[ { "key": "2C9WJ7MV", "version": 12, "library": { "type": "group", "id": 335985, "name": "Cardiogenic shock", "links": { "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/335985/items/2C9WJ7MV", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock/items/2C9WJ7MV", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/335985/items/Q539IHEU", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1161085, "username": "webakerma", "name": "William Baker", "links": { "alternate": { "href": "https://www.zotero.org/webakerma", "type": "text/html" } } } }, "data": { "key": "2C9WJ7MV", "version": 12, "parentItem": "Q539IHEU", "itemType": "attachment", "linkMode": "imported_url", "title": "Snapshot", "accessDate": "2015-03-11T01:30:04Z", "url": "http://jccm.ro/eficacy-of-trichloroacetic-acid-peel-versus-15-topical-azelaic-acid-gel-in-the-treatment-of-acne-vulgaris-a-comparative-study/", "note": "", "contentType": "text/html", "charset": "utf-8", "filename": "eficacy-of-trichloroacetic-acid-peel-versus-15-topical-azelaic-acid-gel-in-the-treatment-of-acn.html", "md5": "1cc49d5a118f3d218864f1ab8b1a3334", "mtime": 1426037404000, "tags": [], "relations": {}, "dateAdded": "2015-03-11T01:30:04Z", "dateModified": "2015-03-11T01:30:04Z" } }, { "key": "Q539IHEU", "version": 11, "library": { "type": "group", "id": 335985, "name": "Cardiogenic shock", "links": { "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/335985/items/Q539IHEU", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock/items/Q539IHEU", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1161085, "username": "webakerma", "name": "William Baker", "links": { "alternate": { "href": "https://www.zotero.org/webakerma", "type": "text/html" } } }, "creatorSummary": "administrare", "numChildren": 1 }, "data": { "key": "Q539IHEU", "version": 11, "itemType": "blogPost", "title": "Current Concepts and New Trends in the Treatment of Cardiogenic Shock Complicating Acute Myocardial Infarction | The Journal of Critical Care Medicine", "creators": [ { "creatorType": "author", "name": "administrare" } ], "abstractNote": "", "blogTitle": "", "websiteType": "", "date": "", "DOI": "", "citationKey": "", "url": "http://jccm.ro/eficacy-of-trichloroacetic-acid-peel-versus-15-topical-azelaic-acid-gel-in-the-treatment-of-acne-vulgaris-a-comparative-study/", "accessDate": "2015-03-11T01:30:04Z", "ISSN": "", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-03-11T01:30:04Z", "dateModified": "2015-03-11T01:30:04Z" } }, { "key": "CK8UTC9T", "version": 14, "library": { "type": "group", "id": 335985, "name": "Cardiogenic shock", "links": { "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/335985/items/CK8UTC9T", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock/items/CK8UTC9T", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1161085, "username": "webakerma", "name": "William Baker", "links": { "alternate": { "href": "https://www.zotero.org/webakerma", "type": "text/html" } } }, "creatorSummary": "Lawler et al.", "parsedDate": "2015-02-17", "numChildren": 1 }, "data": { "key": "CK8UTC9T", "version": 14, "itemType": "journalArticle", "title": "Extracorporeal membrane oxygenation in adults with cardiogenic shock", "creators": [ { "creatorType": "author", "firstName": "Patrick R.", "lastName": "Lawler" }, { "creatorType": "author", "firstName": "David A.", "lastName": "Silver" }, { "creatorType": "author", "firstName": "Benjamin M.", "lastName": "Scirica" }, { "creatorType": "author", "firstName": "Gregory S.", "lastName": "Couper" }, { "creatorType": "author", "firstName": "Gerald L.", "lastName": "Weinhouse" }, { "creatorType": "author", "firstName": "Phillip C.", "lastName": "Camp" } ], "abstractNote": "", "publicationTitle": "Circulation", "publisher": "", "place": "", "date": "Feb 17, 2015", "volume": "131", "issue": "7", "section": "", "partNumber": "", "partTitle": "", "pages": "676-680", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Circulation", "DOI": "10.1161/CIRCULATIONAHA.114.006647", "citationKey": "", "url": "", "accessDate": "", "PMID": "25691703", "PMCID": "", "ISSN": "1524-4539", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-03-11T01:26:48Z", "dateModified": "2015-03-11T01:26:48Z" } }, { "key": "2N6QSRTI", "version": 10, "library": { "type": "group", "id": 335985, "name": "Cardiogenic shock", "links": { "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/335985/items/2N6QSRTI", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock/items/2N6QSRTI", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/335985/items/CK8UTC9T", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1161085, "username": "webakerma", "name": "William Baker", "links": { "alternate": { "href": "https://www.zotero.org/webakerma", "type": "text/html" } } } }, "data": { "key": "2N6QSRTI", "version": 10, "parentItem": "CK8UTC9T", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2015-03-11T01:26:48Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/25691703", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-03-11T01:26:48Z", "dateModified": "2015-03-11T01:26:48Z" } }, { "key": "M7IBHEEX", "version": 14, "library": { "type": "group", "id": 335985, "name": "Cardiogenic shock", "links": { "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/335985/items/M7IBHEEX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock/items/M7IBHEEX", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1161085, "username": "webakerma", "name": "William Baker", "links": { "alternate": { "href": "https://www.zotero.org/webakerma", "type": "text/html" } } }, "creatorSummary": "Cheng et al.", "parsedDate": "2014-02", "numChildren": 1 }, "data": { "key": "M7IBHEEX", "version": 14, "itemType": "journalArticle", "title": "Complications of extracorporeal membrane oxygenation for treatment of cardiogenic shock and cardiac arrest: a meta-analysis of 1,866 adult patients", "creators": [ { "creatorType": "author", "firstName": "Richard", "lastName": "Cheng" }, { "creatorType": "author", "firstName": "Rory", "lastName": "Hachamovitch" }, { "creatorType": "author", "firstName": "Michelle", "lastName": "Kittleson" }, { "creatorType": "author", "firstName": "Jignesh", "lastName": "Patel" }, { "creatorType": "author", "firstName": "Francisco", "lastName": "Arabia" }, { "creatorType": "author", "firstName": "Jaime", "lastName": "Moriguchi" }, { "creatorType": "author", "firstName": "Fardad", "lastName": "Esmailian" }, { "creatorType": "author", "firstName": "Babak", "lastName": "Azarbal" } ], "abstractNote": "BACKGROUND: Venoarterial extracorporeal membrane oxygenation (ECMO) has been used successfully for treatment of cardiogenic shock or cardiac arrest. The exact complication rate is not well understood, in part because of small study sizes. In the absence of large clinical trials, performance of pooled analysis represents the best method for ascertaining complication rates for ECMO.\nMETHODS: A systematic PubMed search was conducted on ECMO for treatment of cardiogenic shock or cardiac arrest in adult patients only, updated to November 2012. Studies with more than 10 patients published in the year 2000 or later that reported complication rates for ECMO were included. Specific complications analyzed included lower extremity ischemia, fasciotomy or compartment syndrome, amputation, stroke, neurologic complications, acute kidney injury, renal replacement therapy, major or significant bleeding, rethoracotomy for bleeding or tamponade, and significant infection. For studies that included overlapping patients, the largest study was included and the others excluded. Cochran's Q and I-squared were calculated. A more conservative random-effects model was chosen for all analyses.\nRESULTS: Twenty studies were included in the analyses encompassing 1,866 patients. Seventeen studies reported survival to hospital discharge, with a cumulative survival rate of 534 of 1,529, and a range of 20.8% to 65.4%. Analyses encompassed 192 to 1,452 patients depending on the specific complication analyzed. The pooled estimate rates of complications with 95% confidence intervals were as follows: lower extremity ischemia, 16.9% (12.5% to 22.6%); fasciotomy or compartment syndrome, 10.3% (7.3% to 14.5%); lower extremity amputation, 4.7% (2.3% to 9.3%); stroke, 5.9% (4.2% to 8.3%); neurologic complications, 13.3% (9.9% to 17.7%); acute kidney injury, 55.6% (35.5% to 74.0%); renal replacement therapy, 46.0% (36.7% to 55.5%); major or significant bleeding, 40.8% (26.8% to 56.6%); rethoracotomy for bleeding or tamponade in postcardiotomy patients, 41.9% (24.3% to 61.8%); and significant infection, 30.4% (19.5% to 44.0%).\nCONCLUSIONS: Although ECMO can improve survival of patients with advanced heart disease, there is significant associated morbidity with performance of this intervention. These findings should be incorporated in the risk-benefit analysis when initiation of ECMO for cardiogenic shock is being considered.", "publicationTitle": "The Annals of Thoracic Surgery", "publisher": "", "place": "", "date": "Feb 2014", "volume": "97", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "610-616", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Ann. Thorac. Surg.", "DOI": "10.1016/j.athoracsur.2013.09.008", "citationKey": "", "url": "", "accessDate": "", "PMID": "24210621", "PMCID": "", "ISSN": "1552-6259", "archive": "", "archiveLocation": "", "shortTitle": "Complications of extracorporeal membrane oxygenation for treatment of cardiogenic shock and cardiac arrest", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Extracorporeal Membrane Oxygenation", "type": 1 }, { "tag": "Heart Arrest", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Postoperative Complications", "type": 1 }, { "tag": "Shock, Cardiogenic", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2015-03-11T01:26:36Z", "dateModified": "2015-03-11T01:26:36Z" } }, { "key": "6WQZNPX2", "version": 10, "library": { "type": "group", "id": 335985, "name": "Cardiogenic shock", "links": { "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/335985/items/6WQZNPX2", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock/items/6WQZNPX2", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/335985/items/M7IBHEEX", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1161085, "username": "webakerma", "name": "William Baker", "links": { "alternate": { "href": "https://www.zotero.org/webakerma", "type": "text/html" } } } }, "data": { "key": "6WQZNPX2", "version": 10, "parentItem": "M7IBHEEX", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2015-03-11T01:26:36Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/24210621", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-03-11T01:26:36Z", "dateModified": "2015-03-11T01:26:36Z" } }, { "key": "SJMSGSUG", "version": 13, "library": { "type": "group", "id": 335985, "name": "Cardiogenic shock", "links": { "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/335985/items/SJMSGSUG", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock/items/SJMSGSUG", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1161085, "username": "webakerma", "name": "William Baker", "links": { "alternate": { "href": "https://www.zotero.org/webakerma", "type": "text/html" } } }, "creatorSummary": "Greenwood and Herr", "parsedDate": "2014-11", "numChildren": 1 }, "data": { "key": "SJMSGSUG", "version": 13, "itemType": "journalArticle", "title": "Mechanical circulatory support", "creators": [ { "creatorType": "author", "firstName": "John C.", "lastName": "Greenwood" }, { "creatorType": "author", "firstName": "Daniel L.", "lastName": "Herr" } ], "abstractNote": "The role for temporary and durable mechanical circulatory support is rapidly expanding. As the use of these technologies continues to grow, the emergency physician has an increasing opportunity to participate in the advancement of these potentially life-saving technologies. This review discusses the current role of the intra-aortic balloon pump in cardiogenic shock, describes the complications and management strategies for the critically ill patient with a left ventricular assist device, and explores the emerging role of ECMO in the emergency department for patients presenting in refractory cardiogenic shock and cardiac arrest.", "publicationTitle": "Emergency Medicine Clinics of North America", "publisher": "", "place": "", "date": "Nov 2014", "volume": "32", "issue": "4", "section": "", "partNumber": "", "partTitle": "", "pages": "851-869", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Emerg. Med. Clin. North Am.", "DOI": "10.1016/j.emc.2014.07.009", "citationKey": "", "url": "", "accessDate": "", "PMID": "25441039", "PMCID": "", "ISSN": "1558-0539", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Assisted Circulation", "type": 1 }, { "tag": "Emergency Service, Hospital", "type": 1 }, { "tag": "Equipment Design", "type": 1 }, { "tag": "Extracorporeal Membrane Oxygenation", "type": 1 }, { "tag": "Heart Arrest", "type": 1 }, { "tag": "Heart-Assist Devices", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Intra-Aortic Balloon Pumping", "type": 1 }, { "tag": "Shock, Cardiogenic", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2015-03-11T01:17:53Z", "dateModified": "2015-03-11T01:17:53Z" } }, { "key": "VMU7TNEF", "version": 9, "library": { "type": "group", "id": 335985, "name": "Cardiogenic shock", "links": { "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/335985/items/VMU7TNEF", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock/items/VMU7TNEF", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/335985/items/SJMSGSUG", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1161085, "username": "webakerma", "name": "William Baker", "links": { "alternate": { "href": "https://www.zotero.org/webakerma", "type": "text/html" } } } }, "data": { "key": "VMU7TNEF", "version": 9, "parentItem": "SJMSGSUG", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2015-03-11T01:17:53Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/25441039", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-03-11T01:17:53Z", "dateModified": "2015-03-11T01:17:53Z" } }, { "key": "Q5D746CR", "version": 13, "library": { "type": "group", "id": 335985, "name": "Cardiogenic shock", "links": { "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/335985/items/Q5D746CR", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock/items/Q5D746CR", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1161085, "username": "webakerma", "name": "William Baker", "links": { "alternate": { "href": "https://www.zotero.org/webakerma", "type": "text/html" } } }, "creatorSummary": "Truby et al.", "parsedDate": "2014-12-04", "numChildren": 1 }, "data": { "key": "Q5D746CR", "version": 13, "itemType": "journalArticle", "title": "Important role of mechanical circulatory support in acute myocardial infarction complicated by cardiogenic shock", "creators": [ { "creatorType": "author", "firstName": "Lauren", "lastName": "Truby" }, { "creatorType": "author", "firstName": "Yoshifumi", "lastName": "Naka" }, { "creatorType": "author", "firstName": "Bindu", "lastName": "Kalesan" }, { "creatorType": "author", "firstName": "Takeyoshi", "lastName": "Ota" }, { "creatorType": "author", "firstName": "Ajay J.", "lastName": "Kirtane" }, { "creatorType": "author", "firstName": "Susheel", "lastName": "Kodali" }, { "creatorType": "author", "firstName": "Natasha", "lastName": "Nikic" }, { "creatorType": "author", "firstName": "Lily", "lastName": "Mundy" }, { "creatorType": "author", "firstName": "Paolo", "lastName": "Colombo" }, { "creatorType": "author", "firstName": "Ulrich P.", "lastName": "Jorde" }, { "creatorType": "author", "firstName": "Hiroo", "lastName": "Takayama" } ], "abstractNote": "OBJECTIVES: Acute myocardial infarction (AMI) complicated by cardiogenic shock (CS) remains associated with significant mortality despite the widespread application of early revascularization strategies. Recent evidence suggests that the use of intra-aortic balloon pump (IABP) counterpulsation does not improve mortality in this cohort of patients. We summarize our experience with mechanical circulatory support (MCS) therapy for AMI/CS.\nMETHODS: This is a retrospective review of 61 patients who received MCS therapy for AMI/CS at our institution between March 2007 and March 2013.\nRESULTS: Mean age was 60.2 ± 10.3 years; mean ejection fraction was 24 ± 15% and 29% of patients were receiving active cardiopulmonary resuscitation at the time of support initiation. Prior to the initiation of MCS, 70.5% of patients had an IABP. Mean arterial pressure improved significantly with MCS (63 mmHg prior to MCS, 82 mmHg after MCS, P ≤ 0.01). Mean length of support was 9.5 ± 11.0 days, and overall survival to 30 days was 59.0%. Among 30-day survivors, 44.4% required device exchange to a durable MCS device. Ultimately, only 31% (52.8% of patients who survived to 30 days) achieved myocardial recovery.\nCONCLUSIONS: Short-term MCS therapy with subsequent aggressive use of durable MCS device may improve the unacceptably high mortality rate in AMI/CS. Rigorous prospective studies of MCS therapy in AMI/CS are warranted.", "publicationTitle": "European Journal of Cardio-Thoracic Surgery: Official Journal of the European Association for Cardio-Thoracic Surgery", "publisher": "", "place": "", "date": "Dec 4, 2014", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Eur J Cardiothorac Surg", "DOI": "10.1093/ejcts/ezu478", "citationKey": "", "url": "", "accessDate": "", "PMID": "25480935", "PMCID": "", "ISSN": "1873-734X", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "ENG", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-03-11T01:15:58Z", "dateModified": "2015-03-11T01:15:58Z" } }, { "key": "IMBU46ZQ", "version": 8, "library": { "type": "group", "id": 335985, "name": "Cardiogenic shock", "links": { "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/335985/items/IMBU46ZQ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock/items/IMBU46ZQ", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/335985/items/Q5D746CR", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1161085, "username": "webakerma", "name": "William Baker", "links": { "alternate": { "href": "https://www.zotero.org/webakerma", "type": "text/html" } } } }, "data": { "key": "IMBU46ZQ", "version": 8, "parentItem": "Q5D746CR", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2015-03-11T01:15:58Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/25480935", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-03-11T01:15:58Z", "dateModified": "2015-03-11T01:15:58Z" } }, { "key": "9D2QH57X", "version": 13, "library": { "type": "group", "id": 335985, "name": "Cardiogenic shock", "links": { "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/335985/items/9D2QH57X", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock/items/9D2QH57X", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1161085, "username": "webakerma", "name": "William Baker", "links": { "alternate": { "href": "https://www.zotero.org/webakerma", "type": "text/html" } } }, "creatorSummary": "Jeger", "parsedDate": "2012-02", "numChildren": 1 }, "data": { "key": "9D2QH57X", "version": 13, "itemType": "journalArticle", "title": "New therapies for cardiogenic shock", "creators": [ { "creatorType": "author", "firstName": "R. V.", "lastName": "Jeger" } ], "abstractNote": "Cardiogenic shock is a serious complication of acute myocardial infarction and occurs as a consequence of acute left ventricular failure and subsequent inappropriate tissue perfusion. While its incidence has been reported to be as high as 10% in the late 90ties, it has been steadily declining to currently less than 6% since the implementation of early revascularization as a class I indication in current guidelines. Despite recent advances in the treatment of cardiogenic shock, mortality is still high at approximately 50%. Current therapeutic approaches include early revascularization, fluid resuscitation, inotropic and vasopressor therapy, and mechanical circulatory support using intra-aortic balloon counterpulsation or percutaneous left ventricular assist devices. Novel treatment options such as specific inhibitors of inducible nitric oxide synthase or newer developments in mechanical circulatory support might be beneficial and should be tested in adequately powered randomized trials. However, difficulties in enrolling cardiogenic shock patients in randomized controlled trials are considerable. Until more data are available, cardiogenic shock patients should be treated aggressively with early revascularization and mechanical circulatory support to increase their probability of survival.", "publicationTitle": "Minerva Cardioangiologica", "publisher": "", "place": "", "date": "Feb 2012", "volume": "60", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "101-109", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Minerva Cardioangiol", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "22322578", "PMCID": "", "ISSN": "0026-4725", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Forecasting", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Shock, Cardiogenic", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2015-03-11T01:14:38Z", "dateModified": "2015-03-11T01:14:38Z" } }, { "key": "R7NN9EDX", "version": 7, "library": { "type": "group", "id": 335985, "name": "Cardiogenic shock", "links": { "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/335985/items/R7NN9EDX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock/items/R7NN9EDX", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/335985/items/9D2QH57X", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1161085, "username": "webakerma", "name": "William Baker", "links": { "alternate": { "href": "https://www.zotero.org/webakerma", "type": "text/html" } } } }, "data": { "key": "R7NN9EDX", "version": 7, "parentItem": "9D2QH57X", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2015-03-11T01:14:38Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/22322578", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-03-11T01:14:38Z", "dateModified": "2015-03-11T01:14:38Z" } }, { "key": "A8BUCFAU", "version": 13, "library": { "type": "group", "id": 335985, "name": "Cardiogenic shock", "links": { "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/335985/items/A8BUCFAU", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock/items/A8BUCFAU", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1161085, "username": "webakerma", "name": "William Baker", "links": { "alternate": { "href": "https://www.zotero.org/webakerma", "type": "text/html" } } }, "creatorSummary": "Van Herck et al.", "parsedDate": "2015-01-26", "numChildren": 1 }, "data": { "key": "A8BUCFAU", "version": 13, "itemType": "journalArticle", "title": "Management of cardiogenic shock complicating acute myocardial infarction", "creators": [ { "creatorType": "author", "firstName": "Jozef L.", "lastName": "Van Herck" }, { "creatorType": "author", "firstName": "Marc J.", "lastName": "Claeys" }, { "creatorType": "author", "firstName": "Rudi", "lastName": "De Paep" }, { "creatorType": "author", "firstName": "Paul L.", "lastName": "Van Herck" }, { "creatorType": "author", "firstName": "Christiaan J.", "lastName": "Vrints" }, { "creatorType": "author", "firstName": "Philippe G.", "lastName": "Jorens" } ], "abstractNote": "Cardiogenic shock complicates approximately 5-10% of cases with acute myocardial infarction and carries a poor prognosis. Early revascularization remains the cornerstone treatment of cardiogenic shock complicating myocardial infarction. Inotropic and/or vasopressor agents can be used for haemodynamic stabilization, although this comes at the expense of increased myocardial oxygen consumption and extended myocardial ischaemia. In recent years, the use of mechanical circulatory support has significantly increased. However, there is only limited data available from randomized trials evaluating the different percutaneous support systems. This review summarizes the available literature concerning the management of cardiogenic shock and gives an overview of the recommendations of the European and German-Austrian guidelines on cardiogenic shock.", "publicationTitle": "European Heart Journal. Acute Cardiovascular Care", "publisher": "", "place": "", "date": "Jan 26, 2015", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Eur Heart J Acute Cardiovasc Care", "DOI": "10.1177/2048872614568294", "citationKey": "", "url": "", "accessDate": "", "PMID": "25624526", "PMCID": "", "ISSN": "2048-8734", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "ENG", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-03-11T01:13:14Z", "dateModified": "2015-03-11T01:13:14Z" } }, { "key": "XPRC8JPQ", "version": 6, "library": { "type": "group", "id": 335985, "name": "Cardiogenic shock", "links": { "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/335985/items/XPRC8JPQ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock/items/XPRC8JPQ", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/335985/items/A8BUCFAU", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1161085, "username": "webakerma", "name": "William Baker", "links": { "alternate": { "href": "https://www.zotero.org/webakerma", "type": "text/html" } } } }, "data": { "key": "XPRC8JPQ", "version": 6, "parentItem": "A8BUCFAU", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2015-03-11T01:13:14Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/25624526", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-03-11T01:13:14Z", "dateModified": "2015-03-11T01:13:14Z" } }, { "key": "BTSWRS3A", "version": 13, "library": { "type": "group", "id": 335985, "name": "Cardiogenic shock", "links": { "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/335985/items/BTSWRS3A", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock/items/BTSWRS3A", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1161085, "username": "webakerma", "name": "William Baker", "links": { "alternate": { "href": "https://www.zotero.org/webakerma", "type": "text/html" } } }, "creatorSummary": "de Waha et al.", "parsedDate": "2012-06", "numChildren": 1 }, "data": { "key": "BTSWRS3A", "version": 13, "itemType": "journalArticle", "title": "What is the evidence for IABP in STEMI with and without cardiogenic shock?", "creators": [ { "creatorType": "author", "firstName": "Suzanne", "lastName": "de Waha" }, { "creatorType": "author", "firstName": "Steffen", "lastName": "Desch" }, { "creatorType": "author", "firstName": "Ingo", "lastName": "Eitel" }, { "creatorType": "author", "firstName": "Georg", "lastName": "Fuernau" }, { "creatorType": "author", "firstName": "Philipp", "lastName": "Lurz" }, { "creatorType": "author", "firstName": "Antoinette", "lastName": "de Waha" }, { "creatorType": "author", "firstName": "Gerhard", "lastName": "Schuler" }, { "creatorType": "author", "firstName": "Holger", "lastName": "Thiele" } ], "abstractNote": "Intraaortic balloon pump (IABP) is the most widely used left ventricular support device in a variety of indications. This review focuses on the current literature and discusses the evidence of IABP in ST-elevation myocardial infarction (STEMI) with and without cardiogenic shock. In high-risk STEMI patients without cardiogenic shock several randomized clinical trials have been performed. The majority of the studies could not demonstrate an efficacy benefit for IABP as adjunctive therapy in comparison to standard treatment alone. Hence, recent meta-analyses could not reveal diverging mortality rates at a higher incidence of stroke and major bleedings with IABP use independent of the type of reperfusion therapy. IABP in STEMI patients with cardiogenic shock is recommended according to current American College of Cardiology/American Heart Association (AHA/ACC) and European Society of Cardiology (ESC) guidelines. In recent meta-analyses, IABP in cardiogenic shock complicated by STEMI has been shown to be associated with decreased mortality. However, these beneficial effects are limited to patients treated with thrombolysis, whereas in patients undergoing mechanical revascularization IABP therapy is associated with an increase in mortality. Nevertheless, these data only arise from prospective and retrospective cohort studies, as up to date only one very small randomized clinical trial has been completed. In summary, in high-risk STEMI patients without cardiogenic shock, current data do not support the use of IABP and should only be considered as a standby and bailout strategy if patients develop haemodynamic instability. Current data on IABP in patients with cardiogenic shock complicated by STEMI are scarce and highly limited due to the nonrandomized design of previous trials. However, according to current AHA/ACC and ESC guidelines its use is recommended. Although recent meta-analyses challenge current AHA/ACC/ESC guidelines, adequately powered randomized studies are needed to elucidate the role of IABP in patients with acute myocardial infarction complicated by cardiogenic shock.", "publicationTitle": "Therapeutic Advances in Cardiovascular Disease", "publisher": "", "place": "", "date": "Jun 2012", "volume": "6", "issue": "3", "section": "", "partNumber": "", "partTitle": "", "pages": "123-132", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Ther Adv Cardiovasc Dis", "DOI": "10.1177/1753944712446669", "citationKey": "", "url": "", "accessDate": "", "PMID": "22569335", "PMCID": "", "ISSN": "1753-9455", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Angioplasty, Balloon, Coronary", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Intra-Aortic Balloon Pumping", "type": 1 }, { "tag": "Myocardial Infarction", "type": 1 }, { "tag": "Practice Guidelines as Topic", "type": 1 }, { "tag": "Randomized Controlled Trials as Topic", "type": 1 }, { "tag": "Shock, Cardiogenic", "type": 1 }, { "tag": "Thrombolytic Therapy", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2015-03-11T01:06:38Z", "dateModified": "2015-03-11T01:06:38Z" } }, { "key": "DZCCU2T9", "version": 5, "library": { "type": "group", "id": 335985, "name": "Cardiogenic shock", "links": { "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/335985/items/DZCCU2T9", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock/items/DZCCU2T9", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/335985/items/BTSWRS3A", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1161085, "username": "webakerma", "name": "William Baker", "links": { "alternate": { "href": "https://www.zotero.org/webakerma", "type": "text/html" } } } }, "data": { "key": "DZCCU2T9", "version": 5, "parentItem": "BTSWRS3A", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2015-03-11T01:06:38Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/22569335", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-03-11T01:06:38Z", "dateModified": "2015-03-11T01:06:38Z" } }, { "key": "H5SRNV48", "version": 13, "library": { "type": "group", "id": 335985, "name": "Cardiogenic shock", "links": { "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/335985/items/H5SRNV48", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock/items/H5SRNV48", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1161085, "username": "webakerma", "name": "William Baker", "links": { "alternate": { "href": "https://www.zotero.org/webakerma", "type": "text/html" } } }, "creatorSummary": "Khashan and Pinsky", "parsedDate": "2013", "numChildren": 1 }, "data": { "key": "H5SRNV48", "version": 13, "itemType": "journalArticle", "title": "Does intra-aortic balloon support for myocardial infarction with cardiogenic shock improve outcome?", "creators": [ { "creatorType": "author", "firstName": "Mohamed Y.", "lastName": "Khashan" }, { "creatorType": "author", "firstName": "Michael R.", "lastName": "Pinsky" } ], "abstractNote": "CITATION: Thiele H, Zeymer U, Neumann FJ, Ferenc M, Olbrich HG, Hausleiter J, Richardt G, Hennersdorf M, Empen K, Fuernau G, Desch S, Eitel I, Hambrecht R, Fuhrmann J, Böhm M, Ebelt H, Schneider S, Schuler G, Werdan K; IABP-SHOCK II Trial Investigators: Intraaortic balloon support for myocardial infarction with cardiogenic shock. N Engl J Med 2012, 367:1287-1296.\nBACKGROUND: In the current international guidelines, intra-aortic balloon pump (IABP) counterpulsation is considered a class I treatment for acute myocardial infarction complicated by cardiogenic shock. However, evidence is based mainly on registry data, and there is a paucity of randomized clinical trials.\nMETHODS: OBJECTIVE: To test the hypothesis that IABP counterpulsation, as compared with the best available medical therapy alone, results in a reduction in mortality among patients with acute myocardial infarction complicated by cardiogenic shock for whom early revascularization is planned.\nDESIGN: Randomized, prospective, open-label, multicenter trial.\nSETTING: Thirty-seven centers in Germany.\nSUBJECTS: All adults had acute myocardial infarction complicated by cardiogenic shock and were expected to undergo early revascularization (by means of percutaneous coronary intervention or bypass surgery).\nINTERVENTION: After enrollment, 600 patients were randomly assigned to intra-aortic balloon counterpulsation (IABP group, 301 patients) or no IABP counterpulsation (control group, 299 patients).\nOUTCOMES: The primary efficacy endpoint is 30-day all-cause mortality.\nRESULTS: At 30 days, 119 patients in the IABP group (39.7%) and 123 patients in the control group (41.3%) had died (relative risk with IABP, 0.96; 95% confidence interval, 0.79 to 1.17; P=0.69). There were no significant differences in secondary endpoints or in process-of-care measures, including the time to hemodynamic stabilization, the length of stay in the intensive care unit, serum lactate levels, the dose and duration of catecholamine therapy, and renal function.\nCONCLUSIONS: The use of IABP counterpulsation did not significantly reduce 30-day mortality in patients with acute myocardial infarction complicated by cardiogenic shock for whom an early revascularization strategy was planned.", "publicationTitle": "Critical Care (London, England)", "publisher": "", "place": "", "date": "2013", "volume": "17", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "307", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Crit Care", "DOI": "10.1186/cc12520", "citationKey": "", "url": "", "accessDate": "", "PMID": "23472937", "PMCID": "PMC3672473", "ISSN": "1466-609X", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-03-11T01:05:46Z", "dateModified": "2015-03-11T01:05:46Z" } }, { "key": "7BNGVGUP", "version": 4, "library": { "type": "group", "id": 335985, "name": "Cardiogenic shock", "links": { "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/335985/items/7BNGVGUP", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock/items/7BNGVGUP", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/335985/items/H5SRNV48", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1161085, "username": "webakerma", "name": "William Baker", "links": { "alternate": { "href": "https://www.zotero.org/webakerma", "type": "text/html" } } } }, "data": { "key": "7BNGVGUP", "version": 4, "parentItem": "H5SRNV48", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2015-03-11T01:05:46Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/23472937", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-03-11T01:05:46Z", "dateModified": "2015-03-11T01:05:46Z" } }, { "key": "5NUAM83F", "version": 13, "library": { "type": "group", "id": 335985, "name": "Cardiogenic shock", "links": { "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/335985/items/5NUAM83F", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock/items/5NUAM83F", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1161085, "username": "webakerma", "name": "William Baker", "links": { "alternate": { "href": "https://www.zotero.org/webakerma", "type": "text/html" } } }, "creatorSummary": "Sanborn et al.", "parsedDate": "2000-09", "numChildren": 1 }, "data": { "key": "5NUAM83F", "version": 13, "itemType": "journalArticle", "title": "Impact of thrombolysis, intra-aortic balloon pump counterpulsation, and their combination in cardiogenic shock complicating acute myocardial infarction: a report from the SHOCK Trial Registry. SHould we emergently revascularize Occluded Coronaries for cardiogenic shocK?", "creators": [ { "creatorType": "author", "firstName": "T. A.", "lastName": "Sanborn" }, { "creatorType": "author", "firstName": "L. A.", "lastName": "Sleeper" }, { "creatorType": "author", "firstName": "E. R.", "lastName": "Bates" }, { "creatorType": "author", "firstName": "A. K.", "lastName": "Jacobs" }, { "creatorType": "author", "firstName": "J.", "lastName": "Boland" }, { "creatorType": "author", "firstName": "J. K.", "lastName": "French" }, { "creatorType": "author", "firstName": "J.", "lastName": "Dens" }, { "creatorType": "author", "firstName": "V.", "lastName": "Dzavik" }, { "creatorType": "author", "firstName": "S. T.", "lastName": "Palmeri" }, { "creatorType": "author", "firstName": "J. G.", "lastName": "Webb" }, { "creatorType": "author", "firstName": "M.", "lastName": "Goldberger" }, { "creatorType": "author", "firstName": "J. S.", "lastName": "Hochman" } ], "abstractNote": "OBJECTIVES: We sought to investigate the potential benefit of thrombolytic therapy (TT) and intra-aortic balloon pump counterpulsation (IABP) on in-hospital mortality rates of patients enrolled in a prospective, multi-center Registry of acute myocardial infarction (MI) complicated by cardiogenic shock (CS).\nBACKGROUND: Retrospective studies suggest that patients suffering from CS due to MI have lower in-hospital mortality rates when IABP support is added to TT. This hypothesis has not heretofore been examined prospectively in a study devoted to CS.\nMETHODS: Of 1,190 patients enrolled at 36 participating centers, 884 patients had CS due to predominant left ventricular (LV) failure. Excluding 26 patients with IABP placed prior to shock onset and 2 patients with incomplete data, 856 patients were evaluated regarding TT and IABP utilization. Treatments, selected by local physicians, fell into four categories: no TT, no IABP (33%; n = 285); IABP only (33%; n = 279); TT only (15%; n = 132); and TT and IABP (19%; n = 160).\nRESULTS: Patients in CS treated with TT had a lower in-hospital mortality than those who did not receive TT (54% vs. 64%, p = 0.005), and those selected for IABP had a lower in-hospital mortality than those who did not receive IABP (50% vs. 72%, p < 0.0001). Furthermore, there was a significant difference in in-hospital mortality among the four treatment groups: TT + IABP (47%), IABP only (52%), TT only (63%), no TT, no IABP (77%) (p < 0.0001). Patients receiving early IABP (< or = 6 h after thrombolytic therapy, n = 72) had in-hospital mortality similar to those with late IABP (53% vs. 41%, n = 64, respectively, p = 0.172). Revascularization rates differed among the four groups: no TT, no IABP (18%); IABP only (70%); TT only (20%); TT and IABP (68%, p < 0.0001); this influenced in-hospital mortality significantly (39% with revascularization vs. 78% without revascularization, p < 0.0001).\nCONCLUSIONS: Treatment of patients in cardiogenic shock due to predominant LV failure with TT, IABP and revascularization by PTCA/CABG was associated with lower in-hospital mortality rates than standard medical therapy in this Registry. For hospitals without revascularization capability, a strategy of early TT and IABP followed by immediate transfer for PTCA or CABG may be appropriate. However, selection bias is evident and further investigation is required.", "publicationTitle": "Journal of the American College of Cardiology", "publisher": "", "place": "", "date": "Sep 2000", "volume": "36", "issue": "3 Suppl A", "section": "", "partNumber": "", "partTitle": "", "pages": "1123-1129", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J. Am. Coll. Cardiol.", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "10985715", "PMCID": "", "ISSN": "0735-1097", "archive": "", "archiveLocation": "", "shortTitle": "Impact of thrombolysis, intra-aortic balloon pump counterpulsation, and their combination in cardiogenic shock complicating acute myocardial infarction", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Aged", "type": 1 }, { "tag": "Cardiac Catheterization", "type": 1 }, { "tag": "Coronary Angiography", "type": 1 }, { "tag": "Electrocardiography", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Fibrinolytic Agents", "type": 1 }, { "tag": "Hemodynamics", "type": 1 }, { "tag": "Hospital Mortality", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Intra-Aortic Balloon Pumping", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Middle Aged", "type": 1 }, { "tag": "Myocardial Infarction", "type": 1 }, { "tag": "Myocardial Revascularization", "type": 1 }, { "tag": "Prospective Studies", "type": 1 }, { "tag": "Registries", "type": 1 }, { "tag": "Shock, Cardiogenic", "type": 1 }, { "tag": "Thrombolytic Therapy", "type": 1 }, { "tag": "Treatment Outcome", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2015-03-11T01:05:36Z", "dateModified": "2015-03-11T01:05:36Z" } }, { "key": "77I3GA2M", "version": 4, "library": { "type": "group", "id": 335985, "name": "Cardiogenic shock", "links": { "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/335985/items/77I3GA2M", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock/items/77I3GA2M", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/335985/items/5NUAM83F", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1161085, "username": "webakerma", "name": "William Baker", "links": { "alternate": { "href": "https://www.zotero.org/webakerma", "type": "text/html" } } } }, "data": { "key": "77I3GA2M", "version": 4, "parentItem": "5NUAM83F", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2015-03-11T01:05:36Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/10985715", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-03-11T01:05:36Z", "dateModified": "2015-03-11T01:05:36Z" } }, { "key": "MDEXEQRP", "version": 13, "library": { "type": "group", "id": 335985, "name": "Cardiogenic shock", "links": { "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/335985/items/MDEXEQRP", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock/items/MDEXEQRP", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1161085, "username": "webakerma", "name": "William Baker", "links": { "alternate": { "href": "https://www.zotero.org/webakerma", "type": "text/html" } } }, "creatorSummary": "Thiele et al.", "parsedDate": "2007-09", "numChildren": 1 }, "data": { "key": "MDEXEQRP", "version": 13, "itemType": "journalArticle", "title": "Percutaneous left ventricular assist devices in acute myocardial infarction complicated by cardiogenic shock", "creators": [ { "creatorType": "author", "firstName": "Holger", "lastName": "Thiele" }, { "creatorType": "author", "firstName": "Richard W.", "lastName": "Smalling" }, { "creatorType": "author", "firstName": "Gerhard C.", "lastName": "Schuler" } ], "abstractNote": "Cardiogenic shock (CS) remains the most common cause of death in patients with acute myocardial infarction (AMI). In addition to percutaneous coronary intervention, inotropes, and fluids, intraaortic balloon pumping (IABP) is most widely used for initial haemodynamic stabilization. However, the main limitation of IABP is the lack of active circulatory support and the requirement of a certain level of left ventricular (LV) function. In many patients with severe depression of LV function, haemodynamic support and LV unloading derived from IABP is insufficient to reverse CS. The use of percutaneous LV assist devices (LVAD) with active circulatory support might be beneficial in CS patients not responding to standard treatment including IABP support. This review reports the current experience of percutaneous LVAD in CS complicating AMI.", "publicationTitle": "European Heart Journal", "publisher": "", "place": "", "date": "Sep 2007", "volume": "28", "issue": "17", "section": "", "partNumber": "", "partTitle": "", "pages": "2057-2063", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Eur. Heart J.", "DOI": "10.1093/eurheartj/ehm191", "citationKey": "", "url": "", "accessDate": "", "PMID": "17586541", "PMCID": "", "ISSN": "0195-668X", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Cardiopulmonary Bypass", "type": 1 }, { "tag": "Heart-Assist Devices", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Myocardial Infarction", "type": 1 }, { "tag": "Shock, Cardiogenic", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2015-03-11T01:04:59Z", "dateModified": "2015-03-11T01:04:59Z" } }, { "key": "HTRG6Z4I", "version": 3, "library": { "type": "group", "id": 335985, "name": "Cardiogenic shock", "links": { "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/335985/items/HTRG6Z4I", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock/items/HTRG6Z4I", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/335985/items/MDEXEQRP", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1161085, "username": "webakerma", "name": "William Baker", "links": { "alternate": { "href": "https://www.zotero.org/webakerma", "type": "text/html" } } } }, "data": { "key": "HTRG6Z4I", "version": 3, "parentItem": "MDEXEQRP", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2015-03-11T01:04:59Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/17586541", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-03-11T01:04:59Z", "dateModified": "2015-03-11T01:04:59Z" } }, { "key": "4HPUWVH3", "version": 13, "library": { "type": "group", "id": 335985, "name": "Cardiogenic shock", "links": { "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/335985/items/4HPUWVH3", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock/items/4HPUWVH3", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1161085, "username": "webakerma", "name": "William Baker", "links": { "alternate": { "href": "https://www.zotero.org/webakerma", "type": "text/html" } } }, "creatorSummary": "Thiele et al.", "parsedDate": "2012-06", "numChildren": 1 }, "data": { "key": "4HPUWVH3", "version": 13, "itemType": "journalArticle", "title": "Intraaortic balloon counterpulsation in acute myocardial infarction complicated by cardiogenic shock: design and rationale of the Intraaortic Balloon Pump in Cardiogenic Shock II (IABP-SHOCK II) trial", "creators": [ { "creatorType": "author", "firstName": "Holger", "lastName": "Thiele" }, { "creatorType": "author", "firstName": "Gerhard", "lastName": "Schuler" }, { "creatorType": "author", "firstName": "Franz-Josef", "lastName": "Neumann" }, { "creatorType": "author", "firstName": "Jörg", "lastName": "Hausleiter" }, { "creatorType": "author", "firstName": "Hans-Georg", "lastName": "Olbrich" }, { "creatorType": "author", "firstName": "Bettina", "lastName": "Schwarz" }, { "creatorType": "author", "firstName": "Marcus", "lastName": "Hennersdorf" }, { "creatorType": "author", "firstName": "Klaus", "lastName": "Empen" }, { "creatorType": "author", "firstName": "Georg", "lastName": "Fuernau" }, { "creatorType": "author", "firstName": "Steffen", "lastName": "Desch" }, { "creatorType": "author", "firstName": "Suzanne", "lastName": "de Waha" }, { "creatorType": "author", "firstName": "Ingo", "lastName": "Eitel" }, { "creatorType": "author", "firstName": "Rainer", "lastName": "Hambrecht" }, { "creatorType": "author", "firstName": "Michael", "lastName": "Böhm" }, { "creatorType": "author", "firstName": "Volkhard", "lastName": "Kurowski" }, { "creatorType": "author", "firstName": "Bernward", "lastName": "Lauer" }, { "creatorType": "author", "firstName": "Hans-Heinrich", "lastName": "Minden" }, { "creatorType": "author", "firstName": "Hans-Reiner", "lastName": "Figulla" }, { "creatorType": "author", "firstName": "Rüdiger C.", "lastName": "Braun-Dullaeus" }, { "creatorType": "author", "firstName": "Ruth H.", "lastName": "Strasser" }, { "creatorType": "author", "firstName": "Kristin", "lastName": "Rochor" }, { "creatorType": "author", "firstName": "Sebastian K. G.", "lastName": "Maier" }, { "creatorType": "author", "firstName": "Helge", "lastName": "Möllmann" }, { "creatorType": "author", "firstName": "Steffen", "lastName": "Schneider" }, { "creatorType": "author", "firstName": "Henning", "lastName": "Ebelt" }, { "creatorType": "author", "firstName": "Karl", "lastName": "Werdan" }, { "creatorType": "author", "firstName": "Uwe", "lastName": "Zeymer" } ], "abstractNote": "BACKGROUND: In current guidelines, intraaortic balloon pumping (IABP) is considered a class 1 indication in cardiogenic shock complicating acute myocardial infarction. However, evidence is mainly based on retrospective or prospective registries with a lack of randomized clinical trials. Therefore, IABP is currently only used in 20% to 40% of cardiogenic shock cases. The hypothesis of this trial is that IABP in addition to early revascularization by either percutaneous coronary intervention or coronary artery bypass grafting will improve clinical outcome of patients in cardiogenic shock.\nSTUDY DESIGN: The IABP-SHOCK II study is a 600-patient, prospective, multicenter, randomized, open-label, controlled trial. The study is designed to compare the efficacy and safety of IABP versus optimal medical therapy on the background of early revascularization by either percutaneous coronary intervention or coronary artery bypass grafting. Patients will be randomized in a 1:1 fashion to 1 of the 2 treatments. The primary efficacy end point of IABP-SHOCK II is 30-day all-cause mortality. Secondary outcome measures, such as hemodynamic, laboratory, and clinical parameters, will serve as surrogate end points for prognosis. Furthermore, an intermediate and long-term follow-up at 6 and 12 months will be performed. Safety will be assessed, by the GUSTO bleeding definition, peripheral ischemic complications, sepsis, and stroke.\nCONCLUSIONS: The IABP-SHOCK II trial addresses important questions regarding the efficacy and safety of IABP in addition to early revascularization in patients with cardiogenic shock complicating myocardial infarction.", "publicationTitle": "American Heart Journal", "publisher": "", "place": "", "date": "Jun 2012", "volume": "163", "issue": "6", "section": "", "partNumber": "", "partTitle": "", "pages": "938-945", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Am. Heart J.", "DOI": "10.1016/j.ahj.2012.03.012", "citationKey": "", "url": "", "accessDate": "", "PMID": "22709745", "PMCID": "", "ISSN": "1097-6744", "archive": "", "archiveLocation": "", "shortTitle": "Intraaortic balloon counterpulsation in acute myocardial infarction complicated by cardiogenic shock", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Coronary Artery Bypass", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Intra-Aortic Balloon Pumping", "type": 1 }, { "tag": "Myocardial Infarction", "type": 1 }, { "tag": "Prognosis", "type": 1 }, { "tag": "Prospective Studies", "type": 1 }, { "tag": "Research Design", "type": 1 }, { "tag": "Shock, Cardiogenic", "type": 1 }, { "tag": "Thiazoles", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2015-03-11T01:04:49Z", "dateModified": "2015-03-11T01:04:49Z" } }, { "key": "I25GK99F", "version": 3, "library": { "type": "group", "id": 335985, "name": "Cardiogenic shock", "links": { "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/335985/items/I25GK99F", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock/items/I25GK99F", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/335985/items/4HPUWVH3", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1161085, "username": "webakerma", "name": "William Baker", "links": { "alternate": { "href": "https://www.zotero.org/webakerma", "type": "text/html" } } } }, "data": { "key": "I25GK99F", "version": 3, "parentItem": "4HPUWVH3", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2015-03-11T01:04:49Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/22709745", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-03-11T01:04:49Z", "dateModified": "2015-03-11T01:04:49Z" } }, { "key": "Z6QDNJ26", "version": 13, "library": { "type": "group", "id": 335985, "name": "Cardiogenic shock", "links": { "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/335985/items/Z6QDNJ26", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cardiogenic_shock/items/Z6QDNJ26", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1161085, "username": "webakerma", "name": "William Baker", "links": { "alternate": { "href": "https://www.zotero.org/webakerma", "type": "text/html" } } }, "creatorSummary": "Thiele et al.", "parsedDate": "2015-03-01", "numChildren": 1 }, "data": { "key": "Z6QDNJ26", "version": 13, "itemType": "journalArticle", "title": "Management of cardiogenic shock", "creators": [ { "creatorType": "author", "firstName": "Holger", "lastName": "Thiele" }, { "creatorType": "author", "firstName": "E. Magnus", "lastName": "Ohman" }, { "creatorType": "author", "firstName": "Steffen", "lastName": "Desch" }, { "creatorType": "author", "firstName": "Ingo", "lastName": "Eitel" }, { "creatorType": "author", "firstName": "Suzanne", "lastName": "de Waha" } ], "abstractNote": "Cardiogenic shock (CS) remains the most common cause of death in patients with acute myocardial infarction although mortality could be reduced from formerly ∼80% to 40-50%. In addition to percutaneous coronary intervention or coronary artery bypass grafting, catecholamines, fluids, intraaortic balloon pumping (IABP), and also active assist devices are widely used for CS management. However, there is only limited evidence for any of the above treatments except for early revascularization and the relative ineffectiveness of IABP. This updated review will therefore outline the management of CS complicating acute myocardial infarction with major focus on evidence-based revascularization techniques, intensive care unit treatment including ventilation, transfusion regimens, adjunctive medication, and mechanical support devices.", "publicationTitle": "European Heart Journal", "publisher": "", "place": "", "date": "Mar 1, 2015", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Eur. Heart J.", "DOI": "10.1093/eurheartj/ehv051", "citationKey": "", "url": "", "accessDate": "", "PMID": "25732762", "PMCID": "", "ISSN": "1522-9645", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "ENG", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-03-11T01:04:29Z", "dateModified": "2015-03-11T01:04:29Z" } } ]