[
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            "creatorSummary": "Shirakawa et al.",
            "parsedDate": "1989-03",
            "numChildren": 0
        },
        "data": {
            "key": "QXRDQNN9",
            "version": 2,
            "itemType": "journalArticle",
            "title": "Interleukin 1 and cyclic AMP induce kappa immunoglobulin light-chain expression via activation of an NF-kappa B-like DNA-binding protein",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "F",
                    "lastName": "Shirakawa"
                },
                {
                    "creatorType": "author",
                    "firstName": "M",
                    "lastName": "Chedid"
                },
                {
                    "creatorType": "author",
                    "firstName": "J",
                    "lastName": "Suttles"
                },
                {
                    "creatorType": "author",
                    "firstName": "B A",
                    "lastName": "Pollok"
                },
                {
                    "creatorType": "author",
                    "firstName": "S B",
                    "lastName": "Mizel"
                }
            ],
            "abstractNote": "Interleukin 1 (IL-1) induces the synthesis of kappa immunoglobulin light chains and the expression of surface immunoglobulin in the murine pre-B-cell line 70Z/3 (J. G. Giri, P. W. Kincade, and S. B. Mizel, J. Immunol. 132:223-228, 1984). In the present study, we found that these effects of IL-1 are mimicked by cyclic AMP (cAMP) analogs and cAMP-elevating drugs. The induction of kappa immunoglobulin light-chain gene expression by IL-1 was associated with an increase in intracellular cAMP levels. Incubation of 70Z/3 cells with IL-1 or cAMP resulted in the activation of the kappa immunoglobulin enhancer, as detected by the induction of chloramphenicol acetyltransferase (CAT) in cells transfected with a kappa enhancer-CAT expression plasmid. In contrast, CAT plasmids lacking a kappa immunoglobulin enhancer were inactive in the presence of IL-1 or cAMP. Furthermore, IL-1 and cAMP analogs and inducers were found to induce the activation of a NF-kappa B-like DNA-binding protein that exhibited specificity for the kappa immunoglobulin enhancer. These results suggest that cAMP may play an important role as a second messenger for IL-1 in the induction of kappa immunoglobulin light-chain synthesis in pre-B cells via the activation of a DNA-binding protein that is similar or identical to NF-kappa B.",
            "publicationTitle": "Molecular and Cellular Biology",
            "publisher": "",
            "place": "",
            "date": "Mar 1989",
            "volume": "9",
            "issue": "3",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "959-964",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "Mol. Cell. Biol",
            "DOI": "",
            "citationKey": "",
            "url": "http://www.ncbi.nlm.nih.gov.gate2.inist.fr/pubmed/2542770",
            "accessDate": "2010-01-15T10:44:39Z",
            "PMID": "",
            "PMCID": "",
            "ISSN": "0270-7306",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "",
            "language": "",
            "libraryCatalog": "NCBI PubMed",
            "callNumber": "",
            "rights": "",
            "extra": "PMID: 2542770",
            "tags": [
                {
                    "tag": "Animals",
                    "type": 1
                },
                {
                    "tag": "B-Lymphocytes",
                    "type": 1
                },
                {
                    "tag": "Cell Line",
                    "type": 1
                },
                {
                    "tag": "Cyclic AMP",
                    "type": 1
                },
                {
                    "tag": "DNA-Binding Proteins",
                    "type": 1
                },
                {
                    "tag": "Enhancer Elements, Genetic",
                    "type": 1
                },
                {
                    "tag": "Gene Expression Regulation",
                    "type": 1
                },
                {
                    "tag": "Genes, Immunoglobulin",
                    "type": 1
                },
                {
                    "tag": "Immunoglobulin kappa-Chains",
                    "type": 1
                },
                {
                    "tag": "Interleukin-1",
                    "type": 1
                },
                {
                    "tag": "Mice",
                    "type": 1
                },
                {
                    "tag": "NF-kappa B",
                    "type": 1
                },
                {
                    "tag": "Transcription Factors",
                    "type": 1
                }
            ],
            "collections": [],
            "relations": {},
            "dateAdded": "2013-05-16T10:43:12Z",
            "dateModified": "2013-05-16T10:43:12Z"
        }
    }
]