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Department of Health and Human Services, Food and Drug Administration", "place": "", "DOI": "", "citationKey": "", "url": "http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm078757.pdf", "accessDate": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-11-29T19:06:50Z", "dateModified": "2015-11-29T19:09:48Z" } }, { "key": "DW9HRRZU", "version": 31, "library": { "type": "group", "id": 434432, "name": "alzheimer333", "links": { "alternate": { "href": "https://www.zotero.org/groups/alzheimer333", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/434432/items/DW9HRRZU", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/alzheimer333/items/DW9HRRZU", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2650401, "username": "engelbee", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/engelbee", "type": "text/html" } } }, "creatorSummary": "Deputy Commissioner for Operations", "parsedDate": "1996-09-12", "numChildren": 0 }, "data": { "key": "DW9HRRZU", "version": 31, "itemType": "webpage", "title": "Testimony on Supplemental Indications for Approved Prescription Drugs by Michael Friedman", "creators": [ { "creatorType": "author", "firstName": "Food and Drug Administration", "lastName": "Deputy Commissioner for Operations" } ], "abstractNote": "", "websiteTitle": "Assistant Secretary for Legislation(ASL)", "websiteType": "", "date": "9/12/1996", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://www.hhs.gov/asl/testify/t960912a.html", "accessDate": "2015-11-28", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-11-29T18:59:01Z", "dateModified": "2015-11-29T19:04:41Z" } }, { "key": "UNCC5GUP", "version": 21, "library": { "type": "group", "id": 434432, "name": "alzheimer333", "links": { "alternate": { "href": "https://www.zotero.org/groups/alzheimer333", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/434432/items/UNCC5GUP", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/alzheimer333/items/UNCC5GUP", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2651534, "username": "mkrstyen", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mkrstyen", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "UNCC5GUP", "version": 21, "itemType": "attachment", "linkMode": "imported_file", "title": "Guidance for Industry Expidited Programs for Serious Conditions.pdf", "accessDate": "", "url": "", "note": "

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Cross-sectional studies of neurofibrillary pathology in AD reveal a stereotypic spatiotemporal pattern of neuronal vulnerability that correlates with disease severity; however, the relationship of this pattern to disease progression is less certain and exceptions to the typical pattern have been described in a subset of AD patients. The basis for the selective vulnerability of specific populations of neurons to tau pathology and cell death is largely unknown, although there have been a number of hypotheses based upon shared properties of vulnerable neurons (e.g., degree of axonal myelination or synaptic plasticity). A recent hypothesis for selective vulnerability takes into account the emerging science of functional connectivity based upon resting state functional magnetic resonance imaging, where subsets of neurons that fire synchronously define patterns of degeneration similar to specific neurodegenerative disorders, including various tauopathies. In the past 6 years, the concept of tau propagation has emerged from numerous studies in cell and animal models suggesting that tau moves from cell-to-cell and that this may trigger aggregation and region-to-region spread of tau pathology within the brain. How the spread of tau pathology relates to functional connectivity is an area of active investigation. Observations of templated folding and propagation of tau have prompted comparisons of tau to prions, the pathogenic proteins in transmissible spongiform encephalopathies. In this review, we discuss the most compelling studies in the field, discuss their shortcomings and consider their implications with respect to human tauopathies as well as the controversy that tauopathies may be prion-like disorders.", "publicationTitle": "Acta Neuropathologica", "publisher": "", "place": "", "date": "Nov 17, 2015", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Acta Neuropathol.", "DOI": "10.1007/s00401-015-1507-z", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1432-0533", "archive": "", "archiveLocation": "", "shortTitle": "Propagation of tau pathology", "language": "ENG", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "PMID: 26576562", "tags": [ { "tag": "Conformational templating", "type": 1 }, { "tag": "Macropinocytosis", "type": 1 }, { "tag": "Neurofibrillary tangles", "type": 1 }, { "tag": "Prion", "type": 1 }, { "tag": "Propagation", "type": 1 }, { "tag": "Seeding", "type": 1 }, { "tag": "Selective vulnerability", "type": 1 }, { "tag": "Tau", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2015-11-27T21:25:48Z", "dateModified": "2015-11-27T21:25:48Z" } }, { "key": "85C7ECQP", "version": 12, "library": { "type": "group", "id": 434432, "name": "alzheimer333", "links": { "alternate": { "href": "https://www.zotero.org/groups/alzheimer333", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/434432/items/85C7ECQP", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/alzheimer333/items/85C7ECQP", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/434432/items/HD6C3TMT", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2607155, "username": "ychalabi", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/ychalabi", "type": "text/html" } } } }, "data": { "key": "85C7ECQP", "version": 12, "parentItem": "HD6C3TMT", "itemType": "attachment", "linkMode": "imported_url", "title": "Snapshot", "accessDate": "2015-11-25T20:00:27Z", "url": "http://www.cdc.gov/diabetes/prevention/about.htm", "note": "", "contentType": "text/html", "charset": "utf-8", "filename": "about.html", "md5": "4e6e6a96f60cebfec06fc49e5f9b3902", "mtime": 1448481627000, "tags": [], "relations": {}, "dateAdded": "2015-11-25T20:00:27Z", "dateModified": "2015-11-25T20:00:27Z" } }, { "key": "HD6C3TMT", "version": 11, "library": { "type": "group", "id": 434432, "name": "alzheimer333", "links": { "alternate": { "href": "https://www.zotero.org/groups/alzheimer333", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/434432/items/HD6C3TMT", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/alzheimer333/items/HD6C3TMT", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2607155, "username": "ychalabi", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/ychalabi", "type": "text/html" } } }, "numChildren": 1 }, "data": { "key": "HD6C3TMT", "version": 11, "itemType": "webpage", "title": "CDC - About the Program - National Diabetes Prevention Program - Diabetes DDT", "creators": [], "abstractNote": "This page contains information about the National Diabetes Prevention Program.", "websiteTitle": "", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://www.cdc.gov/diabetes/prevention/about.htm", "accessDate": "2015-11-25T20:00:26Z", "shortTitle": "", "language": "en-us", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-11-25T20:00:26Z", "dateModified": "2015-11-25T20:00:26Z" } }, { "key": "ZWWXAHA8", "version": 8, "library": { "type": "group", "id": 434432, "name": "alzheimer333", "links": { "alternate": { "href": "https://www.zotero.org/groups/alzheimer333", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/434432/items/ZWWXAHA8", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/alzheimer333/items/ZWWXAHA8", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2607513, "username": "nlassiter15", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/nlassiter15", "type": "text/html" } } }, "creatorSummary": "Terzi et al.", "parsedDate": "2007-05", "numChildren": 1 }, "data": { "key": "ZWWXAHA8", "version": 8, "itemType": "journalArticle", "title": "Cerebrospinal fluid total tau protein levels in patients with multiple sclerosis", "creators": [ { "creatorType": "author", "firstName": "M.", "lastName": "Terzi" }, { "creatorType": "author", "firstName": "A.", "lastName": "Birinci" }, { "creatorType": "author", "firstName": "E.", "lastName": "Cetinkaya" }, { "creatorType": "author", "firstName": "M. K.", "lastName": "Onar" } ], "abstractNote": "BACKGROUND: Tau protein is present in the microtubules of axons. Markers of various types have been used to demonstrate multiple sclerosis (MS) activity and axonal damage. This study aimed to demonstrate the association between cerebrospinal fluid (CSF) tau protein concentrations and clinical prognosis in MS patients.\nMETHODS: We included 45 patients that were diagnosed according to the McDonald's criteria. The control group was made up of 38 patients that had no signs or symptoms related to the primary central nervous system lesion correlated with the patient group. CSF total tau protein was measured using the ELISA method based on the sandwich method with Innogenetics Innotest hTau antigen kit in pg/ml type.\nRESULTS: In the patient group, the mean CSF total tau protein level was 238.66 +/- 237.44, whereas it was 93.65 +/- 82.14 in the control group. The mean total tau protein was higher in the three clinical forms when compared with the control group and it was statistically significant (P<0.05).\nCONCLUSIONS: High tau protein level may be an early marker of axonal damage and this marker may be used for monitoring axon preventing therapies in the follow-up.", "publicationTitle": "Acta Neurologica Scandinavica", "publisher": "", "place": "", "date": "May 2007", "volume": "115", "issue": "5", "section": "", "partNumber": "", "partTitle": "", "pages": "325-330", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Acta Neurol. Scand.", "DOI": "10.1111/j.1600-0404.2007.00782.x", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0001-6314", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "PMID: 17489943", "tags": [ { "tag": "Adult", "type": 1 }, { "tag": "Biological Markers", "type": 1 }, { "tag": "Disease Progression", "type": 1 }, { "tag": "Early Diagnosis", "type": 1 }, { "tag": "Enzyme-Linked Immunosorbent Assay", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Multiple Sclerosis", "type": 1 }, { "tag": "Predictive Value of Tests", "type": 1 }, { "tag": "Prognosis", "type": 1 }, { "tag": "tau Proteins", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2015-11-25T00:04:37Z", "dateModified": "2015-11-25T00:04:37Z" } } ]