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            "creatorSummary": "Osamura",
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            "title": "Endocrine Pathology: SY08-2 SURGICAL ENDOCRINE PATHOLOGY DIAGNOSTIC UPDATE: NEUROENDOCRINE TUMORS",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Robert Y.",
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            "abstractNote": "In our daily practice of surgical pathology, neuroendcorine tumors are not very frequent specimens, but do get them from time to time and we have to be prepared to give appropriate diagnosis and information, both prognostic and predictive. In this lecture, gastro-entero-pancreatic neuroendocrine tumors (GEPNET) are discussed based on the WHO classification 2010. The tumors are designated as neuroendocrine neoplasms (NEN) and are subdivided into neuroendocrine tumor (NET) Grade (G)1, G2, neuroendocrine carcinoma (NEC) and mixed adenoneuroendocrine carcinoma (MANEC). The classification of NET G1, NET G2, NEC is done by the proliferative activities of the tumor cells, i.e., either mitotic index or Ki-67 index (%). This classification suggests prognostic and predictive information, i.e., the better prognosis and biotherapy for NET G1, NET G and the poorer prognosis and chemotherapy for NEC. TNM and vascular invasion are also important factors which should be included in the pathology report. Immunohistochemistry for neuroendocrine markers and somatostatin receptor 2 (SSTR2) are performed for definitive diagnosis and octreotide therapy. Mutational analysis is also recommended in the suspected cases for MEN1 and VHL. This lecture emphasizes what to look for and how to make diagnosis of neuroendocrine tumors.",
            "publicationTitle": "Pathology",
            "publisher": "",
            "place": "",
            "date": "Oct 2014",
            "volume": "46 Suppl 2",
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            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "S14",
            "series": "",
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            "seriesText": "",
            "journalAbbreviation": "Pathology",
            "DOI": "10.1097/01.PAT.0000454097.75997.2d",
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            "PMID": "",
            "PMCID": "",
            "ISSN": "1465-3931",
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            "shortTitle": "Endocrine Pathology",
            "language": "eng",
            "libraryCatalog": "NCBI PubMed",
            "callNumber": "",
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            "extra": "PMID: 25188067",
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            "dateAdded": "2014-09-15T21:10:59Z",
            "dateModified": "2014-09-15T21:10:59Z"
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            "creatorSummary": "Jiang et al.",
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            "title": "Decreased RGS6 expression is associated with poor prognosis in pancreatic cancer patients",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Nan",
                    "lastName": "Jiang"
                },
                {
                    "creatorType": "author",
                    "firstName": "Ruihua",
                    "lastName": "Xue"
                },
                {
                    "creatorType": "author",
                    "firstName": "Fangfang",
                    "lastName": "Bu"
                },
                {
                    "creatorType": "author",
                    "firstName": "Xin",
                    "lastName": "Tong"
                },
                {
                    "creatorType": "author",
                    "firstName": "Jiankun",
                    "lastName": "Qiang"
                },
                {
                    "creatorType": "author",
                    "firstName": "Rong",
                    "lastName": "Liu"
                }
            ],
            "abstractNote": "Regulator of G-protein signaling 6 (RGS6), a member of a family of RGS proteins, has been reported to involve in multiple processes during tumor development. However, its role in pancreatic cancer has not been studied yet. In this study, we aimed to investigate the expression of RGS6 in pancreatic cancer and its role in predicting outcomes of patients with pancreatic cancer. We first measured the expression of RGS6 mRNA in 20 cases of tumor tissues and matched adjacent non-tumorous tissues by quantitative real-time PCR and examined RGS6 protein by immunohistochemistry in tissue microarrays containing 90 tumor and 90 paired adjacent non-tumor tissues. Decreased RGS6 mRNA detected in primary tumor, compared with their non-tumor counterparts. In addition, decreased RGS6 protein expression was associated with tumor differentiation (P = 0.027), pT classification (P = 0.034), smoking status (P = 0.041) and a poor survival (P = 0.007). Cox proportional hazards regression modeling analysis revealed that lymph node metastasis (P = 0.001; hazard ratio, 2.347, 95% CI, 1.387-3.972), tumor differentiation (P = 0.015; hazard ratio, 0.505, 95% CI, 0.291-0.876) and RGS6 expression (P = 0.048; hazard ratio, 0.567, 95% CI, 0.324-0.994) were three independent prognostic factors. Taken together, these date demonstrate that RGS6 decreases in tumor tissue and may serve as a novel biomarker for outcomes in pancreatic cancer patients and be a potential therapeutic target potential therapeutic target.",
            "publicationTitle": "International Journal of Clinical and Experimental Pathology",
            "publisher": "",
            "place": "",
            "date": "2014",
            "volume": "7",
            "issue": "7",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "4120-4127",
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            "journalAbbreviation": "Int J Clin Exp Pathol",
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            "PMCID": "",
            "ISSN": "1936-2625",
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            "language": "eng",
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            "extra": "PMID: 25120791 \nPMCID: PMC4129026",
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            "dateAdded": "2014-09-15T21:10:59Z",
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