Trouvé à partir de PubMed
\nMots clé : Proton therapy ; radiotherapy ; protein beam
\nCet article nous a été donné par la faculté dans le cadre de notre exposé
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\nMots clé : protontherapie ; neurologie
", "tags": [], "relations": {}, "dateAdded": "2014-12-19T16:33:38Z", "dateModified": "2014-12-19T16:33:38Z" } }, { "key": "PX4CP8MD", "version": 5, "library": { "type": "group", "id": 315714, "name": "Groupe 29 Alexandra Doguet, Vanessa Guo, Melanie Vo, Thomas Vong", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_29_alexandra_doguet_vanessa_guo_melanie_vo_thomas_vong", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/315714/items/PX4CP8MD", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_29_alexandra_doguet_vanessa_guo_melanie_vo_thomas_vong/items/PX4CP8MD", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/315714/items/846NPRNJ", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2242587, "username": "alexandra.doguet", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/alexandra.doguet", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "PX4CP8MD", "version": 5, "parentItem": "846NPRNJ", "itemType": "note", "note": "Trouvé à partir de ScienceDirect
\nMots clés : Proton therapy ; brain
", "tags": [], "relations": {}, "dateAdded": "2014-12-19T16:33:38Z", "dateModified": "2014-12-19T16:33:38Z" } }, { "key": "DN2GKXTG", "version": 5, "library": { "type": "group", "id": 315714, "name": "Groupe 29 Alexandra Doguet, Vanessa Guo, Melanie Vo, Thomas Vong", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_29_alexandra_doguet_vanessa_guo_melanie_vo_thomas_vong", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/315714/items/DN2GKXTG", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_29_alexandra_doguet_vanessa_guo_melanie_vo_thomas_vong/items/DN2GKXTG", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/315714/items/VQVNSX29", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2242587, "username": "alexandra.doguet", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/alexandra.doguet", "type": "text/html" } } } }, "data": { "key": "DN2GKXTG", "version": 5, "parentItem": "VQVNSX29", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-12-19T14:23:58Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/24267972", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-12-19T16:33:38Z", "dateModified": "2014-12-19T16:33:38Z" } }, { "key": "RBRRI4MB", "version": 5, "library": { "type": "group", "id": 315714, "name": "Groupe 29 Alexandra Doguet, Vanessa Guo, Melanie Vo, Thomas Vong", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_29_alexandra_doguet_vanessa_guo_melanie_vo_thomas_vong", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/315714/items/RBRRI4MB", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_29_alexandra_doguet_vanessa_guo_melanie_vo_thomas_vong/items/RBRRI4MB", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/315714/items/VQVNSX29", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2242587, "username": "alexandra.doguet", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/alexandra.doguet", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "RBRRI4MB", "version": 5, "parentItem": "VQVNSX29", "itemType": "note", "note": "Trouvé à partir de PubMed
\nMots clés : Proton therapy ; irradiation
", "tags": [], "relations": {}, "dateAdded": "2014-12-19T16:33:38Z", "dateModified": "2014-12-19T16:33:38Z" } }, { "key": "FVTK8G3G", "version": 5, "library": { "type": "group", "id": 315714, "name": "Groupe 29 Alexandra Doguet, Vanessa Guo, Melanie Vo, Thomas Vong", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_29_alexandra_doguet_vanessa_guo_melanie_vo_thomas_vong", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/315714/items/FVTK8G3G", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_29_alexandra_doguet_vanessa_guo_melanie_vo_thomas_vong/items/FVTK8G3G", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/315714/items/5FZJ9PUX", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2242587, "username": "alexandra.doguet", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/alexandra.doguet", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "FVTK8G3G", "version": 5, "parentItem": "5FZJ9PUX", "itemType": "note", "note": "Trouvé à partir de PubMed
\nMots clés : Proton therapy ; Cancer ; Head
", "tags": [], "relations": {}, "dateAdded": "2014-12-19T16:33:38Z", "dateModified": "2014-12-19T16:33:38Z" } }, { "key": "HTQJ3TN7", "version": 5, "library": { "type": "group", "id": 315714, "name": "Groupe 29 Alexandra Doguet, Vanessa Guo, Melanie Vo, Thomas Vong", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_29_alexandra_doguet_vanessa_guo_melanie_vo_thomas_vong", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/315714/items/HTQJ3TN7", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_29_alexandra_doguet_vanessa_guo_melanie_vo_thomas_vong/items/HTQJ3TN7", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2242587, "username": "alexandra.doguet", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/alexandra.doguet", "type": "text/html" } } }, "creatorSummary": "Smith", "parsedDate": "2009-02", "numChildren": 2 }, "data": { "key": "HTQJ3TN7", "version": 5, "itemType": "journalArticle", "title": "Vision 20/20: proton therapy", "creators": [ { "creatorType": "author", "firstName": "Alfred R.", "lastName": "Smith" } ], "abstractNote": "The first patients were treated with proton beams in 1955 at the Lawrence Berkeley Laboratory in California. In 1970, proton beams began to be used in research facilities to treat cancer patients using fractionated treatment regimens. It was not until 1990 that proton treatments were carried out in hospital-based facilities using technology and techniques that were comparable to those for modern photon therapy. Clinical data strongly support the conclusion that proton therapy is superior to conventional radiation therapy in a number of disease sites. Treatment planning studies have shown that proton dose distributions are superior to those for photons in a wide range of disease sites indicating that additional clinical gains can be achieved if these treatment plans can be reliably delivered to patients. Optimum proton dose distributions can be achieved with intensity modulated protons (IMPT), but very few patients have received this advanced form of treatment. It is anticipated widespread implementation of IMPT would provide additional improvements in clinical outcomes. Advances in the last decade have led to an increased interest in proton therapy. Currently, proton therapy is undergoing transitions that will move it into the mainstream of cancer treatment. For example, proton therapy is now reimbursed, there has been rapid development in proton therapy technology, and many new options are available for equipment, facility configuration, and financing. During the next decade, new developments will increase the efficiency and accuracy of proton therapy and enhance our ability to verify treatment planning calculations and perform quality assurance for proton therapy delivery. With the implementation of new multi-institution clinical studies and the routine availability of IMPT, it may be possible, within the next decade, to quantify the clinical gains obtained from optimized proton therapy. During this same period several new proton therapy facilities will be built and the cost of proton therapy is expected to decrease, making proton therapy routinely available to a larger population of cancer patients.", "publicationTitle": "Medical Physics", "publisher": "", "place": "", "date": "Feb 2009", "volume": "36", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "556-568", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Med Phys", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0094-2405", "archive": "", "archiveLocation": "", "shortTitle": "Vision 20/20", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 19291995", "tags": [ { "tag": "Carbon", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Positron-Emission Tomography", "type": 1 }, { "tag": "Protons", "type": 1 }, { "tag": "Radiotherapy Planning, Computer-Assisted", "type": 1 }, { "tag": "Radiotherapy, Intensity-Modulated", "type": 1 }, { "tag": "Tomography, X-Ray Computed", "type": 1 } ], "collections": [ "U78U9JAT" ], "relations": {}, "dateAdded": "2014-12-19T16:33:38Z", "dateModified": "2014-12-19T16:33:38Z" } }, { "key": "VQVNSX29", "version": 5, "library": { "type": "group", "id": 315714, "name": "Groupe 29 Alexandra Doguet, Vanessa Guo, Melanie Vo, Thomas Vong", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_29_alexandra_doguet_vanessa_guo_melanie_vo_thomas_vong", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/315714/items/VQVNSX29", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_29_alexandra_doguet_vanessa_guo_melanie_vo_thomas_vong/items/VQVNSX29", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2242587, "username": "alexandra.doguet", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/alexandra.doguet", "type": "text/html" } } }, "creatorSummary": "McDonald et al.", "parsedDate": "2013-12-01", "numChildren": 2 }, "data": { "key": "VQVNSX29", "version": 5, "itemType": "journalArticle", "title": "Proton therapy for reirradiation of progressive or recurrent chordoma", "creators": [ { "creatorType": "author", "firstName": "Mark W.", "lastName": "McDonald" }, { "creatorType": "author", "firstName": "Okechuckwu R.", "lastName": "Linton" }, { "creatorType": "author", "firstName": "Mitesh V.", "lastName": "Shah" } ], "abstractNote": "PURPOSE: To report the results in patients reirradiated with proton therapy for recurrent or progressive chordoma, with or without salvage surgery.\nMETHODS AND MATERIALS: A retrospective review of 16 consecutive patients treated from 2005 to 2012 was performed. All patients had received at least 1 prior course of radiation therapy to the same area, and all but 1 patient had at least 1 surgical resection for disease before receiving reirradiation. At the time of recurrence or progression, half of the patients underwent additional salvage surgery before receiving reirradiation. The median prior dose of radiation was 75.2 Gy (range, 40-79.2 Gy). Six patients had received prior proton therapy, and the remainder had received photon radiation. The median gross tumor volume at the time of reirradiation was 71 cm(3) (range, 0-701 cm(3)). Reirradiation occurred at a median interval of 37 months after prior radiation (range, 12-129 months), and the median dose of reirradiation was 75.6 Gy (relative biological effectiveness [RBE]) (range. 71.2-79.2 Gy [RBE]), given in standard daily fractionation (n=14) or hyperfractionation (n=2).\nRESULTS: The median follow-up time was 23 months (range, 6-63 months); it was 26 months in patients alive at the last follow-up visit (range, 12-63 months). The 2-year estimate for local control was 85%, overall survival 80%, chordoma-specific survival 88%, and development of distant metastases 20%. Four patients have had local progression: 3 in-field and 1 marginal. Late toxicity included grade 3 bitemporal lobe radionecrosis in 1 patient that improved with hyperbaric oxygen, a grade 4 cerebrospinal fluid leak with meningitis in 1 patient, and a grade 4 ischemic brainstem stroke (out of radiation field) in 1 patient, with subsequent neurologic recovery.\nCONCLUSIONS: Full-dose proton reirradiation provided encouraging initial disease control and overall survival for patients with recurrent or progressive chordoma, although additional toxicities may develop with longer follow-up times.", "publicationTitle": "International Journal of Radiation Oncology, Biology, Physics", "publisher": "", "place": "", "date": "Dec 1, 2013", "volume": "87", "issue": "5", "section": "", "partNumber": "", "partTitle": "", "pages": "1107-1114", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Int. J. Radiat. Oncol. Biol. Phys.", "DOI": "10.1016/j.ijrobp.2013.09.038", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1879-355X", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 24267972", "tags": [ { "tag": "Adult", "type": 1 }, { "tag": "Aged", "type": 1 }, { "tag": "Chordoma", "type": 1 }, { "tag": "Disease Progression", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Middle Aged", "type": 1 }, { "tag": "Neoplasm Recurrence, Local", "type": 1 }, { "tag": "Proton Therapy", "type": 1 }, { "tag": "Radiotherapy Dosage", "type": 1 }, { "tag": "Retreatment", "type": 1 }, { "tag": "Retrospective Studies", "type": 1 }, { "tag": "Salvage Therapy", "type": 1 }, { "tag": "Spinal Neoplasms", "type": 1 }, { "tag": "Time Factors", "type": 1 }, { "tag": "Treatment Outcome", "type": 1 }, { "tag": "Tumor Burden", "type": 1 } ], "collections": [ "U78U9JAT" ], "relations": {}, "dateAdded": "2014-12-19T16:33:38Z", "dateModified": "2014-12-19T16:33:38Z" } }, { "key": "5FZJ9PUX", "version": 5, "library": { "type": "group", "id": 315714, "name": "Groupe 29 Alexandra Doguet, Vanessa Guo, Melanie Vo, Thomas Vong", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_29_alexandra_doguet_vanessa_guo_melanie_vo_thomas_vong", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/315714/items/5FZJ9PUX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_29_alexandra_doguet_vanessa_guo_melanie_vo_thomas_vong/items/5FZJ9PUX", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2242587, "username": "alexandra.doguet", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/alexandra.doguet", "type": "text/html" } } }, "creatorSummary": "Mali", "parsedDate": "2014-11-11", "numChildren": 2 }, "data": { "key": "5FZJ9PUX", "version": 5, "itemType": "journalArticle", "title": "Proton therapy for head neck cancer", "creators": [ { "creatorType": "author", "firstName": "Shrikant Balasaheb", "lastName": "Mali" } ], "abstractNote": "", "publicationTitle": "Oral Oncology", "publisher": "", "place": "", "date": "Nov 11, 2014", "volume": "50", "issue": "11", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Oral Oncol.", "DOI": "10.1016/j.oraloncology.2014.10.015", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1879-0593", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "ENG", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 25467208", "tags": [], "collections": [ "U78U9JAT" ], "relations": {}, "dateAdded": "2014-12-19T16:33:38Z", "dateModified": "2014-12-19T16:33:38Z" } }, { "key": "6GG5FXK6", "version": 5, "library": 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\nMots clés : proton therapy ; particle therapy ; hadron therapy ; radiation oncology
\nCet article nous a été donné par la faculté dans le cadre de notre sujet
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\nMots clés : Centre protontherapie
\nIl s'agit du site internet du centre de Protontherapie d'Orsay où travaille la personne de nous devions contacté dans le cadre de notre exposé.
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P.", "lastName": "Levin" }, { "creatorType": "author", "firstName": "H.", "lastName": "Kooy" }, { "creatorType": "author", "firstName": "J. S.", "lastName": "Loeffler" }, { "creatorType": "author", "firstName": "T. F.", "lastName": "DeLaney" } ], "abstractNote": "Conventional radiation therapy directs photons (X-rays) and electrons at tumours with the intent of eradicating the neoplastic tissue while preserving adjacent normal tissue. Radiation-induced damage to healthy tissue and second malignancies are always a concern, however, when administering radiation. Proton beam radiotherapy, one form of charged particle therapy, allows for excellent dose distributions, with the added benefit of no exit dose. These characteristics make this form of radiotherapy an excellent choice for the treatment of tumours located next to critical structures such as the spinal cord, eyes, and brain, as well as for paediatric malignancies.", "publicationTitle": "British Journal of Cancer", "publisher": "", "place": "", "date": "Oct 17, 2005", "volume": "93", "issue": "8", "section": "", "partNumber": "", "partTitle": "", "pages": "849-854", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Br. J. Cancer", "DOI": "10.1038/sj.bjc.6602754", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0007-0920", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 16189526 \nPMCID: PMC2361650", "tags": [ { "tag": "Adult", "type": 1 }, { "tag": "Central Nervous System Neoplasms", "type": 1 }, { "tag": "Child", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Protons", "type": 1 }, { "tag": "Radiation Injuries", "type": 1 }, { "tag": "Radiometry", "type": 1 }, { "tag": "Radiotherapy", "type": 1 } ], "collections": [ "U78U9JAT" ], "relations": {}, "dateAdded": "2014-12-19T16:33:38Z", "dateModified": "2014-12-19T16:33:38Z" } }, { "key": "X2Q73TP7", "version": 5, "library": { "type": "group", "id": 315714, "name": "Groupe 29 Alexandra Doguet, Vanessa Guo, Melanie Vo, Thomas Vong", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_29_alexandra_doguet_vanessa_guo_melanie_vo_thomas_vong", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/315714/items/X2Q73TP7", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_29_alexandra_doguet_vanessa_guo_melanie_vo_thomas_vong/items/X2Q73TP7", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2242587, "username": "alexandra.doguet", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/alexandra.doguet", "type": "text/html" } } }, "numChildren": 2 }, "data": { "key": "X2Q73TP7", "version": 5, "itemType": "webpage", "title": "Protonthérapie", "creators": [], "abstractNote": "", "websiteTitle": "http://protontherapie.curie.fr/", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://protontherapie.curie.fr/", "accessDate": "2014-12-19T15:09:45Z", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [ "U78U9JAT" ], "relations": {}, "dateAdded": "2014-12-19T16:33:38Z", "dateModified": "2014-12-19T16:33:38Z" } }, { "key": "MUWKFVDI", "version": 5, "library": { "type": "group", "id": 315714, "name": "Groupe 29 Alexandra Doguet, Vanessa Guo, Melanie Vo, Thomas Vong", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_29_alexandra_doguet_vanessa_guo_melanie_vo_thomas_vong", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/315714/items/MUWKFVDI", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_29_alexandra_doguet_vanessa_guo_melanie_vo_thomas_vong/items/MUWKFVDI", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2242587, "username": "alexandra.doguet", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/alexandra.doguet", "type": "text/html" } } }, "creatorSummary": "HANNOUCHE", "parsedDate": "1994", "numChildren": 4 }, "data": { "key": "MUWKFVDI", "version": 5, "itemType": "thesis", "title": "LA PROTONTHERAPIE DANS LES ANGIOMES CHOROIDIENS: A PROPOS DE 13 CAS", "creators": [ { "creatorType": "author", "firstName": "DANIELE", "lastName": "HANNOUCHE" }, { "creatorType": "contributor", "firstName": "E.", "lastName": "FRAU" } ], "abstractNote": "", "thesisType": "TH.", "university": "", "place": "France", "date": "1994", "series": "", "seriesNumber": "", "numPages": "", "DOI": "", "ISBN": "", "citationKey": "", "url": "", "accessDate": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "LA PROTONTHERAPIE DANS LES ANGIOMES CHOROIDIENS", "language": "français", "libraryCatalog": "Library Catalog - www.sudoc.abes.fr", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "ANGIOME", "type": 1 }, { "tag": "CHOROIDE", "type": 1 }, { "tag": "MEDECINE : OPHTAMOLOGIE", "type": 1 }, { "tag": "PROTONTHERAPIE", "type": 1 } ], "collections": [ "U78U9JAT" ], "relations": {}, "dateAdded": "2014-12-19T16:33:38Z", "dateModified": "2014-12-19T16:33:38Z" } }, { "key": "846NPRNJ", "version": 5, "library": { "type": "group", "id": 315714, "name": "Groupe 29 Alexandra Doguet, Vanessa Guo, Melanie Vo, Thomas Vong", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_29_alexandra_doguet_vanessa_guo_melanie_vo_thomas_vong", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/315714/items/846NPRNJ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_29_alexandra_doguet_vanessa_guo_melanie_vo_thomas_vong/items/846NPRNJ", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2242587, "username": "alexandra.doguet", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/alexandra.doguet", "type": "text/html" } } }, "creatorSummary": "Combs et al.", "parsedDate": "2013", "numChildren": 3 }, "data": { "key": "846NPRNJ", "version": 5, "itemType": "journalArticle", "title": "Clinical Controversies: Proton Radiation Therapy for Brain and Skull Base Tumors", "creators": [ { "creatorType": "author", "firstName": "Stephanie E.", "lastName": "Combs" }, { "creatorType": "author", "firstName": "Normand", "lastName": "Laperriere" }, { "creatorType": "author", "firstName": "Michael", "lastName": "Brada" } ], "abstractNote": "Proton radiotherapy offers distinct physical properties that could lead to an improvement of dose distribution with subsequent reduction of integral dose to the patient. This supports the potential use of proton beams in tumors close to sensitive structures, such as the skull base and the brain. In the present manuscript, the literature on proton therapy for brain and skull base tumors is critically reviewed and compared with results obtained with modern photon techniques. Treatment planning comparisons demonstrate that dose distributions within the target are comparable. In terms of normal tissue dose distribution, protons offer an advantage in the intermediate- and low-dose regions, and this may result in long-term clinical benefit, although to date no randomized or long-term follow-up data demonstrate this. Considering the excellent long-term results seen with photons in localized tumors, this benefit may be modest and difficult to demonstrate. Protons may allow for safe delivery of higher local doses with the potential to improve local control in some tumors. However, improvements in photon techniques also enable safe dose escalation, and therefore, the comparison of the techniques of delivery is likely to need randomized trials. Proton therapy offers effective treatment for a range of brain tumors. However, the limited availability, the cost, and the lack of evidence of superiority mean that advanced photon radiotherapy continues to be the treatment of choice. It is hoped that advances in technology, both in proton and photon radiotherapy delivery, and increasing information on the efficacy and toxicity of the two modalities will lead to further improvement in radiotherapy approaches and provide the basis for the best choice of treatment for the individual patient.", "publicationTitle": "Seminars in Radiation Oncology", "publisher": "", "place": "", "date": "avril 2013", "volume": "23", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "120-126", "series": "Controversies in Proton Therapy", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Seminars in Radiation Oncology", "DOI": "10.1016/j.semradonc.2012.11.011", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/S1053429612001142", "accessDate": "2014-12-19T14:46:39Z", "PMID": "", "PMCID": "", "ISSN": "1053-4296", "archive": "", "archiveLocation": "", "shortTitle": "Clinical Controversies", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "U78U9JAT" ], "relations": {}, "dateAdded": "2014-12-19T16:33:38Z", "dateModified": "2014-12-19T16:33:38Z" } }, { "key": "WE2JGE9P", "version": 4, "library": { "type": "group", "id": 315714, "name": "Groupe 29 Alexandra Doguet, Vanessa Guo, Melanie Vo, Thomas Vong", "links": { "alternate": { "href": "https://www.zotero.org/groups/groupe_29_alexandra_doguet_vanessa_guo_melanie_vo_thomas_vong", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/315714/items/WE2JGE9P", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/groupe_29_alexandra_doguet_vanessa_guo_melanie_vo_thomas_vong/items/WE2JGE9P", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/315714/items/CX686KFI", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2242589, "username": "vanessa_guo", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/vanessa_guo", "type": "text/html" } } } }, "data": { "key": "WE2JGE9P", "version": 4, "parentItem": "CX686KFI", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-12-19T15:33:54Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/21527064", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-12-19T16:30:59Z", "dateModified": "2014-12-19T16:30:59Z" } } ]