[ { "key": "XGKGXVAR", "version": 76, "library": { "type": "group", "id": 393033, "name": "UALR Cheminformatics Group1", "links": { "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/393033/items/XGKGXVAR", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1/items/XGKGXVAR", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2607154, "username": "sahouse2510", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/sahouse2510", "type": "text/html" } } }, "creatorSummary": "Laurie J. Morrison, MD et al", "parsedDate": "2000-05-24", "numChildren": 0 }, "data": { "key": "XGKGXVAR", "version": 76, "itemType": "journalArticle", "title": "Mortality and Prehospital Thrombolysis for Acute Myocardial Infarction", "creators": [ { "creatorType": "author", "firstName": "", "lastName": "Laurie J. Morrison, MD et al" } ], "abstractNote": "Context Early administration of thrombolysis for acute myocardial infarction (AMI) may improve survival if safely and appropriately delivered. No systematic reviews that have comprehensively examined this topic exist in the literature.\n\nObjective To perform a meta-analysis of randomized controlled trials of prehospital vs in-hospital thrombolysis for AMI measuring in-hospital mortality.\n\nData Sources The Cochrane search strategy was used to search MEDLINE, EMBASE, and the Science Citation Index (1982-1999); Dissertation Abstracts (1987-1999); and Current Contents (1994-1999) for the terms thrombolysis, thrombolysis therapy, prehospital, and acute myocardial infarction. In addition, text and journal article bibliographies were hand searched, the National Institutes of Health Web site was reviewed, and primary authors and thrombolytic drug manufacturers were contacted for unpublished studies.\n\nStudy Selection Randomized controlled trials of prehospital vs in-hospital thrombolysis for AMI measuring all-cause hospital mortality were included. Two authors independently reviewed 175 citations by title, abstract, or complete article. After exclusion of 30 duplicate citations, 145 studies remained, of which 6 studies and 3 follow-up studies met the inclusion criteria.\n\nData Extraction Independent data abstraction by 2 reviewers blinded to the journal, title, and author was confirmed by consensus. Trial quality was independently assessed by 2 other coauthors, blinded to the author, title, journal, introduction, and discussion.\n\nData Synthesis The results of the 6 randomized trials (n=6434) were pooled and indicated significantly decreased all-cause hospital mortality among patients treated with prehospital thrombolysis compared with in-hospital thrombolysis (odds ratio, 0.83; 95% confidence interval, 0.70-0.98). Results were similar regardless of trial quality or training and experience of the provider. Estimated (SE) time to thrombolysis was 104 (7) minutes for the prehospital group and 162 (16) minutes for the in-hospital thrombolysis group (P=.007).\n\nConclusions Our meta-analysis suggests that prehospital thrombolysis for AMI significantly decreases the time to thrombolysis and all-cause hospital mortality.", "publicationTitle": "The Journal of the American Medicall Association", "publisher": "", "place": "", "date": "May 24, 2000", "volume": "283", "issue": "20", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "0.1001", "citationKey": "", "url": "http://jama.jamanetwork.com/article.aspx?articleid=192728", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "87RC8PNG" ], "relations": {}, "dateAdded": "2015-09-07T16:10:24Z", "dateModified": "2015-09-07T16:10:24Z" } }, { "key": "MSTRZ2G8", "version": 76, "library": { "type": "group", "id": 393033, "name": "UALR Cheminformatics Group1", "links": { "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/393033/items/MSTRZ2G8", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1/items/MSTRZ2G8", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2607154, "username": "sahouse2510", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/sahouse2510", "type": "text/html" } } }, "creatorSummary": "Wanda L Rivera-Bou, MD,", "parsedDate": "2014-03-11", "numChildren": 0 }, "data": { "key": "MSTRZ2G8", "version": 76, "itemType": "webpage", "title": "Thrombolytic Therapy", "creators": [ { "creatorType": "author", "firstName": "", "lastName": "Wanda L Rivera-Bou, MD," } ], "abstractNote": "Thrombosis is an important part of the normal hemostatic response that limits hemorrhage caused by microscopic or macroscopic vascular injury. Physiologic thrombosis is counterbalanced by intrinsic antithrombotic properties and fibrinolysis. Under normal conditions, a thrombus is confined to the immediate area of injury and does not obstruct flow to critical areas, unless the blood vessel lumen is already diminished, as it is in atherosclerosis.\n\nUnder pathologic conditions, a thrombus can propagate into otherwise normal vessels. A thrombus that has propagated where it is not needed can obstruct flow in critical vessels; it can also obliterate valves and other structures that are essential to normal hemodynamic function. The principal clinical syndromes that result are as follows:\n\nAcute myocardial infarction (AMI)\nDeep vein thrombosis (DVT)\nPulmonary embolism (PE)\nAcute ischemic stroke (AIS)\nAcute peripheral arterial occlusion\nOcclusion of indwelling catheters", "websiteTitle": "Medscape", "websiteType": "", "date": "March 11, 2014", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://emedicine.medscape.com/article/811234-overview", "accessDate": "", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [ "87RC8PNG" ], "relations": {}, "dateAdded": "2015-09-07T16:04:37Z", "dateModified": "2015-09-07T16:04:37Z" } }, { "key": "5FT4GVZD", "version": 76, "library": { "type": "group", "id": 393033, "name": "UALR Cheminformatics Group1", "links": { "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/393033/items/5FT4GVZD", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1/items/5FT4GVZD", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2607154, "username": "sahouse2510", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/sahouse2510", "type": "text/html" } } }, "creatorSummary": "NA", "numChildren": 0 }, "data": { "key": "5FT4GVZD", "version": 76, "itemType": "webpage", "title": "Thrombolytics", "creators": [ { "creatorType": "author", "firstName": "", "lastName": "NA" } ], "abstractNote": "", "websiteTitle": "Drugs.com", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://www.drugs.com/drug-class/thrombolytics.html", "accessDate": "", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [ "87RC8PNG" ], "relations": {}, "dateAdded": "2015-09-07T16:00:34Z", "dateModified": "2015-09-07T16:00:34Z" } }, { "key": "54XZNDMJ", "version": 76, "library": { "type": "group", "id": 393033, "name": "UALR Cheminformatics Group1", "links": { "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/393033/items/54XZNDMJ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1/items/54XZNDMJ", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2607154, "username": "sahouse2510", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/sahouse2510", "type": "text/html" } } }, "creatorSummary": "Gheorge-Andrei Dan", "numChildren": 0 }, "data": { "key": "54XZNDMJ", "version": 76, "itemType": "book", "title": "Atrial Fibrillation Therapy (Current Cardiovascular Therapy)", "creators": [ { "creatorType": "author", "firstName": "", "lastName": "Gheorge-Andrei Dan" } ], "abstractNote": "", "series": "", "seriesNumber": "", "volume": "", "numberOfVolumes": "", "edition": "", "date": "", "publisher": "Springer", "place": "", "originalDate": "", "originalPublisher": "", "originalPlace": "", "format": "", "numPages": "", "ISBN": "", "DOI": "", "citationKey": "", "url": "https://jet.com/product/product/8a8adf69b31d469fad5d2fd537391bd7?jcmp=pla:ggl:media_a2:books_a2_other:na:na:na:na:na:2&code=PLA15&k_clickid=7676ef2e-ad1c-4109-3b0b-00005d316149&kpid=8a8adf69b31d469fad5d2fd537391bd7&gclid=CjwKEAjw67SvBRC1m5zPv4GboAUSJAB6MJlknExno-489zrxRyP4ZEfTkBMPm7r4_7YNTueYu4ZTjxoCtDLw_wcB", "accessDate": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "87RC8PNG" ], "relations": {}, "dateAdded": "2015-09-07T15:58:15Z", "dateModified": "2015-09-07T15:58:15Z" } }, { "key": "BA3MZTCF", "version": 76, "library": { "type": "group", "id": 393033, "name": "UALR Cheminformatics Group1", "links": { "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/393033/items/BA3MZTCF", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1/items/BA3MZTCF", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2607154, "username": "sahouse2510", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/sahouse2510", "type": "text/html" } } }, "creatorSummary": "Bossavy JP et al", "parsedDate": "1999", "numChildren": 0 }, "data": { "key": "BA3MZTCF", "version": 76, "itemType": "journalArticle", "title": "Antithrombotic efficacy of the vitamin K antagonist fluindione in a human Ex vivo model of arterial thrombosis : effect of anticoagulation level and combination therapy with aspirin", "creators": [ { "creatorType": "author", "firstName": "", "lastName": "Bossavy JP et al" } ], "abstractNote": "Thrombin is a main mediator of arterial thrombus formation, and its inhibition is an important antithrombotic strategy. However, the place of vitamin K antagonists among the different therapeutic strategies for preventing arterial thrombus formation is still debated. We studied the antithrombotic efficacy of the vitamin K antagonist fluindione in a human ex vivo model of arterial thrombosis and determined whether aspirin enhances fluindione efficacy. Ten healthy male volunteers were randomly assigned to receive fluindione, alone or in combination with aspirin (325 mg/d). Fluindione was given at increasing doses to give a stable international normalized ratio (INR) between 1.5 and 2.0 and between 2.1 and 3.0. We induced arterial thrombus formation ex vivo by exposing collagen- or tissue factor (TF)-coated coverslips in a parallel-plate perfusion chamber to native blood for 3 minutes at an arterial wall shear rate of 2600 s(-1). Platelet and fibrin deposition were measured by immunoenzymatic methods. Fluindione inhibited thrombus formation on TF-coated coverslips in a dose-dependent manner by 50% and 80% at INR 1.5 to 2.0 and INR 2.1 to 3.0, respectively (P<0.05). Fluindione in combination with aspirin inhibited TF-induced thrombus formation in a comparable manner. Collagen-induced thrombus formation was not reduced in subjects treated by fluindione. It was reduced by 50% to 60% in those treated with fluindione plus aspirin, regardless of the level of anticoagulation (P<0.05). Thus, the effectiveness of fluindione for preventing arterial thrombosis is dependent on the nature of the thrombogenic trigger. Fluindione is very effective in preventing TF- but not collagen-triggered thrombus formation. Aspirin enhances the antithrombotic effectiveness of fluindione, because combined treatment interrupts both TF- and collagen-induced thrombus formation.", "publicationTitle": "", "publisher": "", "place": "", "date": "09/1999", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "2269-75", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/10479672", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "87RC8PNG" ], "relations": {}, "dateAdded": "2015-09-07T15:35:16Z", "dateModified": "2015-09-07T15:47:50Z" } }, { "key": "MB6S444N", "version": 76, "library": { "type": "group", "id": 393033, "name": "UALR Cheminformatics Group1", "links": { "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/393033/items/MB6S444N", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1/items/MB6S444N", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2607154, "username": "sahouse2510", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/sahouse2510", "type": "text/html" } } }, "creatorSummary": "Sam S Rebello, et al", "numChildren": 0 }, "data": { "key": "MB6S444N", "version": 76, "itemType": "manuscript", "title": "Antithrombotic efficacy of a novel factor Xa inhibitor, FXV673, in a canine model of coronary artery thrombolysis", "creators": [ { "creatorType": "author", "firstName": "", "lastName": "Sam S Rebello, et al" } ], "abstractNote": "We compared the antithrombotic efficacy of a potent factor Xa inhibitor, FXV673, to heparin and RPR109891, a GPIIb/IIIa antagonist, when used as adjunctive therapy in a canine model of rt-PA-induced coronary thrombolysis.\nThrombus formation was induced by electrolytic injury to stenosed coronary artery. After thrombotic occlusion, a 135 min infusion of saline (n=8), FXV673 (10, 30 or 100 μg kg−1+1, 3, or 10 μg kg−1 min−1, respectively; n=8 per dose), heparin (60 u kg−1+0.7 u kg−1 min−1, n=8), or RPR109891 (30 μg kg−1+0.45 μg kg−1 min−1, n=8), was initiated. Aspirin (5 mg kg−1, i.v.) was administered to all animals. Fifteen minutes after the start of drug infusion, rt-PA was administered (100 μg kg−1+20 μg kg−1 min−1 for 60 min).\nThe incidence of reperfusion in the high dose FXV673 (8/8, 100%) was significantly greater than that in the heparin group (4/8, 50%), with a trend to faster reperfusion (23±5 min for FXV673 versus 41±11 min for heparin). Only 2/8 (25%) of the vessels reoccluded in the high dose FXV673 group, compared to 4/4 (100%) and 5/5 (100%) vessels in the heparin and RPR109891 groups, respectively (P<0.05).\nThroughout the protocol, blood flow was higher in the FXV673 treated group compared to other groups. FXV673 enhanced vessel patency in a dose-dependent manner.\nCompared to vehicle and heparin groups, the thrombus mass was decreased by 60% in the high dose FXV673. FXV673, heparin and RPR109891 increased the bleeding time by 2.7, 1.7 and 4 fold, and APTT by 2.8, 2.7 and 1.2 fold, respectively.\nIn conclusion, FXV673 is more effective than heparin and at least as effective as RPR109891 when used as an adjunct during rt-PA-induced coronary thrombolysis.", "manuscriptType": "Database", "institution": "", "place": "Br J Pharmacol", "date": "08/15", "numPages": "", "number": "", "DOI": "", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1572886/", "accessDate": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "DOI: 10.1038/sj.bjp.0704182", "tags": [], "collections": [ "87RC8PNG" ], "relations": {}, "dateAdded": "2015-09-07T15:29:28Z", "dateModified": "2015-09-07T15:44:28Z" } }, { "key": "I4CGH97E", "version": 76, "library": { "type": "group", "id": 393033, "name": "UALR Cheminformatics Group1", "links": { "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/393033/items/I4CGH97E", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1/items/I4CGH97E", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2607154, "username": "sahouse2510", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/sahouse2510", "type": "text/html" } } }, "creatorSummary": "Michelle Christina Johansen, MD", "numChildren": 0 }, "data": { "key": "I4CGH97E", "version": 76, "itemType": "blogPost", "title": "Initiation of antithrombotic therapy after ICH: Do we do it?", "creators": [ { "creatorType": "author", "firstName": "", "lastName": "Michelle Christina Johansen, MD" } ], "abstractNote": "", "blogTitle": "Blogging Stroke", "websiteType": "", "date": "2015-08-17 8/17/15", "DOI": "", "citationKey": "", "url": "http://strokeblog.strokeahajournal.org/2015/08/initiation-of-antithrombotic-therapy.html", "accessDate": "", "ISSN": "", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [ "87RC8PNG" ], "relations": {}, "dateAdded": "2015-09-07T15:39:16Z", "dateModified": "2015-09-07T15:39:16Z" } }, { "key": "7Q7HZMNU", "version": 76, "library": { "type": "group", "id": 393033, "name": "UALR Cheminformatics Group1", "links": { "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/393033/items/7Q7HZMNU", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1/items/7Q7HZMNU", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2607154, "username": "sahouse2510", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/sahouse2510", "type": "text/html" } } }, "creatorSummary": "NA", "numChildren": 0 }, "data": { "key": "7Q7HZMNU", "version": 76, "itemType": "webpage", "title": "LEARN MORE ABOUR ANTITHROMBOTICS", "creators": [ { "creatorType": "author", "firstName": "", "lastName": "NA" } ], "abstractNote": "", "websiteTitle": "Sanofi", "websiteType": "", "date": "2015-09-03 9/3/15", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://en.sanofi.com/Images/21175_Antithrombotics_backgrounder.pdf", "accessDate": "", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [ "87RC8PNG" ], "relations": {}, "dateAdded": "2015-09-07T15:37:01Z", "dateModified": "2015-09-07T15:37:01Z" } }, { "key": "4297QWKP", "version": 76, "library": { "type": "group", "id": 393033, "name": "UALR Cheminformatics Group1", "links": { "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/393033/items/4297QWKP", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1/items/4297QWKP", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2604971, "username": "John House", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/john_house", "type": "text/html" } } }, "creatorSummary": "Lee et al.", "numChildren": 0 }, "data": { "key": "4297QWKP", "version": 76, "itemType": "journalArticle", "title": "Antithrombotic and antiplatelet activities of Soshiho-tang extract", "creators": [ { "creatorType": "author", "firstName": "C", "lastName": "Lee" }, { "creatorType": "author", "firstName": "T", "lastName": "Kim" }, { "creatorType": "author", "firstName": "W", "lastName": "Cho" } ], "abstractNote": "", "publicationTitle": "BMC Complementary and Alternative Medicine 2013", "publisher": "", "place": "", "date": "", "volume": "13:137", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1186/1472-6882-13-137", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "87RC8PNG" ], "relations": {}, "dateAdded": "2015-09-05T12:35:26Z", "dateModified": "2015-09-07T01:40:59Z" } }, { "key": "7KRXDKW4", "version": 76, "library": { "type": "group", "id": 393033, "name": "UALR Cheminformatics Group1", "links": { "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/393033/items/7KRXDKW4", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1/items/7KRXDKW4", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2604971, "username": "John House", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/john_house", "type": "text/html" } } }, "creatorSummary": "Bell et al.", "parsedDate": "1998", "numChildren": 0 }, "data": { "key": "7KRXDKW4", "version": 76, "itemType": "book", "title": "Antithrombotics", "creators": [ { "creatorType": "author", "firstName": "Robert", "lastName": "Bell" }, { "creatorType": "author", "firstName": "A", "lastName": "Uprichard" }, { "creatorType": "author", "firstName": "K", "lastName": "Gallager" } ], "abstractNote": "", "series": "", "seriesNumber": "", "volume": "", "numberOfVolumes": "", "edition": "", "date": "1998", "publisher": "Springer", "place": "", "originalDate": "", "originalPublisher": "", "originalPlace": "", "format": "", "numPages": "", "ISBN": "3540646914, 9783540646914", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "87RC8PNG" ], "relations": {}, "dateAdded": "2015-09-02T01:15:49Z", "dateModified": "2015-09-07T01:37:55Z" } }, { "key": "E3ED7GR5", "version": 76, "library": { "type": "group", "id": 393033, "name": "UALR Cheminformatics Group1", "links": { "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/393033/items/E3ED7GR5", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1/items/E3ED7GR5", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2604971, "username": "John House", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/john_house", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "E3ED7GR5", "version": 76, "itemType": "webpage", "title": "Antithrombotic Therapy", "creators": [], "abstractNote": "", "websiteTitle": "American Society of Hematology", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://www.hematology.org/About/History/50-Years/1523.aspx", "accessDate": "", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [ "87RC8PNG" ], "relations": {}, "dateAdded": "2015-09-02T01:23:18Z", "dateModified": "2015-09-07T01:35:47Z" } }, { "key": "XGB5K6RP", "version": 76, "library": { "type": "group", "id": 393033, "name": "UALR Cheminformatics Group1", "links": { "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/393033/items/XGB5K6RP", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1/items/XGB5K6RP", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2604971, "username": "John House", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/john_house", "type": "text/html" } } }, "creatorSummary": "Parlow et al.", "parsedDate": "2003-08-09", "numChildren": 0 }, "data": { "key": "XGB5K6RP", "version": 76, "itemType": "journalArticle", "title": "Design, Parallel Synthesis, and Crystal Structures of Pyrazinone Antithrombotics as Selective Inhibitors of the Tissue Factor VIIa Complex", "creators": [ { "creatorType": "author", "firstName": "J", "lastName": "Parlow" }, { "creatorType": "author", "firstName": "D", "lastName": "Jones" }, { "creatorType": "author", "firstName": "B", "lastName": "Case" } ], "abstractNote": "Structure-based drug design (SBDD) and polymer-assisted solution-phase (PASP) library synthesis were used to develop a series of pyrazinone inhibitors of the Tissue Factor/Factor VIIa (TF/VIIa) complex. The crystal structure of a tripeptide-α-ketothiazole complexed with TF/VIIa was utilized in a docking experiment to identify the pyrazinone core as a starting scaffold. The pyrazinone core could orient the substituents in the correct spatial arrangement to probe the S1, S2, and S3 pockets of the enzyme. A multistep PASP library synthesis was designed to prepare the substituted pyrazinones varying the P1, P2, and P3 moieties. Hundreds of pyrazinone TF/VIIa inhibitors were prepared and tested in several serine protease enzyme assays involved in the coagulation cascade. The inhibitors exhibited modest activity on TF/VIIa with excellent selectivity over thrombin (IIa) and Factor Xa. The structure−activity relationship of the pyrazinone inhibitors will be discussed and X-ray crystal structures of selected compounds complexed with the TF/VIIa enzyme will be described. This study ultimately led to the synthesis of compound 34, which exhibited 16 nM (IC50) activity on TF/VIIa with >6250× selectivity vs Factor Xa and thrombin. This potent and highly selective inhibitor of TF/VIIa was chosen for preclinical, intravenous proof-of-concept studies to demonstrate the separation between antithrombotic efficacy and bleeding side effects in a nonhuman primate model of electrolytic-induced arterial thrombosis.", "publicationTitle": "Journal of Medicinal Chemistry", "publisher": "", "place": "", "date": "9 August 2003", "volume": "46 (19)", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "4050-4062", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1021/jm030131l", "citationKey": "", "url": "http://pubs.acs.org/doi/abs/10.1021/jm030131l", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "87RC8PNG" ], "relations": {}, "dateAdded": "2015-09-01T22:50:53Z", "dateModified": "2015-09-07T01:34:39Z" } }, { "key": "WMQ3G73T", "version": 76, "library": { "type": "group", "id": 393033, "name": "UALR Cheminformatics Group1", "links": { "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/393033/items/WMQ3G73T", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1/items/WMQ3G73T", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2604971, "username": "John House", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/john_house", "type": "text/html" } } }, "creatorSummary": "Suleymanov et al.", "numChildren": 0 }, "data": { "key": "WMQ3G73T", "version": 76, "itemType": "journalArticle", "title": "Pharmacological Interruption of Acute Thrombus Formation with Minimal Hemorrhagic Complications by a Small Molecule Tissue Factor/Factor VIIa Inhibitor: Comparison to Factor Xa and Thrombin Inhibition in a Nonhuman Primate Thrombosis Model", "creators": [ { "creatorType": "author", "firstName": "OD", "lastName": "Suleymanov" }, { "creatorType": "author", "firstName": "JA", "lastName": "Szalony" }, { "creatorType": "author", "firstName": "AK", "lastName": "Salyers" } ], "abstractNote": "", "publicationTitle": "", "publisher": "", "place": "", "date": "", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1124/jpet.103.052779.", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "87RC8PNG" ], "relations": {}, "dateAdded": "2015-09-02T01:22:01Z", "dateModified": "2015-09-07T01:31:42Z" } }, { "key": "ZT73IPUW", "version": 76, "library": { "type": "group", "id": 393033, "name": "UALR Cheminformatics Group1", "links": { "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/393033/items/ZT73IPUW", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1/items/ZT73IPUW", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2604971, "username": "John House", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/john_house", "type": "text/html" } } }, "creatorSummary": "Shin et al.", "parsedDate": "2012-12-27", "numChildren": 0 }, "data": { "key": "ZT73IPUW", "version": 76, "itemType": "journalArticle", "title": "Subacute toxicity and stability of Soshiho-tang, a traditional herbal formula, in Sprague–Dawley rats", "creators": [ { "creatorType": "author", "firstName": "In", "lastName": "Shin" }, { "creatorType": "author", "firstName": "L", "lastName": "Mee" }, { "creatorType": "author", "firstName": "K", "lastName": "Youngbum" } ], "abstractNote": "Soshiho-tang (SST, Xiao-chai-hu-tang in Chinese and Sho-saiko-to in Japanese), an oriental herbal formula, is used for treatment of chronic liver diseases. Although many researchers have studied the pharmacological properties of SST, information about its safety and toxicity is limited. Therefore, we evaluated the potential safety of SST in Sprague–Dawley rats over a period of 4-weeks.", "publicationTitle": "BMC Complementary and Alternative Medicine 2012", "publisher": "", "place": "", "date": "27 December 2012", "volume": "12:266", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1186/1472-6882-12-266", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "87RC8PNG" ], "relations": {}, "dateAdded": "2015-09-05T12:37:22Z", "dateModified": "2015-09-07T01:30:47Z" } }, { "key": "35REASX6", "version": 76, "library": { "type": "group", "id": 393033, "name": "UALR Cheminformatics Group1", "links": { "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/393033/items/35REASX6", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1/items/35REASX6", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2604971, "username": "John House", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/john_house", "type": "text/html" } } }, "creatorSummary": "Lu et al.", "parsedDate": "2010-02-25", "numChildren": 0 }, "data": { "key": "35REASX6", "version": 76, "itemType": "manuscript", "title": "Discovery and clinical evaluation of 1-{N-[2-(amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a thrombin inhibitor with an oxyguanidine P1 motif.", "creators": [ { "creatorType": "author", "firstName": "T", "lastName": "Lu" }, { "creatorType": "author", "firstName": "T", "lastName": "Markotan" }, { "creatorType": "author", "firstName": "SK", "lastName": "Ballentine" } ], "abstractNote": "We have identified RWJ-671818 (8) as a novel, low molecular weight, orally active inhibitor of human alpha-thrombin (K(i) = 1.3 nM) that is potentially useful for the acute and chronic treatment of venous and arterial thrombosis. In a rat deep venous thrombosis model used to assess antithrombotic efficacy, oral administration of 8 at 30 and 50 mg/kg reduced thrombus weight by 87 and 94%, respectively. In an anesthetized rat antithrombotic model, where electrical stimulation of the carotid artery created a thrombus, 8 prolonged occlusion time 2- and 3-fold at 0.1 and 1.0 mg/kg, i.v., respectively, and more than doubled activated clotting time and activated partial thromboplastin time at the higher dose. This compound had excellent oral bioavailability of 100% in dogs with an estimated half-life of approximately 3 h. On the basis of its noteworthy preclinical data, 8 was advanced into human clinical trials and successfully progressed through phase 1 studies.", "manuscriptType": "Research", "institution": "", "place": "Journal of Medicinal Chemistry", "date": "2010 Feb 25", "numPages": "", "number": "", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "archive": "PubMed", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "doi: 10.1021/jm901802n.", "tags": [], "collections": [ "87RC8PNG" ], "relations": {}, "dateAdded": "2015-09-02T01:19:32Z", "dateModified": "2015-09-07T01:29:52Z" } }, { "key": "K374RIBU", "version": 76, "library": { "type": "group", "id": 393033, "name": "UALR Cheminformatics Group1", "links": { "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/393033/items/K374RIBU", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1/items/K374RIBU", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2604971, "username": "John House", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/john_house", "type": "text/html" } } }, "creatorSummary": "Guyatt", "parsedDate": "2012-02-19", "numChildren": 0 }, "data": { "key": "K374RIBU", "version": 76, "itemType": "blogPost", "title": "What you need to know about antithrombotic guidelines", "creators": [ { "creatorType": "author", "firstName": "Gourdon", "lastName": "Guyatt" } ], "abstractNote": "The lack of evidence supporting the “economy class syndrome” myth in air travel made major news headlines recently. While certainly interesting and accurate, that topic was just one among many topics addressed in the larger framework of the new evidence-based guidelines.", "blogTitle": "Kevin MD", "websiteType": "Blog", "date": "Feb 19 2012", "DOI": "", "citationKey": "", "url": "http://www.kevinmd.com/blog/2012/02/antithrombotic-guidelines.html", "accessDate": "", "ISSN": "", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [ "87RC8PNG" ], "relations": {}, "dateAdded": "2015-09-02T01:26:53Z", "dateModified": "2015-09-07T01:22:53Z" } }, { "key": "6FTD4XAB", "version": 34, "library": { "type": "group", "id": 393033, "name": "UALR Cheminformatics Group1", "links": { "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/393033/items/6FTD4XAB", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1/items/6FTD4XAB", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/393033/items/PZM77GS8", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2604537, "username": "krooks685", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/krooks685", "type": "text/html" } } } }, "data": { "key": "6FTD4XAB", "version": 34, "parentItem": "PZM77GS8", "itemType": "attachment", "linkMode": "imported_file", "title": "", "accessDate": "", "url": "", "note": "", "contentType": "", "charset": "", "filename": "", "md5": null, "mtime": null, "tags": [], "relations": {}, "dateAdded": "2015-09-03T20:38:28Z", "dateModified": "2015-09-03T20:38:28Z" } }, { "key": "AN8R7GU5", "version": 33, "library": { "type": "group", "id": 393033, "name": "UALR Cheminformatics Group1", "links": { "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/393033/items/AN8R7GU5", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1/items/AN8R7GU5", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/393033/items/PZM77GS8", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2604537, "username": "krooks685", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/krooks685", "type": "text/html" } } } }, "data": { "key": "AN8R7GU5", "version": 33, "parentItem": "PZM77GS8", "itemType": "attachment", "linkMode": "imported_file", "title": "", "accessDate": "", "url": "", "note": "", "contentType": "", "charset": "", "filename": "", "md5": null, "mtime": null, "tags": [], "relations": {}, "dateAdded": "2015-09-03T20:36:36Z", "dateModified": "2015-09-03T20:36:36Z" } }, { "key": "DA37CXRE", "version": 32, "library": { "type": "group", "id": 393033, "name": "UALR Cheminformatics Group1", "links": { "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/393033/items/DA37CXRE", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1/items/DA37CXRE", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/393033/items/PZM77GS8", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2604537, "username": "krooks685", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/krooks685", "type": "text/html" } } } }, "data": { "key": "DA37CXRE", "version": 32, "parentItem": "PZM77GS8", "itemType": "attachment", "linkMode": "imported_file", "title": "", "accessDate": "", "url": "", "note": "", "contentType": "", "charset": "", "filename": "", "md5": null, "mtime": null, "tags": [], "relations": {}, "dateAdded": "2015-09-03T20:36:35Z", "dateModified": "2015-09-03T20:36:35Z" } }, { "key": "PZM77GS8", "version": 76, "library": { "type": "group", "id": 393033, "name": "UALR Cheminformatics Group1", "links": { "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/393033/items/PZM77GS8", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1/items/PZM77GS8", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2604537, "username": "krooks685", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/krooks685", "type": "text/html" } } }, "creatorSummary": "Jeffrey I. Weitz , MD , FCC and Meyer Michel Samama , MD", "numChildren": 3 }, "data": { "key": "PZM77GS8", "version": 76, "itemType": "journalArticle", "title": "Antithrombotic Therapy and Prevention of Thrombosis, \n9th ed: American College of Chest Physicians \nEvidence-Based Clinical Practice Guidelines", "creators": [ { "creatorType": "author", "firstName": "; John W. Eikelboom , MBBS", "lastName": "Jeffrey I. Weitz , MD , FCC" }, { "creatorType": "author", "firstName": "", "lastName": "Meyer Michel Samama , MD" } ], "abstractNote": "This article focuses on new antithrombotic drugs that are in or are entering phase 3 clinical testing. \nDevelopment of these new agents was prompted by the limitations of existing antiplatelet, anti-\ncoagulant, or fi\n brinolytic drugs. Addressing these unmet needs, this article (1) outlines the ratio-\nnale for development of new antithrombotic agents; (2) describes the new antiplatelet, anticoagulant, \nand fi\n brinolytic drugs; and (3) provides clinical perspectives on the opportunities and challenges \nfaced by these novel agents.", "publicationTitle": "ANTITHROMBOTIC THERAPY AND PREVENTION OF THROMBOSIS, 9TH ED: ACCP GUIDELINES", "publisher": "", "place": "", "date": "", "volume": "9th", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "32", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "English", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "87RC8PNG" ], "relations": {}, "dateAdded": "2015-09-03T20:36:00Z", "dateModified": "2015-09-03T20:36:00Z" } }, { "key": "UE4UN2JN", "version": 28, "library": { "type": "group", "id": 393033, "name": "UALR Cheminformatics Group1", "links": { "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/393033/items/UE4UN2JN", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1/items/UE4UN2JN", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/393033/items/GINSZM58", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2604537, "username": "krooks685", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/krooks685", "type": "text/html" } } } }, "data": { "key": "UE4UN2JN", "version": 28, "parentItem": "GINSZM58", "itemType": "attachment", "linkMode": "imported_file", "title": "ABC of Antithrombotic Therapy.docx", "accessDate": "", "url": "", "note": "", "contentType": "", "charset": "", "filename": "ABC of Antithrombotic Therapy.docx", "md5": "999d41ee32e1a1401f48cddf81635b19", "mtime": 1441305197653, "tags": [], "relations": {}, "dateAdded": "2015-09-03T18:18:56Z", "dateModified": "2015-09-03T18:18:56Z" } }, { "key": "GINSZM58", "version": 76, "library": { "type": "group", "id": 393033, "name": "UALR Cheminformatics Group1", "links": { "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/393033/items/GINSZM58", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ualr_cheminformatics_group1/items/GINSZM58", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2604537, "username": "krooks685", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/krooks685", "type": "text/html" } } }, "creatorSummary": "Department of Haematology, East Surrey Hospital, Redhill RH1 5RH, UK", "numChildren": 1 }, "data": { "key": "GINSZM58", "version": 76, "itemType": "book", "title": "ABC of Antithrombotic Therapy", "creators": [ { "creatorType": "author", "firstName": "", "lastName": "Department of Haematology, East Surrey Hospital, Redhill RH1 5RH, UK" } ], "abstractNote": "An admittedly unscientific survey of fellow district general hospital consultant haematologists has confirmed my impression that the subject about which we receive the most requests for an opinion is, by some distance, anticoagulation in all its guises. These inquiries emanate from clinical teams from the full range of specialties, general practice and, increasingly, nurse-led preadmission surgical clinics. 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