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"links": { "self": { "href": "https://api.zotero.org/groups/36480/items/Z6BMTZ69", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/share_with_ethicshare/items/Z6BMTZ69", "type": "text/html" } }, "meta": { "createdByUser": { "id": 166412, "username": "libsys", "name": "Chad Fennell", "links": { "alternate": { "href": "https://www.zotero.org/libsys", "type": "text/html" } } }, "creatorSummary": "Fang et al.", "parsedDate": "2007", "numChildren": 0 }, "data": { "key": "Z6BMTZ69", "version": 1, "itemType": "webpage", "title": "Stem cells and combinatorial science", "creators": [ { "creatorType": "author", "firstName": "Yue Qi", "lastName": "Fang" }, { "creatorType": "author", "firstName": "Wan Qin", "lastName": "Wong" }, { "creatorType": "author", "firstName": "Yan We", "lastName": "Yap" }, { "creatorType": "author", "firstName": "Brendan", "lastName": "Orner" } ], "abstractNote": "Stem cell-based technologies have the potential to help cure a number of cell degenerative diseases. Combinatorial and high throughput screening techniques could provide tools to control and manipulate the self-renewal and differentiation of stem cells. This review chronicles historic and recent progress in the stem cell field involving both pluripotent and multipotent cells, and it highlights relevant cellular signal transduction pathways. This review further describes screens using libraries of soluble, small-molecule ligands, and arrays of molecules immobilized onto surfaces while proposing future trends in similar studies. It is hoped that by reviewing both the stem cell and the relevant high throughput screening literature, this paper can act as a resource to the combinatorial science community", "websiteTitle": "Combinatorial chemistry & high throughput screenin", "websiteType": "", "date": "2007", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [ { "tag": "Cell Culture Technique", "type": 1 }, { "tag": "Cell Differentiatio", "type": 1 }, { "tag": "Cell Divisio", "type": 1 }, { "tag": "Combinatorial Chemistry Technique", "type": 1 }, { "tag": "Embryonic Stem Cell", "type": 1 }, { "tag": "Hematopoietic Stem Cell", "type": 1 }, { "tag": "Ligand", "type": 1 }, { "tag": "Microarray Analysi", "type": 1 }, { "tag": "Phenotyp", "type": 1 }, { "tag": "Pluripotent Stem Cell", "type": 1 }, { "tag": "Regeneratio", "type": 1 }, { "tag": "Signal Transductio", "type": 1 }, { "tag": "Stem Cell", "type": 1 }, { "tag": "Stem Cell Transplantatio", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2011-02-01T21:05:21Z", "dateModified": "2011-02-01T21:05:21Z" } }, { "key": "EVDBB728", "version": 1, "library": { "type": "group", "id": 36480, "name": "Share with EthicShare", "links": { "alternate": { "href": "https://www.zotero.org/groups/share_with_ethicshare", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/36480/items/EVDBB728", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/share_with_ethicshare/items/EVDBB728", "type": "text/html" } }, "meta": { "createdByUser": { "id": 166412, "username": "libsys", "name": "Chad Fennell", "links": { "alternate": { "href": "https://www.zotero.org/libsys", "type": "text/html" } } }, "creatorSummary": "Mauron and Jaconi", "parsedDate": "2007", "numChildren": 0 }, "data": { "key": "EVDBB728", "version": 1, "itemType": "webpage", "title": "Stem cell science: current ethical and policy issues", "creators": [ { "creatorType": "author", "firstName": "", "lastName": "Mauron" }, { "creatorType": "author", "firstName": "M", "lastName": "Jaconi" } ], "abstractNote": "There is increasing support for embryonic stem (ES) cell research on both sides of the Atlantic. In the United States, the outcome is more funding from non-federal sources, despite the current administration's opposing views. In Europe, a similar pragmatic turn is in the making, but the future is still uncertain. Acceptance of ES cells is mitigated by the uncritical belief that their use is ethically more suspect than is the case for adult cells", "websiteTitle": "Clinical pharmacology and therapeutic", "websiteType": "", "date": "2007", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "shortTitle": "Stem cell science", "language": "", "rights": "", "extra": "", "tags": [ { "tag": "Adult Stem Cell", "type": 1 }, { "tag": "Embryonic Stem Cell", "type": 1 }, { "tag": "Europ", "type": 1 }, { "tag": "Human", "type": 1 }, { "tag": "Politic", "type": 1 }, { "tag": "Stem Cell", "type": 1 }, { "tag": "Stem Cell Transplantatio", "type": 1 }, { "tag": "United State", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2011-02-01T21:05:21Z", "dateModified": "2011-02-01T21:05:21Z" } }, { "key": "B8HA84DN", "version": 1, "library": { "type": "group", "id": 36480, "name": "Share with EthicShare", "links": { "alternate": { "href": "https://www.zotero.org/groups/share_with_ethicshare", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/36480/items/B8HA84DN", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/share_with_ethicshare/items/B8HA84DN", "type": "text/html" } }, "meta": { "createdByUser": { "id": 166412, "username": "libsys", "name": "Chad Fennell", "links": { "alternate": { "href": "https://www.zotero.org/libsys", "type": "text/html" } } }, "creatorSummary": "Denker", "parsedDate": "2006-11", "numChildren": 0 }, "data": { "key": "B8HA84DN", "version": 1, "itemType": "webpage", "title": "Potentiality of embryonic stem cells: an ethical problem even with alternative stem cell sources", "creators": [ { "creatorType": "author", "firstName": "H-", "lastName": "Denker" } ], "abstractNote": "The recent discussions about alternative sources of human embryonic stem cells (White Paper of the US President's Council on Bioethics, 2005), while stirring new interest in the developmental potential of the various abnormal embryos or constructs proposed as such sources, also raise questions about the potential of the derived embryonic stem cells. The data on the developmental potential of embryonic stem cells that seem relevant for ethical considerations and aspects of patentability are discussed. Particular attention is paid to the meaning of \"totipotency, omnipotency and pluripotency\" as illustrated by a comparison of the developmental potential of three-dimensional clusters of blastomeres (morula), embryonic stem cells, somatic or (adult) stem cells or other somatic (non-stem) cells. This paper focuses on embryoid bodies and on direct cloning by tetraploid complementation. Usage and patenting of these cells cannot be considered to be ethically sound as long as totipotency and tetraploid complementability of embryonic stem cells are not excluded for the specific cell line in question. Testing this poses an ethical problem in itself and needs to be discussed in the future", "websiteTitle": "Journal of medical ethic", "websiteType": "", "date": "November 2006", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "shortTitle": "Potentiality of embryonic stem cells", "language": "", "rights": "", "extra": "", "tags": [ { "tag": "Adul", "type": 1 }, { "tag": "Adult Stem Cell", "type": 1 }, { "tag": "Blastomere", "type": 1 }, { "tag": "Cell Culture Technique", "type": 1 }, { "tag": "Cell Differentiatio", "type": 1 }, { "tag": "Clone Cell", "type": 1 }, { "tag": "Embryonic Stem Cell", "type": 1 }, { "tag": "Ethics, Medica", "type": 1 }, { "tag": "Human", "type": 1 }, { "tag": "Morul", "type": 1 }, { "tag": "Multipotent Stem Cell", "type": 1 }, { "tag": "Pluripotent Stem Cell", "type": 1 }, { "tag": "Teratom", "type": 1 }, { "tag": "Totipotent Stem Cell", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2011-02-01T21:05:21Z", "dateModified": "2011-02-01T21:05:21Z" } }, { "key": "K7DXT2AN", "version": 1, "library": { "type": "group", "id": 36480, "name": "Share with EthicShare", "links": { "alternate": { "href": "https://www.zotero.org/groups/share_with_ethicshare", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/36480/items/K7DXT2AN", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/share_with_ethicshare/items/K7DXT2AN", "type": "text/html" } }, "meta": { "createdByUser": { "id": 166412, "username": "libsys", "name": "Chad Fennell", "links": { "alternate": { "href": "https://www.zotero.org/libsys", "type": "text/html" } } }, "creatorSummary": "Rosenthal", "parsedDate": "2003-07-17", "numChildren": 0 }, "data": { "key": "K7DXT2AN", "version": 1, "itemType": "webpage", "title": "Prometheus's vulture and the stem-cell promise", "creators": [ { "creatorType": "author", "firstName": "Nadi", "lastName": "Rosenthal" } ], "abstractNote": "", "websiteTitle": "The New England journal of medicin", "websiteType": "", "date": "July 17, 2003", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [ { "tag": "Adul", "type": 1 }, { "tag": "Animal", "type": 1 }, { "tag": "Cells, Culture", "type": 1 }, { "tag": "Embryo Researc", "type": 1 }, { "tag": "Embryo, Mammalia", "type": 1 }, { "tag": "Human", "type": 1 }, { "tag": "Pluripotent Stem Cell", "type": 1 }, { "tag": "Regeneratio", "type": 1 }, { "tag": "Stem Cell", "type": 1 }, { "tag": "Stem Cell Transplantatio", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2011-02-01T21:05:21Z", "dateModified": "2011-02-01T21:05:21Z" } }, { "key": "Z55G3BW7", "version": 1, "library": { "type": "group", "id": 36480, "name": "Share with EthicShare", "links": { "alternate": { "href": "https://www.zotero.org/groups/share_with_ethicshare", "type": 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Protein, nucleic acid, enzym", "websiteType": "", "date": "2006", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [ { "tag": "Animal", "type": 1 }, { "tag": "Bioethic", "type": 1 }, { "tag": "Cell Differentiatio", "type": 1 }, { "tag": "Cell Divisio", "type": 1 }, { "tag": "Cell Separatio", "type": 1 }, { "tag": "Human", "type": 1 }, { "tag": "Multipotent Stem Cell", "type": 1 }, { "tag": "Pluripotent Stem Cell", "type": 1 }, { "tag": "Regenerative Medicin", "type": 1 }, { "tag": "Stem Cell", "type": 1 }, { "tag": "Stem Cell Transplantatio", "type": 1 }, { "tag": "Totipotent Stem Cell", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2011-02-01T21:05:21Z", "dateModified": "2011-02-01T21:05:21Z" } } ]