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A report from the drug epidemiology unit and the Boston collaborative drug surveillance program", "creators": [ { "creatorType": "author", "firstName": "C", "lastName": "Swett" } ], "abstractNote": "Phenothiazine-induced bone marrow depression (BMD) was evaluated in three separate but complementary data bases: (1) Among 1,048 patients admitted to psychiatric hospitals, there was no evidence of subclinical depression of the white blood cell (WBC) count attributable to phenothiazines used before admission. (2) Among 18,587 medical inpatients, there were 34 patients admitted for BMD in the absence of neoplasia or prior cytotoxic drug therapy; one of the latter reported using chlorpromazine hydrochloride, but it is doubtful whether this drug was the cause of the BMD. (3) Among 24,795 medical, surgical, and gynecological patients surveyed over a ten-month period in 1972, there were four who were admitted for BMD; one of the latter had a reversible leukopenia attributed to trifluoperazine hydrochloride.", "publicationTitle": "Archives of General Psychiatry", "publisher": "", "place": "", "date": "Nov 1975", "volume": "32", "issue": "11", "section": "", "partNumber": "", "partTitle": "", "pages": "1416-1418", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Arch. Gen. Psychiatry", "DOI": "", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/978", "accessDate": "", "PMID": "978", "PMCID": "", "ISSN": "0003-990X", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "R4H79DI6" ], "relations": {}, "dateAdded": "2011-05-10T14:29:43Z", "dateModified": "2011-05-10T14:29:43Z" } }, { "key": "XD44SGU3", "version": 8838, "library": { "type": "group", "id": 45038, "name": "papers projects", "links": { "alternate": { "href": "https://www.zotero.org/groups/papers_projects", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/45038/items/XD44SGU3", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/papers_projects/items/XD44SGU3", "type": "text/html" } }, "meta": { "createdByUser": { "id": 16810, "username": "juank", "name": "Juan Castillo", "links": { "alternate": { "href": "https://www.zotero.org/juank", "type": "text/html" } } }, "creatorSummary": "Assem and Chong", "parsedDate": "1976-07", "numChildren": 0 }, "data": { "key": "XD44SGU3", "version": 8838, "itemType": "journalArticle", "title": "Profiles of different anti-allergy effects of a new histamine antagonist, BM 15,100 [proceedings]", "creators": [ { "creatorType": "author", "firstName": "E S", "lastName": "Assem" }, { "creatorType": "author", "firstName": "E K", "lastName": "Chong" } ], "abstractNote": "", "publicationTitle": "British Journal of Pharmacology", "publisher": "", "place": "", "date": "Jul 1976", "volume": "57", "issue": "3", "section": "", "partNumber": "", "partTitle": "", "pages": "437P-438P", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Br. 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Pharmacol", "DOI": "", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/10032", "accessDate": "", "PMID": "10032", "PMCID": "", "ISSN": "0007-1188", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "R4H79DI6" ], "relations": {}, "dateAdded": "2011-05-10T14:29:43Z", "dateModified": "2011-05-10T14:29:43Z" } }, { "key": "8KTGTJ44", "version": 8838, "library": { "type": "group", "id": 45038, "name": "papers projects", "links": { "alternate": { "href": "https://www.zotero.org/groups/papers_projects", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/45038/items/8KTGTJ44", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/papers_projects/items/8KTGTJ44", "type": "text/html" } }, "meta": { "createdByUser": { "id": 16810, "username": "juank", "name": "Juan Castillo", "links": { "alternate": { "href": "https://www.zotero.org/juank", "type": "text/html" } } }, "creatorSummary": "Stucki", "parsedDate": "1976-09-15", "numChildren": 0 }, "data": { "key": "8KTGTJ44", "version": 8838, "itemType": "journalArticle", "title": "Efficiency of oxidative phosphorylation and energy dissipation by H+ ion recycling in rat-liver mitochondrial metabolizing pyruvate", "creators": [ { "creatorType": "author", "firstName": "J W", "lastName": "Stucki" } ], "abstractNote": "A method was developed for the calculation of metabolic fluxes through individual enzymatic reactions of pyruvate metabolism including the citric acid cycle in rat liver mitochondrial incubated at metabolic states between state 4 and state 3. This method is based on the measurement of the specific radioactivities of the products formed from [2-14C]pyruvate. With this procedure the energy balance of mitochondria incubated in the presence of [2-14C]pyruvate, ATP, bicarbonate and phosphate at different ATP/ADP ratios in the medium was calculated. The ATP/ADP ratios were maintained at a steady state with creatine kinase plus creatine as a phosphoryl acceptor. The calculations revealed that by adding increasing concentrations of creatine up to 20 mM the energy dissipated by the mitochondria decreased but showed a local maximum at 13mM creatine. Omission of bicarbonate from the medium led to a shift of this maximum. When energy dissipation was minimal the overall P/O ratio was maximal. The amount of energy dissipated was paralleled by the magnitude of the pH gradient across the inner membrane. From these results it was concluded that the recycling of H+ ions which consists of a passive leakage of H+ ions into the matrix and an active extrusion of these ions out of this compartment, is an important energy dissipating process. The H+ ion recycling is thus one of the processes which give rise to the state 4 respiration in mitochondria.", "publicationTitle": "European Journal of Biochemistry / FEBS", "publisher": "", "place": "", "date": "Sep 15, 1976", "volume": "68", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "551-562", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Eur. J. 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