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"https://api.zotero.org/groups/399145/items/6GU2FEV8", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/orphan_drug/items/6GU2FEV8", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2081977, "username": "jnicho14", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jnicho14", "type": "text/html" } } }, "creatorSummary": "Thibert et al.", "parsedDate": "2013-04", "numChildren": 1 }, "data": { "key": "6GU2FEV8", "version": 59, "itemType": "journalArticle", "title": "Neurologic Manifestations of Angelman Syndrome", "creators": [ { "creatorType": "author", "firstName": "Ronald L.", "lastName": "Thibert" }, { "creatorType": "author", "firstName": "Anna M.", "lastName": "Larson" }, { "creatorType": "author", "firstName": "David T.", "lastName": "Hsieh" }, { "creatorType": "author", "firstName": "Annabel R.", "lastName": "Raby" }, { "creatorType": "author", "firstName": "Elizabeth A.", "lastName": "Thiele" } ], "abstractNote": "Angelman syndrome is a neurogenetic disorder characterized by the loss or reduction of the ubiquitin-protein ligase E3A enzyme. Angelman syndrome results from a deletion or mutation of the maternally inherited 15q11.2-13.1 region, paternal uniparental disomy of chromosome 15, or an imprinting error. Epilepsy is common and may present with multiple seizure types, including nonconvulsive status epilepticus. Seizures are often intractable and typically require broad-spectrum antiepileptic medications. Dietary therapy has also proved successful in Angelman syndrome. Electroencephalographic patterns include notched δ and rhythmic θ activity and epileptiform discharges. Sleep disorders are also common, often characterized by abnormal sleep-wake cycles. Movement disorders are nearly universal in Angelman syndrome, most frequently presenting with ataxia and tremor. Neurocognitive impairment is always present to varying degrees, and expressive speech is typically severely affected. Individuals with Angelman syndrome often manifest psychiatric comorbidities including hyperactivity, anxiety, and challenging behaviors such as aggression and self-injury. We focus on a comprehensive whole-child approach to the diagnosis and long-term clinical care of individuals with Angelman syndrome.", "publicationTitle": "Pediatric Neurology", "publisher": "", "place": "", "date": "April 2013", "volume": "48", "issue": "4", "section": "", "partNumber": "", "partTitle": "", "pages": "271-279", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Pediatric Neurology", "DOI": "10.1016/j.pediatrneurol.2012.09.015", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/S0887899412004833", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0887-8994", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-10-22T22:39:38Z", "dateModified": "2015-10-22T22:39:38Z" } }, { "key": "6XMFF7HP", "version": 58, "library": { "type": "group", "id": 399145, "name": "Orphan Drug", "links": { "alternate": { "href": "https://www.zotero.org/groups/orphan_drug", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/399145/items/6XMFF7HP", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/orphan_drug/items/6XMFF7HP", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2081977, "username": "jnicho14", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jnicho14", "type": "text/html" } } }, "creatorSummary": "Thibert et al.", "parsedDate": "2009-11-01", "numChildren": 1 }, "data": { "key": "6XMFF7HP", "version": 58, "itemType": "journalArticle", "title": "Epilepsy in Angelman syndrome: A questionnaire-based assessment of the natural history and current treatment options", "creators": [ { "creatorType": "author", "firstName": "Ronald L.", "lastName": "Thibert" }, { "creatorType": "author", "firstName": "Kerry D.", "lastName": "Conant" }, { "creatorType": "author", "firstName": "Eileen K.", "lastName": "Braun" }, { "creatorType": "author", "firstName": "Patricia", "lastName": "Bruno" }, { "creatorType": "author", "firstName": "Rana R.", "lastName": "Said" }, { "creatorType": "author", "firstName": "Mark P.", "lastName": "Nespeca" }, { "creatorType": "author", "firstName": "Elizabeth A.", "lastName": "Thiele" } ], "abstractNote": "", "publicationTitle": "Epilepsia", "publisher": "", "place": "", "date": "November 1, 2009", "volume": "50", "issue": "11", "section": "", "partNumber": "", "partTitle": "", "pages": "2369-2376", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1111/j.1528-1167.2009.02108.x", "citationKey": "", "url": "http://dx.doi.org/10.1111/j.1528-1167.2009.02108.x", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1528-1167", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Angelman syndrome" }, { "tag": "Antiepileptic medications" }, { "tag": "Chromosome 15" }, { "tag": "Epilepsy" } ], "collections": [], "relations": {}, "dateAdded": "2015-10-22T22:38:41Z", "dateModified": "2015-10-22T22:38:41Z" } }, { "key": "XEWGTEV7", "version": 58, "library": { "type": "group", "id": 399145, "name": "Orphan Drug", "links": { "alternate": { "href": "https://www.zotero.org/groups/orphan_drug", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/399145/items/XEWGTEV7", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/orphan_drug/items/XEWGTEV7", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/399145/items/6XMFF7HP", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2081977, "username": "jnicho14", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jnicho14", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "XEWGTEV7", "version": 58, "parentItem": "6XMFF7HP", "itemType": "attachment", "linkMode": "imported_file", "title": "Thibert_et_al-2009-Epilepsia.pdf", "accessDate": "", "url": "", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Thibert_et_al-2009-Epilepsia.pdf", "md5": null, "mtime": null, "tags": [], "relations": {}, "dateAdded": "2015-10-22T22:38:41Z", "dateModified": "2015-10-22T22:38:41Z" } }, { "key": "27RMQ94N", "version": 57, "library": { "type": "group", "id": 399145, "name": "Orphan Drug", "links": { "alternate": { "href": "https://www.zotero.org/groups/orphan_drug", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/399145/items/27RMQ94N", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/orphan_drug/items/27RMQ94N", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2081977, "username": "jnicho14", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jnicho14", "type": "text/html" } } }, "creatorSummary": "Van Buggenhout and Fryns", "parsedDate": "2009-05-20", "numChildren": 1 }, "data": { "key": "27RMQ94N", "version": 57, "itemType": "journalArticle", "title": "Angelman syndrome (AS, MIM 105830)", "creators": [ { "creatorType": "author", "firstName": "Griet", "lastName": "Van Buggenhout" }, { "creatorType": "author", "firstName": "Jean-Pierre", "lastName": "Fryns" } ], "abstractNote": "", "publicationTitle": "Eur J Hum Genet", "publisher": "", "place": "", "date": "May 20, 2009", "volume": "17", "issue": "11", "section": "", "partNumber": "", "partTitle": "", "pages": "1367-1373", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Eur J Hum Genet", "DOI": "", "citationKey": "", "url": "http://dx.doi.org/10.1038/ejhg.2009.67", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1018-4813", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-10-22T22:29:46Z", "dateModified": "2015-10-22T22:29:46Z" } }, { "key": "9MTMICSX", "version": 56, "library": { "type": "group", "id": 399145, "name": "Orphan Drug", "links": { "alternate": { "href": "https://www.zotero.org/groups/orphan_drug", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/399145/items/9MTMICSX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/orphan_drug/items/9MTMICSX", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/399145/items/I687RQEJ", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2081977, "username": "jnicho14", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jnicho14", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "9MTMICSX", "version": 56, "parentItem": "I687RQEJ", "itemType": "attachment", "linkMode": "imported_file", "title": 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"itemType": "journalArticle", "title": "Angelman syndrome: review of clinical and molecular aspects", "creators": [ { "creatorType": "author", "firstName": "Lynne M", "lastName": "Bird" } ], "abstractNote": "“Angelman syndrome” (AS) is a neurodevelopmental disorder whose main features are intellectual disability, lack of speech, seizures, and a characteristic behavioral profile. The behavioral features of AS include a happy demeanor, easily provoked laughter, short attention span, hypermotoric behavior, mouthing of objects, sleep disturbance, and an affinity for water. Microcephaly and subtle dysmorphic features, as well as ataxia and other movement disturbances, are additional features seen in most affected individuals. AS is due to deficient expression of the ubiquitin protein ligase E3A (UBE3A) gene, which displays paternal imprinting. There are four molecular classes of AS, and some genotype–phenotype correlations have emerged. Much remains to be understood regarding how insufficiency of E6-AP, the protein product of UBE3A, results in the observed neurodevelopmental deficits. Studies of mouse models of AS have implicated UBE3A in experience-dependent synaptic remodeling.", "publicationTitle": "The Application of Clinical Genetics", "publisher": "", "place": "", "date": "2014", "volume": "7", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "93-104", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.2147/TACG.S57386", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036146/", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1178-704X", "archive": "PMC", "archiveLocation": "PMC4036146", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-10-22T22:16:25Z", "dateModified": "2015-10-22T22:16:25Z" } }, { "key": "FQID7VT5", "version": 55, "library": { "type": "group", "id": 399145, "name": "Orphan Drug", "links": { "alternate": { "href": "https://www.zotero.org/groups/orphan_drug", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/399145/items/FQID7VT5", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/orphan_drug/items/FQID7VT5", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/399145/items/DTSJZWUF", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2031966, "username": "mlussier", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mlussier", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "FQID7VT5", "version": 55, "parentItem": "DTSJZWUF", "itemType": "attachment", "linkMode": "imported_file", "title": "UBE3A.pdf", "accessDate": "", "url": "", "note": "", "contentType": "application/pdf", "charset": "", "filename": "UBE3A.pdf", "md5": null, "mtime": null, "tags": [], "relations": {}, "dateAdded": "2015-10-22T22:14:28Z", "dateModified": "2015-10-22T22:14:28Z" } }, { "key": "6C4Z2E8K", "version": 54, "library": { "type": "group", "id": 399145, "name": "Orphan Drug", "links": { "alternate": { "href": "https://www.zotero.org/groups/orphan_drug", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/399145/items/6C4Z2E8K", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/orphan_drug/items/6C4Z2E8K", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2081977, "username": "jnicho14", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jnicho14", "type": "text/html" } } }, "creatorSummary": "Valente et al.", "parsedDate": "2013-07", "numChildren": 1 }, "data": { "key": "6C4Z2E8K", "version": 54, "itemType": "journalArticle", "title": "Angelman syndrome caused by deletion: A genotype–phenotype correlation determined by breakpoint", "creators": [ { "creatorType": "author", "firstName": "Kette D.", "lastName": "Valente" }, { "creatorType": "author", "firstName": "Monica Castro", "lastName": "Varela" }, { "creatorType": "author", "firstName": "Celia Priszkulnik", "lastName": "Koiffmann" }, { "creatorType": "author", "firstName": "Joaquina Queiroz", "lastName": "Andrade" }, { "creatorType": "author", "firstName": "Rosi", "lastName": "Grossmann" }, { "creatorType": "author", "firstName": "Fernando", "lastName": "Kok" }, { "creatorType": "author", "firstName": "Maria Joaquina", "lastName": "Marques-Dias" } ], "abstractNote": "SummaryObjectives\nDeletion of the chromosome 15q11-q13, the most common genetic mechanism associated with Angelman syndrome (AS), is highly associated with a severe phenotype. However, deletion is not a genetically homogeneous group as it is composed by two main groups: Class I with breakpoints at BP1 (proximal) and BP3 (distal) and Class II present breakpoints at BP2 (proximal) and BP3 (distal). In this study, we aimed to evaluate the impact of the breakpoint on the electroclinical profile.\nMethods\nWe evaluated 16 patients with AS caused by 15q11-13 deletion (6 were Class I; 10 were Class II). We characterized epilepsy features by clinical history obtained from parents and caretakers with a pre-standard questionnaire. These data were corroborated by medical records, contact with previous physicians, and video-EEG monitoring. Suggestive EEG patterns for AS were classified according to the classical description of Boyd et al. (1988).\nResults\nAS patients with BP1–BP3 deletion had significantly more daily and disabling seizures than AS patients with BP1–BP2 deletion. They also presented a significant higher frequency of status epilepticus and epilepsy aggravated by fever. Need for polytherapy was significantly more frequent in BP1–BP3 patients. EEG features were similar in both groups.\nConclusion\nThis study shows a significant correlation between the two deletion classes and AS clinical, but not the electrographic phenotype. Epilepsy is more severe and refractory to treatment in patients with larger deletions. Deletion is not a homogeneous group and knowledge on the breakpoint may have a clinical implication and represent an important factor in parental counseling.", "publicationTitle": "Epilepsy Research", "publisher": "", "place": "", "date": "July 2013", "volume": "105", "issue": "1–2", "section": "", "partNumber": "", "partTitle": "", "pages": "234-239", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Epilepsy Research", "DOI": "10.1016/j.eplepsyres.2012.12.005", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/S0920121112003877", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0920-1211", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Angelman syndrome" }, { "tag": "Breakpoint" }, { "tag": "Deletion" }, { "tag": "Epilepsy" } ], "collections": [], "relations": {}, "dateAdded": "2015-10-22T22:12:52Z", "dateModified": "2015-10-22T22:12:52Z" } }, { "key": "4P6PJNN8", "version": 53, "library": { "type": "group", "id": 399145, "name": "Orphan Drug", "links": { "alternate": { "href": "https://www.zotero.org/groups/orphan_drug", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/399145/items/4P6PJNN8", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/orphan_drug/items/4P6PJNN8", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/399145/items/ZRAFWD54", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2081977, "username": "jnicho14", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jnicho14", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "4P6PJNN8", "version": 53, "parentItem": "ZRAFWD54", "itemType": "attachment", "linkMode": "imported_file", "title": "ng0197-70.pdf", "accessDate": "", "url": "", "note": "", "contentType": "application/pdf", "charset": "", "filename": "ng0197-70.pdf", "md5": null, "mtime": null, "tags": [], "relations": {}, "dateAdded": "2015-10-22T22:09:21Z", "dateModified": "2015-10-22T22:09:21Z" } }, { "key": "ZRAFWD54", "version": 53, "library": { "type": "group", "id": 399145, "name": "Orphan Drug", "links": { "alternate": { "href": "https://www.zotero.org/groups/orphan_drug", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/399145/items/ZRAFWD54", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/orphan_drug/items/ZRAFWD54", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2081977, "username": "jnicho14", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jnicho14", "type": "text/html" } } }, "creatorSummary": "Kishino et al.", "parsedDate": "1997-01", "numChildren": 1 }, "data": { "key": "ZRAFWD54", "version": 53, "itemType": "journalArticle", "title": "UBE3A/E6-AP mutations cause Angelman syndrome", "creators": [ { "creatorType": "author", "firstName": "Tatsuya", "lastName": "Kishino" }, { "creatorType": "author", "firstName": "Marc", "lastName": "Lalande" }, { "creatorType": "author", "firstName": "Joseph", "lastName": "Wagstaff" } ], "abstractNote": "", "publicationTitle": "Nature Genetics", "publisher": "", "place": "", "date": "January 1997", "volume": "15", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "70-73", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-10-22T22:07:17Z", "dateModified": "2015-10-22T22:09:12Z" } }, { "key": "B3UUEZ3K", "version": 49, "library": { "type": "group", "id": 399145, "name": "Orphan Drug", "links": { "alternate": { "href": "https://www.zotero.org/groups/orphan_drug", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/399145/items/B3UUEZ3K", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/orphan_drug/items/B3UUEZ3K", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2081977, "username": "jnicho14", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jnicho14", "type": "text/html" } } }, "creatorSummary": "Meijers-Heijboer et al.", "parsedDate": "1992-12-01", "numChildren": 0 }, "data": { "key": "B3UUEZ3K", "version": 49, "itemType": "journalArticle", "title": "Linkage analysis with chromosome 15q11-13 markers shows genomic imprinting in familial Angelman syndrome.", "creators": [ { "creatorType": "author", "firstName": "E J", "lastName": "Meijers-Heijboer" }, { "creatorType": "author", "firstName": "L A", "lastName": "Sandkuijl" }, { "creatorType": "author", "firstName": "H G", "lastName": "Brunner" }, { "creatorType": "author", "firstName": "H J", "lastName": "Smeets" }, { "creatorType": "author", "firstName": "A J", "lastName": "Hoogeboom" }, { "creatorType": "author", "firstName": "W H", "lastName": "Deelen" }, { "creatorType": "author", "firstName": "J O", "lastName": "van Hemel" }, { "creatorType": "author", "firstName": "M R", "lastName": "Nelen" }, { "creatorType": "author", "firstName": "D F", "lastName": "Smeets" }, { "creatorType": "author", "firstName": "M F", "lastName": "Niermeijer" } ], "abstractNote": "Angelman syndrome (AS) and Prader-Willi syndrome (PWS) have become the classical examples of genomic imprinting in man, as completely different phenotypes are generated by the absence of maternal (AS) or paternal (PWS) contributions to the q11-13 region of chromosome 15 as a result of deletion or uniparental disomy. Apparently, most patients are sporadic cases. The genetic mechanism underlying familial AS has remained enigmatic for a long time. Recently, evidence has been emerging suggesting autosomal dominant inheritance of a detectable or undetectable defect in a gene or genes at 15q11-13, subject to genomic imprinting. The present report describes an unusually large pedigree with segregation of AS through maternal inheritance and apparent asymptomatic transmission through several male ancestors. Deletion and paternal disomy at 15q11-13 were excluded. However, the genetic defect is still located in this region, as we obtained a maximum lod score of 5.40 for linkage to the GABA receptor locus GABRB3 and the anonymous DNA marker D15S10, which have been mapped within or adjacent to the AS critical region at 15q11-13. The size of the pedigree allowed calculation of an odds ratio in favour of genomic imprinting of 9.25 x 10(5). This family illustrates the necessity of extensive pedigree analysis when considering recurrence risks for relatives of AS patients, those without detectable deletion or disomy in particular.", "publicationTitle": "Journal of Medical Genetics", "publisher": "", "place": "", "date": "December 1, 1992", "volume": "29", "issue": "12", "section": "", "partNumber": "", "partTitle": "", "pages": "853-857", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Journal of Medical Genetics", "DOI": "10.1136/jmg.29.12.853", "citationKey": "", "url": "http://jmg.bmj.com/content/29/12/853.abstract", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-10-22T22:04:03Z", "dateModified": "2015-10-22T22:04:03Z" } }, { "key": "2VUPUR3A", "version": 48, "library": { "type": "group", "id": 399145, "name": "Orphan Drug", "links": { "alternate": { "href": "https://www.zotero.org/groups/orphan_drug", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/399145/items/2VUPUR3A", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/orphan_drug/items/2VUPUR3A", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/399145/items/TXXXZ4UC", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2031966, "username": "mlussier", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mlussier", "type": "text/html" } } } }, "data": { "key": "2VUPUR3A", "version": 48, "parentItem": "TXXXZ4UC", "itemType": "attachment", "linkMode": "imported_url", "title": "Minocycline in the Treatment of Angelman Syndrome - 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