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            "title": "Leprosy stigma: ironing out the creases",
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                    "firstName": "Omobolanle",
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            "abstractNote": "Oft-cited as a deterrent to elimination of the disease, stigma is still a critical feature of the leprosy landscape leading to ostracism, loss of employment, loss of housing, ridicule and rejection from society. The reason for leprosy-stigma rests historically and culturally on the mythology about the disease's origin and transmission, and its aesthetic features such as the enigmatic physical disfigurement, and the distinctive ulcers consequent of untreated leprosy. While the literature on leprosy has been consistent in showing that stigma is a social complication of the condition worldwide, there is seldom recognition of processes of stigmatisation in broader contexts. Effective and sustainable interventions directed at curbing leprosy stigma and so improving its social course must, however, be informed by an appreciation of such contexts; particularly in the light of the goal to eliminate the disease worldwide. Examining stigma in the broader contexts of historical, social, economic, political contexts is the aim of this paper. The paper also has implications for broad ranging intervention efforts aimed at de-constructing leprosy-stigma in order to craft a more accommodating ambiance of acceptance, care and support for people affected by leprosy.",
            "publicationTitle": "Leprosy Review",
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            "date": "Jun 2011",
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            "pages": "103-108",
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            "title": "RIESGO DE ADICCIÓN A ANALGÉSICOS OPIOIDES EN EL TRATAMIENTO DE DOLOR CRÓNICO NO ONCOLÓGICO",
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                    "firstName": "Juan Pablo",
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            "abstractNote": "Los analgésicos opioides son eficaces en el alivio del dolor crónico no oncológico (DCNO). Sin embargo, en tratamiento a largo plazo genera tolerancia, dependencia física y riesgo de desarrollar adicción. Estos fenómenos son causados por el efecto agonista en los receptores opioides que modulan las vías del dolor y producen un efecto hedónico intenso en el sistema de recompensa cerebral. La exposición repetida a opioides produce neuroadaptación que disminuye el efecto analgésico, produce anhedonia, aparición síntomas de abstinencia y cambios conductuales que pueden gatillar abuso y dependencia.El conocimiento actual nos permite entender la dependencia a opioides como una enfermedad cerebral de origen multifactorial. En pacientes con DCNO se ha podido establecer que el riesgo a desarrollar una adicción a opioides aumenta cuando hay antecedentes de abuso y dependencia a sustancias, presencia de psicomorbilidades, un ambiente social favorecedor al consumo, y cuando se prescriben dosis superiores a 120mg de morfina equivalente al día (MME). Por otra parte, el aumento de la prescripción indiscriminada de estos fármacos ha causado graves consecuencias en la población general en muchos países, incrementando la poblacion dependiente, la mortalidad por sobredosis de opioides y el tráfico a nivel mundial. Guías clínicas basadas en la evidencia y consenso de expertos recomiendan que los opioides en DCNO deben ser parte de un manejo multidisciplinario, ponderando la presencia de factores de riesgo y el beneficio esperado. Aunque es difícil demostrar con evidencia que estas recomendaciones tengan impacto en reducir el riesgo, todas dan énfasis en estrategias de prevención, pesquisa precoz y seguimiento específico para el uso de estos fármacos.",
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            "date": "2019",
            "volume": "30",
            "issue": "6",
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