Cited By :4
", "tags": [], "relations": {}, "dateAdded": "2018-09-10T13:55:05Z", "dateModified": "2018-09-10T13:57:00Z" } }, { "key": "MF4ZT2FX", "version": 8169, "library": { "type": "group", "id": 41682, "name": "Publications de l'Anses Laboratoire de Fougères", "links": { "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/41682/items/MF4ZT2FX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres/items/MF4ZT2FX", "type": "text/html" } }, "meta": { "createdByUser": { "id": 564506, "username": "Doclab", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/doclab", "type": "text/html" } } }, "creatorSummary": "Henri et al.", "parsedDate": "2017", "numChildren": 1 }, "data": { "key": "MF4ZT2FX", "version": 8169, "itemType": "journalArticle", "title": "A physiologically based pharmacokinetic model for chickens exposed to feed supplemented with monensin during their lifetime", "creators": [ { "creatorType": "author", "firstName": "J.", "lastName": "Henri" }, { "creatorType": "author", "firstName": "R.", "lastName": "Carrez" }, { "creatorType": "author", "firstName": "B.", "lastName": "Méda" }, { "creatorType": "author", "firstName": "M.", "lastName": "Laurentie" }, { "creatorType": "author", "firstName": "P.", "lastName": "Sanders" } ], "abstractNote": "We developed a flow-limited physiologically based pharmacokinetic model for residues of monensin in chickens and evaluated its predictive ability by comparing it with an external data set describing concentration decays after the end of treatment. One advantage of this model is that the values for most parameters (34 of 38) were taken directly from the literature or from field data (for growth and feed intake). Our model included growth (changes in body weight) to describe exposure throughout the life of the chicken. We carried out a local sensitivity analysis to evaluate the relative importance of model parameters on model outputs and revealed the predominant influence of 19 parameters (including three estimated ones): seven pharmacokinetic parameters, five physiological parameters and seven animal performance parameters. Our model estimated the relative bioavailability of monensin as feed additive at 3.9%, which is even lower than the absolute bioavailability in solution (29.91%). Our model can be used for extrapolations of farming conditions, such as monensin supplementation or building lighting programme (which may have a significant impact for short half-life molecules such as monensin). This validated PBPK model may also be useful for interspecies extrapolations or withdrawal period calculations for modified dosage regimens. © 2016 John Wiley & Sons Ltd", "publicationTitle": "Journal of Veterinary Pharmacology and Therapeutics", "publisher": "", "place": "", "date": "2017", "volume": "40", "issue": "4", "section": "", "partNumber": "", "partTitle": "", "pages": "370-382", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1111/jvp.12370", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "Scopus", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "Scopus", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": { "dc:replaces": "http://zotero.org/groups/41682/items/RSG6D5MG" }, "dateAdded": "2018-03-20T09:03:37Z", "dateModified": "2018-09-10T13:57:00Z" } }, { "key": "VUVTM2ME", "version": 8171, "library": { "type": "group", "id": 41682, "name": "Publications de l'Anses Laboratoire de Fougères", "links": { "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/41682/items/VUVTM2ME", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres/items/VUVTM2ME", "type": "text/html" } }, "meta": { "createdByUser": { "id": 564506, "username": "Doclab", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/doclab", "type": "text/html" } } }, "creatorSummary": "Munk et al.", "parsedDate": "2018", "numChildren": 0 }, "data": { "key": "VUVTM2ME", "version": 8171, "itemType": "journalArticle", "title": "Abundance and diversity of the faecal resistome in slaughter pigs and broilers in nine European countries", "creators": [ { "creatorType": "author", "firstName": "P.", "lastName": "Munk" }, { "creatorType": "author", "firstName": "B.E.", "lastName": "Knudsen" }, { "creatorType": "author", "firstName": "O.", "lastName": "Lukjacenko" }, { "creatorType": "author", "firstName": "A.S.R.", "lastName": "Duarte" }, { "creatorType": "author", "firstName": "Gompel", "lastName": "Van" }, { "creatorType": "author", "firstName": "R.E.C.", "lastName": "Luiken" }, { "creatorType": "author", "firstName": "L.A.M.", "lastName": "Smit" }, { "creatorType": "author", "firstName": "H.", "lastName": "Schmitt" }, { "creatorType": "author", "firstName": "A.D.", "lastName": "Garcia" }, { "creatorType": "author", "firstName": "R.B.", "lastName": "Hansen" }, { "creatorType": "author", "firstName": "T.N.", "lastName": "Petersen" }, { "creatorType": "author", "firstName": "A.", "lastName": "Bossers" }, { "creatorType": "author", "firstName": "E.", "lastName": "Ruppé" }, { "creatorType": "author", "firstName": "H.", "lastName": "Graveland" }, { "creatorType": "author", "firstName": "Essen", "lastName": "van" }, { "creatorType": "author", "firstName": "B.", "lastName": "Gonzalez-Zorn" }, { "creatorType": "author", "firstName": "G.", "lastName": "Moyano" }, { "creatorType": "author", "firstName": "P.", "lastName": "Sanders" }, { "creatorType": "author", "firstName": "C.", "lastName": "Chauvin" }, { "creatorType": "author", "firstName": "J.", "lastName": "David" }, { "creatorType": "author", "firstName": "A.", "lastName": "Battisti" }, { "creatorType": "author", "firstName": "A.", "lastName": "Caprioli" }, { "creatorType": "author", "firstName": "J.", "lastName": "Dewulf" }, { "creatorType": "author", "firstName": "T.", "lastName": "Blaha" }, { "creatorType": "author", "firstName": "K.", "lastName": "Wadepohl" }, { "creatorType": "author", "firstName": "M.", "lastName": "Brandt" }, { "creatorType": "author", "firstName": "D.", "lastName": "Wasyl" }, { "creatorType": "author", "firstName": "M.", "lastName": "Skarzyńska" }, { "creatorType": "author", "firstName": "M.", "lastName": "Zajac" }, { "creatorType": "author", "firstName": "H.", "lastName": "Daskalov" }, { "creatorType": "author", "firstName": "H.W.", "lastName": "Saatkamp" }, { "creatorType": "author", "firstName": "K.D.C.", "lastName": "Stärk" }, { "creatorType": "author", "firstName": "O.", "lastName": "Lund" }, { "creatorType": "author", "firstName": "T.", "lastName": "Hald" }, { "creatorType": "author", "firstName": "S.J.", "lastName": "Pamp" }, { "creatorType": "author", "firstName": "H.", "lastName": "Vigre" }, { "creatorType": "author", "firstName": "D.", "lastName": "Heederik" }, { "creatorType": "author", "firstName": "J.A.", "lastName": "Wagenaar" }, { "creatorType": "author", "firstName": "D.", "lastName": "Mevius" }, { "creatorType": "author", "firstName": "F.M.", "lastName": "Aarestrup" }, { "creatorType": "author", "firstName": "Group", "lastName": "EFFORT" } ], "abstractNote": "Antimicrobial resistance (AMR) in bacteria and associated human morbidity and mortality is increasing. The use of antimicrobials in livestock selects for AMR that can subsequently be transferred to humans. This flow of AMR between reservoirs demands surveillance in livestock and in humans. We quantified and characterized the acquired resistance gene pools (resistomes) of 181 pig and 178 poultry farms from nine European countries, sequencing more than 5,000 Gb of DNA using shotgun metagenomics. We quantified acquired AMR using the ResFinder database and a second database constructed for this study, consisting of AMR genes identified through screening environmental DNA. The pig and poultry resistomes were very different in abundance and composition. There was a significant country effect on the resistomes, more so in pigs than in poultry. We found higher AMR loads in pigs, whereas poultry resistomes were more diverse. We detected several recently described, critical AMR genes, including mcr-1 and optrA, the abundance of which differed both between host species and between countries. We found that the total acquired AMR level was associated with the overall country-specific antimicrobial usage in livestock and that countries with comparable usage patterns had similar resistomes. However, functionally determined AMR genes were not associated with total drug use. © 2018, The Author(s).", "publicationTitle": "Nature Microbiology", "publisher": "", "place": "", "date": "2018", "volume": "3", "issue": "8", "section": "", "partNumber": "", "partTitle": "", "pages": "898-908", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1038/s41564-018-0192-9", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "Scopus", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "Scopus", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2018-09-10T13:55:09Z", "dateModified": "2018-09-10T13:55:09Z" } }, { "key": "PNCU7M9A", "version": 8172, "library": { "type": "group", "id": 41682, "name": "Publications de l'Anses Laboratoire de Fougères", "links": { "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/41682/items/PNCU7M9A", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres/items/PNCU7M9A", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/41682/items/3999ACZ2", "type": "application/json" } }, "meta": { "createdByUser": { "id": 564506, "username": "Doclab", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/doclab", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "PNCU7M9A", "version": 8172, "parentItem": "3999ACZ2", "itemType": "note", "note": "Cited By :4
", "tags": [], "relations": {}, "dateAdded": "2018-09-10T13:55:08Z", "dateModified": "2018-09-10T13:55:08Z" } }, { "key": "VXC34XGA", "version": 8171, "library": { "type": "group", "id": 41682, "name": "Publications de l'Anses Laboratoire de Fougères", "links": { "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/41682/items/VXC34XGA", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres/items/VXC34XGA", "type": "text/html" } }, "meta": { "createdByUser": { "id": 564506, "username": "Doclab", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/doclab", "type": "text/html" } } }, "creatorSummary": "Krause et al.", "parsedDate": "2018", "numChildren": 0 }, "data": { "key": "VXC34XGA", "version": 8171, "itemType": "journalArticle", "title": "Characterization of aluminum, aluminum oxide and titanium dioxide nanomaterials using a combination of methods for particle surface and size analysis", "creators": [ { "creatorType": "author", "firstName": "B.", "lastName": "Krause" }, { "creatorType": "author", "firstName": "T.", "lastName": "Meyer" }, { "creatorType": "author", "firstName": "H.", "lastName": "Sieg" }, { "creatorType": "author", "firstName": "C.", "lastName": "Kästner" }, { "creatorType": "author", "firstName": "P.", "lastName": "Reichardt" }, { "creatorType": "author", "firstName": "J.", "lastName": "Tentschert" }, { "creatorType": "author", "firstName": "H.", "lastName": "Jungnickel" }, { "creatorType": "author", "firstName": "I.", "lastName": "Estrela-Lopis" }, { "creatorType": "author", "firstName": "A.", "lastName": "Burel" }, { "creatorType": "author", "firstName": "S.", "lastName": "Chevance" }, { "creatorType": "author", "firstName": "F.", "lastName": "Gauffre" }, { "creatorType": "author", "firstName": "P.", "lastName": "Jalili" }, { "creatorType": "author", "firstName": "J.", "lastName": "Meijer" }, { "creatorType": "author", "firstName": "L.", "lastName": "Böhmert" }, { "creatorType": "author", "firstName": "A.", "lastName": "Braeuning" }, { "creatorType": "author", "firstName": "A.F.", "lastName": "Thünemann" }, { "creatorType": "author", "firstName": "F.", "lastName": "Emmerling" }, { "creatorType": "author", "firstName": "V.", "lastName": "Fessard" }, { "creatorType": "author", "firstName": "P.", "lastName": "Laux" }, { "creatorType": "author", "firstName": "A.", "lastName": "Lampen" }, { "creatorType": "author", "firstName": "A.", "lastName": "Luch" } ], "abstractNote": "The application of appropriate analytical techniques is essential for nanomaterial (NM) characterization. In this study, we compared different analytical techniques for NM analysis. Regarding possible adverse health effects, ionic and particulate NM effects have to be taken into account. As NMs behave quite differently in physiological media, special attention was paid to techniques which are able to determine the biosolubility and complexation behavior of NMs. Representative NMs of similar size were selected: aluminum (Al0) and aluminum oxide (Al2O3), to compare the behavior of metal and metal oxides. In addition, titanium dioxide (TiO2) was investigated. Characterization techniques such as dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) were evaluated with respect to their suitability for fast characterization of nanoparticle dispersions regarding a particle's hydrodynamic diameter and size distribution. By application of inductively coupled plasma mass spectrometry in the single particle mode (SP-ICP-MS), individual nanoparticles were quantified and characterized regarding their size. SP-ICP-MS measurements were correlated with the information gained using other characterization techniques, i.e. transmission electron microscopy (TEM) and small angle X-ray scattering (SAXS). The particle surface as an important descriptor of NMs was analyzed by X-ray diffraction (XRD). NM impurities and their co-localization with biomolecules were determined by ion beam microscopy (IBM) and confocal Raman microscopy (CRM). We conclude advantages and disadvantages of the different techniques applied and suggest options for their complementation. Thus, this paper may serve as a practical guide to particle characterization techniques. © 2018 The Royal Society of Chemistry.", "publicationTitle": "RSC Advances", "publisher": "", "place": "", "date": "2018", "volume": "8", "issue": "26", "section": "", "partNumber": "", "partTitle": "", "pages": "14377-14388", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1039/c8ra00205c", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "Scopus", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "Scopus", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2018-09-10T13:55:07Z", "dateModified": "2018-09-10T13:55:07Z" } }, { "key": "MVUQIYHE", "version": 8172, "library": { "type": "group", "id": 41682, "name": "Publications de l'Anses Laboratoire de Fougères", "links": { "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/41682/items/MVUQIYHE", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres/items/MVUQIYHE", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/41682/items/9WAQH67K", "type": "application/json" } }, "meta": { "createdByUser": { "id": 564506, "username": "Doclab", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/doclab", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "MVUQIYHE", "version": 8172, "parentItem": "9WAQH67K", "itemType": "note", "note": "Article in Press
", "tags": [], "relations": {}, "dateAdded": "2018-09-10T13:55:04Z", "dateModified": "2018-09-10T13:55:04Z" } }, { "key": "SAGAXDQJ", "version": 8172, "library": { "type": "group", "id": 41682, "name": "Publications de l'Anses Laboratoire de Fougères", "links": { "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/41682/items/SAGAXDQJ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres/items/SAGAXDQJ", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/41682/items/FIHJVDX4", "type": "application/json" } }, "meta": { "createdByUser": { "id": 564506, "username": "Doclab", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/doclab", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "SAGAXDQJ", "version": 8172, "parentItem": "FIHJVDX4", "itemType": "note", "note": "Cited By :30
", "tags": [], "relations": {}, "dateAdded": "2018-09-10T13:55:01Z", "dateModified": "2018-09-10T13:55:01Z" } }, { "key": "JHH72RRH", "version": 8172, "library": { "type": "group", "id": 41682, "name": "Publications de l'Anses Laboratoire de Fougères", "links": { "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/41682/items/JHH72RRH", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres/items/JHH72RRH", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/41682/items/6RKXZA54", "type": "application/json" } }, "meta": { "createdByUser": { "id": 564506, "username": "Doclab", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/doclab", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "JHH72RRH", "version": 8172, "parentItem": "6RKXZA54", "itemType": "note", "note": "Cited By :6
", "tags": [], "relations": {}, "dateAdded": "2018-09-10T13:54:59Z", "dateModified": "2018-09-10T13:54:59Z" } }, { "key": "LQH2NZ44", "version": 8172, "library": { "type": "group", "id": 41682, "name": "Publications de l'Anses Laboratoire de Fougères", "links": { "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/41682/items/LQH2NZ44", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres/items/LQH2NZ44", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/41682/items/LNAKWLFI", "type": "application/json" } }, "meta": { "createdByUser": { "id": 564506, "username": "Doclab", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/doclab", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "LQH2NZ44", "version": 8172, "parentItem": "LNAKWLFI", "itemType": "note", "note": "Cited By :5
", "tags": [], "relations": {}, "dateAdded": "2018-09-10T13:54:57Z", "dateModified": "2018-09-10T13:54:57Z" } }, { "key": "LNAKWLFI", "version": 8171, "library": { "type": "group", "id": 41682, "name": "Publications de l'Anses Laboratoire de Fougères", "links": { "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/41682/items/LNAKWLFI", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres/items/LNAKWLFI", "type": "text/html" } }, "meta": { "createdByUser": { "id": 564506, "username": "Doclab", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/doclab", "type": "text/html" } } }, "creatorSummary": "El et al.", "parsedDate": "2017", "numChildren": 1 }, "data": { "key": "LNAKWLFI", "version": 8171, "itemType": "journalArticle", "title": "Development and validation of a multiclass method for the determination of antibiotic residues in honey using liquid chromatography-tandem mass spectrometry", "creators": [ { "creatorType": "author", "firstName": "Hawari", "lastName": "El" }, { "creatorType": "author", "firstName": "S.", "lastName": "Mokh" }, { "creatorType": "author", "firstName": "S.", "lastName": "Doumyati" }, { "creatorType": "author", "firstName": "Iskandarani", "lastName": "Al" }, { "creatorType": "author", "firstName": "E.", "lastName": "Verdon" } ], "abstractNote": "A new, simple and fast method was developed for the determination of multi-class antibiotic residues in honey (sulfonamides, tetracyclines, macrolides, lincosamides and aminoglycosides). Separation and determination were carried out by LC-MS/MS. During sample preparation, various parameters affecting extraction efficiency were examined, including the type of solvent, pH, efficiencies of cleavage of N-glycosidic linkages by hydrochloric acid, ultrasonic extraction and its duration compared with shaking, along with dispersive SPE clean-up. Experiments with fortified samples demonstrated that 10 min of ultrasonic treatment with acidified methanol (HCl 2 M) followed by dispersive SPE clean-up with 50 mg PSA gave an effective sample preparation method for several classes of antibiotics in honey. Anhydroerythromycin A, erythromycin A enol ether and desmycosin were used as markers for the presence of erythromycin A and tylosin A in honey samples. The method was validated according to European Commission Decision (EC) No. 2002/657. The recoveries of analytes ranged from 85% to 111%. Repeatability and intra-laboratory reproducibility were < 20.6% and 26.8%, respectively. Decision limit (CCα) and detection capability (CCβ) ranged from 6 to 9 µg kg– 1 and from 7 to 13 µg kg– 1, respectively, except for streptomycin and neomycin, which showed slightly higher CCα at 25 µg kg– 1 and CCβ at 34 µg kg– 1. Finally, the method was applied to the honey test material 02270 through a FAPAS proficiency test (PT) for the determination of tetracyclines. PT results were obtained within a z-score range of ±2, proving that the validated method is suitable for routine analysis to ensure the quality of honey. © 2016 Informa UK Limited, trading as Taylor & Francis Group.", "publicationTitle": "Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment", "publisher": "", "place": "", "date": "2017", "volume": "34", "issue": "4", "section": "", "partNumber": "", "partTitle": "", "pages": "582-597", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1080/19440049.2016.1232491", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "Scopus", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "Scopus", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "LC-MS/MS", "type": 1 }, { "tag": "Multi-class analysis", "type": 1 }, { "tag": "honey", "type": 1 }, { "tag": "validation", "type": 1 }, { "tag": "veterinary drugs", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2018-09-10T13:54:57Z", "dateModified": "2018-09-10T13:54:57Z" } }, { "key": "XG3QB96G", "version": 8171, "library": { "type": "group", "id": 41682, "name": "Publications de l'Anses Laboratoire de Fougères", "links": { "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/41682/items/XG3QB96G", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres/items/XG3QB96G", "type": "text/html" } }, "meta": { "createdByUser": { "id": 564506, "username": "Doclab", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/doclab", "type": "text/html" } } }, "creatorSummary": "Charles et al.", "parsedDate": "2018", "numChildren": 0 }, "data": { "key": "XG3QB96G", "version": 8171, "itemType": "journalArticle", "title": "Assessment of the in vitro genotoxicity of TiO2nanoparticles in a regulatory context", "creators": [ { "creatorType": "author", "firstName": "S.", "lastName": "Charles" }, { "creatorType": "author", "firstName": "S.", "lastName": "Jomini" }, { "creatorType": "author", "firstName": "V.", "lastName": "Fessard" }, { "creatorType": "author", "firstName": "E.", "lastName": "Bigorgne-Vizade" }, { "creatorType": "author", "firstName": "C.", "lastName": "Rousselle" }, { "creatorType": "author", "firstName": "C.", "lastName": "Michel" } ], "abstractNote": "A review of in vitro genotoxicity studies on titanium dioxide nanoparticles (TiO2-NPs) published between 2010 and 2016 was performed by France in the framework of the CLP Regulation 1272/2008/EC. Neither the few in vivo studies of low quality nor the larger number of acceptable in vitro studies available for genotoxicity allowed France to conclude on the genotoxicity of TiO2-NPs. Based on this work, it was decided to compare the acceptable in vitro studies to understand the reasons for the diverging results observed, such as the materials tested or of the protocols used and their inherent interferences. The systematic review performed on in vitro genotoxicity data for TiO2-NPs was then restricted to studies with the highest level of confidence among studies following OECD guidelines and the largely applied comet assay. Indeed, the aim of this article is to understand why, even if judged of good quality, the 36 publications selected and analyzed did not lead to a clear picture. Some recommendations to be taken into account before performing new in vitro genotoxicity assays for insoluble particles such as TiO2-NPs are proposed. Although secondary genotoxic effects consequent to oxidative stress seem to be the major mechanism responsible for the genotoxicity of TiO2-NPs reported in some studies, primary genotoxic effects cannot be excluded. Further studies are needed to clarify the exact mode of action of TiO2-NPs and to highlight which physicochemical properties lead to their genotoxicity in vitro to ultimately identify a specific combination of parameters that could represent a risk in vivo. © 2018 Informa UK Limited, trading as Taylor & Francis Group.", "publicationTitle": "Nanotoxicology", "publisher": "", "place": "", "date": "2018", "volume": "12", "issue": "4", "section": "", "partNumber": "", "partTitle": "", "pages": "357-374", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1080/17435390.2018.1451567", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "Scopus", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "Scopus", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Titanium dioxide", "type": 1 }, { "tag": "genotoxicity", "type": 1 }, { "tag": "in vitro", "type": 1 }, { "tag": "nanoparticles", "type": 1 }, { "tag": "regulation", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2018-09-10T13:54:45Z", "dateModified": "2018-09-10T13:54:45Z" } }, { "key": "EFHQK57K", "version": 8172, "library": { "type": "group", "id": 41682, "name": "Publications de l'Anses Laboratoire de Fougères", "links": { "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/41682/items/EFHQK57K", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres/items/EFHQK57K", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/41682/items/EAUQEBSV", "type": "application/json" } }, "meta": { "createdByUser": { "id": 564506, "username": "Doclab", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/doclab", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "EFHQK57K", "version": 8172, "parentItem": "EAUQEBSV", "itemType": "note", "note": "Cited By :2
", "tags": [], "relations": {}, "dateAdded": "2018-09-10T13:54:41Z", "dateModified": "2018-09-10T13:54:41Z" } }, { "key": "SPSN4TPR", "version": 8171, "library": { "type": "group", "id": 41682, "name": "Publications de l'Anses Laboratoire de Fougères", "links": { "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/41682/items/SPSN4TPR", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres/items/SPSN4TPR", "type": "text/html" } }, "meta": { "createdByUser": { "id": 564506, "username": "Doclab", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/doclab", "type": "text/html" } } }, "creatorSummary": "Bridier et al.", "parsedDate": "2017", "numChildren": 0 }, "data": { "key": "SPSN4TPR", "version": 8171, "itemType": "journalArticle", "title": "Spatial organization plasticity as an adaptive driver of surface microbial communities", "creators": [ { "creatorType": "author", "firstName": "A.", "lastName": "Bridier" }, { "creatorType": "author", "firstName": "J.-C.", "lastName": "Piard" }, { "creatorType": "author", "firstName": "C.", "lastName": "Pandin" }, { "creatorType": "author", "firstName": "S.", "lastName": "Labarthe" }, { "creatorType": "author", "firstName": "F.", "lastName": "Dubois-Brissonnet" }, { "creatorType": "author", "firstName": "R.", "lastName": "Briandet" } ], "abstractNote": "Biofilms are dynamic habitats which constantly evolve in response to environmental fluctuations and thereby constitute remarkable survival strategies for microorganisms. The modulation of biofilm functional properties is largely governed by the active remodeling of their three-dimensional structure and involves an arsenal of microbial self-produced components and interconnected mechanisms. The production of matrix components, the spatial reorganization of ecological interactions, the generation of physiological heterogeneity, the regulation of motility, the production of actives enzymes are for instance some of the processes enabling such spatial organization plasticity. In this contribution, we discussed the foundations of architectural plasticity as an adaptive driver of biofilms through the review of the different microbial strategies involved. Moreover, the possibility to harness such characteristics to sculpt biofilm structure as an attractive approach to control their functional properties, whether beneficial or deleterious, is also discussed. © 2017 Bridier, Piard, Pandin, Labarthe, Dubois-Brissonnet and Briandet.", "publicationTitle": "Frontiers in Microbiology", "publisher": "", "place": "", "date": "2017", "volume": "8", "issue": "JUL", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.3389/fmicb.2017.01364", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "Scopus", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "Scopus", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Adaptative response", "type": 1 }, { "tag": "Microbial biofilm", "type": 1 }, { "tag": "Spatial dynamic", "type": 1 }, { "tag": "Structure/function", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2018-09-10T13:54:31Z", "dateModified": "2018-09-10T13:54:31Z" } }, { "key": "B5TQKYIX", "version": 8172, "library": { "type": "group", "id": 41682, "name": "Publications de l'Anses Laboratoire de Fougères", "links": { "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/41682/items/B5TQKYIX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres/items/B5TQKYIX", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/41682/items/KJY4XIEL", "type": "application/json" } }, "meta": { "createdByUser": { "id": 564506, "username": "Doclab", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/doclab", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "B5TQKYIX", "version": 8172, "parentItem": "KJY4XIEL", "itemType": "note", "note": "Cited By :3
", "tags": [], "relations": {}, "dateAdded": "2018-09-10T13:54:26Z", "dateModified": "2018-09-10T13:54:26Z" } }, { "key": "QXB3ZHVM", "version": 8172, "library": { "type": "group", "id": 41682, "name": "Publications de l'Anses Laboratoire de Fougères", "links": { "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/41682/items/QXB3ZHVM", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres/items/QXB3ZHVM", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/41682/items/BNNW9VD2", "type": "application/json" } }, "meta": { "createdByUser": { "id": 564506, "username": "Doclab", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/doclab", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "QXB3ZHVM", "version": 8172, "parentItem": "BNNW9VD2", "itemType": "note", "note": "Cited By :2
", "tags": [], "relations": {}, "dateAdded": "2018-09-10T13:54:24Z", "dateModified": "2018-09-10T13:54:24Z" } }, { "key": "QG6V5I3V", "version": 8172, "library": { "type": "group", "id": 41682, "name": "Publications de l'Anses Laboratoire de Fougères", "links": { "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/41682/items/QG6V5I3V", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres/items/QG6V5I3V", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/41682/items/XGZ24JUS", "type": "application/json" } }, "meta": { "createdByUser": { "id": 564506, "username": "Doclab", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/doclab", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "QG6V5I3V", "version": 8172, "parentItem": "XGZ24JUS", "itemType": "note", "note": "Cited By :9
", "tags": [], "relations": {}, "dateAdded": "2018-09-10T13:54:17Z", "dateModified": "2018-09-10T13:54:17Z" } }, { "key": "XGZ24JUS", "version": 8171, "library": { "type": "group", "id": 41682, "name": "Publications de l'Anses Laboratoire de Fougères", "links": { "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/41682/items/XGZ24JUS", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres/items/XGZ24JUS", "type": "text/html" } }, "meta": { "createdByUser": { "id": 564506, "username": "Doclab", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/doclab", "type": "text/html" } } }, "creatorSummary": "Pisapia et al.", "parsedDate": "2017", "numChildren": 1 }, "data": { "key": "XGZ24JUS", "version": 8171, "itemType": "journalArticle", "title": "Maitotoxin-4, a novel MTX analog produced by Gambierdiscus excentricus", "creators": [ { "creatorType": "author", "firstName": "F.", "lastName": "Pisapia" }, { "creatorType": "author", "firstName": "M.L.", "lastName": "Sibat" }, { "creatorType": "author", "firstName": "C.", "lastName": "Herrenknecht" }, { "creatorType": "author", "firstName": "K.", "lastName": "Lhaute" }, { "creatorType": "author", "firstName": "G.", "lastName": "Gaiani" }, { "creatorType": "author", "firstName": "P.-J.", "lastName": "Ferron" }, { "creatorType": "author", "firstName": "V.", "lastName": "Fessard" }, { "creatorType": "author", "firstName": "S.", "lastName": "Fraga" }, { "creatorType": "author", "firstName": "S.M.", "lastName": "Nascimento" }, { "creatorType": "author", "firstName": "R.W.", "lastName": "Litaker" }, { "creatorType": "author", "firstName": "W.C.", "lastName": "Holland" }, { "creatorType": "author", "firstName": "C.", "lastName": "Roullier" }, { "creatorType": "author", "firstName": "P.", "lastName": "Hess" } ], "abstractNote": "Maitotoxins (MTXs) are among the most potent toxins known. These toxins are produced by epi-benthic dinoflagellates of the genera Gambierdiscus and Fukuyoa and may play a role in causing the symptoms associated with Ciguatera Fish Poisoning. A recent survey revealed that, of the species tested, the newly described species from the Canary Islands, G. excentricus, is one of the most maitotoxic. The goal of the present study was to characterize MTX-related compounds produced by this species. Initially, lysates of cells from two Canary Island G. excentricus strains VGO791 and VGO792 were partially purified by (i) liquid-liquid partitioning between dichloromethane and aqueous methanol followed by (ii) size-exclusion chromatography. Fractions from chromatographic separation were screened for MTX toxicity using both the neuroblastoma neuro-2a (N2a) cytotoxicity and Ca2+ flux functional assays. Fractions containing MTX activity were analyzed using liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) to pinpoint potential MTX analogs. Subsequent non-targeted HRMS analysis permitted the identification of a novel MTX analog, maitotoxin-4 (MTX4, accurate mono-isotopic mass of 3292.4860 Da, as free acid form) in the most toxic fractions. HRMS/MS spectra of MTX4 as well as of MTX are presented. In addition, crude methanolic extracts of five other strains of G. excentricus and 37 other strains representing one Fukuyoa species and ten species, one ribotype and one undetermined strain/species of Gambierdiscus were screened for the presence of MTXs using low resolution tandem mass spectrometry (LRMS/MS). This targeted analysis indicated the original maitotoxin (MTX) was only present in one strain (G. australes S080911_1). Putative maitotoxin-2 (p-MTX2) and maitotoxin-3 (p-MTX3) were identified in several other species, but confirmation was not possible because of the lack of reference material. Maitotoxin-4 was detected in all seven strains of G. excentricus examined, independently of their origin (Brazil, Canary Islands and Caribbean), and not detected in any other species. MTX4 may therefore serve as a biomarker for the highly toxic G. excentricus in the Atlantic area. 2017 by the authors. Licensee MDPI.", "publicationTitle": "Marine Drugs", "publisher": "", "place": "", "date": "2017", "volume": "15", "issue": "7", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.3390/md15070220", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "Scopus", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "Scopus", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Bioguided fractionation", "type": 1 }, { "tag": "Gambierdiscus excentricus", "type": 1 }, { "tag": "LC-HRMS/MS (Q-Tof 6550)", "type": 1 }, { "tag": "LC-LRMS/MS (API4000 QTrap)", "type": 1 }, { "tag": "Maitotoxin-4", "type": 1 }, { "tag": "Neuro-2a (N2a) assay", "type": 1 }, { "tag": "Size-exclusion chromatography (LH-20)", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2018-09-10T13:54:17Z", "dateModified": "2018-09-10T13:54:17Z" } }, { "key": "VPZLHL74", "version": 8172, "library": { "type": "group", "id": 41682, "name": "Publications de l'Anses Laboratoire de Fougères", "links": { "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/41682/items/VPZLHL74", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres/items/VPZLHL74", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/41682/items/QF775DZY", "type": "application/json" } }, "meta": { "createdByUser": { "id": 564506, "username": "Doclab", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/doclab", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "VPZLHL74", "version": 8172, "parentItem": "QF775DZY", "itemType": "note", "note": "Cited By :1
", "tags": [], "relations": {}, "dateAdded": "2018-09-10T13:54:13Z", "dateModified": "2018-09-10T13:54:13Z" } }, { "key": "9HJTNXM5", "version": 8171, "library": { "type": "group", "id": 41682, "name": "Publications de l'Anses Laboratoire de Fougères", "links": { "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/41682/items/9HJTNXM5", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres/items/9HJTNXM5", "type": "text/html" } }, "meta": { "createdByUser": { "id": 564506, "username": "Doclab", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/doclab", "type": "text/html" } } }, "creatorSummary": "Theuerkauf et al.", "parsedDate": "2018", "numChildren": 0 }, "data": { "key": "9HJTNXM5", "version": 8171, "itemType": "journalArticle", "title": "Fraternal Polyandry and Clannish Spatial Organization in a Flightless Island Bird", "creators": [ { "creatorType": "author", "firstName": "J.", "lastName": "Theuerkauf" }, { "creatorType": "author", "firstName": "R.", "lastName": "Kuehn" }, { "creatorType": "author", "firstName": "S.", "lastName": "Rouys" }, { "creatorType": "author", "firstName": "H.", "lastName": "Bloc" }, { "creatorType": "author", "firstName": "R.", "lastName": "Gula" } ], "abstractNote": "Polyandry has been studied in many species, especially birds [1]. Exclusively fraternal polyandry (several full or half-brothers with one unrelated female) is only known in human societies [2, 3], in which it is an important mechanism for limiting reproductive output [3] in association with scarce environmental resources [2]. However, the social organization of the Kagu Rhynochetos jubatus, a bird species endemic to New Caledonia, has the characteristics of this mating system. Kagu are cooperative breeders and evolved in the absence of predators [4, 5]. Breeding birds and their helpers contributes to the care and defense of the chick [6]. Kagu populations occur in both poor and rich habitats [7] and differ substantially in food supply and associated reproduction rates [8]. This enabled us to verify whether fraternal polyandry increased reproductive output in low-density situations but limited reproduction in high-density populations. Our 15-year study revealed that, regardless of resource availability, Kagu were organized in facultative fraternal polyandrous families grouped in clans. Within a clan, all breeding females were unrelated, whereas all males were related. There was no extra-clan paternity. An average family size of four to five adults was optimal for breeding success. Males that have long-established families in their own territory regularly visited their parents. We conclude that fraternal polyandry in Kagu increases reproductive output under poor environmental conditions but limits population growth when the population is near carrying capacity because the clannish spatial organization prevents new families from establishing territories. Theuerkauf et al. reveal a striking social organization in a flightless bird, the Kagu, otherwise only known from human societies. Kagu are organized in facultative fraternal polyandrous families grouped in clans of related males. Male offspring that have established their own families within the clan still keep regular contacts with their parents. © 2018 Elsevier Ltd", "publicationTitle": "Current Biology", "publisher": "", "place": "", "date": "2018", "volume": "28", "issue": "9", "section": "", "partNumber": "", "partTitle": "", "pages": "1482-1488.e3", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1016/j.cub.2018.03.059", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "Scopus", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "Scopus", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Kagu", "type": 1 }, { "tag": "New Caledonia", "type": 1 }, { "tag": "Pacific", "type": 1 }, { "tag": "Rhynochetos jubatus", "type": 1 }, { "tag": "cooperative breeding", "type": 1 }, { "tag": "extra-pair paternity", "type": 1 }, { "tag": "genetic relatedness", "type": 1 }, { "tag": "kinship selection", "type": 1 }, { "tag": "male-skewed sex ratio", "type": 1 }, { "tag": "social organization", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2018-09-10T13:54:02Z", "dateModified": "2018-09-10T13:54:02Z" } }, { "key": "YP46YZKR", "version": 8172, "library": { "type": "group", "id": 41682, "name": "Publications de l'Anses Laboratoire de Fougères", "links": { "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/41682/items/YP46YZKR", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres/items/YP46YZKR", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/41682/items/KUZJIR9S", "type": "application/json" } }, "meta": { "createdByUser": { "id": 564506, "username": "Doclab", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/doclab", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "YP46YZKR", "version": 8172, "parentItem": "KUZJIR9S", "itemType": "note", "note": "Cited By :3
", "tags": [], "relations": {}, "dateAdded": "2018-09-10T13:53:53Z", "dateModified": "2018-09-10T13:53:53Z" } }, { "key": "5M28A3GU", "version": 8172, "library": { "type": "group", "id": 41682, "name": "Publications de l'Anses Laboratoire de Fougères", "links": { "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/41682/items/5M28A3GU", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres/items/5M28A3GU", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/41682/items/2EHLFIBU", "type": "application/json" } }, "meta": { "createdByUser": { "id": 564506, "username": "Doclab", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/doclab", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "5M28A3GU", "version": 8172, "parentItem": "2EHLFIBU", "itemType": "note", "note": "Cited By :2
", "tags": [], "relations": {}, "dateAdded": "2018-09-10T13:53:38Z", "dateModified": "2018-09-10T13:53:38Z" } }, { "key": "2EHLFIBU", "version": 8170, "library": { "type": "group", "id": 41682, "name": "Publications de l'Anses Laboratoire de Fougères", "links": { "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/41682/items/2EHLFIBU", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres/items/2EHLFIBU", "type": "text/html" } }, "meta": { "createdByUser": { "id": 564506, "username": "Doclab", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/doclab", "type": "text/html" } } }, "creatorSummary": "Kopp et al.", "parsedDate": "2018", "numChildren": 1 }, "data": { "key": "2EHLFIBU", "version": 8170, "itemType": "journalArticle", "title": "Genotoxicity of 11 heavy metals detected as food contaminants in two human cell lines", "creators": [ { "creatorType": "author", "firstName": "B.", "lastName": "Kopp" }, { "creatorType": "author", "firstName": "D.", "lastName": "Zalko" }, { "creatorType": "author", "firstName": "M.", "lastName": "Audebert" } ], "abstractNote": "Heavy metals, such as arsenic (As), antimony (Sb), barium (Ba), cadmium (Cd), cobalt (Co), germanium (Ge), lead (Pb), nickel (Ni), tellurium (Te), and vanadium (V) are widely distributed in the environment and in the food chain. Human exposure to heavy metals through water and food has been reported by different international agencies. Although some of these heavy metals are essential elements for human growth and development, they may also be toxic at low concentrations due to indirect mechanisms. In this study, the genotoxic and cytotoxic properties of 15 different oxidation statuses of 11 different heavy metals were investigated using high-throughput screening (γH2AX assay) in two human cell lines (HepG2 and LS-174T) representative of target organs (liver and colon) for food contaminants. Base on their lowest observed adverse effect concentration, the genotoxic potency of each heavy metal in each cell line was ranked in decreasing order, NaAsO2 > CdCl2 > PbCl2 (only in LS-174T cells) > As2O5 > SbCl3 > K2TeO3 > As2O3. No significant genotoxicity was observed with the other heavy metals tested. Cell viability data indicate that several heavy metals (As, Cd, Co, Ni, Sb, and Te) induce cytotoxicity at high concentrations, whereas an increase in the number of cells was observed for lead concentrations >100 µM in both cell lines tested, suggesting that lead stimulates cell growth. All these results highlight the possible human health hazards associated with the presence of heavy metals present in food. Environ. Mol. Mutagen. 59:202–210, 2018. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.", "publicationTitle": "Environmental and Molecular Mutagenesis", "publisher": "", "place": "", "date": "2018", "volume": "59", "issue": "3", "section": "", "partNumber": "", "partTitle": "", "pages": "202-210", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1002/em.22157", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "Scopus", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "Scopus", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "H2AX", "type": 1 }, { "tag": "genotoxicity", "type": 1 }, { "tag": "heavy metals", "type": 1 }, { "tag": "human cells", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2018-09-10T13:53:38Z", "dateModified": "2018-09-10T13:53:38Z" } }, { "key": "68GJHTD6", "version": 8172, "library": { "type": "group", "id": 41682, "name": "Publications de l'Anses Laboratoire de Fougères", "links": { "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/41682/items/68GJHTD6", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres/items/68GJHTD6", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/41682/items/YL68VRJE", "type": "application/json" } }, "meta": { "createdByUser": { "id": 564506, "username": "Doclab", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/doclab", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "68GJHTD6", "version": 8172, "parentItem": "YL68VRJE", "itemType": "note", "note": "Cited By :1
", "tags": [], "relations": {}, "dateAdded": "2018-09-10T13:53:27Z", "dateModified": "2018-09-10T13:53:27Z" } }, { "key": "7JH57NK8", "version": 8172, "library": { "type": "group", "id": 41682, "name": "Publications de l'Anses Laboratoire de Fougères", "links": { "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/41682/items/7JH57NK8", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/publications_de_lanses_laboratoire_de_fougres/items/7JH57NK8", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/41682/items/7Q3D8PW3", "type": "application/json" } }, "meta": { "createdByUser": { "id": 564506, "username": "Doclab", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/doclab", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "7JH57NK8", "version": 8172, "parentItem": "7Q3D8PW3", "itemType": "note", "note": "Cited By :1
", "tags": [], "relations": {}, "dateAdded": "2018-09-10T13:53:14Z", "dateModified": "2018-09-10T13:53:14Z" } } ]