[ { "key": "UUMXCIZX", "version": 58, "library": { "type": "group", "id": 308696, "name": "ALS 333 - Team Groot", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/308696/items/UUMXCIZX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot/items/UUMXCIZX", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2074526, "username": "jkrass14", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jkrass14", "type": "text/html" } } }, "creatorSummary": "Hamermesh et al.", "parsedDate": "2013-10-24", "numChildren": 0 }, "data": { "key": "UUMXCIZX", "version": 58, "itemType": "journalArticle", "title": "Gene Patents", "creators": [ { "creatorType": "author", "firstName": "Richard", "lastName": "Hamermesh" }, { "creatorType": "author", "firstName": "David", "lastName": "Kiron" }, { "creatorType": "author", "firstName": "Phillip", "lastName": "Andrews" } ], "abstractNote": "", "publicationTitle": "Harvard Business School", "publisher": "", "place": "", "date": "Rev: Octover 24, 2013", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "26", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "9-811-089", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "8W522VXI" ], "relations": {}, "dateAdded": "2015-02-26T08:00:59Z", "dateModified": "2015-02-26T08:04:16Z" } }, { "key": "M5SERVIF", "version": 52, "library": { "type": "group", "id": 308696, "name": "ALS 333 - Team Groot", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/308696/items/M5SERVIF", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot/items/M5SERVIF", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2074526, "username": "jkrass14", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jkrass14", "type": "text/html" } } }, "creatorSummary": "Goodpaster and Mathews", "parsedDate": "1981-02", "numChildren": 0 }, "data": { "key": "M5SERVIF", "version": 52, "itemType": "document", "title": "Can a Corporation Have a Conscience?", "creators": [ { "creatorType": "author", "firstName": "Kenneth", "lastName": "Goodpaster" }, { "creatorType": "author", "firstName": "John", "lastName": "Mathews" } ], "abstractNote": "", "type": "", "date": "February 1981", "publisher": "Harvard Business Review", "place": "", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-02-17T06:03:20Z", "dateModified": "2015-02-17T06:07:14Z" } }, { "key": "3RPU2ISC", "version": 52, "library": { "type": "group", "id": 308696, "name": "ALS 333 - Team Groot", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/308696/items/3RPU2ISC", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot/items/3RPU2ISC", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2074526, "username": "jkrass14", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jkrass14", "type": "text/html" } } }, "creatorSummary": "Presley", "numChildren": 0 }, "data": { "key": "3RPU2ISC", "version": 52, "itemType": "journalArticle", "title": "Vioxx and the Merck Team Effort", "creators": [ { "creatorType": "author", "firstName": "Holly", "lastName": "Presley" } ], "abstractNote": "", "publicationTitle": "The Kenan Institute for Ethics at Duke University", "publisher": "", "place": "", "date": "", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "22", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-02-17T05:44:27Z", "dateModified": "2015-02-17T05:49:18Z" } }, { "key": "27PNHTPT", "version": 52, "library": { "type": "group", "id": 308696, "name": "ALS 333 - Team Groot", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/308696/items/27PNHTPT", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot/items/27PNHTPT", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2074526, "username": "jkrass14", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jkrass14", "type": "text/html" } } }, "creatorSummary": "Smith", "parsedDate": "2015-01-28", "numChildren": 0 }, "data": { "key": "27PNHTPT", "version": 52, "itemType": "presentation", "title": "Goodpaster Moral Point of View", "creators": [ { "creatorType": "presenter", "firstName": "Jeffery", "lastName": "Smith" } ], "abstractNote": "", "presentationType": "", "date": "January 28, 2015", "meetingName": "", "place": "", "series": "", "sessionTitle": "", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-02-17T05:26:54Z", "dateModified": "2015-02-17T05:34:22Z" } }, { "key": "THSABUQ2", "version": 39, "library": { "type": "group", "id": 308696, "name": "ALS 333 - Team Groot", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/308696/items/THSABUQ2", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot/items/THSABUQ2", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/308696/items/8DZNPH6T", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2055809, "username": "Aster123", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/aster123", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "THSABUQ2", "version": 39, "parentItem": "8DZNPH6T", "itemType": "attachment", "linkMode": "imported_url", "title": "ScienceDirect Full Text PDF", "accessDate": "2014-11-25T07:05:02Z", "url": "http://www.sciencedirect.com/science/article/pii/S1359644612000529/pdfft?md5=c6455db56a2d88b312b04031da564af1&pid=1-s2.0-S1359644612000529-main.pdf", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Meekings et al. - 2012 - Orphan drug development an economically viable st.pdf", "md5": "b851ef03f939ce3627611580e13f4d97", "mtime": 1416899107692, "tags": [], "relations": {}, "dateAdded": "2014-11-25T07:05:02Z", "dateModified": "2014-11-25T07:05:07Z" } }, { "key": "CK8IRE6K", "version": 39, "library": { "type": "group", "id": 308696, "name": "ALS 333 - Team Groot", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/308696/items/CK8IRE6K", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot/items/CK8IRE6K", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/308696/items/8DZNPH6T", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2055809, "username": "Aster123", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/aster123", "type": "text/html" } } } }, "data": { "key": "CK8IRE6K", "version": 39, "parentItem": "8DZNPH6T", "itemType": "attachment", "linkMode": "imported_url", "title": "ScienceDirect Snapshot", "accessDate": "2014-11-25T07:05:02Z", "url": "http://www.sciencedirect.com/science/article/pii/S1359644612000529", "note": "", "contentType": "text/html", "charset": "utf-8", "filename": "S1359644612000529.html", "md5": "9b93177f351ebf6a61705032d35c9bc3", "mtime": 1416899102935, "tags": [], "relations": {}, "dateAdded": "2014-11-25T07:05:02Z", "dateModified": "2014-11-25T07:05:02Z" } }, { "key": "8DZNPH6T", "version": 38, "library": { "type": "group", "id": 308696, "name": "ALS 333 - Team Groot", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/308696/items/8DZNPH6T", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot/items/8DZNPH6T", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2055809, "username": "Aster123", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/aster123", "type": "text/html" } } }, "creatorSummary": "Meekings et al.", "parsedDate": "2012-07", "numChildren": 2 }, "data": { "key": "8DZNPH6T", "version": 38, "itemType": "journalArticle", "title": "Orphan drug development: an economically viable strategy for biopharma R&D", "creators": [ { "creatorType": "author", "firstName": "Kiran N.", "lastName": "Meekings" }, { "creatorType": "author", "firstName": "Cory S. M.", "lastName": "Williams" }, { "creatorType": "author", "firstName": "John E.", "lastName": "Arrowsmith" } ], "abstractNote": "Orphan drug incentives have stimulated research into diseases with significant unmet medical need. Although the targeting of orphan diseases is seen by industry as an attractive strategy, there are limited economic data available to support its use. In this paper we show that the revenue-generating potential of orphan drugs is as great as for non-orphan drugs, even though patient populations for rare diseases are significantly smaller. Moreover, we suggest that orphan drugs have greater profitability when considered in the full context of developmental drivers including government financial incentives, smaller clinical trial sizes, shorter clinical trial times and higher rates of regulatory success. The data support the targeting of rare diseases as an important component of a successful biopharma R&D strategy.", "publicationTitle": "Drug Discovery Today", "publisher": "", "place": "", "date": "July 2012", "volume": "17", "issue": "13–14", "section": "", "partNumber": "", "partTitle": "", "pages": "660-664", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Drug Discovery Today", "DOI": "10.1016/j.drudis.2012.02.005", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/S1359644612000529", "accessDate": "2014-11-25T07:05:02Z", "PMID": "", "PMCID": "", "ISSN": "1359-6446", "archive": "", "archiveLocation": "", "shortTitle": "Orphan drug development", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-11-25T07:05:02Z", "dateModified": "2014-11-25T07:05:02Z" } }, { "key": "VSV6QIXV", "version": 37, "library": { "type": "group", "id": 308696, "name": "ALS 333 - Team Groot", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/308696/items/VSV6QIXV", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot/items/VSV6QIXV", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2055809, "username": "Aster123", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/aster123", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "VSV6QIXV", "version": 37, "itemType": "attachment", "linkMode": "imported_url", "title": "The_Science_of_Hope_the_need,_the_challanges_and_three_proven_strategies_for_successful_orphan_drug_development.pdf", "accessDate": "2014-11-25T07:03:26Z", "url": "http://premier-research.com/images/uploads/The_Science_of_Hope_the_need,_the_challanges_and_three_proven_strategies_for_successful_orphan_drug_development.pdf", "note": "", "contentType": "application/pdf", "charset": "", "filename": "The_Science_of_Hope_the_need,_the_challanges_and_three_proven_strategies_for_successful_orphan_drug_development.pdf", "md5": "0c707e22a1a47903f57fb5e6274797fa", "mtime": 1416899022565, "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-11-25T07:03:26Z", "dateModified": "2014-11-25T07:03:42Z" } }, { "key": "IAUBAUTQ", "version": 35, "library": { "type": "group", "id": 308696, "name": "ALS 333 - Team Groot", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/308696/items/IAUBAUTQ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot/items/IAUBAUTQ", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/308696/items/4PPH2XI9", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2055809, "username": "Aster123", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/aster123", "type": "text/html" } } } }, "data": { "key": "IAUBAUTQ", "version": 35, "parentItem": "4PPH2XI9", "itemType": "attachment", "linkMode": "imported_url", "title": "Snapshot", "accessDate": "2014-11-25T06:58:57Z", "url": "http://www.fda.gov/ForIndustry/DevelopingProductsforRareDiseasesConditions/ucm2005525.htm", "note": "", "contentType": "text/html", "charset": "utf-8", "filename": "ucm2005525.html", "md5": "797ae0c0150abb112a29abe49473c6da", "mtime": 1416898738104, "tags": [], "relations": {}, "dateAdded": "2014-11-25T06:58:57Z", "dateModified": "2014-11-25T06:58:57Z" } }, { "key": "4PPH2XI9", "version": 34, "library": { "type": "group", "id": 308696, "name": "ALS 333 - Team Groot", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/308696/items/4PPH2XI9", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot/items/4PPH2XI9", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2055809, "username": "Aster123", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/aster123", "type": "text/html" } } }, "creatorSummary": "Commissioner", "numChildren": 1 }, "data": { "key": "4PPH2XI9", "version": 34, "itemType": "webpage", "title": "Developing Products for Rare Diseases & Conditions", "creators": [ { "creatorType": "author", "firstName": "Office of the", "lastName": "Commissioner" } ], "abstractNote": "", "websiteTitle": "", "websiteType": "WebContent", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://www.fda.gov/ForIndustry/DevelopingProductsforRareDiseasesConditions/ucm2005525.htm", "accessDate": "2014-11-25T06:58:57Z", "shortTitle": "", "language": "en", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-11-25T06:58:57Z", "dateModified": "2014-11-25T06:58:57Z" } }, { "key": "FQDRDKJA", "version": 33, "library": { "type": "group", "id": 308696, "name": "ALS 333 - Team Groot", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/308696/items/FQDRDKJA", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot/items/FQDRDKJA", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/308696/items/UUCNN75V", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2055809, "username": "Aster123", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/aster123", "type": "text/html" } } } }, "data": { "key": "FQDRDKJA", "version": 33, "parentItem": "UUCNN75V", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Central Link", "accessDate": "2014-11-25T06:53:50Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996062/", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-11-25T06:53:50Z", "dateModified": "2014-11-25T06:53:50Z" } }, { "key": "UUCNN75V", "version": 33, "library": { "type": "group", "id": 308696, "name": "ALS 333 - Team Groot", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/308696/items/UUCNN75V", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot/items/UUCNN75V", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2055809, "username": "Aster123", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/aster123", "type": "text/html" } } }, "creatorSummary": "Sharma et al.", "parsedDate": "2010", "numChildren": 1 }, "data": { "key": "UUCNN75V", "version": 33, "itemType": "journalArticle", "title": "Orphan drug: Development trends and strategies", "creators": [ { "creatorType": "author", "firstName": "Aarti", "lastName": "Sharma" }, { "creatorType": "author", "firstName": "Abraham", "lastName": "Jacob" }, { "creatorType": "author", "firstName": "Manas", "lastName": "Tandon" }, { "creatorType": "author", "firstName": "Dushyant", "lastName": "Kumar" } ], "abstractNote": "The growth of pharma industries has slowed in recent years because of various reasons such as patent expiries, generic competition, drying pipelines, and increasingly stringent regulatory guidelines. Many blockbuster drugs will loose their exclusivity in next 5 years. Therefore, the current economic situation plus the huge generic competition shifted the focus of pharmaceutical companies from the essential medicines to the new business model — niche busters, also called orphan drugs. Orphan drugs may help pharma companies to reduce the impact of revenue loss caused by patent expiries of blockbuster drugs. The new business model of orphan drugs could offer an integrated healthcare solution that enables pharma companies to develop newer areas of therapeutics, diagnosis, treatment, monitoring, and patient support. Incentives for drug development provided by governments, as well as support from the FDA and EU Commission in special protocols, are a further boost for the companies developing orphan drugs. Although there may still be challenges ahead for the pharmaceutical industry, orphan drugs seem to offer the key to recovery and stability within the market. In our study, we have compared the policies and orphan drug incentives worldwide alongwith the challenges faced by the pharmaceutical companies. Recent developments are seen in orphan drug approval, the various drugs in orphan drug pipeline, and the future prospectives for orphan drugs and diseases.", "publicationTitle": "Journal of Pharmacy and Bioallied Sciences", "publisher": "", "place": "", "date": "2010", "volume": "2", "issue": "4", "section": "", "partNumber": "", "partTitle": "", "pages": "290-299", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Pharm Bioallied Sci", "DOI": "10.4103/0975-7406.72128", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996062/", "accessDate": "2014-11-25T06:53:50Z", "PMID": "", "PMCID": "", "ISSN": "0976-4879", "archive": "", "archiveLocation": "", "shortTitle": "Orphan drug", "language": "", "libraryCatalog": "PubMed Central", "callNumber": "", "rights": "", "extra": "PMID: 21180460\nPMCID: PMC2996062", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-11-25T06:53:50Z", "dateModified": "2014-11-25T06:53:50Z" } }, { "key": "RPMQN6A8", "version": 32, "library": { "type": "group", "id": 308696, "name": "ALS 333 - Team Groot", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/308696/items/RPMQN6A8", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot/items/RPMQN6A8", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/308696/items/VNU5TGGC", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2055809, "username": "Aster123", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/aster123", "type": "text/html" } } } }, "data": { "key": "RPMQN6A8", "version": 32, "parentItem": "VNU5TGGC", "itemType": "attachment", "linkMode": "imported_url", "title": "Snapshot", "accessDate": "2014-11-25T06:29:38Z", "url": "http://www.telegraph.co.uk/news/picturegalleries/howaboutthat/6818324/Tree-man-new-pictures-Dede-Koswara-continues-treatment-in-Indonesia.html?image=9", "note": "", "contentType": "text/html", "charset": "utf-8", "filename": "Tree-man-new-pictures-Dede-Koswara-continues-treatment-in-Indonesia.html", "md5": "12f3542bf697e3e82587a0cafa19ec68", "mtime": 1416896981335, "tags": [], "relations": {}, "dateAdded": "2014-11-25T06:30:13Z", "dateModified": "2014-11-25T06:30:13Z" } }, { "key": "VNU5TGGC", "version": 31, "library": { "type": "group", "id": 308696, "name": "ALS 333 - Team Groot", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/308696/items/VNU5TGGC", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot/items/VNU5TGGC", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2055809, "username": "Aster123", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/aster123", "type": "text/html" } } }, "parsedDate": "2009-12-15", "numChildren": 1 }, "data": { "key": "VNU5TGGC", "version": 31, "itemType": "newspaperArticle", "title": "'Tree man' new pictures: Dede Koswara continues treatment in Indonesia", "creators": [], "abstractNote": "'Tree man' Dede Koswara continues treatment for his growths in Indonesia.", "publicationTitle": "", "publisher": "", "place": "", "date": "12/15/2009", "volume": "", "issue": "", "edition": "", "section": "", "pages": "", "ISSN": "", "DOI": "", "citationKey": "", "url": "http://www.telegraph.co.uk/news/picturegalleries/howaboutthat/6818324/Tree-man-new-pictures-Dede-Koswara-continues-treatment-in-Indonesia.html?image=9", "accessDate": "2014-11-25T06:29:38Z", "archive": "", "archiveLocation": "", "shortTitle": "'Tree man' new pictures", "language": "", "libraryCatalog": "www.telegraph.co.uk", "callNumber": "6818324", "rights": "", "extra": "", "tags": [ { "tag": "How about that", "type": 1 }, { "tag": "News", "type": 1 }, { "tag": "Picture Galleries", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2014-11-25T06:30:13Z", "dateModified": "2014-11-25T06:30:13Z" } }, { "key": "SC9542T4", "version": 30, "library": { "type": "group", "id": 308696, "name": "ALS 333 - Team Groot", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/308696/items/SC9542T4", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot/items/SC9542T4", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/308696/items/G57HEXIH", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2055809, "username": "Aster123", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/aster123", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "SC9542T4", "version": 30, "parentItem": "G57HEXIH", "itemType": "attachment", "linkMode": "imported_url", "title": "1881.full.pdf", "accessDate": "2014-11-25T03:53:16Z", "url": "http://vir.sgmjournals.org/content/84/7/1881.full.pdf", "note": "", "contentType": "application/pdf", "charset": "", "filename": "1881.full.pdf", "md5": "44edd178bebc07b5176aca4f74a6d054", "mtime": 1416887596412, "tags": [], "relations": {}, "dateAdded": "2014-11-25T03:53:16Z", "dateModified": "2014-11-25T03:53:22Z" } }, { "key": "G57HEXIH", "version": 29, "library": { "type": "group", "id": 308696, "name": "ALS 333 - Team Groot", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/308696/items/G57HEXIH", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot/items/G57HEXIH", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2055809, "username": "Aster123", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/aster123", "type": "text/html" } } }, "creatorSummary": "Antonsson", "parsedDate": "2003-07-01", "numChildren": 1 }, "data": { "key": "G57HEXIH", "version": 29, "itemType": "journalArticle", "title": "Prevalence and type spectrum of human papillomaviruses in healthy skin samples collected in three continents", "creators": [ { "creatorType": "author", "firstName": "A.", "lastName": "Antonsson" } ], "abstractNote": "", "publicationTitle": "Journal of General Virology", "publisher": "", "place": "", "date": "2003-07-01", "volume": "84", "issue": "7", "section": "", "partNumber": "", "partTitle": "", "pages": "1881-1886", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1099/vir.0.18836-0", "citationKey": "", "url": "http://vir.sgmjournals.org/cgi/doi/10.1099/vir.0.18836-0", "accessDate": "2014-11-25T03:53:21Z", "PMID": "", "PMCID": "", "ISSN": "0022-1317, 1465-2099", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-11-25T03:53:21Z", "dateModified": "2014-11-25T03:53:21Z" } }, { "key": "H6EUKU74", "version": 28, "library": { "type": "group", "id": 308696, "name": "ALS 333 - Team Groot", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/308696/items/H6EUKU74", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot/items/H6EUKU74", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2041363, "username": "pnelso14", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/pnelso14", "type": "text/html" } } }, "creatorSummary": "Kinman", "parsedDate": "2013-06-14", "numChildren": 0 }, "data": { "key": "H6EUKU74", "version": 28, "itemType": "webpage", "title": "Sublingual and Buccal Medication Administration", "creators": [ { "creatorType": "author", "firstName": "Tricia", "lastName": "Kinman" } ], "abstractNote": "", "websiteTitle": "Healthline", "websiteType": "Reference Library", "date": "June 14, 2013", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://www.healthline.com/health/sublingual-and-buccal-medication-administration#Definition1", "accessDate": "", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-11-25T03:20:38Z", "dateModified": "2014-11-25T03:20:38Z" } }, { "key": "86BU2QAN", "version": 28, "library": { "type": "group", "id": 308696, "name": "ALS 333 - Team Groot", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/308696/items/86BU2QAN", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot/items/86BU2QAN", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2041363, "username": "pnelso14", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/pnelso14", "type": "text/html" } } }, "creatorSummary": "Standford", "numChildren": 0 }, "data": { "key": "86BU2QAN", "version": 28, "itemType": "webpage", "title": "Human Papillomavirus- Serotype 5 (HPV-5)", "creators": [ { "creatorType": "author", "firstName": "", "lastName": "Standford" } ], "abstractNote": "", "websiteTitle": "Human Papillomavirus- Serotype 5 (HPV-5)", "websiteType": "College Site", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://web.stanford.edu/group/virus/pox/2000/HPV5.html", "accessDate": "", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-11-25T03:20:38Z", "dateModified": "2014-11-25T03:20:38Z" } }, { "key": "8NUCHNZU", "version": 22, "library": { "type": "group", "id": 308696, "name": "ALS 333 - Team Groot", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/308696/items/8NUCHNZU", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot/items/8NUCHNZU", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2055809, "username": "Aster123", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/aster123", "type": "text/html" } } }, "creatorSummary": "SAYER A and SCHWEIG J", "parsedDate": "1942-08-01", "numChildren": 0 }, "data": { "key": "8NUCHNZU", "version": 22, "itemType": "journalArticle", "title": "Epidermodysplasia verruciformis (lewandowsky-lutz): Report of a case with all the essential features", "creators": [ { "creatorType": "author", "name": "SAYER A" }, { "creatorType": "author", "name": "SCHWEIG J" } ], "abstractNote": "Epidermodysplasia verruciformis was first described by Lewandowsky and Lutz1 in 1922. Since then nearly 50 cases purporting to be instances of this disease have been recorded in the literature. It is considered to be a genodermatosis and is essentially an inherited tendency of the upper layers of the epidermis to undergo a peculiar dysplasia.Up to 1939, 42 probable cases of epidermodysplasia verruciformis were recorded in the literature. The first 24 of these cases were tabulated by Mashkilleison2 in 1928, and 18 other cases subsequently reported were tabulated by Sullivan and Ellis3 in 1939. It is noteworthy that about 40 per cent of the patients whose cases were reported were Japanese and Russian Asiatics, and the rest, except 1, were Europeans. In a critical analysis of these cases it was shown that in many instances the acceptance of the diagnosis was often based on either inconclusive evidence", "publicationTitle": "Archives of Dermatology and Syphilology", "publisher": "", "place": "", "date": "August 1, 1942", "volume": "46", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "234-241", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Arch Derm Syphilol", "DOI": "10.1001/archderm.1942.01500140050007", "citationKey": "", "url": "http://dx.doi.org/10.1001/archderm.1942.01500140050007", "accessDate": "2014-11-25T01:58:50Z", "PMID": "", "PMCID": "", "ISSN": "0096-6029", "archive": "", "archiveLocation": "", "shortTitle": "Epidermodysplasia verruciformis (lewandowsky-lutz)", "language": "", "libraryCatalog": "Silverchair", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-11-25T01:58:50Z", "dateModified": "2014-11-25T01:58:50Z" } }, { "key": "XJ2TR5PT", "version": 19, "library": { "type": "group", "id": 308696, "name": "ALS 333 - Team Groot", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/308696/items/XJ2TR5PT", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot/items/XJ2TR5PT", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/308696/items/96V3T9SI", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2031344, "username": "olved", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/olved", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "XJ2TR5PT", "version": 19, "parentItem": "96V3T9SI", "itemType": "attachment", "linkMode": "imported_file", "title": "Seoane-Vazquez et al. - 2008 - Incentives for orphan drug research and developmen.pdf", "accessDate": "", "url": "", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Seoane-Vazquez et al. - 2008 - Incentives for orphan drug research and developmen.pdf", "md5": "b93c509c6b84bde8d45a62fc2dceed51", "mtime": 1416880081905, "tags": [], "relations": {}, "dateAdded": "2014-11-25T01:47:42Z", "dateModified": "2014-11-25T01:48:02Z" } }, { "key": "96V3T9SI", "version": 18, "library": { "type": "group", "id": 308696, "name": "ALS 333 - Team Groot", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/308696/items/96V3T9SI", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot/items/96V3T9SI", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2031344, "username": "olved", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/olved", "type": "text/html" } } }, "creatorSummary": "Seoane-Vazquez et al.", "parsedDate": "2008", "numChildren": 1 }, "data": { "key": "96V3T9SI", "version": 18, "itemType": "journalArticle", "title": "Incentives for orphan drug research and development in the United States", "creators": [ { "creatorType": "author", "firstName": "Enrique", "lastName": "Seoane-Vazquez" }, { "creatorType": "author", "firstName": "Rosa", "lastName": "Rodriguez-Monguio" }, { "creatorType": "author", "firstName": "Sheryl L", "lastName": "Szeinbach" }, { "creatorType": "author", "firstName": "Jay", "lastName": "Visaria" } ], "abstractNote": "", "publicationTitle": "Orphanet Journal of Rare Diseases", "publisher": "", "place": "", "date": "2008", "volume": "3", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "33", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1186/1750-1172-3-33", "citationKey": "", "url": "http://www.ojrd.com/content/3/1/33", "accessDate": "2014-11-25T01:47:46Z", "PMID": "", "PMCID": "", "ISSN": "1750-1172", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-11-25T01:47:46Z", "dateModified": "2014-11-25T01:47:46Z" } }, { "key": "FB6FAIFA", "version": 17, "library": { "type": "group", "id": 308696, "name": "ALS 333 - Team Groot", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/308696/items/FB6FAIFA", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot/items/FB6FAIFA", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/308696/items/ZMW3QEPD", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2055809, "username": "Aster123", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/aster123", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "FB6FAIFA", "version": 17, "parentItem": "ZMW3QEPD", "itemType": "attachment", "linkMode": "imported_url", "title": "20-5-173.pdf", "accessDate": "2014-11-25T01:42:50Z", "url": "https://www.iasusa.org/sites/default/files/tam/20-5-173.pdf", "note": "", "contentType": "application/pdf", "charset": "", "filename": "20-5-173.pdf", "md5": "0762a918e1199cefdf25fef8423a65b3", "mtime": 1416879782303, "tags": [], "relations": {}, "dateAdded": "2014-11-25T01:43:46Z", "dateModified": "2014-11-25T01:43:46Z" } }, { "key": "ZMW3QEPD", "version": 16, "library": { "type": "group", "id": 308696, "name": "ALS 333 - Team Groot", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/308696/items/ZMW3QEPD", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot/items/ZMW3QEPD", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2055809, "username": "Aster123", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/aster123", "type": "text/html" } } }, "creatorSummary": "Kaushal et al.", "parsedDate": "2012", "numChildren": 1 }, "data": { "key": "ZMW3QEPD", "version": 16, "itemType": "journalArticle", "title": "Epidermodysplasia Verruciformis in an HIV-Infected Man: A Case Report and Review of the Literature", "creators": [ { "creatorType": "author", "firstName": "Amit", "lastName": "Kaushal" }, { "creatorType": "author", "firstName": "Shane", "lastName": "Silver" }, { "creatorType": "author", "firstName": "Ken", "lastName": "Kasper" }, { "creatorType": "author", "firstName": "Alberto", "lastName": "Severini" }, { "creatorType": "author", "firstName": "Sate", "lastName": "Hamza" }, { "creatorType": "author", "firstName": "Yoav", "lastName": "Keynan" } ], "abstractNote": "", "publicationTitle": "Topics in antiviral medicine", "publisher": "", "place": "", "date": "2012", "volume": "20", "issue": "5", "section": "", "partNumber": "", "partTitle": "", "pages": "173–179", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "https://www.iasusa.org/sites/default/files/tam/20-5-173.pdf", "accessDate": "2014-11-25T01:43:33Z", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "Epidermodysplasia Verruciformis in an HIV-Infected Man", "language": "", "libraryCatalog": "Google Scholar", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-11-25T01:43:46Z", "dateModified": "2014-11-25T01:43:46Z" } }, { "key": "E56BPREV", "version": 15, "library": { "type": "group", "id": 308696, "name": "ALS 333 - Team Groot", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/308696/items/E56BPREV", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot/items/E56BPREV", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/308696/items/4VJQZC84", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2031344, "username": "olved", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/olved", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "E56BPREV", "version": 15, "parentItem": "4VJQZC84", "itemType": "attachment", "linkMode": "imported_file", "title": "DiMasi et al. - 2003 - The price of innovation new estimates of drug dev.pdf", "accessDate": "", "url": "", "note": "", "contentType": "application/pdf", "charset": "", "filename": "DiMasi et al. - 2003 - The price of innovation new estimates of drug dev.pdf", "md5": "e6b3c86deb012181e4edb843bfae0f44", "mtime": 1416878601114, "tags": [], "relations": {}, "dateAdded": "2014-11-25T01:23:05Z", "dateModified": "2014-11-25T01:23:22Z" } }, { "key": "4VJQZC84", "version": 14, "library": { "type": "group", "id": 308696, "name": "ALS 333 - Team Groot", "links": { "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/308696/items/4VJQZC84", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/als_333_-_team_groot/items/4VJQZC84", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2031344, "username": "olved", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/olved", "type": "text/html" } } }, "creatorSummary": "DiMasi et al.", "parsedDate": "2003", "numChildren": 1 }, "data": { "key": "4VJQZC84", "version": 14, "itemType": "journalArticle", "title": "The price of innovation: new estimates of drug development costs", "creators": [ { "creatorType": "author", "firstName": "Joseph A", "lastName": "DiMasi" }, { "creatorType": "author", "firstName": "Ronald W", "lastName": "Hansen" }, { "creatorType": "author", "firstName": "Henry G", "lastName": "Grabowski" } ], "abstractNote": "", "publicationTitle": "Journal of Health Economics", "publisher": "", "place": "", "date": "3/2003", "volume": "22", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "151-185", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1016/S0167-6296(02)00126-1", "citationKey": "", "url": "http://linkinghub.elsevier.com/retrieve/pii/S0167629602001261", "accessDate": "2014-11-25T01:23:14Z", "PMID": "", "PMCID": "", "ISSN": "01676296", "archive": "", "archiveLocation": "", "shortTitle": "The price of innovation", "language": "en", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-11-25T01:23:14Z", "dateModified": "2014-11-25T01:23:14Z" } } ]