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            "title": "Market assessment of tuberculosis diagnostics in India in 2013",
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            "abstractNote": "BACKGROUND: India represents a significant potential market for new tests. We assessed India's market for tuberculosis (TB) diagnostics in 2013.METHODS: Test volumes and unit costs were assessed for tuberculin tests, interferon-gamma release assays, sputum smear microscopy, serology, culture, speciation testing, nucleic-acid amplification tests (i.e., in-house polymerase chain reaction, Xpert® MTB/RIF, line-probe assays) and drug susceptibility testing. Data from the public sector were collected from the Revised National TB Control Programme reports. Private sector data were collected through a survey of private laboratories and practitioners. Data were also collected from manufacturers.RESULTS: In 2013, India's public sector performed 19.2 million tests, with a market value of US$22.9 million. The private sector performed 13.6 million tests, with a market value of US$60.4 million when prices charged to the patient were applied. The overall market was US$70.8 million when unit costs from the ingredient approach were used for the 32.8 million TB tests performed in the entire country. Smear microscopy was the most common test performed, accounting for 25% of the overall market value.CONCLUSION: India's estimated market value for TB diagnostics in 2013 was US$70.8 million. These data should be of relevance to test developers, donors and implementers.",
            "publicationTitle": "The International Journal of Tuberculosis and Lung Disease",
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            "version": 116,
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            "title": "Potential Market for Novel Tuberculosis Diagnostics: Worth the Investment?",
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                    "creatorType": "author",
                    "firstName": "Sandra V.",
                    "lastName": "Kik"
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                {
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            "publisher": "",
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            "version": 114,
            "itemType": "journalArticle",
            "title": "Target Product Profile of a Molecular Drug-Susceptibility Test for Use in Microscopy Centers",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Claudia M.",
                    "lastName": "Denkinger"
                },
                {
                    "creatorType": "author",
                    "firstName": "David",
                    "lastName": "Dolinger"
                },
                {
                    "creatorType": "author",
                    "firstName": "Marco",
                    "lastName": "Schito"
                },
                {
                    "creatorType": "author",
                    "firstName": "William",
                    "lastName": "Wells"
                },
                {
                    "creatorType": "author",
                    "firstName": "Frank",
                    "lastName": "Cobelens"
                },
                {
                    "creatorType": "author",
                    "firstName": "Madhukar",
                    "lastName": "Pai"
                },
                {
                    "creatorType": "author",
                    "firstName": "Matteo",
                    "lastName": "Zignol"
                },
                {
                    "creatorType": "author",
                    "firstName": "Daniela Maria",
                    "lastName": "Cirillo"
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                {
                    "creatorType": "author",
                    "firstName": "David",
                    "lastName": "Alland"
                },
                {
                    "creatorType": "author",
                    "firstName": "Martina",
                    "lastName": "Casenghi"
                },
                {
                    "creatorType": "author",
                    "firstName": "Jim",
                    "lastName": "Gallarda"
                },
                {
                    "creatorType": "author",
                    "firstName": "Catharina C.",
                    "lastName": "Boehme"
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                {
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                    "firstName": "Mark D.",
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            "abstractNote": "Background. Current phenotypic testing for drug resistance in patients with tuberculosis is inadequate primarily with respect to turnaround time. Molecular tests hold the promise of an improved time to diagnosis.\nMethods. A target product profile for a molecular drug-susceptibility test (DST) was developed on the basis of a collaborative effort that included opinions gathered from researchers, clinicians, policy makers, and test developers on optimal clinical and operational characteristics in settings of intended use. In addition, the current diagnostic ecosystem and the diagnostic development landscape were mapped.\nResults. Molecular DSTs for detecting tuberculosis in microscopy centers should ideally evaluate for resistance to rifampin, fluoroquinolones, isoniazid, and pyrazinamide and enable the selection of the most appropriate treatment regimen. Performance characteristics of DSTs need to be optimized, but compromises can be made that depend on the trade-off between a false-positive result and a false-negative result. The operational requirements of a test will vary depending on the site of implementation. However, the most-important considerations pertain to quality control, maintenance and calibration, and the ability to export data.\nConclusion. This target product profile defines the needs as perceived by the tuberculosis stakeholder community and attempts to provide a means of communication with test developers to ensure that fit-for-purpose DSTs are being developed.",
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