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Article en anglais sur le sujet radiothérapie posté sur dokéos.

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Effets de la radiothéarpie expliqués aux patients

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Choix d'un article provenant de google scholar qui montre les avantages et les inconvénients de 2 approches du traitements par radiothérapie du cancer du sein : radiothérapie externe et radiothérapie intraopératoire

\n

 

", "tags": [], "relations": {}, "dateAdded": "2016-01-04T09:46:44Z", "dateModified": "2016-01-04T09:46:44Z" } }, { "key": "6G4FEFU9", "version": 18, "library": { "type": "group", "id": 444704, "name": "n°35+ Léonie Saudou, Camille Larousse, Clémence Roche, Margot Lecomte", "links": { "alternate": { "href": "https://www.zotero.org/groups/n35_lonie_saudou_camille_larousse_clmence_roche_margot_lecomte", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/444704/items/6G4FEFU9", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/n35_lonie_saudou_camille_larousse_clmence_roche_margot_lecomte/items/6G4FEFU9", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2741551, "username": "leonie.saudou", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/leonie.saudou", "type": "text/html" } } }, "creatorSummary": "Mackenzie et al.", "parsedDate": "2014", "numChildren": 1 }, "data": { "key": "6G4FEFU9", "version": 18, "itemType": "journalArticle", "title": "Radiotherapy for breast cancer, the TARGIT-A trial", "creators": [ { "creatorType": "author", "firstName": "Penny", "lastName": "Mackenzie" }, { "creatorType": "author", "firstName": "Anthony", "lastName": "Fyles" }, { "creatorType": "author", "firstName": "Caroline", "lastName": "Chung" } ], "abstractNote": "", "publicationTitle": "The Lancet", "publisher": "", "place": "", "date": "05/2014", "volume": "383", "issue": "9930", "section": "", "partNumber": "", "partTitle": "", "pages": "1717", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1016/S0140-6736(14)60827-8", "citationKey": "", "url": "http://linkinghub.elsevier.com/retrieve/pii/S0140673614608278", "accessDate": "2015-12-13T17:42:46Z", "PMID": "", "PMCID": "", "ISSN": "01406736", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2016-01-04T09:46:44Z", "dateModified": "2016-01-04T09:46:44Z" } }, { "key": "JP872QXI", "version": 17, "library": { "type": "group", "id": 444704, "name": "n°35+ Léonie Saudou, Camille Larousse, Clémence Roche, Margot Lecomte", "links": { "alternate": { "href": "https://www.zotero.org/groups/n35_lonie_saudou_camille_larousse_clmence_roche_margot_lecomte", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/444704/items/JP872QXI", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/n35_lonie_saudou_camille_larousse_clmence_roche_margot_lecomte/items/JP872QXI", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/444704/items/84IZIQTN", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2741551, "username": "leonie.saudou", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/leonie.saudou", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "JP872QXI", "version": 17, "parentItem": "84IZIQTN", "itemType": "note", "note": "

Je suis allée sur youtube et j'ai tapé \"radiothérapie mammaire\". Cette vidéo ayant été publiée par l'hôpital Saint Louis elle est de source sûre. D'autre part elle explique en quoi la radiothérapie est utile en plus de la chirurgie, et cela spécifiquement dans le cancer du sein.

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J'ai trouvé ce pdf en tapant \"radiothérapie\" dans le moteur de recherche Google. Il est issu de l'institut Curie et correspond donc à une référence sure. j'ai trouvé qu'il expliquait précisément et clairement l'évolution de la radiothérapie au cours des siècles. Il nous permet de bien introduire le sujet afin d'avoir une vision globale des avancées.

", "contentType": "application/pdf", "charset": "utf-8", "filename": "dp_061003_fr.pdf", "md5": "44b5cda451605e20c82f9131f6a9e5b9", "mtime": 1450261635000, "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-12-16T10:27:15Z", "dateModified": "2016-01-03T11:35:33Z" } }, { "key": "WXV9RSU2", "version": 16, "library": { "type": "group", "id": 444704, "name": "n°35+ Léonie Saudou, Camille Larousse, Clémence Roche, Margot Lecomte", "links": { "alternate": { "href": "https://www.zotero.org/groups/n35_lonie_saudou_camille_larousse_clmence_roche_margot_lecomte", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/444704/items/WXV9RSU2", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/n35_lonie_saudou_camille_larousse_clmence_roche_margot_lecomte/items/WXV9RSU2", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/444704/items/HPD97S3T", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2741551, "username": "leonie.saudou", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/leonie.saudou", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "WXV9RSU2", "version": 16, "parentItem": "HPD97S3T", "itemType": "note", "note": "

Pour trouver cet article je suis allée dans ScienceDirect à partir du portail de la BU. Ensuite j'ai tapé dans \"Search all fields\" radiothérapie peropératoire, et dans les filtres j'ai coché \"Cancer/Radiothérapie\" pour le titre de la publication et \"Journal\" pour le type de publication. Ce texte me parait intéressant pour déterminer l'intérêt et les perspectives de la radiothérapie peropératoire dans le cancer du sein.

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Pour trouver cet article je suis allée dans ScienceDirect à partir du portail de la BU. Ensuite j'ai tapé dans \"Search all fields \"radiosensibilité cancer du sein\". Puis dans les filtes j'ai coché uniquement les articles. Cet article développe les notions de radiosensibilité et de radiorésistance dans le cancer du sein de façons claire et accessible. Il pourrait constituer une ouverture à notre exposé.

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Ce sont les diapositives du cours sur la radiothérapie fait à la faculté le 15 décembre dernier par le professeur Jean Chavaudra. Ce document a été posté sur dokéos.

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J'ai tapé dans le moteur de recherche \"site de radiothérapie\". Il s'agit d'un document extrait du site de la SFRO (Société française de radiothérapie oncologique) adressé aux patients. Ce site est animé par des médecins et des professionnels donc les sources sont fiables tout en étant clair et schématisé.

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Les importantes avancées enregistrées dans les années 1990 dans ce domaine, conduisant à des indications d'irradiation locorégionale de plus en plus larges, font cependant émerger trois questions : comment comprendre et lever la radiorésistance de certaines tumeurs mammaires ? Comment reconnaître les femmes susceptibles de bénéficier réellement de l'irradiation et ainsi envisager une désescalade thérapeutique dans les autres catégories ? Comment identifier les sujets hypersensibles à l'irradiation, à haut risque de toxicité à long terme, et adapter les techniques ou les indications dans ces populations ? Les progrès majeurs de la génétique des tumeurs du sein dans les dernières années devraient aider les cliniciens à résoudre ces importantes questions. Dans cet article sont revues les principales bases moléculaires de la radiosensibilité des cancers du sein, qu'elles soient constitutionnelles (BRCA1, BRCA2, ATM …) ou somatiques (p53, récepteurs à tyrosine kinase, acteurs du cycle cellulaire, des voies de transduction du signal, de l'apoptose, de la réparation de l'ADN …). Les méthodes récentes d'exploration du patrimoine génétique constitutionnel ou tumoral (profils d'expression ADN, ARN ou protéines) sont également discutées comme outils majeurs de la cancérologie mammaire des prochaines années.\n\nLocal-regional radiation therapy is one of the major therapeutic means in the management of breast cancer. Three questions however arise from the important advances achieved in this domain in the past years. The first question concerns the possibilities to identify and overcome the radioresistance of a subset of tumours. The second question is how to recognize women likely to benefit from adjuvant radiation therapy, and therefore to diminish treatment indications in other groups. Finally, the third question is how to identify subjects at high risk for long term injury following breast irradiation, in order to adapt techniques and indications in such populations. The major advances of breast cancer molecular genetics in the past years should provide clinicians with tools to answer these important questions. In this paper, we review the molecular germline (BRCA1, BRCA2, ATM, …) and somatic (p53, tyrosine kinase receptors, as well as actors of cell cycle, signal transduction, apoptosis, DNA repair …) main bases of breast cancer radiosensitivity. Recent methods of exploration of the genetic background of both the host and the tumours (gene and protein expression profiles) are also reviewed as major tools of breast cancer management in the next few years.", "publicationTitle": "Cancer/Radiothérapie", "publisher": "", "place": "", "date": "mars 2005", "volume": "9", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "77-86", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Cancer/Radiothérapie", "DOI": "10.1016/j.canrad.2004.11.003", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/S1278321804001337", "accessDate": "2015-12-16T10:23:07Z", "PMID": "", "PMCID": "", "ISSN": "1278-3218", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Breast cancer", "type": 1 }, { "tag": "Genetics", "type": 1 }, { "tag": "Génétique", "type": 1 }, { "tag": "Radiosensibilité", "type": 1 }, { "tag": "Radiosensitivity", "type": 1 }, { "tag": "ésCancer du sein", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2015-12-16T10:23:07Z", "dateModified": "2016-01-02T15:52:45Z" } }, { "key": "HMJJJW4T", "version": 7, "library": { "type": "group", "id": 444704, "name": "n°35+ Léonie Saudou, Camille Larousse, Clémence Roche, Margot Lecomte", "links": { "alternate": { "href": "https://www.zotero.org/groups/n35_lonie_saudou_camille_larousse_clmence_roche_margot_lecomte", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/444704/items/HMJJJW4T", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/n35_lonie_saudou_camille_larousse_clmence_roche_margot_lecomte/items/HMJJJW4T", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/444704/items/DSHMDVA6", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2741551, "username": "leonie.saudou", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/leonie.saudou", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "HMJJJW4T", "version": 7, "parentItem": "DSHMDVA6", "itemType": "attachment", "linkMode": "imported_url", "title": "ScienceDirect Full Text PDF", "accessDate": "2015-12-16T10:23:48Z", "url": "http://www.sciencedirect.com.proxy.scd.u-psud.fr:2048/science/article/pii/S1278321804001337/pdfft?md5=ef8bd788304c19dfafcbda27e777e100&pid=1-s2.0-S1278321804001337-main.pdf", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Delaloge et Marsiglia - 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