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Several new studies highlight the destructive nature of obstructive sleep apnea, a chronic disease that increases the risk of high blood pressure, heart disease, Type 2 diabetes, stroke and depression.", "websiteTitle": "AASM", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://www.aasmnet.org/articles.aspx?id=5043", "accessDate": "2015-04-17T04:39:34Z", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [ "AHNJZ4WG" ], "relations": {}, "dateAdded": "2015-04-17T04:39:34Z", "dateModified": "2015-04-17T04:39:34Z" } }, { "key": "E3BK59H7", "version": 86, "library": { "type": "group", "id": 339306, "name": "Medical device--Inspire Upper Airway Stimulation", "links": { "alternate": { "href": "https://www.zotero.org/groups/medical_device--inspire_upper_airway_stimulation", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/339306/items/E3BK59H7", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/medical_device--inspire_upper_airway_stimulation/items/E3BK59H7", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2053577, "username": "Zhibin Liang", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/zhibin_liang", "type": "text/html" } } }, "creatorSummary": "Schwartz AR et al.", "parsedDate": "2001-10-01", "numChildren": 1 }, "data": { "key": "E3BK59H7", "version": 86, "itemType": "journalArticle", "title": "Therapeutic electrical stimulation of the hypoglossal nerve in obstructive sleep apnea", "creators": [ { "creatorType": "author", "name": "Schwartz AR" }, { "creatorType": "author", "name": "Bennett ML" }, { "creatorType": "author", "name": "Smith PL" }, { "creatorType": "author", "name": "et al" } ], "abstractNote": "Background \nHypoglossal nerve stimulation has been demonstrated to relieve upper airway obstruction acutely, but its effect on obstructive sleep apnea is not known.Objective\nTo determine the response in obstructive sleep apnea to electrical stimulation of the hypoglossal nerve.Methods\nEight patients with obstructive sleep apnea were implanted with a device that stimulated the hypoglossal nerve unilaterally during inspiration. Sleep and breathing patterns were examined at baseline before implantation and after implantation at 1, 3, and 6 months and last follow-up.Results\nUnilateral hypoglossal nerve stimulation decreased the severity of obstructive sleep apnea throughout the entire study period. Specifically, stimulation significantly reduced the mean apnea-hypopnea indices in non–rapid eye movement (mean ± SD episodes per hour, 52.0 ± 20.4 for baseline nights and 22.6 ± 12.1 for stimulation nights; P<.001) and rapid eye movement (48.2 ± 30.5 and 16.6 ± 17.1, respectively; P<.001) sleep and reduced the severity of oxyhemoglobin desaturations. With improvement in sleep apnea, a trend toward deeper stages of non–rapid eye movement sleep was observed. Moreover, all patients tolerated long-term stimulation at night and did not experience any adverse effects from stimulation. Even after completing the study protocol, the 3 patients who remained free from stimulator malfunction continued to use this device as primary treatment.Conclusion\nThe findings demonstrate the feasibility and therapeutic potential for hypoglossal nerve stimulation in obstructive sleep apnea.", "publicationTitle": "Archives of Otolaryngology–Head & Neck Surgery", "publisher": "", "place": "", "date": "October 1, 2001", "volume": "127", "issue": "10", "section": "", "partNumber": "", "partTitle": "", "pages": "1216-1223", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Archives of Otolaryngology–Head & Neck Surgery", "DOI": "10.1001/archotol.127.10.1216", "citationKey": "", "url": "http://dx.doi.org/10.1001/archotol.127.10.1216", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0886-4470", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "582HW7QG" ], "relations": {}, "dateAdded": "2015-04-17T02:09:28Z", "dateModified": "2015-04-17T02:09:45Z" } }, { "key": "SZRS5XHR", "version": 85, "library": { "type": "group", "id": 339306, "name": "Medical device--Inspire Upper Airway Stimulation", "links": { "alternate": { "href": "https://www.zotero.org/groups/medical_device--inspire_upper_airway_stimulation", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/339306/items/SZRS5XHR", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/medical_device--inspire_upper_airway_stimulation/items/SZRS5XHR", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/339306/items/E3BK59H7", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2053577, "username": "Zhibin Liang", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/zhibin_liang", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "SZRS5XHR", "version": 85, "parentItem": "E3BK59H7", "itemType": "note", "note": "

10.1001/archotol.127.10.1216

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