dans la semaine précédant et suivant l’irradiation, prévient les conséquences de l’irradiation sur les péricytes. Les communications entre péricytes et cellules endothéliales sont maintenues ainsi que les fonctions contractiles des péricytes. L’imperméabilité de la barrière hématoencéphalique est également préservée. La voie de signalisation PDGF-β/PDGFR-β essentielle au recrutement des péricytes par les cellules endothéliales, est, au moins partiellement, impliquée dans l’effet protecteur de la thalidomide. Des études supplémentaires sont nécessaires pour définir les mécanismes sous tendant l’effet de l’irradiation sur les péricytes ainsi que l’effet protecteur de la thalidomide. Nous avons en parallèle mis au point un modèle murin de lymphome cérébral luciférase positif pour vérifier, dans un premier temps, l’innocuité de l’association de la radiothérapie et de la thalidomide et de ses dérivés de la classe des immunomodulateurs (iMids), le lénalidomide et le pomalidomide. Ces trois molécules ne diminuent pas l’effet antitumoral de la radiothérapie, mais l’association de radiothérapie et de pomalidomide est synergique sur la décroissance tumorale mesurée par l’évolution des courbes de bioluminescence. Le concept de normalisation de la vascularisation tumorale fait référence aux molécules capables, non pas de faire régresser les vaisseaux tumoraux anormaux, mais de les « normaliser » pour améliorer, d’une part, la disponibilité des chimiothérapies au sein de la tumeur, et d’autre part, l’oxygénation tumorale pour accroitre l’efficacité de la radiothérapie. Nos résultats sont en faveur d’un tel effet exercé par le pomalidomide dans notre modèle murin de lymphome cérébral, caractérisé par une infiltration tumorale périvasculaire, une fuite capillaire mais sans néo angiogenèse. Nos travaux fournissent un rationnel biologique à de futurs essais cliniques avec les iMids dans le traitement des lymphomes cérébraux primitifs voire des tumeurs malignes cérébrales", "thesisType": "", "university": "s.n.", "place": "S.l.", "date": "2014", "series": "", "seriesNumber": "", "numPages": "", "DOI": "", "ISBN": "", "citationKey": "", "url": "", "accessDate": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "fre", "libraryCatalog": "Library Catalog (Koha)", "callNumber": "570", "rights": "", "extra": "", "tags": [ { "tag": "Immunomodulateurs", "type": 1 }, { "tag": "Lymphome cérébral", "type": 1 }, { "tag": "Neurotoxicité", "type": 1 } ], "collections": [ "KM2NHMAF" ], "relations": {}, "dateAdded": "2016-01-03T19:20:01Z", "dateModified": "2016-01-03T19:20:01Z" } }, { "key": "ZPI925MC", "version": 35, "library": { "type": "group", "id": 455961, "name": "Groupe 33 HAKKAKIAN Kevin, PUSSIEUX Chloé, GASC Lorian, LAVACQUERY Pierre", "links": { 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