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Presented by Krithika Ramachandran on 2015-05-20

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Contents

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Presented by Aurimas Vinckevicius on 2015-05-13

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Contents

", "contentType": "application/pdf", "charset": "", "filename": "ncomms7186.pdf", "md5": "bce80f7095810d26aaba7331033040f3", "mtime": 1432745187117, "tags": [], "relations": {}, "dateAdded": "2015-05-27T16:46:29Z", "dateModified": "2015-05-27T16:46:33Z" } }, { "key": "CZC9I77N", "version": 61, "library": { "type": "group", "id": 354552, "name": "Debu-Grant Labs", "links": { "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/354552/items/CZC9I77N", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs/items/CZC9I77N", "type": "text/html" } }, "meta": { "createdByUser": { "id": 275915, "username": "aurimas", "name": "Aurimas Vinckevicius", "links": { "alternate": { "href": "https://www.zotero.org/aurimas", "type": "text/html" } } }, "creatorSummary": "Bailey et al.", "parsedDate": "2015-02-03", "numChildren": 2 }, "data": { "key": "CZC9I77N", "version": 61, "itemType": "journalArticle", "title": "ZNF143 provides sequence specificity to secure chromatin interactions at gene promoters", "creators": [ { "creatorType": "author", "firstName": "Swneke D.", "lastName": "Bailey" }, { "creatorType": "author", "firstName": "Xiaoyang", "lastName": "Zhang" }, { "creatorType": "author", "firstName": "Kinjal", "lastName": "Desai" }, { "creatorType": "author", "firstName": "Malika", "lastName": "Aid" }, { "creatorType": "author", "firstName": "Olivia", "lastName": "Corradin" }, { "creatorType": "author", "firstName": "Richard", "lastName": "Cowper-Sal·lari" }, { "creatorType": "author", "firstName": "Batool", "lastName": "Akhtar-Zaidi" }, { "creatorType": "author", "firstName": "Peter C.", "lastName": "Scacheri" }, { "creatorType": "author", "firstName": "Benjamin", "lastName": "Haibe-Kains" }, { "creatorType": "author", "firstName": "Mathieu", "lastName": "Lupien" } ], "abstractNote": "", "publicationTitle": "Nature Communications", "publisher": "", "place": "", "date": "2015-2-3", "volume": "2", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "6186", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1038/ncomms7186", "citationKey": "", "url": "http://www.nature.com/doifinder/10.1038/ncomms7186", "accessDate": "2015-05-27T16:45:45Z", "PMID": "", "PMCID": "", "ISSN": "2041-1723", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "PFJBHEWZ" ], "relations": {}, "dateAdded": "2015-05-27T16:45:45Z", "dateModified": "2015-05-27T16:45:45Z" } }, { "key": "D9N7JAK2", "version": 57, "library": { "type": "group", "id": 354552, "name": "Debu-Grant Labs", "links": { "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/354552/items/D9N7JAK2", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs/items/D9N7JAK2", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/354552/items/XIUX8PGA", "type": "application/json" } }, "meta": { "createdByUser": { "id": 275915, "username": "aurimas", "name": "Aurimas Vinckevicius", "links": { "alternate": { "href": "https://www.zotero.org/aurimas", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "D9N7JAK2", "version": 57, "parentItem": "XIUX8PGA", "itemType": "note", "note": "

Presented by Hanwei Yin on 2015-04-15

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Contents

", "contentType": "application/pdf", "charset": "", "filename": "Palumbo-Zerr et al. - 2015 - Orphan nuclear receptor NR4A1 regulates transformi.pdf", "md5": "9ca43e0fe64b77df7100718ae7cc5c44", "mtime": 1432744944016, "tags": [], "relations": {}, "dateAdded": "2015-05-27T16:42:18Z", "dateModified": "2015-05-27T16:42:25Z" } }, { "key": "XIUX8PGA", "version": 57, "library": { "type": "group", "id": 354552, "name": "Debu-Grant Labs", "links": { "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/354552/items/XIUX8PGA", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs/items/XIUX8PGA", "type": "text/html" } }, "meta": { "createdByUser": { "id": 275915, "username": "aurimas", "name": "Aurimas Vinckevicius", "links": { "alternate": { "href": "https://www.zotero.org/aurimas", "type": "text/html" } } }, "creatorSummary": "Palumbo-Zerr et al.", "parsedDate": "2015-02", "numChildren": 2 }, "data": { "key": "XIUX8PGA", "version": 57, "itemType": "journalArticle", "title": "Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis", "creators": [ { "creatorType": "author", "firstName": "Katrin", "lastName": "Palumbo-Zerr" }, { "creatorType": "author", "firstName": "Pawel", "lastName": "Zerr" }, { "creatorType": "author", "firstName": "Alfiya", "lastName": "Distler" }, { "creatorType": "author", "firstName": "Judith", "lastName": "Fliehr" }, { "creatorType": "author", "firstName": "Rossella", "lastName": "Mancuso" }, { "creatorType": "author", "firstName": "Jingang", "lastName": "Huang" }, { "creatorType": "author", "firstName": "Dirk", "lastName": "Mielenz" }, { "creatorType": "author", "firstName": "Michal", "lastName": "Tomcik" }, { "creatorType": "author", "firstName": "Barbara G.", "lastName": "Fürnrohr" }, { "creatorType": "author", "firstName": "Carina", "lastName": "Scholtysek" }, { "creatorType": "author", "firstName": "Clara", "lastName": "Dees" }, { "creatorType": "author", "firstName": "Christian", "lastName": "Beyer" }, { "creatorType": "author", "firstName": "Gerhard", "lastName": "Krönke" }, { "creatorType": "author", "firstName": "Daniel", "lastName": "Metzger" }, { "creatorType": "author", "firstName": "Oliver", "lastName": "Distler" }, { "creatorType": "author", "firstName": "Georg", "lastName": "Schett" }, { "creatorType": "author", "firstName": "Jörg H. W.", "lastName": "Distler" } ], "abstractNote": "Mesenchymal responses are an essential aspect of tissue repair. Failure to terminate this repair process correctly, however, results in fibrosis and organ dysfunction. Therapies that block fibrosis and restore tissue homeostasis are not yet available for clinical use. Here we characterize the nuclear receptor NR4A1 as an endogenous inhibitor of transforming growth factor-β (TGF-β) signaling and as a potential target for anti-fibrotic therapies. NR4A1 recruits a repressor complex comprising SP1, SIN3A, CoREST, LSD1, and HDAC1 to TGF-β target genes, thereby limiting pro-fibrotic TGF-β effects. Even though temporary upregulation of TGF-β in physiologic wound healing induces NR4A1 expression and thereby creates a negative feedback loop, the persistent activation of TGF-β signaling in fibrotic diseases uses AKT- and HDAC-dependent mechanisms to inhibit NR4A1 expression and activation. Small-molecule NR4A1 agonists can overcome this lack of active NR4A1 and inhibit experimentally-induced skin, lung, liver, and kidney fibrosis in mice. Our data demonstrate a regulatory role of NR4A1 in TGF-β signaling and fibrosis, providing the first proof of concept for targeting NR4A1 in fibrotic diseases.", "publicationTitle": "Nature Medicine", "publisher": "", "place": "", "date": "February 2015", "volume": "21", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "150-158", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Nat Med", "DOI": "10.1038/nm.3777", "citationKey": "", "url": "http://www.nature.com/nm/journal/v21/n2/full/nm.3777.html", "accessDate": "2015-05-27T16:42:18Z", "PMID": "", "PMCID": "", "ISSN": "1078-8956", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "www.nature.com", "callNumber": "", "rights": "© 2014 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.", "extra": "", "tags": [], "collections": [ "F76DKXJQ" ], "relations": {}, "dateAdded": "2015-05-27T16:42:18Z", "dateModified": "2015-05-27T16:42:18Z" } }, { "key": "4TNHXDFV", "version": 55, "library": { "type": "group", "id": 354552, "name": "Debu-Grant Labs", "links": { "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/354552/items/4TNHXDFV", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs/items/4TNHXDFV", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/354552/items/EJ5PTJH9", "type": "application/json" } }, "meta": { "createdByUser": { "id": 275915, "username": "aurimas", "name": "Aurimas Vinckevicius", "links": { "alternate": { "href": "https://www.zotero.org/aurimas", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "4TNHXDFV", "version": 55, "parentItem": "EJ5PTJH9", "itemType": "note", "note": "

Presented by Mthabisi Moyo on 2015-04-01

", "tags": [], "relations": {}, "dateAdded": "2015-05-27T16:40:56Z", "dateModified": "2015-05-27T16:41:08Z" } }, { "key": "2NBSJI99", "version": 56, "library": { "type": "group", "id": 354552, "name": "Debu-Grant Labs", "links": { "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/354552/items/2NBSJI99", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs/items/2NBSJI99", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/354552/items/EJ5PTJH9", "type": "application/json" } }, "meta": { "createdByUser": { "id": 275915, "username": "aurimas", "name": "Aurimas Vinckevicius", "links": { "alternate": { "href": "https://www.zotero.org/aurimas", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "2NBSJI99", "version": 56, "parentItem": "EJ5PTJH9", "itemType": "attachment", "linkMode": "imported_url", "title": "ScienceDirect Full Text PDF", "accessDate": "2015-05-27T16:40:53Z", "url": "http://www.sciencedirect.com/science/article/pii/S0092867415002044/pdfft?md5=08b9506acbd146d42b796dedf69dd6f7&pid=1-s2.0-S0092867415002044-main.pdf", "note": "

Contents

", "contentType": "application/pdf", "charset": "", "filename": "Chen et al. - 2015 - Genome-wide CRISPR Screen in a Mouse Model of Tumo.pdf", "md5": "ff4d761e603899b08445cf31f8ad4541", "mtime": 1432744857876, "tags": [], "relations": {}, "dateAdded": "2015-05-27T16:40:53Z", "dateModified": "2015-05-27T16:40:58Z" } }, { "key": "EJ5PTJH9", "version": 55, "library": { "type": "group", "id": 354552, "name": "Debu-Grant Labs", "links": { "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/354552/items/EJ5PTJH9", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs/items/EJ5PTJH9", "type": "text/html" } }, "meta": { "createdByUser": { "id": 275915, "username": "aurimas", "name": "Aurimas Vinckevicius", "links": { "alternate": { "href": "https://www.zotero.org/aurimas", "type": "text/html" } } }, "creatorSummary": "Chen et al.", "parsedDate": "2015-03-12", "numChildren": 2 }, "data": { "key": "EJ5PTJH9", "version": 55, "itemType": "journalArticle", "title": "Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis", "creators": [ { "creatorType": "author", "firstName": "Sidi", "lastName": "Chen" }, { "creatorType": "author", "firstName": "Neville E.", "lastName": "Sanjana" }, { "creatorType": "author", "firstName": "Kaijie", "lastName": "Zheng" }, { "creatorType": "author", "firstName": "Ophir", "lastName": "Shalem" }, { "creatorType": "author", "firstName": "Kyungheon", "lastName": "Lee" }, { "creatorType": "author", "firstName": "Xi", "lastName": "Shi" }, { "creatorType": "author", "firstName": "David A.", "lastName": "Scott" }, { "creatorType": "author", "firstName": "Jun", "lastName": "Song" }, { "creatorType": "author", "firstName": "Jen Q.", "lastName": "Pan" }, { "creatorType": "author", "firstName": "Ralph", "lastName": "Weissleder" }, { "creatorType": "author", "firstName": "Hakho", "lastName": "Lee" }, { "creatorType": "author", "firstName": "Feng", "lastName": "Zhang" }, { "creatorType": "author", "firstName": "Phillip A.", "lastName": "Sharp" } ], "abstractNote": "Summary\nGenetic screens are powerful tools for identifying genes responsible for diverse phenotypes. Here we describe a genome-wide CRISPR/Cas9-mediated loss-of-function screen in tumor growth and metastasis. We mutagenized a non-metastatic mouse cancer cell line using a genome-scale library with 67,405 single-guide RNAs (sgRNAs). The mutant cell pool rapidly generates metastases when transplanted into immunocompromised mice. Enriched sgRNAs in lung metastases and late-stage primary tumors were found to target a small set of genes, suggesting that specific loss-of-function mutations drive tumor growth and metastasis. Individual sgRNAs and a small pool of 624 sgRNAs targeting the top-scoring genes from the primary screen dramatically accelerate metastasis. In all of these experiments, the effect of mutations on primary tumor growth positively correlates with the development of metastases. Our study demonstrates Cas9-based screening as a robust method to systematically assay gene phenotypes in cancer evolution in vivo.", "publicationTitle": "Cell", "publisher": "", "place": "", "date": "March 12, 2015", "volume": "160", "issue": "6", "section": "", "partNumber": "", "partTitle": "", "pages": "1246-1260", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Cell", "DOI": "10.1016/j.cell.2015.02.038", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/S0092867415002044", "accessDate": "2015-05-27T16:40:53Z", "PMID": "", "PMCID": "", "ISSN": "0092-8674", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "VNCAQBRJ" ], "relations": {}, "dateAdded": "2015-05-27T16:40:53Z", "dateModified": "2015-05-27T16:40:53Z" } }, { "key": "CXI6XE44", "version": 54, "library": { "type": "group", "id": 354552, "name": "Debu-Grant Labs", "links": { "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/354552/items/CXI6XE44", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs/items/CXI6XE44", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/354552/items/SKFA3UGV", "type": "application/json" } }, "meta": { "createdByUser": { "id": 275915, "username": "aurimas", "name": "Aurimas Vinckevicius", "links": { "alternate": { "href": "https://www.zotero.org/aurimas", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "CXI6XE44", "version": 54, "parentItem": "SKFA3UGV", "itemType": "note", "note": "

Presented by Madhavi Senagolage on 2015-03-04

", "tags": [], "relations": {}, "dateAdded": "2015-05-27T16:39:45Z", "dateModified": "2015-05-27T16:40:22Z" } }, { "key": "A6BP4E8U", "version": 52, "library": { "type": "group", "id": 354552, "name": "Debu-Grant Labs", "links": { "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/354552/items/A6BP4E8U", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs/items/A6BP4E8U", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/354552/items/SKFA3UGV", "type": "application/json" } }, "meta": { "createdByUser": { "id": 275915, "username": "aurimas", "name": "Aurimas Vinckevicius", "links": { "alternate": { "href": "https://www.zotero.org/aurimas", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "A6BP4E8U", "version": 52, "parentItem": "SKFA3UGV", "itemType": "attachment", "linkMode": "imported_url", "title": "ScienceDirect Full Text PDF", "accessDate": "2015-05-27T16:39:25Z", "url": "http://www.sciencedirect.com/science/article/pii/S1550413114005658/pdfft?md5=f592013fbaaca8f6c6f5740e881b1b85&pid=1-s2.0-S1550413114005658-main.pdf", "note": "

Contents

", "contentType": "application/pdf", "charset": "", "filename": "Multhaup et al. - 2015 - Mouse-Human Experimental Epigenetic Analysis Unmas.pdf", "md5": "aec3d68984c0140c52f392a5f9a68081", "mtime": 1432744767707, "tags": [], "relations": {}, "dateAdded": "2015-05-27T16:39:25Z", "dateModified": "2015-05-27T16:39:28Z" } }, { "key": "SKFA3UGV", "version": 50, "library": { "type": "group", "id": 354552, "name": "Debu-Grant Labs", "links": { "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/354552/items/SKFA3UGV", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs/items/SKFA3UGV", "type": "text/html" } }, "meta": { "createdByUser": { "id": 275915, "username": "aurimas", "name": "Aurimas Vinckevicius", "links": { "alternate": { "href": "https://www.zotero.org/aurimas", "type": "text/html" } } }, "creatorSummary": "Multhaup et al.", "parsedDate": "2015-01-06", "numChildren": 2 }, "data": { "key": "SKFA3UGV", "version": 50, "itemType": "journalArticle", "title": "Mouse-Human Experimental Epigenetic Analysis Unmasks Dietary Targets and Genetic Liability for Diabetic Phenotypes", "creators": [ { "creatorType": "author", "firstName": "Michael L.", "lastName": "Multhaup" }, { "creatorType": "author", "firstName": "Marcus M.", "lastName": "Seldin" }, { "creatorType": "author", "firstName": "Andrew E.", "lastName": "Jaffe" }, { "creatorType": "author", "firstName": "Xia", "lastName": "Lei" }, { "creatorType": "author", "firstName": "Henriette", "lastName": "Kirchner" }, { "creatorType": "author", "firstName": "Prosenjit", "lastName": "Mondal" }, { "creatorType": "author", "firstName": "Yuanyuan", "lastName": "Li" }, { "creatorType": "author", "firstName": "Varenka", "lastName": "Rodriguez" }, { "creatorType": "author", "firstName": "Alexander", "lastName": "Drong" }, { "creatorType": "author", "firstName": "Mehboob", "lastName": "Hussain" }, { "creatorType": "author", "firstName": "Cecilia", "lastName": "Lindgren" }, { "creatorType": "author", "firstName": "Mark", "lastName": "McCarthy" }, { "creatorType": "author", "firstName": "Erik", "lastName": "Näslund" }, { "creatorType": "author", "firstName": "Juleen R.", "lastName": "Zierath" }, { "creatorType": "author", "firstName": "G. William", "lastName": "Wong" }, { "creatorType": "author", "firstName": "Andrew P.", "lastName": "Feinberg" } ], "abstractNote": "Summary\nUsing a functional approach to investigate the epigenetics of type 2 diabetes (T2D), we combine three lines of evidence—diet-induced epigenetic dysregulation in mouse, epigenetic conservation in humans, and T2D clinical risk evidence—to identify genes implicated in T2D pathogenesis through epigenetic mechanisms related to obesity. Beginning with dietary manipulation of genetically homogeneous mice, we identify differentially DNA-methylated genomic regions. We then replicate these results in adipose samples from lean and obese patients pre- and post-Roux-en-Y gastric bypass, identifying regions where both the location and direction of methylation change are conserved. These regions overlap with 27 genetic T2D risk loci, only one of which was deemed significant by GWAS alone. Functional analysis of genes associated with these regions revealed four genes with roles in insulin resistance, demonstrating the potential general utility of this approach for complementing conventional human genetic studies by integrating cross-species epigenomics and clinical genetic risk.", "publicationTitle": "Cell Metabolism", "publisher": "", "place": "", "date": "January 6, 2015", "volume": "21", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "138-149", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Cell Metabolism", "DOI": "10.1016/j.cmet.2014.12.014", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/S1550413114005658", "accessDate": "2015-05-27T16:39:25Z", "PMID": "", "PMCID": "", "ISSN": "1550-4131", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "AKVRNBQB" ], "relations": {}, "dateAdded": "2015-05-27T16:39:25Z", "dateModified": "2015-05-27T16:39:25Z" } }, { "key": "PM73FIVM", "version": 48, "library": { "type": "group", "id": 354552, "name": "Debu-Grant Labs", "links": { "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/354552/items/PM73FIVM", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs/items/PM73FIVM", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/354552/items/HDZNQNCC", "type": "application/json" } }, "meta": { "createdByUser": { "id": 275915, "username": "aurimas", "name": "Aurimas Vinckevicius", "links": { "alternate": { "href": "https://www.zotero.org/aurimas", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "PM73FIVM", "version": 48, "parentItem": "HDZNQNCC", "itemType": "note", "note": "

Presented by Ji-Young Kim on 2015-02-11

", "tags": [], "relations": {}, "dateAdded": "2015-05-27T16:38:41Z", "dateModified": "2015-05-27T16:38:53Z" } }, { "key": "WP6QKHD6", "version": 49, "library": { "type": "group", "id": 354552, "name": "Debu-Grant Labs", "links": { "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/354552/items/WP6QKHD6", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs/items/WP6QKHD6", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/354552/items/HDZNQNCC", "type": "application/json" } }, "meta": { "createdByUser": { "id": 275915, "username": "aurimas", "name": "Aurimas Vinckevicius", "links": { "alternate": { "href": "https://www.zotero.org/aurimas", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "WP6QKHD6", "version": 49, "parentItem": "HDZNQNCC", "itemType": "attachment", "linkMode": "imported_url", "title": "ScienceDirect Full Text PDF", "accessDate": "2015-05-27T16:38:32Z", "url": "http://www.sciencedirect.com/science/article/pii/S0092867413014256/pdfft?md5=4537632db5e9183ccce6a27c6552fffe&pid=1-s2.0-S0092867413014256-main.pdf", "note": "

Contents

", "contentType": "application/pdf", "charset": "", "filename": "Arora et al. - 2013 - Glucocorticoid Receptor Confers Resistance to Anti.pdf", "md5": "38dee7296fa1617965e18d53d15e46c8", "mtime": 1432744717276, "tags": [], "relations": {}, "dateAdded": "2015-05-27T16:38:32Z", "dateModified": "2015-05-27T16:38:38Z" } }, { "key": "HDZNQNCC", "version": 48, "library": { "type": "group", "id": 354552, "name": "Debu-Grant Labs", "links": { "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/354552/items/HDZNQNCC", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs/items/HDZNQNCC", "type": "text/html" } }, "meta": { "createdByUser": { "id": 275915, "username": "aurimas", "name": "Aurimas Vinckevicius", "links": { "alternate": { "href": "https://www.zotero.org/aurimas", "type": "text/html" } } }, "creatorSummary": "Arora et al.", "parsedDate": "2013-12-05", "numChildren": 2 }, "data": { "key": "HDZNQNCC", "version": 48, "itemType": "journalArticle", "title": "Glucocorticoid Receptor Confers Resistance to Antiandrogens by Bypassing Androgen Receptor Blockade", "creators": [ { "creatorType": "author", "firstName": "Vivek K.", "lastName": "Arora" }, { "creatorType": "author", "firstName": "Emily", "lastName": "Schenkein" }, { "creatorType": "author", "firstName": "Rajmohan", "lastName": "Murali" }, { "creatorType": "author", "firstName": "Sumit K.", "lastName": "Subudhi" }, { "creatorType": "author", "firstName": "John", "lastName": "Wongvipat" }, { "creatorType": "author", "firstName": "Minna D.", "lastName": "Balbas" }, { "creatorType": "author", "firstName": "Neel", "lastName": "Shah" }, { "creatorType": "author", "firstName": "Ling", "lastName": "Cai" }, { "creatorType": "author", "firstName": "Eleni", "lastName": "Efstathiou" }, { "creatorType": "author", "firstName": "Chris", "lastName": "Logothetis" }, { "creatorType": "author", "firstName": "Deyou", "lastName": "Zheng" }, { "creatorType": "author", "firstName": "Charles L.", "lastName": "Sawyers" } ], "abstractNote": "Summary\nThe treatment of advanced prostate cancer has been transformed by novel antiandrogen therapies such as enzalutamide. Here, we identify induction of glucocorticoid receptor (GR) expression as a common feature of drug-resistant tumors in a credentialed preclinical model, a finding also confirmed in patient samples. GR substituted for the androgen receptor (AR) to activate a similar but distinguishable set of target genes and was necessary for maintenance of the resistant phenotype. The GR agonist dexamethasone was sufficient to confer enzalutamide resistance, whereas a GR antagonist restored sensitivity. Acute AR inhibition resulted in GR upregulation in a subset of prostate cancer cells due to relief of AR-mediated feedback repression of GR expression. These findings establish a mechanism of escape from AR blockade through expansion of cells primed to drive AR target genes via an alternative nuclear receptor upon drug exposure.", "publicationTitle": "Cell", "publisher": "", "place": "", "date": "December 5, 2013", "volume": "155", "issue": "6", "section": "", "partNumber": "", "partTitle": "", "pages": "1309-1322", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Cell", "DOI": "10.1016/j.cell.2013.11.012", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/S0092867413014256", "accessDate": "2015-05-27T16:38:32Z", "PMID": "", "PMCID": "", "ISSN": "0092-8674", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "KUS7MQAM" ], "relations": {}, "dateAdded": "2015-05-27T16:38:32Z", "dateModified": "2015-05-27T16:38:32Z" } }, { "key": "ZX5FHGNW", "version": 46, "library": { "type": "group", "id": 354552, "name": "Debu-Grant Labs", "links": { "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/354552/items/ZX5FHGNW", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs/items/ZX5FHGNW", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/354552/items/8GIVQHS2", "type": "application/json" } }, "meta": { "createdByUser": { "id": 275915, "username": "aurimas", "name": "Aurimas Vinckevicius", "links": { "alternate": { "href": "https://www.zotero.org/aurimas", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "ZX5FHGNW", "version": 46, "parentItem": "8GIVQHS2", "itemType": "note", "note": "

Presented by Meredith Chase on 2015-01-28

", "tags": [], "relations": {}, "dateAdded": "2015-05-27T16:37:15Z", "dateModified": "2015-05-27T16:37:44Z" } }, { "key": "4HCH6TCK", "version": 47, "library": { "type": "group", "id": 354552, "name": "Debu-Grant Labs", "links": { "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/354552/items/4HCH6TCK", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs/items/4HCH6TCK", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/354552/items/8GIVQHS2", "type": "application/json" } }, "meta": { "createdByUser": { "id": 275915, "username": "aurimas", "name": "Aurimas Vinckevicius", "links": { "alternate": { "href": "https://www.zotero.org/aurimas", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "4HCH6TCK", "version": 47, "parentItem": "8GIVQHS2", "itemType": "attachment", "linkMode": "imported_url", "title": "ScienceDirect Full Text PDF", "accessDate": "2015-05-27T16:37:11Z", "url": "http://www.sciencedirect.com/science/article/pii/S0092867414011799/pdfft?md5=dabfd840c3b426001d574d7a5d11dae0&pid=1-s2.0-S0092867414011799-main.pdf", "note": "

Contents

", "contentType": "application/pdf", "charset": "", "filename": "Dowen et al. - 2014 - Control of Cell Identity Genes Occurs in Insulated.pdf", "md5": "58a0312def8753d9dac815fa925b1569", "mtime": 1432744634712, "tags": [], "relations": {}, "dateAdded": "2015-05-27T16:37:11Z", "dateModified": "2015-05-27T16:37:16Z" } }, { "key": "8GIVQHS2", "version": 46, "library": { "type": "group", "id": 354552, "name": "Debu-Grant Labs", "links": { "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/354552/items/8GIVQHS2", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs/items/8GIVQHS2", "type": "text/html" } }, "meta": { "createdByUser": { "id": 275915, "username": "aurimas", "name": "Aurimas Vinckevicius", "links": { "alternate": { "href": "https://www.zotero.org/aurimas", "type": "text/html" } } }, "creatorSummary": "Dowen et al.", "parsedDate": "2014-10-09", "numChildren": 2 }, "data": { "key": "8GIVQHS2", "version": 46, "itemType": "journalArticle", "title": "Control of Cell Identity Genes Occurs in Insulated Neighborhoods in Mammalian Chromosomes", "creators": [ { "creatorType": "author", "firstName": "Jill M.", "lastName": "Dowen" }, { "creatorType": "author", "firstName": "Zi Peng", "lastName": "Fan" }, { "creatorType": "author", "firstName": "Denes", "lastName": "Hnisz" }, { "creatorType": "author", "firstName": "Gang", "lastName": "Ren" }, { "creatorType": "author", "firstName": "Brian J.", "lastName": "Abraham" }, { "creatorType": "author", "firstName": "Lyndon N.", "lastName": "Zhang" }, { "creatorType": "author", "firstName": "Abraham S.", "lastName": "Weintraub" }, { "creatorType": "author", "firstName": "Jurian", "lastName": "Schuijers" }, { "creatorType": "author", "firstName": "Tong Ihn", "lastName": "Lee" }, { "creatorType": "author", "firstName": "Keji", "lastName": "Zhao" }, { "creatorType": "author", "firstName": "Richard A.", "lastName": "Young" } ], "abstractNote": "Summary\nThe pluripotent state of embryonic stem cells (ESCs) is produced by active transcription of genes that control cell identity and repression of genes encoding lineage-specifying developmental regulators. Here, we use ESC cohesin ChIA-PET data to identify the local chromosomal structures at both active and repressed genes across the genome. The results produce a map of enhancer-promoter interactions and reveal that super-enhancer-driven genes generally occur within chromosome structures that are formed by the looping of two interacting CTCF sites co-occupied by cohesin. These looped structures form insulated neighborhoods whose integrity is important for proper expression of local genes. We also find that repressed genes encoding lineage-specifying developmental regulators occur within insulated neighborhoods. These results provide insights into the relationship between transcriptional control of cell identity genes and control of local chromosome structure.", "publicationTitle": "Cell", "publisher": "", "place": "", "date": "October 9, 2014", "volume": "159", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "374-387", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Cell", "DOI": "10.1016/j.cell.2014.09.030", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/S0092867414011799", "accessDate": "2015-05-27T16:37:11Z", "PMID": "", "PMCID": "", "ISSN": "0092-8674", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "57XK5GZC" ], "relations": {}, "dateAdded": "2015-05-27T16:37:11Z", "dateModified": "2015-05-27T16:37:11Z" } }, { "key": "Z39VETT4", "version": 44, "library": { "type": "group", "id": 354552, "name": "Debu-Grant Labs", "links": { "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/354552/items/Z39VETT4", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/debu-grant_labs/items/Z39VETT4", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/354552/items/3ZFTHW3J", "type": "application/json" } }, "meta": { "createdByUser": { "id": 275915, "username": "aurimas", "name": "Aurimas Vinckevicius", "links": { "alternate": { "href": "https://www.zotero.org/aurimas", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "Z39VETT4", "version": 44, "parentItem": "3ZFTHW3J", "itemType": "note", "note": "

Presented by Mthabisi Moyo on 2014-12-03

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Here, we provide the first biochemical and structural insights into the molecular architecture of this large multiprotein assembly. We identified several direct interactions within the complex and show that KANSL1 acts as a scaffold protein interacting with four other subunits, including WDR5, which in turn binds KANSL2. Structural analysis of the KANSL1/WDR5/KANSL2 subcomplex reveals how WDR5 is recruited into the NSL complex via conserved linear motifs of KANSL1 and KANSL2. Using structure-based KANSL1 mutants in transgenic flies, we show that the KANSL1–WDR5 interaction is required for proper assembly, efficient recruitment of the NSL complex to target promoters, and fly viability. Our data clearly show that the interactions of WDR5 with the MOF-containing NSL complex and MLL/COMPASS histone methyltransferase complexes are mutually exclusive. We propose that rather than being a shared subunit, WDR5 plays an important role in assembling distinct histone-modifying complexes with different epigenetic regulatory roles.", "publicationTitle": "Genes & Development", "publisher": "", "place": "", "date": "05/01/2014", "volume": "28", "issue": "9", "section": "", "partNumber": "", "partTitle": "", "pages": "929-942", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Genes Dev.", "DOI": "10.1101/gad.240200.114", "citationKey": "", "url": "http://genesdev.cshlp.org/content/28/9/929", "accessDate": "2015-05-27T16:34:46Z", "PMID": "", "PMCID": "", "ISSN": "0890-9369, 1549-5477", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "genesdev.cshlp.org", "callNumber": "", "rights": "", "extra": "PMID: 24788516", "tags": [], "collections": [ "UFXK2IG7" ], "relations": {}, "dateAdded": "2015-05-27T16:34:46Z", "dateModified": "2015-05-27T16:34:46Z" } } ]