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This imposes the need for an intense flux of metabolic intermediates between segregated enzymatic activities, as seen for the sequential transport of neosynthesized proteins through the segments of the secretory pathway during their post-translational modification. For lipid synthesis, the identification of proteins that transfer lipids between membranes has revealed an additional mechanism for this intercompartment exchange. The intense interest elicited by the lipid-transfer proteins over the last few years has led to the definition of their central role in key processes, such as lipid metabolism, membrane trafficking, and signaling.", "publicationTitle": "Current Opinion in Cell Biology", "publisher": "", "place": "", "date": "Август 2008", "volume": "20", "issue": "4", "section": "", "partNumber": "", "partTitle": "", "pages": "360-370", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1016/j.ceb.2008.03.013", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/S0955067408000550", "accessDate": "2012-04-28T05:37:33Z", "PMID": "", "PMCID": "", "ISSN": "0955-0674", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "Q6NGX2JF" ], "relations": {}, "dateAdded": "2012-04-28T05:37:33Z", "dateModified": "2012-04-28T05:37:33Z" } }, { "key": "5KZ8X7I2", "version": 1, "library": { "type": "group", "id": 37915, "name": "Myosin,Glycine,Neuron and mouse", "links": { "alternate": { "href": "https://www.zotero.org/groups/myosinglycineneuron_and_mouse", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/37915/items/5KZ8X7I2", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/myosinglycineneuron_and_mouse/items/5KZ8X7I2", "type": "text/html" } }, "meta": { "createdByUser": { "id": 506923, "username": "pilat", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/pilat", "type": "text/html" } } }, "creatorSummary": "Kondylis et al.", "parsedDate": "2009", "numChildren": 1 }, "data": { "key": "5KZ8X7I2", "version": 1, "itemType": "journalArticle", "title": "The early secretory pathway in development: A tale of proteins and mRNAs", "creators": [ { "creatorType": "author", "firstName": "Vangelis", "lastName": "Kondylis" }, { "creatorType": "author", "firstName": "Sandrine", "lastName": "Pizette" }, { "creatorType": "author", "firstName": "Catherine", "lastName": "Rabouille" } ], "abstractNote": "The secretory pathway ensures the proper delivery of secreted proteins to the extracellular medium and of transmembrane proteins to almost all membrane cellular compartments. During their transport in the different compartments making up this pathway, newly synthesized proteins are modified and dispatched to their final destinations. So far, this pathway has mostly been studied in tissue cultured cells or yeast but recently, mutations in genes encoding key proteins of this pathway have been shown to lead to severe developmental defects in different model organisms.\n\nIn this review, we describe how specific steps of epithelial, cartilage, notochord and brain development as well as body axis formation are controlled by the early secretory machinery illustrating that it is as crucial as transcriptional programs.", "publicationTitle": "Seminars in Cell & Developmental Biology", "publisher": "", "place": "", "date": "Сентябрь 2009", "volume": "20", "issue": "7", "section": "", "partNumber": "", "partTitle": "", "pages": "817-827", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1016/j.semcdb.2009.03.012", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/S1084952109000470", "accessDate": "2012-04-28T05:37:33Z", "PMID": "", "PMCID": "", "ISSN": "1084-9521", "archive": "", "archiveLocation": "", "shortTitle": "The early secretory pathway in development", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Body axis formation", "type": 1 }, { "tag": "Brain", "type": 1 }, { "tag": "COPI", "type": 1 }, { "tag": "COPII", "type": 1 }, { "tag": "Cartilage", "type": 1 }, { "tag": "Cell junctions", "type": 1 }, { "tag": "Cell polarity", "type": 1 }, { "tag": "Cornichon", "type": 1 }, { "tag": "Craniofacial disease", "type": 1 }, { "tag": "ER exit sites", "type": 1 }, { "tag": "Epithelium", "type": 1 }, { "tag": "Evi", "type": 1 }, { "tag": "GRASP", "type": 1 }, { "tag": "Golgi", "type": 1 }, { "tag": "Golgi outposts", "type": 1 }, { "tag": "Gurken", "type": 1 }, { "tag": "Hydrocephaly", "type": 1 }, { "tag": "Notochord", "type": 1 }, { "tag": "Perlecan", "type": 1 }, { "tag": "RNAs", "type": 1 }, { "tag": "Retromer", "type": 1 }, { "tag": "Rhomboid", "type": 1 }, { "tag": "SNAP", "type": 1 }, { "tag": "Sec23", "type": 1 }, { "tag": "Skeleton", "type": 1 }, { "tag": "Star", "type": 1 }, { "tag": "TRAPP", "type": 1 }, { "tag": "Tral", "type": 1 }, { "tag": "Wnt", "type": 1 } ], "collections": [ "Q6NGX2JF" ], "relations": {}, "dateAdded": "2012-04-28T05:37:33Z", "dateModified": "2012-04-28T05:37:33Z" } }, { "key": "3ZVI93WE", "version": 1, "library": { "type": "group", "id": 37915, "name": "Myosin,Glycine,Neuron and mouse", "links": { "alternate": { "href": "https://www.zotero.org/groups/myosinglycineneuron_and_mouse", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/37915/items/3ZVI93WE", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/myosinglycineneuron_and_mouse/items/3ZVI93WE", "type": "text/html" } }, "meta": { "createdByUser": { "id": 506923, "username": "pilat", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/pilat", "type": "text/html" } } }, "creatorSummary": "Saraste et al.", "parsedDate": "2009", "numChildren": 1 }, "data": { "key": "3ZVI93WE", "version": 1, "itemType": "journalArticle", "title": "Emerging new roles of the pre-Golgi intermediate compartment in biosynthetic-secretory trafficking", "creators": [ { "creatorType": "author", "firstName": "Jaakko", "lastName": "Saraste" }, { "creatorType": "author", "firstName": "Hege A.", "lastName": "Dale" }, { "creatorType": "author", "firstName": "Sarah", "lastName": "Bazzocco" }, { "creatorType": "author", "firstName": "Michaël", "lastName": "Marie" } ], "abstractNote": "The intermediate compartment (IC) between the endoplasmic reticulum (ER) and the Golgi apparatus appears to constitute an autonomous organelle composed of spatially and functionally distinct, but interconnected, vacuolar and tubular subdomains. In mammalian cells the IC network is stably anchored at the cell center, communicating directly with the endocytic pathway via a pericentrosomal membrane system (PCMS). This finding suggests that the secretory pathway divides at the level of the IC, which functions as a sorting station both in Golgi-dependent and -independent trafficking. The tubular subdomain of the IC is capable of expansion in accordance with its proposed biosynthetic functions such as cholesterol synthesis.", "publicationTitle": "FEBS Letters", "publisher": "", "place": "", "date": "Декабрь 3, 2009", "volume": "583", "issue": "23", "section": "", "partNumber": "", "partTitle": "", "pages": "3804-3810", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1016/j.febslet.2009.10.084", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/S001457930900876X", "accessDate": "2012-04-28T05:37:33Z", "PMID": "", "PMCID": "", "ISSN": "0014-5793", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Centrosome", "type": 1 }, { "tag": "Endosome", "type": 1 }, { "tag": "Golgi bypass pathway", "type": 1 }, { "tag": "Intermediate compartment", "type": 1 }, { "tag": "Polarized trafficking", "type": 1 } ], "collections": [ "Q6NGX2JF" ], "relations": {}, "dateAdded": "2012-04-28T05:37:33Z", "dateModified": "2012-04-28T05:37:33Z" } }, { "key": "DNTUDPNE", "version": 1, "library": { "type": "group", "id": 37915, "name": "Myosin,Glycine,Neuron and mouse", "links": { "alternate": { "href": "https://www.zotero.org/groups/myosinglycineneuron_and_mouse", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/37915/items/DNTUDPNE", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/myosinglycineneuron_and_mouse/items/DNTUDPNE", "type": "text/html" } }, "meta": { "createdByUser": { "id": 506923, "username": "pilat", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/pilat", "type": "text/html" } } }, "creatorSummary": "Allan and Kallen", "parsedDate": "1993", "numChildren": 1 }, "data": { "key": "DNTUDPNE", "version": 1, "itemType": "journalArticle", "title": "Transport of lipids to the plasma membrane in animal cells", "creators": [ { "creatorType": "author", "firstName": "David", "lastName": "Allan" }, { "creatorType": "author", "firstName": "Karl-Josef", "lastName": "Kallen" } ], "abstractNote": "", "publicationTitle": "Progress in Lipid Research", "publisher": "", "place": "", "date": "1993", "volume": "32", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "195-219", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1016/0163-7827(93)90015-O", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/016378279390015O", "accessDate": "2012-04-28T05:37:33Z", "PMID": "", "PMCID": "", "ISSN": "0163-7827", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "Q6NGX2JF" ], "relations": {}, "dateAdded": "2012-04-28T05:37:33Z", "dateModified": "2012-04-28T05:37:33Z" } }, { "key": "6XNTZDG7", "version": 1, "library": { "type": "group", "id": 37915, "name": "Myosin,Glycine,Neuron and mouse", "links": { "alternate": { "href": "https://www.zotero.org/groups/myosinglycineneuron_and_mouse", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/37915/items/6XNTZDG7", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/myosinglycineneuron_and_mouse/items/6XNTZDG7", "type": "text/html" } }, "meta": { "createdByUser": { "id": 506923, "username": "pilat", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/pilat", "type": "text/html" } } }, "creatorSummary": "Ziv and Garner", "parsedDate": "2009", "numChildren": 1 }, "data": { "key": "6XNTZDG7", "version": 1, "itemType": "bookSection", "title": "Presynaptic Development and Active Zones", "creators": [ { "creatorType": "author", "firstName": "N.E.", "lastName": "Ziv" }, { "creatorType": "author", "firstName": "C.C.", "lastName": "Garner" }, { "creatorType": "contributor", "firstName": "", "lastName": "Editor-in-Chief:  Larry R. Squire" } ], "abstractNote": "Chemical synapses are specialized sites of cell–cell contact that serve to transmit signals between presynaptic neurons and their respective postsynaptic targets. Presynaptic development involves the transformation of a patch of unspecialized plasma membrane into a complex structure that is highly specialized for sustained, depolarization-evoked synaptic vesicle exocytosis. This transformation is governed by dynamic intracellular and intercellular processes, which include contact formation and stabilization, recruitment of key presynaptic molecules to new contact sites, recruitment and generation of synaptic vesicles, and the subsequent maturation of the nascent presynaptic structures. This article reviews key cellular and molecular mechanisms involved in this transformation process.", "bookTitle": "Encyclopedia of Neuroscience", "series": "", "seriesNumber": "", "volume": "", "numberOfVolumes": "", "edition": "", "date": "2009", "publisher": "Academic Press", "place": "Oxford", "originalDate": "", "originalPublisher": "", "originalPlace": "", "format": "", "pages": "957-966", "ISBN": "978-0-08-045046-9", "DOI": "", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/B9780080450469003491", "accessDate": "2012-04-28T05:37:33Z", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Active zone", "type": 1 }, { "tag": "Cytoskeleton of the active zone", "type": 1 }, { "tag": "Growth cone", "type": 1 }, { "tag": "Live imaging", "type": 1 }, { "tag": "Neuromuscular junction", "type": 1 }, { "tag": "Presynapse", "type": 1 }, { "tag": "Synaptic maturation", "type": 1 }, { "tag": "Synaptic vesicles", "type": 1 }, { "tag": "Synaptogenesis", "type": 1 }, { "tag": "Synaptotrophic", "type": 1 }, { "tag": "Transport packets", "type": 1 } ], "collections": [ "Q6NGX2JF" ], "relations": {}, "dateAdded": "2012-04-28T05:37:33Z", "dateModified": "2012-04-28T05:37:33Z" } } ]