[ { "key": "YSZQ28GZ", "version": 737, "library": { "type": "group", "id": 361204, "name": "Antidepressants in the elderly", "links": { "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/361204/items/YSZQ28GZ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly/items/YSZQ28GZ", "type": "text/html" } }, "meta": { "createdByUser": { "id": 4133376, "username": "lauriemallery", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lauriemallery", "type": "text/html" } } }, "creatorSummary": "Zhuo et al.", "parsedDate": "2017-06", "numChildren": 2 }, "data": { "key": "YSZQ28GZ", "version": 737, "itemType": "journalArticle", "title": "Efficacy of antidepressive medication for depression in Parkinson disease: a network meta-analysis", "creators": [ { "creatorType": "author", "firstName": "Chuanjun", "lastName": "Zhuo" }, { "creatorType": "author", "firstName": "Rong", "lastName": "Xue" }, { "creatorType": "author", "firstName": "Lanlan", "lastName": "Luo" }, { "creatorType": "author", "firstName": "Feng", "lastName": "Ji" }, { "creatorType": "author", "firstName": "Hongjun", "lastName": "Tian" }, { "creatorType": "author", "firstName": "Hongru", "lastName": "Qu" }, { "creatorType": "author", "firstName": "Xiaodong", "lastName": "Lin" }, { "creatorType": "author", "firstName": "Ronghuan", "lastName": "Jiang" }, { "creatorType": "author", "firstName": "Ran", "lastName": "Tao" } ], "abstractNote": "BACKGROUND: Parkinson disease (PD) was considered as the 2nd most prevalent neurodegenerative disorder after Alzheimer disease, while depression is a prevailing nonmotor symptom of PD. Typically used antidepression medication includes tricyclic antidepressants (TCA), selective serotonin reuptake inhibitors (SSRI), serotonin and norepinephrine reuptake inhibitors (SNRI), monoamine-oxidase inhibitors (MAOI), and dopamine agonists (DA). Our study aimed at evaluating the efficacy of antidepressive medications for depression of PD.\nMETHODS: Web of Science, PubMed, Embase, and the Cochrane library were searched for related articles. Traditional meta-analysis and network meta-analysis (NMA) were performed with outcomes including depression score, UPDRS-II, UPDRS-III, and adverse effects. Surface under the cumulative ranking curve (SUCRA) was also performed to illustrate the rank probabilities of different medications on various outcomes. The consistency of direct and indirect evidence was also assessed by node-splitting method.\nRESULTS: Results of traditional pairwise meta-analysis were performed. Concerning depression score, significant improvement was observed in AD, MAOI, SSRI, and SNRI compared with placebo. NMA was performed and more information could be obtained. DA was illustrated to be effective over placebo concerning UPDRS-III, MAOI, and SNRI. DA demonstrated a better prognosis in UPDRS-II scores compared with placebo and MAOI. However, DA and SSRI demonstrated a significant increase in adverse effects compared with placebo. The SUCRA value was calculated to evaluate the ranking probabilities of all medications on investigated outcomes, and the consistency between direct and indirect evidences was assessed by node-splitting method.\nCONCLUSION: SSRI had a satisfying efficacy for the depression of PD patients and could improve activities of daily living and motor function of patient but the adverse effects are unneglectable. SNRI are the safest medication with high efficacy for depression as well while other outcomes are relatively poor.", "publicationTitle": "Medicine", "publisher": "", "place": "", "date": "Jun 2017", "volume": "96", "issue": "22", "section": "", "partNumber": "", "partTitle": "", "pages": "e6698", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Medicine (Baltimore)", "DOI": "10.1097/MD.0000000000006698", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1536-5964", "archive": "", "archiveLocation": "", "shortTitle": "Efficacy of antidepressive medication for depression in Parkinson disease", "language": "eng", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "PMID: 28562526\nPMCID: PMC5459691", "tags": [ { "tag": "Antidepressive Agents", "type": 1 }, { "tag": "Depression", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Network Meta-Analysis", "type": 1 }, { "tag": "Parkinson Disease", "type": 1 } ], "collections": [ "B2RBRZ8J" ], "relations": {}, "dateAdded": "2019-11-04T19:13:59Z", "dateModified": "2019-11-04T19:14:11Z" } }, { "key": "INKWG5Q4", "version": 749, "library": { "type": "group", "id": 361204, "name": "Antidepressants in the elderly", "links": { "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/361204/items/INKWG5Q4", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly/items/INKWG5Q4", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/361204/items/YSZQ28GZ", "type": "application/json" } }, "meta": { "createdByUser": { "id": 4133376, "username": "lauriemallery", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lauriemallery", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "INKWG5Q4", "version": 749, "parentItem": "YSZQ28GZ", "itemType": "attachment", "linkMode": "imported_url", "title": "Full Text", "accessDate": "2019-11-04T19:14:04Z", "url": "https://europepmc.org/articles/pmc5459691?pdf=render", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Zhuo et al. - 2017 - Efficacy of antidepressive medication for depressi.pdf", "md5": "3d1d6382d99d16e5d18f78ebe1673562", "mtime": 1572894844000, "tags": [], "relations": {}, "dateAdded": "2019-11-04T19:14:04Z", "dateModified": "2019-11-04T19:14:04Z" } }, { "key": "D2NG8YXB", "version": 737, "library": { "type": "group", "id": 361204, "name": "Antidepressants in the elderly", "links": { "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/361204/items/D2NG8YXB", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly/items/D2NG8YXB", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/361204/items/YSZQ28GZ", "type": "application/json" } }, "meta": { "createdByUser": { "id": 4133376, "username": "lauriemallery", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lauriemallery", "type": "text/html" } } } }, "data": { "key": "D2NG8YXB", "version": 737, "parentItem": "YSZQ28GZ", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2019-11-04T19:14:00Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/28562526", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2019-11-04T19:14:00Z", "dateModified": "2019-11-04T19:14:00Z" } }, { "key": "H8RQMKI9", "version": 733, "library": { "type": "group", "id": 361204, "name": "Antidepressants in the elderly", "links": { "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/361204/items/H8RQMKI9", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly/items/H8RQMKI9", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/361204/items/3EBF9Z69", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2276084, "username": "cn552914", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/cn552914", "type": "text/html" } } }, "lastModifiedByUser": { "id": 4133376, "username": "lauriemallery", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lauriemallery", "type": "text/html" } } } }, "data": { "key": "H8RQMKI9", "version": 733, "parentItem": "3EBF9Z69", "itemType": "attachment", "linkMode": "imported_url", "title": "Snapshot", "accessDate": "2015-09-29T16:52:40Z", "url": "http://onlinelibrary.wiley.com/doi/10.1002/1099-1166(200012)15:12%3C1113::AID-GPS253%3E3.0.CO;2-Y/abstract", "note": "", "contentType": "text/html", "charset": "utf-8", "filename": "abstract.html", "md5": "e3c2f088e114379950ca6d4e6c4bee30", "mtime": 1443545561511, "tags": [], "relations": {}, "dateAdded": "2015-09-29T16:52:40Z", "dateModified": "2019-08-22T18:51:16Z" } }, { "key": "3EBF9Z69", "version": 728, "library": { "type": "group", "id": 361204, "name": "Antidepressants in the elderly", "links": { "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/361204/items/3EBF9Z69", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly/items/3EBF9Z69", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2276084, "username": "cn552914", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/cn552914", "type": "text/html" } } }, "lastModifiedByUser": { "id": 4133376, "username": "lauriemallery", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lauriemallery", "type": "text/html" } } }, "creatorSummary": "Mottram et al.", "parsedDate": "2000-12-01", "numChildren": 3 }, "data": { "key": "3EBF9Z69", "version": 728, "itemType": "journalArticle", "title": "Validation of the Hamilton Depression Rating Scale and Montgommery and Asberg Rating Scales in terms of AGECAT depression cases", "creators": [ { "creatorType": "author", "firstName": "Patricia", "lastName": "Mottram" }, { "creatorType": "author", "firstName": "Kenneth", "lastName": "Wilson" }, { "creatorType": "author", "firstName": "John", "lastName": "Copeland" } ], "abstractNote": "Objective. To validate the Hamilton Depression (17) and Montgommery and Asberg Depression Scales as research instruments in older depressed community residents. Design. External validation against GMS/AGECAT case level in the recruitment of older community residents for an antidepressant trial. Analyses. Receiver operator curves were generated for each rating scale, using GMS/AGECAT case level in external criterion. The sensitivity, specificity, positive and negative predictive values of both rating instruments were examined in the whole sample and age and gender subgroups. MADRS and HAM-D cut-off scores differentiating GMS/AGECAT cases from subcases were identified. Results. HAM-D cut-off score of 16 and MADRS score of 21 were identified as differentiating case from sub-case. Diagnostic accuracy of both instruments was good, reflecting good sensitivity and specificity across both genders and sub-age groups. Conclusions. Both scales performed well in this population. These scores provide researchers with externally validated and clinically relevant cut-off scores in designing trials in the management of older depressed community residents. Copyright © 2000 John Wiley & Sons, Ltd.", "publicationTitle": "International Journal of Geriatric Psychiatry", "publisher": "", "place": "", "date": "December 1, 2000", "volume": "15", "issue": "12", "section": "", "partNumber": "", "partTitle": "", "pages": "1113-1119", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Int. J. Geriat. Psychiatry", "DOI": "10.1002/1099-1166(200012)15:12<1113::AID-GPS253>3.0.CO;2-Y", "citationKey": "", "url": "http://onlinelibrary.wiley.com/doi/10.1002/1099-1166(200012)15:12<1113::AID-GPS253>3.0.CO;2-Y/abstract", "accessDate": "2015-09-29T16:40:42Z", "PMID": "", "PMCID": "", "ISSN": "1099-1166", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "Wiley Online Library", "callNumber": "", "rights": "Copyright © 2000 John Wiley & Sons, Ltd.", "extra": "", "tags": [ { "tag": "HAM-D", "type": 1 }, { "tag": "MADRS", "type": 1 }, { "tag": "older people", "type": 1 }, { "tag": "validation", "type": 1 } ], "collections": [ "62EJWKFX" ], "relations": { "dc:replaces": "http://zotero.org/groups/361204/items/6NZNPSMU" }, "dateAdded": "2015-09-29T16:40:42Z", "dateModified": "2019-08-22T18:51:16Z" } }, { "key": "QJ6RDJKQ", "version": 734, "library": { "type": "group", "id": 361204, "name": "Antidepressants in the elderly", "links": { "alternate": { "href": 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reliability study in the HIV seropositive populatio", "accessDate": "2015-11-17T13:57:45Z", "url": "http://www.unboundmedicine.com/medline/citation/2137500/The_Neurobehavioral_Rating_Scale:_an_interrater_reliability_study_in_the_HIV_seropositive_population_", "note": "", "contentType": "text/html", "charset": "utf-8", "filename": "The_Neurobehavioral_Rating_Scale_an_interrater_reliability_study_in_the_HIV_seropositive_popula.html", "md5": null, "mtime": null, "tags": [], "relations": {}, "dateAdded": "2015-11-17T15:33:08Z", "dateModified": "2019-08-22T18:51:15Z" } }, { "key": "94KQU7BF", "version": 729, "library": { "type": "group", "id": 361204, "name": "Antidepressants in the elderly", "links": { "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/361204/items/94KQU7BF", "type": "application/json" }, "alternate": { "href": 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"title": "ScienceDirect Snapshot", "accessDate": "2015-10-25T17:41:54Z", "url": "http://www.sciencedirect.com/science/article/pii/S0165032798000706", "note": "", "contentType": "text/html", "charset": "utf-8", "filename": "S0165032798000706.html", "md5": null, "mtime": null, "tags": [], "relations": {}, "dateAdded": "2015-10-25T17:41:54Z", "dateModified": "2019-08-22T18:51:14Z" } }, { "key": "PS2IP6F7", "version": 729, "library": { "type": "group", "id": 361204, "name": "Antidepressants in the elderly", "links": { "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/361204/items/PS2IP6F7", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly/items/PS2IP6F7", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2276084, "username": "cn552914", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/cn552914", "type": "text/html" } } }, "lastModifiedByUser": { "id": 4133376, "username": "lauriemallery", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lauriemallery", "type": "text/html" } } }, "creatorSummary": "Newman", "parsedDate": "1999-01", "numChildren": 4 }, "data": { "key": "PS2IP6F7", "version": 729, "itemType": "journalArticle", "title": "The prevalence of depression in Alzheimer's disease and vascular dementia in a population sample", "creators": [ { "creatorType": "author", "firstName": "Stephen C", "lastName": "Newman" } ], "abstractNote": "Background: Previous studies have shown that depression is more prevalent in vascular dementia than Alzheimer's disease (AD). Subjects for these studies were either psychiatry or neurology patients, raising the issue of whether factors leading to treatment might have introduced sampling bias. Methods: Data for the present study came from the Canadian Study of Health and Aging (CSHA, 1994), a population-based prevalence study of dementia. AD was diagnosed using NINCDS-ADRDA criteria (McKhann et al., 1984), vascular dementia was diagnosed using draft ICD-10 criteria (World Health Organization, 1987) and the Ischemic Scale (Hachinski et al., 1975), major depression was diagnosed using an algorithm based on DSM-III-R criteria (American Psychiatric Association, 1987). The sample for the present study consisted of 481 subjects with AD and 140 with vascular dementia. Results: The weighted prevalence rate of major depression was 3.2% for AD and 21.2% for vascular dementia, giving a crude odds ratio of 8.2 (95% Confidence Interval: 1.7–40.2). This finding was confirmed by a logistic regression analysis which adjusted for age, sex, place of residence (community, institution), self-reported health, severity of cognitive impairment, and antidepressant or beta-blocker use. Limitations: Data on depressive symptoms were more often missing in subjects with dementia resulting in differential loss of potential study subjects. Data on depressive symptoms were not sufficiently detailed to permit DSM-III-R criteria to be implemented rigorously. The method of diagnosing vascular dementia was subject to misclassification. Conclusions: This study confirms in a population sample that depression is more prevalent in vascular dementia compared to AD.", "publicationTitle": "Journal of Affective Disorders", "publisher": "", "place": "", "date": "January 1999", "volume": "52", "issue": "1–3", "section": "", "partNumber": "", "partTitle": "", "pages": "169-176", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Journal of Affective Disorders", "DOI": "10.1016/S0165-0327(98)00070-6", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/S0165032798000706", "accessDate": "2015-10-25T17:37:04Z", "PMID": "", "PMCID": "", "ISSN": "0165-0327", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Alzheimer's disease", "type": 1 }, { "tag": "Prevalence", "type": 1 }, { "tag": "Vascular dementia", "type": 1 }, { "tag": "depression", "type": 1 } ], "collections": [ "BZ68N3B4" ], "relations": { "dc:replaces": "http://zotero.org/groups/361204/items/85WRQ3IM" }, "dateAdded": "2015-10-25T17:37:04Z", "dateModified": "2019-08-22T18:51:14Z" } }, { "key": "X62IQIF2", "version": 733, "library": { "type": "group", "id": 361204, "name": "Antidepressants in the elderly", "links": { "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/361204/items/X62IQIF2", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly/items/X62IQIF2", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/361204/items/Z9BV8B4U", "type": "application/json" } }, "meta": { "createdByUser": { "id": 136169, "username": "TanyaHill", "name": "Tanya MacLeod", "links": { "alternate": { "href": "https://www.zotero.org/tanyahill", "type": "text/html" } } }, "lastModifiedByUser": { "id": 4133376, "username": "lauriemallery", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lauriemallery", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "X62IQIF2", "version": 733, "parentItem": "Z9BV8B4U", "itemType": "attachment", "linkMode": "imported_url", "title": "EBSCO Full Text", "accessDate": "2015-11-03T19:59:18Z", "url": "http://content.ebscohost.com/ContentServer.asp?T=P&P=AN&K=22692725&S=R&D=aph&EbscoContent=dGJyMNLr40SeprE4zOX0OLCmr02ep7JSs6%2B4SbWWxWXS&ContentCustomer=dGJyMPGut0qvrK9IuePfgeyx44Dt6fIA", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Kørner et al. - 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2006 - The Geriatric Depression Scale and the Cornell Sca.pdf", "md5": "92e988f4167df72268cd31303d27e8ea", "mtime": 1443530652126, "tags": [], "relations": {}, "dateAdded": "2015-09-29T12:44:11Z", "dateModified": "2019-08-22T18:51:13Z" } }, { "key": "Z9BV8B4U", "version": 728, "library": { "type": "group", "id": 361204, "name": "Antidepressants in the elderly", "links": { "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/361204/items/Z9BV8B4U", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly/items/Z9BV8B4U", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2276084, "username": "cn552914", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/cn552914", "type": "text/html" } } }, "lastModifiedByUser": { "id": 4133376, "username": "lauriemallery", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lauriemallery", "type": "text/html" } } }, "creatorSummary": "Kørner et al.", "parsedDate": "2006-10", "numChildren": 3 }, "data": { "key": "Z9BV8B4U", "version": 728, "itemType": "journalArticle", "title": "The Geriatric Depression Scale and the Cornell Scale for Depression in Dementia. A validity study", "creators": [ { "creatorType": "author", "firstName": "Alex", "lastName": "Kørner" }, { "creatorType": "author", "firstName": "Lise", "lastName": "Lauritzen" }, { "creatorType": "author", "firstName": "Kirsten", "lastName": "Abelskov" }, { "creatorType": "author", "firstName": "Nils", "lastName": "Gulmann" }, { "creatorType": "author", "firstName": "Anne", "lastName": "Marie Brodersen" }, { "creatorType": "author", "firstName": "Torben", "lastName": "Wedervang-Jensen" }, { "creatorType": "author", "firstName": "Karen", "lastName": "Marie Kjeldgaard" } ], "abstractNote": "The study is a validation study of two psychogeriatric depression rating scales, The Geriatric Depression Scale (GDS) and the Cornell Scale for Depression in Dementia (CSDD). The sensitivity and specificity, and the convergent and criterion validity of the two scales as well as the inter-rater reliability of the CSDD are reported. Two independent clinicians using the ICD-10 for depression and dementia, the Clinical Global Impression (CGI), the Hamilton Depression rating scale 17-items and the Mini-Mental-State Examination (MMSE), interviewed each patient or control subject. One hundred forty-five persons of 65 years or more of age were included, 73 were depressed only, 36 depressed and demented; 36 persons were control subjects, 11 of these were demented. The inter-rater reliabilities were high or very high equalling perfect correlation. There was very high convergent validity between the screening tools and the severity scales; the shorter versions of the GDS (15-, 10- or four-item version) had lower though still almost perfect correlations. The criterion validity in the total population showed the CSDD as the better scale with sensitivity and specificity of 93% and 97% with a cut-off value of ≥⃒6. The GDS versions had sensitivities and specificities ranging from 82% to 90% and 75% to 94% respectively with cut-off values ≥⃒9, 4, 3 and 1. The CSDD retained its validity and specificity as a screening tool for depression in a population of demented, while the GDS versions all diminished in validity. The GDS and the CSDD are both valid screening tools for depression in the elderly; however, the CSDD alone seems to be equally valid in populations of demented and non-demented.", "publicationTitle": "Nordic Journal of Psychiatry", "publisher": "", "place": "", "date": "October 2006", "volume": "60", "issue": "5", "section": "", "partNumber": "", "partTitle": "", "pages": "360-364", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Nordic Journal of Psychiatry", "DOI": "10.1080/08039480600937066", "citationKey": "", "url": "http://ezproxy.library.dal.ca/login?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22692725&site=ehost-live", "accessDate": "2015-09-29T12:43:43Z", "PMID": "", "PMCID": "", "ISSN": "08039488", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "EBSCOhost", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Geriatrics", "type": 1 }, { "tag": "MEDICAL screening", "type": 1 }, { "tag": "MENTAL depression", "type": 1 }, { "tag": "Mental Health", "type": 1 }, { "tag": "Screening scales", "type": 1 }, { "tag": "Validity", "type": 1 }, { "tag": "dementia", "type": 1 }, { "tag": "depression", "type": 1 }, { "tag": "elderly", "type": 1 }, { "tag": "older people", "type": 1 } ], "collections": [ "62EJWKFX", "D6XEXEIQ" ], "relations": { "dc:replaces": [ "http://zotero.org/groups/361204/items/5AGWT9WU", "http://zotero.org/groups/361204/items/88EF8QEV" ] }, "dateAdded": "2015-09-29T12:43:43Z", "dateModified": "2019-08-22T18:51:13Z" } }, { "key": "9HMK9UJB", "version": 734, "library": { "type": "group", "id": 361204, "name": "Antidepressants in the elderly", "links": { "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/361204/items/9HMK9UJB", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly/items/9HMK9UJB", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/361204/items/A5J4BMBR", "type": "application/json" } }, "meta": { "createdByUser": { "id": 136169, "username": "TanyaHill", "name": "Tanya MacLeod", "links": { "alternate": { "href": "https://www.zotero.org/tanyahill", "type": "text/html" } } }, "lastModifiedByUser": { "id": 4133376, "username": "lauriemallery", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lauriemallery", "type": "text/html" } } } }, "data": { "key": "9HMK9UJB", "version": 734, "parentItem": "A5J4BMBR", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2015-12-18T20:03:11Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/18713194", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-12-18T20:03:11Z", "dateModified": "2019-08-22T18:51:12Z" } }, { "key": "A5J4BMBR", "version": 730, "library": { "type": "group", "id": 361204, "name": "Antidepressants in the elderly", "links": { "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/361204/items/A5J4BMBR", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly/items/A5J4BMBR", "type": "text/html" } }, "meta": { "createdByUser": { "id": 136169, "username": "TanyaHill", "name": "Tanya MacLeod", "links": { "alternate": { "href": "https://www.zotero.org/tanyahill", "type": "text/html" } } }, "lastModifiedByUser": { "id": 4133376, "username": "lauriemallery", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lauriemallery", "type": "text/html" } } }, "creatorSummary": "Ridda et al.", "parsedDate": "2008-06", "numChildren": 2 }, "data": { "key": "A5J4BMBR", "version": 730, "itemType": "journalArticle", "title": "The challenges of clinical trials in the exclusion zone: the case of the frail elderly", "creators": [ { "creatorType": "author", "firstName": "Iman", "lastName": "Ridda" }, { "creatorType": "author", "firstName": "Richard", "lastName": "Lindley" }, { "creatorType": "author", "firstName": "Raina C.", "lastName": "MacIntyre" } ], "abstractNote": "Frail older people have been systematically excluded from randomised controlled trials (RCT). We aim to recruit older, frail hospitalised patients in an RCT and evaluate the frailty index (FI) as a measure to describe the types of people included in the study. We recruited 315 hospitalised patients aged 65 years; age ranged from 60 to 102 years. Baseline assessment scores ranged as follow: Mini-Mental Status Examination from 7 to 30, Barthel index from 5 to 100 and FI from 2 to 24. Total deaths were 20 (6%). We demonstrated that it is feasible to recruit frail older people into RCTs. The FI does not show any 'floor' or 'ceiling' effects. We can measure frailty in an RCT cohort, and we believe that clinical trials should include more frail older people and that the use of an FI can facilitate such trials and generate reliable data to guide future medical practice in a rapidly ageing society.", "publicationTitle": "Australasian Journal on Ageing", "publisher": "", "place": "", "date": "Jun 2008", "volume": "27", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "61-66", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Australas J Ageing", "DOI": "10.1111/j.1741-6612.2008.00288.x", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1741-6612", "archive": "", "archiveLocation": "", "shortTitle": "The challenges of clinical trials in the exclusion zone", "language": "eng", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "PMID: 18713194", "tags": [ { "tag": "Activities of Daily Living", "type": 1 }, { "tag": "Age Factors", "type": 1 }, { "tag": "Aged", "type": 1 }, { "tag": "Aged, 80 and over", "type": 1 }, { "tag": "Delivery of Health Care", "type": 1 }, { "tag": "Disability Evaluation", "type": 1 }, { "tag": "Feasibility Studies", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Frail Elderly", "type": 1 }, { "tag": "Geriatric Assessment", "type": 1 }, { "tag": "Hospitalization", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Mental Competency", "type": 1 }, { "tag": "Mobility Limitation", "type": 1 }, { "tag": "Needs Assessment", "type": 1 }, { "tag": "Neuropsychological Tests", "type": 1 }, { "tag": "New South Wales", "type": 1 }, { "tag": "Patient Selection", "type": 1 }, { "tag": "Randomized Controlled Trials as Topic", "type": 1 }, { "tag": "Risk Assessment", "type": 1 }, { "tag": "Sex Factors", "type": 1 } ], "collections": [ "F947WQME" ], "relations": { "dc:replaces": "http://zotero.org/groups/361204/items/K7A9B9S5" }, "dateAdded": "2015-12-18T20:03:01Z", "dateModified": "2019-08-22T18:51:12Z" } }, { "key": "3PNHG86R", "version": 734, "library": { "type": "group", "id": 361204, "name": "Antidepressants in the elderly", "links": { "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/361204/items/3PNHG86R", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly/items/3PNHG86R", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/361204/items/ZNUSMFAK", "type": "application/json" } }, "meta": { "createdByUser": { "id": 136169, "username": "TanyaHill", "name": "Tanya MacLeod", "links": { "alternate": { "href": "https://www.zotero.org/tanyahill", "type": "text/html" } } }, "lastModifiedByUser": { "id": 4133376, "username": "lauriemallery", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lauriemallery", "type": "text/html" } } } }, "data": { "key": "3PNHG86R", "version": 734, "parentItem": "ZNUSMFAK", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2015-12-17T19:51:28Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/11824839", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-12-17T19:51:28Z", "dateModified": "2019-08-22T18:51:11Z" } }, { "key": "ZNUSMFAK", "version": 730, "library": { "type": "group", "id": 361204, "name": "Antidepressants in the elderly", "links": { "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/361204/items/ZNUSMFAK", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly/items/ZNUSMFAK", "type": "text/html" } }, "meta": { "createdByUser": { "id": 136169, "username": "TanyaHill", "name": "Tanya MacLeod", "links": { "alternate": { "href": "https://www.zotero.org/tanyahill", "type": "text/html" } } }, "lastModifiedByUser": { "id": 4133376, "username": "lauriemallery", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lauriemallery", "type": "text/html" } } }, "creatorSummary": "Williams", "parsedDate": "2001", "numChildren": 2 }, "data": { "key": "ZNUSMFAK", "version": 730, "itemType": "journalArticle", "title": "Standardizing the Hamilton Depression Rating Scale: past, present, and future", "creators": [ { "creatorType": "author", "firstName": "J. B.", "lastName": "Williams" } ], "abstractNote": "The Hamilton Depression Rating Scale (HAM-D) has become the most widely used depression severity rating scale in the world. It was originally published by Max Hamilton in 1960 to measure severity of depression in previously diagnosed depressed inpatients. Since that time, multiple versions of the scale have been created, although authors are rarely clear about which version they used. In addition, structured interview guides, self-report forms, and computerized versions have been developed in an effort to standardize administration of the scale and improve the psychometric characteristics of the individual items. The history of the development of these features is discussed, and the various versions of the scale are summarized in tables. This article is a fitting tribute to Per Bech, who has contributed so much to the assessment of depression severity.", "publicationTitle": "European Archives of Psychiatry and Clinical Neuroscience", "publisher": "", "place": "", "date": "2001", "volume": "251 Suppl 2", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "II6-12", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Eur Arch Psychiatry Clin Neurosci", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0940-1334", "archive": "", "archiveLocation": "", "shortTitle": "Standardizing the Hamilton Depression Rating Scale", "language": "eng", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "PMID: 11824839", "tags": [ { "tag": "Depressive Disorder", "type": 1 }, { "tag": "History, 20th Century", "type": 1 }, { "tag": "History, 21st Century", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Psychology", "type": 1 }, { "tag": "Psychometrics", "type": 1 }, { "tag": "Reference Standards", "type": 1 }, { "tag": "Surveys and Questionnaires", "type": 1 }, { "tag": "United States", "type": 1 } ], "collections": [ "62EJWKFX", "D6XEXEIQ" ], "relations": { "dc:replaces": "http://zotero.org/groups/361204/items/AHMZHJ4W" }, "dateAdded": "2015-12-17T14:09:18Z", "dateModified": "2019-08-22T18:51:11Z" } }, { "key": "IWC6FUH3", "version": 735, "library": { "type": "group", "id": 361204, "name": "Antidepressants in the elderly", "links": { "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/361204/items/IWC6FUH3", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly/items/IWC6FUH3", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/361204/items/85B647HE", "type": "application/json" } }, "meta": { "createdByUser": { "id": 4133376, "username": "lauriemallery", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lauriemallery", "type": "text/html" } } } }, "data": { "key": "IWC6FUH3", "version": 735, "parentItem": "85B647HE", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2017-06-28T16:40:20Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/28198686", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2017-06-28T16:40:20Z", "dateModified": "2019-08-22T18:51:10Z" } }, { "key": "85B647HE", "version": 731, "library": { "type": "group", "id": 361204, "name": "Antidepressants in the elderly", "links": { "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/361204/items/85B647HE", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly/items/85B647HE", "type": "text/html" } }, "meta": { "createdByUser": { "id": 4133376, "username": "lauriemallery", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lauriemallery", "type": "text/html" } } }, "creatorSummary": "Mallery et al.", "parsedDate": "2017-02", "numChildren": 2 }, "data": { "key": "85B647HE", "version": 731, "itemType": "journalArticle", "title": "Severely frail elderly patients do not need lipid-lowering drugs", "creators": [ { "creatorType": "author", "firstName": "Laurie Herzig", "lastName": "Mallery" }, { "creatorType": "author", "firstName": "Paige", "lastName": "Moorhouse" }, { "creatorType": "author", "firstName": "Pam", "lastName": "McLean Veysey" }, { "creatorType": "author", "firstName": "Michael", "lastName": "Allen" }, { "creatorType": "author", "firstName": "Isobel", "lastName": "Fleming" } ], "abstractNote": "After performing a systematic review, members of the Palliative and Therapeutic Harmonization (PATH) program and the Dalhousie Academic Detailing Service found that evidence does not support lipid-lowering therapy for severely frail elderly patients.", "publicationTitle": "Cleveland Clinic Journal of Medicine", "publisher": "", "place": "", "date": "Feb 2017", "volume": "84", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "131-142", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Cleve Clin J Med", "DOI": "10.3949/ccjm.84a.15114", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1939-2869", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "PMID: 28198686", "tags": [], "collections": [ "FLBS2U8G", "RHC9W2DZ" ], "relations": { "dc:replaces": "http://zotero.org/groups/361204/items/HEJJPA67" }, "dateAdded": "2017-06-28T16:22:36Z", "dateModified": "2019-08-22T18:51:10Z" } }, { "key": "XQM6698U", "version": 732, "library": { "type": "group", "id": 361204, "name": "Antidepressants in the elderly", "links": { "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/361204/items/XQM6698U", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly/items/XQM6698U", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/361204/items/IT9IMZG4", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2276084, "username": "cn552914", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/cn552914", "type": "text/html" } } }, "lastModifiedByUser": { "id": 4133376, "username": "lauriemallery", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lauriemallery", "type": "text/html" } } } }, "data": { "key": "XQM6698U", "version": 732, "parentItem": "IT9IMZG4", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Central Link", "accessDate": "2015-08-27T17:04:17Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849739/", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-08-27T17:04:17Z", "dateModified": "2019-08-22T18:51:09Z" } }, { "key": "IT9IMZG4", "version": 727, "library": { "type": "group", "id": 361204, "name": "Antidepressants in the elderly", "links": { "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/361204/items/IT9IMZG4", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly/items/IT9IMZG4", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2276084, "username": "cn552914", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/cn552914", "type": "text/html" } } }, "lastModifiedByUser": { "id": 4133376, "username": "lauriemallery", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lauriemallery", "type": "text/html" } } }, "creatorSummary": "Weintraub et al.", "parsedDate": "2010-04", "numChildren": 2 }, "data": { "key": "IT9IMZG4", "version": 727, "itemType": "journalArticle", "title": "Sertraline for the treatment of depression in Alzheimer’s disease: Week-24 outcomes", "creators": [ { "creatorType": "author", "firstName": "Daniel", "lastName": "Weintraub" }, { "creatorType": "author", "firstName": "Paul B.", "lastName": "Rosenberg" }, { "creatorType": "author", "firstName": "Lea T.", "lastName": "Drye" }, { "creatorType": "author", "firstName": "Barbara K.", "lastName": "Martin" }, { "creatorType": "author", "firstName": "Constantine", "lastName": "Frangakis" }, { "creatorType": "author", "firstName": "Jacobo E.", "lastName": "Mintzer" }, { "creatorType": "author", "firstName": "Anton P.", "lastName": "Porsteinsson" }, { "creatorType": "author", "firstName": "Lon S.", "lastName": "Schneider" }, { "creatorType": "author", "firstName": "Peter V.", "lastName": "Rabins" }, { "creatorType": "author", "firstName": "Cynthia A.", "lastName": "Munro" }, { "creatorType": "author", "firstName": "Curtis L.", "lastName": "Meinert" }, { "creatorType": "author", "firstName": "Constantine G.", "lastName": "Lyketsos" } ], "abstractNote": "Background\nDepression and antidepressant use are common in Alzheimer’s disease (AD), but the effect of antidepressant treatment for depression on longer-term outcomes is unknown. We report the week-24 outcomes of patients who participated in a 12-week efficacy study of sertraline for depression of AD.\n\nMethods\n131 participants (sertraline=67, placebo=64) with mild-moderate AD and depression participated in the study. Patients who showed improvement on the modified Alzheimer’s Disease Cooperative Study Clinical Global Impression-Change (mADCS-CGIC) after 12 weeks of randomized treatment with sertraline or placebo continued double-blinded treatment for an additional 12 weeks. Depression response and remission at 24 weeks were based on mADCS-CGIC score and change in Cornell Scale for Depression in Dementia (CSDD) score. Secondary outcome measures included time to remission, non-mood neuropsychiatric symptoms, global cognition, function, and quality of life.\n\nResults\n117 (89.3%) participants completed all study assessments and 74 (56.5%; sertraline=38, placebo=36) completed all 24 weeks on randomized treatment. By 24 weeks, there were no between-group differences in depression response (sertraline=44.8%, placebo=35.9%; odds ratio [95% CI]=1.23 [0.64, 2.35]), change in CSDD score (median difference=0.6 [95% CI −2.26, 3.46], χ2 [df=2]=1.03), remission rates (sertraline=32.8%, placebo=21.8%; odds ratio [95% CI]=1.61 [0.70, 3.68]), or secondary outcomes. Common SSRI-associated adverse events, specifically diarrhea, dizziness, and dry mouth, and pulmonary serious adverse events (SAEs) were more frequent in sertraline-randomized patients than in placebo subjects.\n\nConclusions\nSertraline treatment is not associated with delayed improvement between 12 and 24 weeks of treatment and may not be indicated for the treatment of depression of AD.", "publicationTitle": "The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry", "publisher": "", "place": "", "date": "2010-4", "volume": "18", "issue": "4", "section": "", "partNumber": "", "partTitle": "", "pages": "332-340", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Am J Geriatr Psychiatry", "DOI": "10.1097/JGP.0b013e3181cc0333", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849739/", "accessDate": "2015-08-27T17:03:59Z", "PMID": "", "PMCID": "", "ISSN": "1064-7481", "archive": "", "archiveLocation": "", "shortTitle": "Sertraline for the treatment of depression in Alzheimer’s disease", "language": "", "libraryCatalog": "PubMed Central", "callNumber": "", "rights": "", "extra": "PMID: 20220589\nPMCID: PMC2849739", "tags": [], "collections": [ "G9KS8XWS" ], "relations": { "dc:replaces": "http://zotero.org/groups/361204/items/FW9ANMJX" }, "dateAdded": "2015-08-27T17:03:59Z", "dateModified": "2019-08-22T18:51:09Z" } }, { "key": "VP692DKC", "version": 732, "library": { "type": "group", "id": 361204, "name": "Antidepressants in the elderly", "links": { "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/361204/items/VP692DKC", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly/items/VP692DKC", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/361204/items/6CMCAXNH", "type": "application/json" } }, "meta": { "createdByUser": { "id": 136169, "username": "TanyaHill", "name": "Tanya MacLeod", "links": { "alternate": { "href": "https://www.zotero.org/tanyahill", "type": "text/html" } } }, "lastModifiedByUser": { "id": 4133376, "username": "lauriemallery", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lauriemallery", "type": "text/html" } } } }, "data": { "key": "VP692DKC", "version": 732, "parentItem": "6CMCAXNH", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2015-09-22T12:39:33Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/20087081", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-09-22T12:39:33Z", "dateModified": "2019-08-22T18:51:01Z" } }, { "key": "6CMCAXNH", "version": 727, "library": { "type": "group", "id": 361204, "name": "Antidepressants in the elderly", "links": { "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/361204/items/6CMCAXNH", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly/items/6CMCAXNH", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2276084, "username": "cn552914", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/cn552914", "type": "text/html" } } }, "lastModifiedByUser": { "id": 4133376, "username": "lauriemallery", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lauriemallery", "type": "text/html" } } }, "creatorSummary": "Rosenberg et al.", "parsedDate": "2010-02", "numChildren": 2 }, "data": { "key": "6CMCAXNH", "version": 727, "itemType": "journalArticle", "title": "Sertraline for the treatment of depression in Alzheimer’s disease", "creators": [ { "creatorType": "author", "firstName": "Paul B.", "lastName": "Rosenberg" }, { "creatorType": "author", "firstName": "Lea T.", "lastName": "Drye" }, { "creatorType": "author", "firstName": "Barbara K.", "lastName": "Martin" }, { "creatorType": "author", "firstName": "Constantine", "lastName": "Frangakis" }, { "creatorType": "author", "firstName": "Jacobo E.", "lastName": "Mintzer" }, { "creatorType": "author", "firstName": "Daniel", "lastName": "Weintraub" }, { "creatorType": "author", "firstName": "Anton P.", "lastName": "Porsteinsson" }, { "creatorType": "author", "firstName": "Lon S.", "lastName": "Schneider" }, { "creatorType": "author", "firstName": "Peter V.", "lastName": "Rabins" }, { "creatorType": "author", "firstName": "Cynthia A.", "lastName": "Munro" }, { "creatorType": "author", "firstName": "Curtis L.", "lastName": "Meinert" }, { "creatorType": "author", "firstName": "Constantine G.", "lastName": "Lyketsos" } ], "abstractNote": "Background\nDepression is common in Alzheimer’s disease [AD], and antidepressants are commonly used for its treatment, yet evidence for antidepressant efficacy in this population is lacking. We conducted a multi-center, randomized, placebo-controlled trial titled “Depression in Alzheimer’s Disease-2” (DIADS-2) to assess the efficacy and tolerability of sertraline for depression in AD.\n\nMethods\nOne hundred thiry-one participants from 5 U.S. medical centers with mild-to-moderate AD (Mini-Mental State Examination [MMSE] scores 10–26) and depression of AD were randomized to double-blinded treatment with sertraline (N=67) or placebo (N=64), with a target dosage of 100 mg daily. Efficacy was assessed using logistic regressions and mixed effects models in an intention to treat (ITT) analysis with imputation of missing data. Principal outcome measures were modified Alzheimer’s Disease Cooperative Study-Clinical Global Impression of Change (mADCS-CGIC), change in Cornell Scale for Depression in Dementia (CSDD) scores, and remission defined by both mADCS-CGIC score ≤2 and CSDD score ≤ 6.\n\nFindings\nmADCS-CGIC ratings (OR = 1.01 (95% CI: 0.52, 1.97, p=0.98), CSDD scores (median difference at 12 weeks 1.2,[95% CI -1.65, 4.05], p=0.41), and remission at 12 weeks of followup (OR = 2.06, [95% CI - 0.84, 5.04], p=0.11) did not differ between sertraline (N=67) and placebo (N=64). Sertraline-treated patients experienced more adverse events, most notably gastrointestinal and respiratory, than placebo-treated patients.\n\nInterpretation\nSertraline did not demonstrate efficacy for the treatment depression symptoms in patients with Alzheimer's disease. In addition, its use was associated with an increased incidence of adverse events. Thus, selective serotonin reuptake inhibitors may be of limited value for treating depression in AD patients", "publicationTitle": "The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry", "publisher": "", "place": "", "date": "2010-2", "volume": "18", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "136-145", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Am J Geriatr Psychiatry", "DOI": "10.1097/JGP.0b013e3181c796eb", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842121/", "accessDate": "2015-08-27T17:09:22Z", "PMID": "", "PMCID": "", "ISSN": "1064-7481", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "PubMed Central", "callNumber": "", "rights": "", "extra": "PMID: 20087081\nPMCID: PMC2842121", "tags": [ { "tag": "Aged", "type": 1 }, { "tag": "Alzheimer Disease", "type": 1 }, { "tag": "Double-Blind Method", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Medication Adherence", "type": 1 }, { "tag": "Patient Dropouts", "type": 1 }, { "tag": "Placebos", "type": 1 }, { "tag": "Serotonin Uptake Inhibitors", "type": 1 }, { "tag": "Sertraline", "type": 1 }, { "tag": "Treatment Outcome", "type": 1 }, { "tag": "depression", "type": 1 } ], "collections": [ "G9KS8XWS" ], "relations": { "dc:replaces": "http://zotero.org/groups/361204/items/FHHTP5QV" }, "dateAdded": "2015-08-27T17:09:22Z", "dateModified": "2019-08-22T18:51:01Z" } }, { "key": "6HVMDV28", "version": 734, "library": { "type": "group", "id": 361204, "name": "Antidepressants in the elderly", "links": { "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/361204/items/6HVMDV28", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly/items/6HVMDV28", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/361204/items/WXQ3PNVK", "type": "application/json" } }, "meta": { "createdByUser": { "id": 136169, "username": "TanyaHill", "name": "Tanya MacLeod", "links": { "alternate": { "href": "https://www.zotero.org/tanyahill", "type": "text/html" } } }, "lastModifiedByUser": { "id": 4133376, "username": "lauriemallery", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lauriemallery", "type": "text/html" } } } }, "data": { "key": "6HVMDV28", "version": 734, "parentItem": "WXQ3PNVK", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2016-08-26T19:02:05Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/23152272", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2016-08-26T19:02:05Z", "dateModified": "2019-08-22T18:51:00Z" } }, { "key": "89DMPC8U", "version": 734, "library": { "type": "group", "id": 361204, "name": "Antidepressants in the elderly", "links": { "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/361204/items/89DMPC8U", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/antidepressants_in_the_elderly/items/89DMPC8U", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/361204/items/AHIV9RFT", "type": "application/json" } }, "meta": { "createdByUser": { "id": 136169, "username": "TanyaHill", "name": "Tanya MacLeod", "links": { "alternate": { "href": "https://www.zotero.org/tanyahill", "type": "text/html" } } }, "lastModifiedByUser": { "id": 4133376, "username": "lauriemallery", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lauriemallery", "type": "text/html" } } } }, "data": { "key": "89DMPC8U", "version": 734, "parentItem": "AHIV9RFT", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2016-05-27T15:59:53Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/18199864", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2016-05-27T15:59:53Z", "dateModified": "2019-08-22T18:51:00Z" } } ]