[
    {
        "key": "V8NZNIIA",
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        "meta": {
            "createdByUser": {
                "id": 2666737,
                "username": "Lina María1",
                "name": "",
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            },
            "creatorSummary": "Casseb and Da Silva Duarte",
            "parsedDate": "2005-07",
            "numChildren": 0
        },
        "data": {
            "key": "V8NZNIIA",
            "version": 2,
            "itemType": "journalArticle",
            "title": "Structured intermittent therapy with seven-day cycles of HAART for chronic HIV infection: a pilot study in São Paulo, Brazil",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Jorge",
                    "lastName": "Casseb"
                },
                {
                    "creatorType": "author",
                    "firstName": "Alberto José",
                    "lastName": "Da Silva Duarte"
                }
            ],
            "abstractNote": "In the last 6 years, an impressive impact of the highly active antiretroviral therapy (HAART) on survival and morbidity in HIV-1-infected individuals has been attained. However, their prolonged use may induce metabolic adverse effects such as lipodistrophy, hypertension, diabetes mellitus, osteopenia and hyperlipidemia. Recently, new strategies such as short-cycle structured intermittent therapy (SIT; 7 days without therapy followed by 7 days with HAART) have been suggested. We tested this strategy in seven (four women and three men; mean of age 39 of years) HIV-positive individuals, all of whom had CD4+ T cell counts greater than 500 cells/mm3 and undetectable plasma viral load for at least 2 years. Our results indicated no opportunistic diseases or CD4 cell count decrease over a mean follow-up of 26 months. No plasma viral replication was detected in five of seven cases. There was a decrease in triglyceride levels to normal range (not statistically significant), but no modification of cholesterol levels. Thus, we recommend a larger clinical trial to determine if SIT is cost effective in developing countries.;",
            "publicationTitle": "AIDS Patient Care And Stds",
            "publisher": "",
            "place": "",
            "date": "Julio 2005",
            "volume": "19",
            "issue": "7",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "425-428",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "AIDS Patient Care And Stds",
            "DOI": "",
            "citationKey": "",
            "url": "http://search.ebscohost.com/login.aspx?direct=true&db=mnh&AN=16053399&lang=es&site=ehost-live",
            "accessDate": "2015-09-30T16:52:29Z",
            "PMID": "",
            "PMCID": "",
            "ISSN": "1087-2914",
            "archive": "",
            "archiveLocation": "16053399",
            "shortTitle": "Structured intermittent therapy with seven-day cycles of HAART for chronic HIV infection",
            "language": "",
            "libraryCatalog": "EBSCOhost",
            "callNumber": "",
            "rights": "",
            "extra": "",
            "tags": [
                {
                    "tag": "Adult",
                    "type": 1
                },
                {
                    "tag": "Antiretroviral Therapy, Highly Active/*methods",
                    "type": 1
                },
                {
                    "tag": "Brazil",
                    "type": 1
                },
                {
                    "tag": "CD4-Positive T-Lymphocytes/*immunology",
                    "type": 1
                },
                {
                    "tag": "Chronic Disease",
                    "type": 1
                },
                {
                    "tag": "Dose-Response Relationship, Drug",
                    "type": 1
                },
                {
                    "tag": "Drug Administration Schedule",
                    "type": 1
                },
                {
                    "tag": "Female",
                    "type": 1
                },
                {
                    "tag": "Follow-Up Studies",
                    "type": 1
                },
                {
                    "tag": "HIV Infections/*diagnosis",
                    "type": 1
                },
                {
                    "tag": "HIV Infections/*drug therapy",
                    "type": 1
                },
                {
                    "tag": "Humans",
                    "type": 1
                },
                {
                    "tag": "Male",
                    "type": 1
                },
                {
                    "tag": "Middle Aged",
                    "type": 1
                },
                {
                    "tag": "Pilot Projects",
                    "type": 1
                },
                {
                    "tag": "Risk Assessment",
                    "type": 1
                },
                {
                    "tag": "Sampling Studies",
                    "type": 1
                },
                {
                    "tag": "Severity of Illness Index",
                    "type": 1
                },
                {
                    "tag": "Treatment Outcome",
                    "type": 1
                },
                {
                    "tag": "Urban Population",
                    "type": 1
                },
                {
                    "tag": "Viral Load",
                    "type": 1
                }
            ],
            "collections": [],
            "relations": {},
            "dateAdded": "2015-09-30T17:05:22Z",
            "dateModified": "2015-09-30T17:05:22Z"
        }
    }
]