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"firstName": "Sougat", "lastName": "Ray" }, { "creatorType": "author", "firstName": "A. K.", "lastName": "Jindal" }, { "creatorType": "author", "firstName": "S.", "lastName": "Sengupta" }, { "creatorType": "author", "firstName": "S.", "lastName": "Sinha" } ], "abstractNote": "", "publicationTitle": "Medical Journal Armed Forces India", "publisher": "", "place": "", "date": "2014-07-01", "volume": "70", "issue": "3", "section": "", "partNumber": "", "partTitle": "", "pages": "270-273", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1016/j.mjafi.2013.05.008", "citationKey": "", "url": "http://www.mjafi.net/article/S0377123713000919/abstract", "accessDate": "2014-12-02T16:30:55Z", "PMID": "", "PMCID": "", "ISSN": "0377-1237", "archive": "", "archiveLocation": "", "shortTitle": "Statins", "language": "English", "libraryCatalog": "www.mjafi.net", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Heart disease", "type": 1 }, { "tag": "Primary prevention", "type": 1 }, { "tag": "Statins", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2014-12-03T22:43:43Z", "dateModified": "2014-12-03T22:43:43Z" } }, { "key": "9VJB5CNA", "version": 2, "library": { "type": "group", "id": 311779, "name": "Statin sources for Chris", "links": { "alternate": { "href": "https://www.zotero.org/groups/statin_sources_for_chris", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/311779/items/9VJB5CNA", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/statin_sources_for_chris/items/9VJB5CNA", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2045293, "username": "AyyTran", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/ayytran", "type": "text/html" } } }, "creatorSummary": "Cannon et al.", "parsedDate": "2004-04-08", "numChildren": 1 }, "data": { "key": "9VJB5CNA", "version": 2, "itemType": "journalArticle", "title": "Intensive versus Moderate Lipid Lowering with Statins after Acute Coronary Syndromes", "creators": [ { "creatorType": "author", "firstName": "Christopher P.", "lastName": "Cannon" }, { "creatorType": "author", "firstName": "Eugene", "lastName": "Braunwald" }, { "creatorType": "author", "firstName": "Carolyn H.", "lastName": "McCabe" }, { "creatorType": "author", "firstName": "Daniel J.", "lastName": "Rader" }, { "creatorType": "author", "firstName": "Jean L.", "lastName": "Rouleau" }, { "creatorType": "author", "firstName": "Rene", "lastName": "Belder" }, { "creatorType": "author", "firstName": "Steven V.", "lastName": "Joyal" }, { "creatorType": "author", "firstName": "Karen A.", "lastName": "Hill" }, { "creatorType": "author", "firstName": "Marc A.", "lastName": "Pfeffer" }, { "creatorType": "author", "firstName": "Allan M.", "lastName": "Skene" } ], "abstractNote": "Several large, randomized, controlled trials have documented that cholesterol-lowering therapy with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) reduces the risk of death or cardiovascular events across a wide range of cholesterol levels whether or not patients have a history of coronary artery disease.1–7 The doses of statins used in these trials reduced low-density lipoprotein (LDL) cholesterol levels by 25 to 35 percent, and current guidelines recommend a target LDL cholesterol level of less than 100 mg per deciliter (2.59 mmol per liter) for patients with established coronary artery disease or diabetes.8,9 It is not clear whether lowering lipid . . .", "publicationTitle": "New England Journal of Medicine", "publisher": "", "place": "", "date": "April 8, 2004", "volume": "350", "issue": "15", "section": "", "partNumber": "", "partTitle": "", "pages": "1495-1504", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1056/NEJMoa040583", "citationKey": "", "url": "http://www.nejm.org/doi/full/10.1056/NEJMoa040583", "accessDate": "2014-12-01T21:04:16Z", "PMID": "", "PMCID": "", "ISSN": "0028-4793", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "Taylor and Francis+NEJM", "callNumber": "", "rights": "", "extra": "PMID: 15007110", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-12-03T22:43:43Z", "dateModified": "2014-12-03T22:43:43Z" } }, { "key": "W492NUN5", "version": 2, "library": { "type": "group", "id": 311779, "name": "Statin sources for Chris", "links": { "alternate": { "href": "https://www.zotero.org/groups/statin_sources_for_chris", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/311779/items/W492NUN5", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/statin_sources_for_chris/items/W492NUN5", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2045293, "username": "AyyTran", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/ayytran", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "W492NUN5", "version": 2, "itemType": "document", "title": "Statin Side Effects How Common Are They.pdf", "creators": [], "abstractNote": "", "type": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-12-03T22:43:43Z", "dateModified": "2014-12-03T22:43:43Z" } }, { "key": "W3M768B6", "version": 2, "library": { "type": "group", "id": 311779, "name": "Statin sources for Chris", "links": { "alternate": { "href": "https://www.zotero.org/groups/statin_sources_for_chris", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/311779/items/W3M768B6", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/statin_sources_for_chris/items/W3M768B6", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2045293, "username": "AyyTran", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/ayytran", "type": "text/html" } } }, "numChildren": 1 }, "data": { "key": "W3M768B6", "version": 2, "itemType": "webpage", "title": "Statin adverse effects: Sorting out the evidence : The Journal of Family Practice", "creators": [], "abstractNote": "PRACTICE RECOMMENDATIONS\n› Advise patients starting statin therapy to stop taking the medication and call your office immediately if they develop severe muscle pain or weakness, as statins are associated with a small increased risk of rhabdomyolysis. B› Obtain a baseline creatine kinase level for patients with an increased risk of musculo­skeletal disorders; routine monitoring is needed only for those who experience muscle pain or weakness while on statin therapy. C› Prescribe statins for patients with chronic kidney or liver disease when indicated; statin therapy is not associated with an...", "websiteTitle": "", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://www.jfponline.com/the-publication/past-issue-single-view/statin-adverse-effects-sorting-out-the-evidence/de21bf8db6376d563eb275f2b3406de1.html", "accessDate": "2014-12-02T17:16:11Z", "shortTitle": "Statin adverse effects", "language": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-12-03T22:43:43Z", "dateModified": "2014-12-03T22:43:43Z" } }, { "key": "P7UKZFK6", "version": 2, "library": { "type": "group", "id": 311779, "name": "Statin sources for Chris", "links": { "alternate": { "href": "https://www.zotero.org/groups/statin_sources_for_chris", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/311779/items/P7UKZFK6", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/statin_sources_for_chris/items/P7UKZFK6", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2045293, "username": "AyyTran", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/ayytran", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "P7UKZFK6", "version": 2, "itemType": "document", "title": "Non-tradiational Dosing of Statins in Statin-Intolerant Patients - Is it Worth a Try?", "creators": [], "abstractNote": "", "type": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-12-03T22:43:43Z", "dateModified": "2014-12-03T22:43:43Z" } }, { "key": "HP6U9UQ8", "version": 2, "library": { "type": "group", "id": 311779, "name": "Statin sources for Chris", "links": { "alternate": { "href": "https://www.zotero.org/groups/statin_sources_for_chris", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/311779/items/HP6U9UQ8", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/statin_sources_for_chris/items/HP6U9UQ8", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2045293, "username": "AyyTran", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/ayytran", "type": "text/html" } } }, "creatorSummary": "Simić and Reiner", "parsedDate": "2014-10-13", "numChildren": 1 }, "data": { "key": "HP6U9UQ8", "version": 2, "itemType": "journalArticle", "title": "Adverse Effects of Statins - Myths and Reality", "creators": [ { "creatorType": "author", "firstName": "Iveta", "lastName": "Simić" }, { "creatorType": "author", "firstName": "Zeljko", "lastName": "Reiner" } ], "abstractNote": "Statins reduce cardiovascular mortality and morbidity as well as cardiovascular events in patients with a very high risk of cardiovascular disease (CVD) and also in subjects with high or moderate risk by reducing the levels of low-density lipoprotein cholesterol (LDL-C). Although they are considered to be drugs with a very good safety profile, because of their wide use there are many concerns that their adverse effects might compromise their proven beneficial effects. Therefore this article reviews all the data and provides an evidence-based insight what are the proven adverse effects of statins and what are the \"myths\" about them. The most important side effects include myopathy and rhabdomyolysis. Another side effect is increased activity of liver tests which occurs occasionally and is reversible. However, recent studies even suggest that statin therapy can improve hepatic steatosis. It is beyond any doubt that statins do slightly increase the incidence of type 2 diabetes mellitus in people with two or more components of metabolic syndrome but the cardiovascular benefits of such a treatment by far exceed this risk. Statin therapy has also been associated with some adverse renal effects, eg. acute renal failure, but recent data suggest even a possible protective effect of these drugs on renal dysfunction. Concerns that statins might increase cancer have not been proven. On the contrary, several studies have indicated a possible benefit of these drugs in patients with different types of cancer. Early concerns about cognitive dysfunction and memory loss associated with statins use could not be proven and most recent data even suggest a possible beneficial effect of statins in the prevention of dementia. Systematic reviews and clinical guidelines suggest that the cardiovascular benefits of statins by far out-weight non-cardiovascular harms in patients with cardiovascular risk.", "publicationTitle": "Current Pharmaceutical Design", "publisher": "", "place": "", "date": "Oct 13, 2014", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Curr. Pharm. Des.", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1873-4286", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "ENG", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 25312733", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-12-03T22:43:43Z", "dateModified": "2014-12-03T22:43:43Z" } } ]