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"Knudsen" } ], "abstractNote": "Ex vivo perfusion of the human term placenta is a method to study placental transfer without extrapolation from animal to human and with no ethical concerns for mother and child. However, ex vivo placenta perfusion has a limited potential within chemical screening and testing as the method is time-consuming. This study was an attempt to construct data needed to develop quantitative structure-activity relationship (QSAR) models that are able to predict placental transfer of new compounds. Placental transfer is a biological activity that statistically may be related to the physiochemical properties of a given group of compounds. Benzoic acid, caffeine, and glyphosate were chosen as model compounds because they are small molecules with large differences in physiochemical properties. Caffeine crossed the placenta by passive diffusion. The initial transfer rate of benzoic acid was more limited in the first part of the perfusion compared to caffeine, but reached the same steady-state level by the end of perfusion. The transfer of glyphosate was restricted throughout perfusion, with a lower permeation rate, and only around 15% glyphosate in maternal circulation crossed to the fetal circulation during the study period.", "publicationTitle": "Journal of Toxicology and Environmental Health. Part A", "publisher": "", "place": "", "date": "2008", "volume": "71", "issue": "15", "section": "", "partNumber": "", "partTitle": "", "pages": "984-991", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J. Toxicol. Environ. Health Part A", "DOI": "10.1080/01932690801934513", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1528-7394", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "PMID: 18569607", "tags": [ { "tag": "Adult", "type": 1 }, { "tag": "Benzoic Acid", "type": 1 }, { "tag": "Caffeine", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Glycine", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "In Vitro Techniques", "type": 1 }, { "tag": "Maternal-Fetal Exchange", "type": 1 }, { "tag": "Models, Biological", "type": 1 }, { "tag": "Perfusion", "type": 1 }, { "tag": "Placenta", "type": 1 }, { "tag": "Pregnancy", "type": 1 }, { "tag": "Quantitative Structure-Activity Relationship", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2015-11-12T13:03:37Z", "dateModified": "2015-11-12T13:03:37Z" } }, { "key": "MI8MQAE5", "version": 121, "library": { "type": "group", "id": 426549, "name": "Miljoefaktorer", "links": { "alternate": { "href": "https://www.zotero.org/groups/miljoefaktorer", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/426549/items/MI8MQAE5", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/miljoefaktorer/items/MI8MQAE5", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/426549/items/MN9J4K47", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1834293, "username": "Annabellcmillan", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/annabellcmillan", "type": "text/html" } } } }, "data": { "key": "MI8MQAE5", "version": 121, "parentItem": "MN9J4K47", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2015-11-12T13:01:31Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/1528", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-11-12T13:01:31Z", "dateModified": "2015-11-12T13:01:31Z" } }, { "key": "MN9J4K47", "version": 121, "library": { "type": "group", "id": 426549, "name": "Miljoefaktorer", "links": { "alternate": { "href": "https://www.zotero.org/groups/miljoefaktorer", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/426549/items/MN9J4K47", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/miljoefaktorer/items/MN9J4K47", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1834293, "username": "Annabellcmillan", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/annabellcmillan", "type": "text/html" } } }, "creatorSummary": "Sullivan and Pickett", "parsedDate": "1975-10", "numChildren": 1 }, "data": { "key": "MN9J4K47", "version": 121, "itemType": "journalArticle", "title": "Influence of ejaculation frequency of stallions on characteristics of semen and output of spermatozoa", "creators": [ { "creatorType": "author", "firstName": "J. J.", "lastName": "Sullivan" }, { "creatorType": "author", "firstName": "B. W.", "lastName": "Pickett" } ], "abstractNote": "Approximately 1 week was required to stabilize the extragonadal sperm reserves in stallions ejaculated daily for 10 weeks. The true daily sperm output of a stallion was equal to the mean daily sperm output of seven ejaculates +/- 1-35 X 10(9) spermatozoa. Mean concentrations of spermatozoa/ml and number of spermatozoa/ejaculate were higher (P less than 0-01) for X1 and X3/week ejaculation frequencies than for a X6/week frequency. Sperm output/week was nearly identical for a X6/week frequency. Sperm output/week was nearly identical for the X3 and X6 frequencies and higher (P less than 0-01) than the X1 frequency. Increase of ejaculation frequency from one to two ejaculates/day twice weekly significantly (P less than 0-01) raised the output of spermatozoa/week. Gel-free semen volume, spermatozoa/ml, and number of spermatozoa/ejaculate were higher (P less than 0-01) in the first, than in the second, ejaculate. Collection of semen on alternate days would be a practical ejaculation frequency for inseminating mares. Two ejaculates collected twice a week would be a practical ejaculation frequency for long-term storage of stallion semen.", "publicationTitle": "Journal of Reproduction and Fertility. Supplement", "publisher": "", "place": "", "date": "Oct 1975", "volume": "", "issue": "23", "section": "", "partNumber": "", "partTitle": "", "pages": "29-34", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J. Reprod. Fertil. 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