[ { "key": "NQA43QMD", "version": 26, "library": { "type": "group", "id": 287487, "name": "WP4-Mathematical Modelling", "links": { "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/287487/items/NQA43QMD", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling/items/NQA43QMD", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1863873, "username": "KleaPan", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kleapan", "type": "text/html" } } }, "creatorSummary": "Debray et al.", "parsedDate": "2015", "numChildren": 0 }, "data": { "key": "NQA43QMD", "version": 26, "itemType": "journalArticle", "title": "GetReal in Individual Participant Data (IPD) Meta-Analysis: A review of the methodology", "creators": [ { "creatorType": "author", "firstName": "T. P. A", "lastName": "Debray" }, { "creatorType": "author", "firstName": "K. G. M", "lastName": "Moons" }, { "creatorType": "author", "firstName": "G", "lastName": "van Valkenhoef" }, { "creatorType": "author", "firstName": "O", "lastName": "Efthimiou" }, { "creatorType": "author", "firstName": "N", "lastName": "Hummel" }, { "creatorType": "author", "firstName": "R. H. H", "lastName": "Groenwold" }, { "creatorType": "author", "firstName": "J. B", "lastName": "Reitsma" } ], "abstractNote": "", "publicationTitle": "Journal of Research Synthesis Methods", "publisher": "", "place": "", "date": "2015", "volume": "Submitted", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-07-29T14:22:38Z", "dateModified": "2015-07-30T14:15:47Z" } }, { "key": "MJ2NHEA8", "version": 26, "library": { "type": "group", "id": 287487, "name": "WP4-Mathematical Modelling", "links": { "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/287487/items/MJ2NHEA8", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling/items/MJ2NHEA8", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1863873, "username": "KleaPan", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kleapan", "type": "text/html" } } }, "creatorSummary": "Efthimiou et al.", "parsedDate": "2015", "numChildren": 0 }, "data": { "key": "MJ2NHEA8", "version": 26, "itemType": "journalArticle", "title": "GetReal in Network Meta-Analysis: A review of the methodology", "creators": [ { "creatorType": "author", "firstName": "O", "lastName": "Efthimiou" }, { "creatorType": "author", "firstName": "T. P. A", "lastName": "Debray" }, { "creatorType": "author", "firstName": "G", "lastName": "van Valkenhoef" }, { "creatorType": "author", "firstName": "S", "lastName": "Trelle" }, { "creatorType": "author", "firstName": "K", "lastName": "Panayidou" }, { "creatorType": "author", "firstName": "K. G. M", "lastName": "Moons" }, { "creatorType": "author", "firstName": "J. B", "lastName": "Reitsma" }, { "creatorType": "author", "firstName": "A", "lastName": "Shang" }, { "creatorType": "author", "firstName": "G", "lastName": "Salanti" }, { "creatorType": "author", "firstName": "", "lastName": "on behalf of the GetReal methods review group" } ], "abstractNote": "", "publicationTitle": "Journal of Research Synthesis Methods", "publisher": "", "place": "", "date": "2015", "volume": "Submitted", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-07-29T13:50:26Z", "dateModified": "2015-07-30T14:15:42Z" } }, { "key": "7B8V2XMD", "version": 18, "library": { "type": "group", "id": 287487, "name": "WP4-Mathematical Modelling", "links": { "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/287487/items/7B8V2XMD", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling/items/7B8V2XMD", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1863873, "username": "KleaPan", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kleapan", "type": "text/html" } } }, "creatorSummary": "Spiegelhalter et al.", "parsedDate": "2003-12-09", "numChildren": 0 }, "data": { "key": "7B8V2XMD", "version": 18, "itemType": "book", "title": "Bayesian Approaches to Clinical Trials and Health-Care Evaluation: Spiegelhalter/Clinical Trials and Health-Care Evaluation", "creators": [ { "creatorType": "author", "firstName": "David J.", "lastName": "Spiegelhalter" }, { "creatorType": "author", "firstName": "Keith R.", "lastName": "Abrams" }, { "creatorType": "author", "firstName": "Jonathan P.", "lastName": "Myles" } ], "abstractNote": "", "series": "", "seriesNumber": "", "volume": "", "numberOfVolumes": "", "edition": "", "date": "2003-12-09", "publisher": "John Wiley & Sons, Ltd", "place": "Chichester, UK", "originalDate": "", "originalPublisher": "", "originalPlace": "", "format": "", "numPages": "", "ISBN": "9780470092606 9780471499756", "DOI": "", "citationKey": "", "url": "http://doi.wiley.com/10.1002/0470092602", "accessDate": "2015-07-28T15:29:46Z", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "Bayesian Approaches to Clinical Trials and Health-Care Evaluation", "language": "", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-07-28T15:29:46Z", "dateModified": "2015-07-28T15:29:46Z" } }, { "key": "XM8QAIBN", "version": 18, "library": { "type": "group", "id": 287487, "name": "WP4-Mathematical Modelling", "links": { "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/287487/items/XM8QAIBN", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling/items/XM8QAIBN", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/287487/items/R6PTUCFI", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1863873, "username": "KleaPan", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kleapan", "type": "text/html" } } } }, "data": { "key": "XM8QAIBN", "version": 18, "parentItem": "R6PTUCFI", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2015-07-28T15:25:09Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/18480115", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-07-28T15:25:09Z", "dateModified": "2015-07-28T15:25:09Z" } }, { "key": "R6PTUCFI", "version": 18, "library": { "type": "group", "id": 287487, "name": "WP4-Mathematical Modelling", "links": { "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/287487/items/R6PTUCFI", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling/items/R6PTUCFI", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1863873, "username": "KleaPan", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kleapan", "type": "text/html" } } }, "creatorSummary": "Vrijens et al.", "parsedDate": "2008-05-17", "numChildren": 1 }, "data": { "key": "R6PTUCFI", "version": 18, "itemType": "journalArticle", "title": "Adherence to prescribed antihypertensive drug treatments: longitudinal study of electronically compiled dosing histories", "creators": [ { "creatorType": "author", "firstName": "Bernard", "lastName": "Vrijens" }, { "creatorType": "author", "firstName": "Gäbor", "lastName": "Vincze" }, { "creatorType": "author", "firstName": "Paulus", "lastName": "Kristanto" }, { "creatorType": "author", "firstName": "John", "lastName": "Urquhart" }, { "creatorType": "author", "firstName": "Michel", "lastName": "Burnier" } ], "abstractNote": "OBJECTIVE: To describe characteristics of dosing history in patients prescribed a once a day antihypertensive medication.\nDESIGN: Longitudinal database study.\nSETTING: Clinical studies archived in database for 1989-2006.\nPARTICIPANTS: Patients who participated in the studies whose dosing histories were available through electronic monitoring.\nMAIN OUTCOME MEASURES: Persistence with prescribed antihypertensive treatment and execution of their once a day drug dosing regimens.\nRESULTS: The database contained dosing histories of 4783 patients with hypertension. The data came from 21 phase IV clinical studies, with lengths ranging from 30 to 330 days and involving 43 different antihypertensive drugs, including angiotensin II receptor blockers (n=2088), calcium channel blockers (n=937), angiotensin converting enzyme inhibitors (n=665), beta blockers (n=195), and diuretics (n=155). About half of the patients who were prescribed an antihypertensive drug had stopped taking it within one year. On any day, patients who were still engaged with the drug dosing regimen omitted about 10% of the scheduled doses: 42% of these omissions were of a single day's dose, whereas 43% were part of a sequence of several days (three or more days-that is, drug \"holidays\"). Almost half of the patients had at least one drug holiday a year. The likelihood that a patient would discontinue treatment early was inversely related to the quality of his or her daily execution of the dosing regimen.\nCONCLUSIONS: Early discontinuation of treatment and suboptimal daily execution of the prescribed regimens are the most common facets of poor adherence with once a day antihypertensive drug treatments. The shortfalls in drug exposure that these dosing errors create might be a common cause of low rates of blood pressure control and high variability in responses to prescribed antihypertensive drugs.", "publicationTitle": "BMJ (Clinical research ed.)", "publisher": "", "place": "", "date": "May 17, 2008", "volume": "336", "issue": "7653", "section": "", "partNumber": "", "partTitle": "", "pages": "1114-1117", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "BMJ", "DOI": "10.1136/bmj.39553.670231.25", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1756-1833", "archive": "", "archiveLocation": "", "shortTitle": "Adherence to prescribed antihypertensive drug treatments", "language": "eng", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "PMID: 18480115\nPMCID: PMC2386633", "tags": [ { "tag": "Antihypertensive Agents", "type": 1 }, { "tag": "Cohort Studies", "type": 1 }, { "tag": "Drug Administration Schedule", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Hypertension", "type": 1 }, { "tag": "Longitudinal Studies", "type": 1 }, { "tag": "Medical Records Systems, Computerized", "type": 1 }, { "tag": "Patient Compliance", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2015-07-28T15:25:09Z", "dateModified": "2015-07-28T15:25:09Z" } }, { "key": "F33H5J48", "version": 18, "library": { "type": "group", "id": 287487, "name": "WP4-Mathematical Modelling", "links": { "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/287487/items/F33H5J48", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling/items/F33H5J48", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1863873, "username": "KleaPan", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kleapan", "type": "text/html" } } }, "creatorSummary": "Altman and Royston", "parsedDate": "2000-02-29", "numChildren": 1 }, "data": { "key": "F33H5J48", "version": 18, "itemType": "journalArticle", "title": "What do we mean by validating a prognostic model?", "creators": [ { "creatorType": "author", "firstName": "D. G.", "lastName": "Altman" }, { "creatorType": "author", "firstName": "P.", "lastName": "Royston" } ], "abstractNote": "Prognostic models are used in medicine for investigating patient outcome in relation to patient and disease characteristics. Such models do not always work well in practice, so it is widely recommended that they need to be validated. The idea of validating a prognostic model is generally taken to mean establishing that it works satisfactorily for patients other than those from whose data it was derived. In this paper we examine what is meant by validation and review why it is necessary. We consider how to validate a model and suggest that it is desirable to consider two rather different aspects - statistical and clinical validity - and examine some general approaches to validation. We illustrate the issues using several case studies.", "publicationTitle": "Statistics in Medicine", "publisher": "", "place": "", "date": "Feb 29, 2000", "volume": "19", "issue": "4", "section": "", "partNumber": "", "partTitle": "", "pages": "453-473", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Stat Med", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0277-6715", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "PMID: 10694730", "tags": [ { "tag": "Accidental Falls", "type": 1 }, { "tag": "Aged", "type": 1 }, { "tag": "Asthma", "type": 1 }, { "tag": "Craniocerebral Trauma", "type": 1 }, { "tag": "Decision Support Techniques", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Myocardial Infarction", "type": 1 }, { "tag": "Prognosis", "type": 1 }, { "tag": "Prospective Studies", "type": 1 }, { "tag": "Reproducibility of Results", "type": 1 }, { "tag": "Retrospective Studies", "type": 1 }, { "tag": "Risk Factors", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2015-07-06T13:38:49Z", "dateModified": "2015-07-06T13:38:49Z" } }, { "key": "ZQ82EAQE", "version": 18, "library": { "type": "group", "id": 287487, "name": "WP4-Mathematical Modelling", "links": { "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/287487/items/ZQ82EAQE", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling/items/ZQ82EAQE", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/287487/items/F33H5J48", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1863873, "username": "KleaPan", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kleapan", "type": "text/html" } } } }, "data": { "key": "ZQ82EAQE", "version": 18, "parentItem": "F33H5J48", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2015-07-06T13:38:49Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/10694730", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-07-06T13:38:49Z", "dateModified": "2015-07-06T13:38:49Z" } }, { "key": "S8N9TDXI", "version": 18, "library": { "type": "group", "id": 287487, "name": "WP4-Mathematical Modelling", "links": { "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/287487/items/S8N9TDXI", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling/items/S8N9TDXI", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1863873, "username": "KleaPan", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kleapan", "type": "text/html" } } }, "creatorSummary": "Lee and Honavar", "numChildren": 2 }, "data": { "key": "S8N9TDXI", "version": 18, "itemType": "book", "title": "m-Transportability: Transportability of a Causal Effect from Multiple Environments", "creators": [ { "creatorType": "author", "firstName": "Sanghack", "lastName": "Lee" }, { "creatorType": "author", "firstName": "Vasant", "lastName": "Honavar" } ], "abstractNote": "{shlee, honavar} at iastate.edu We study m-transportability, a generalization of transportability, which offers a license to use causal information elicited from experiments and observations in m ≥ 1 source environments to estimate a causal effect in a given target environment. We provide a novel characterization of m-transportability that directly exploits the completeness of docalculus to obtain the necessary and sufficient conditions for m-transportability. 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Pearl and Bareinboim (2011) established a complete characterization for such transfer between two domains, a source and a target, and this paper generalizes their results to multiple heterogeneous domains. It establishes a necessary and sufficient condition for deciding when effects in the target domain are estimable from both statistical and causal information transferred from the experiments in the source domains. The paper further provides a complete algorithm for computing the transport formula, that is, a way of fusing observational and experimental information to synthesize an unbiased estimate of the desired effects.", "reportNumber": "ID 2343825", "reportType": "SSRN Scholarly Paper", "institution": "Social Science Research Network", "place": "Rochester, NY", "date": "2013/07/22", "seriesTitle": "", "seriesNumber": "", "pages": "", "DOI": "", "ISBN": "", "citationKey": "", "url": "http://papers.ssrn.com/abstract=2343825", "accessDate": "2015-06-30T11:16:44Z", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "Meta-Transportability of Causal Effects", "language": "", "libraryCatalog": "papers.ssrn.com", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Elias Bareinboim", "type": 1 }, { "tag": "Judea Pearl", "type": 1 }, { "tag": "Meta-Transportability of Causal Effects: A Formal Approach", "type": 1 }, { "tag": "SSRN", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2015-06-30T11:16:44Z", "dateModified": "2015-06-30T11:16:44Z" } }, { "key": "HJKP38EJ", "version": 18, "library": { "type": "group", "id": 287487, "name": "WP4-Mathematical Modelling", "links": { "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/287487/items/HJKP38EJ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling/items/HJKP38EJ", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/287487/items/PMMMP7WC", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1863873, "username": "KleaPan", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kleapan", "type": "text/html" } } } }, "data": { "key": "HJKP38EJ", "version": 18, "parentItem": "PMMMP7WC", "itemType": "attachment", "linkMode": "linked_url", "title": "Amazon.com Link", "accessDate": "2015-06-29T15:03:30Z", "url": "http://www.amazon.com/System-Identification-Parameter-State-Estimation/dp/0471249807", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-06-29T15:03:30Z", "dateModified": "2015-06-29T15:03:30Z" } }, { "key": "PMMMP7WC", "version": 18, "library": { "type": "group", "id": 287487, "name": "WP4-Mathematical Modelling", "links": { "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/287487/items/PMMMP7WC", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling/items/PMMMP7WC", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1863873, "username": "KleaPan", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kleapan", "type": "text/html" } } }, "creatorSummary": "Eykhoff", "parsedDate": "1974-05-23", "numChildren": 1 }, "data": { "key": "PMMMP7WC", "version": 18, "itemType": "book", "title": "System Identification Parameter and State Estimation", "creators": [ { "creatorType": "author", "firstName": "P.", "lastName": "Eykhoff" } ], "abstractNote": "Book by Eykhoff, P.", "series": "", "seriesNumber": "", "volume": "", "numberOfVolumes": "", "edition": "1 edition", "date": "May 23, 1974", "publisher": "Wiley", "place": "London ; New York etc.", "originalDate": "", "originalPublisher": "", "originalPlace": "", "format": "", "numPages": "555", "ISBN": "9780471249801", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "English", "libraryCatalog": "Amazon", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-06-29T15:03:30Z", "dateModified": "2015-06-29T15:03:30Z" } }, { "key": "MBDABFNJ", "version": 18, "library": { "type": "group", "id": 287487, "name": "WP4-Mathematical Modelling", "links": { "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/287487/items/MBDABFNJ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling/items/MBDABFNJ", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/287487/items/KK44BGP5", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1863873, "username": "KleaPan", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kleapan", "type": "text/html" } } } }, "data": { "key": "MBDABFNJ", "version": 18, "parentItem": "KK44BGP5", "itemType": "attachment", "linkMode": "linked_url", "title": "Snapshot", "accessDate": "2015-06-29T14:16:39Z", "url": "http://www.abebooks.com/book-search/isbn/0471249807/used/", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-06-29T14:16:39Z", "dateModified": "2015-06-29T14:16:39Z" } }, { "key": "47JQ82UV", "version": 13, "library": { "type": "group", "id": 287487, "name": "WP4-Mathematical Modelling", "links": { "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/287487/items/47JQ82UV", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling/items/47JQ82UV", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1863873, "username": "KleaPan", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kleapan", "type": "text/html" } } }, "lastModifiedByUser": { "id": 1863147, "username": "exifoqua", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/exifoqua", "type": "text/html" } } }, "creatorSummary": "Schneeweiss et al.", "parsedDate": "2011", "numChildren": 0 }, "data": { "key": "47JQ82UV", "version": 13, "itemType": "journalArticle", "title": "Assessing the comparative effectiveness of newly marketed medications: methodological challenges and implications for drug development", "creators": [ { "creatorType": "author", "firstName": "S.", "lastName": "Schneeweiss" }, { "creatorType": "author", "firstName": "J. J.", "lastName": "Gagne" }, { "creatorType": "author", "firstName": "R. J.", "lastName": "Glynn" }, { "creatorType": "author", "firstName": "M.", "lastName": "Ruhl" }, { "creatorType": "author", "firstName": "J. A.", "lastName": "Rassen" } ], "abstractNote": "", "publicationTitle": "Clinical Pharmacology & Therapeutics", "publisher": "", "place": "", "date": "2011", "volume": "90", "issue": "6", "section": "", "partNumber": "", "partTitle": "", "pages": "777–790", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "http://www.nature.com/clpt/journal/v90/n6/abs/clpt2011235a.html", "accessDate": "2014-11-12T11:57:34Z", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "Assessing the comparative effectiveness of newly marketed medications", "language": "", "libraryCatalog": "Google Scholar", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": { "owl:sameAs": [ "http://zotero.org/groups/264915/items/CQUQGKAE", "http://zotero.org/groups/264915/items/C5IRMUES" ], "dc:replaces": "http://zotero.org/groups/287487/items/WJ6VUTJ9" }, "dateAdded": "2014-11-13T07:48:30Z", "dateModified": "2014-11-13T09:58:20Z" } }, { "key": "3WZ92QXX", "version": 13, "library": { "type": "group", "id": 287487, "name": "WP4-Mathematical Modelling", "links": { "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/287487/items/3WZ92QXX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling/items/3WZ92QXX", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1863873, "username": "KleaPan", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kleapan", "type": "text/html" } } }, "lastModifiedByUser": { "id": 1863147, "username": "exifoqua", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/exifoqua", "type": "text/html" } } }, "creatorSummary": "Mueller et al.", "parsedDate": "2006", "numChildren": 0 }, "data": { "key": "3WZ92QXX", "version": 13, "itemType": "journalArticle", "title": "Development and validation of the Economic Assessment of Glycemic Control and Long-Term Effects of diabetes (EAGLE) model", "creators": [ { "creatorType": "author", "firstName": "Elvira", "lastName": "Mueller" }, { "creatorType": "author", "firstName": "Stefanie", "lastName": "Maxion-Bergemann" }, { "creatorType": "author", "firstName": "Dmitry", "lastName": "Gultyaev" }, { "creatorType": "author", "firstName": "Stefan", "lastName": "Walzer" }, { "creatorType": "author", "firstName": "Nick", "lastName": "Freemantle" }, { "creatorType": "author", "firstName": "Chantal", "lastName": "Mathieu" }, { "creatorType": "author", "firstName": "Bjorn", "lastName": "Bolinder" }, { "creatorType": "author", "firstName": "Robert", "lastName": "Gerber" }, { "creatorType": "author", "firstName": "Marion", "lastName": "Kvasz" }, { "creatorType": "author", "firstName": "Rito", "lastName": "Bergemann" } ], "abstractNote": "", "publicationTitle": "Diabetes technology & therapeutics", "publisher": "", "place": "", "date": "2006", "volume": "8", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "219–236", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "http://online.liebertpub.com/doi/abs/10.1089/dia.2006.8.219", "accessDate": "2014-11-12T11:49:03Z", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "Google Scholar", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": { "owl:sameAs": [ "http://zotero.org/groups/264915/items/TZU24EPK", "http://zotero.org/groups/264915/items/7UAX3S5J" ], "dc:replaces": "http://zotero.org/groups/287487/items/IIN6A744" }, "dateAdded": "2014-11-13T07:48:30Z", "dateModified": "2014-11-13T09:58:19Z" } }, { "key": "P3429M2W", "version": 13, "library": { "type": "group", "id": 287487, "name": "WP4-Mathematical Modelling", "links": { "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/287487/items/P3429M2W", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling/items/P3429M2W", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1863873, "username": "KleaPan", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kleapan", "type": "text/html" } } }, "lastModifiedByUser": { "id": 1863147, "username": "exifoqua", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/exifoqua", "type": "text/html" } } }, "creatorSummary": "Clarke et al.", "parsedDate": "2004-10", "numChildren": 1 }, "data": { "key": "P3429M2W", "version": 13, "itemType": "journalArticle", "title": "A model to estimate the lifetime health outcomes of patients with type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS) Outcomes Model (UKPDS no. 68)", "creators": [ { "creatorType": "author", "firstName": "P M", "lastName": "Clarke" }, { "creatorType": "author", "firstName": "A M", "lastName": "Gray" }, { "creatorType": "author", "firstName": "A", "lastName": "Briggs" }, { "creatorType": "author", "firstName": "A J", "lastName": "Farmer" }, { "creatorType": "author", "firstName": "P", "lastName": "Fenn" }, { "creatorType": "author", "firstName": "R J", "lastName": "Stevens" }, { "creatorType": "author", "firstName": "D R", "lastName": "Matthews" }, { "creatorType": "author", "firstName": "I M", "lastName": "Stratton" }, { "creatorType": "author", "firstName": "R R", "lastName": "Holman" }, { "creatorType": "author", "name": "UK Prospective Diabetes Study (UKDPS) Group" } ], "abstractNote": "AIMS/HYPOTHESIS: The aim of this study was to develop a simulation model for type 2 diabetes that can be used to estimate the likely occurrence of major diabetes-related complications over a lifetime, in order to calculate health economic outcomes such as quality-adjusted life expectancy.\nMETHODS: Equations for forecasting the occurrence of seven diabetes-related complications and death were estimated using data on 3642 patients from the United Kingdom Prospective Diabetes Study (UKPDS). After examining the internal validity, the UKPDS Outcomes Model was used to simulate the mean difference in expected quality-adjusted life years between the UKPDS regimens of intensive and conventional blood glucose control.\nRESULTS: The model's forecasts fell within the 95% confidence interval for the occurrence of observed events during the UKPDS follow-up period. When the model was used to simulate event history over patients' lifetimes, those treated with a regimen of conventional glucose control could expect 16.35 undiscounted quality-adjusted life years, and those receiving treatment with intensive glucose control could expect 16.62 quality-adjusted life years, a difference of 0.27 (95% CI: -0.48 to 1.03).\nCONCLUSIONS/INTERPRETATIONS: The UKPDS Outcomes Model is able to simulate event histories that closely match observed outcomes in the UKPDS and that can be extrapolated over patients' lifetimes. Its validity in estimating outcomes in other groups of patients, however, remains to be evaluated. The model allows simulation of a range of long-term outcomes, which should assist in informing future economic evaluations of interventions in type 2 diabetes.", "publicationTitle": "Diabetologia", "publisher": "", "place": "", "date": "Oct 2004", "volume": "47", "issue": "10", "section": "", "partNumber": "", "partTitle": "", "pages": "1747-1759", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Diabetologia", "DOI": "10.1007/s00125-004-1527-z", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0012-186X", "archive": "", "archiveLocation": "", "shortTitle": "A model to estimate the lifetime health outcomes of patients with type 2 diabetes", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "00256 PMID: 15517152", "tags": [ { "tag": "Amputation", "type": 1 }, { "tag": "Blood Glucose", "type": 1 }, { "tag": "Cardiovascular Diseases", "type": 1 }, { "tag": "Computer Simulation", "type": 1 }, { "tag": "Diabetes", "type": 1 }, { "tag": "Diabetes Mellitus, Type 2", "type": 1 }, { "tag": "Diabetes-related complications", "type": 1 }, { "tag": "Diabetic Angiopathies", "type": 1 }, { "tag": "Diabetic Retinopathy", "type": 1 }, { "tag": "Economic evaluation", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Great Britain", "type": 1 }, { "tag": "Health Status", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Life Expectancy", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Middle Aged", "type": 1 }, { "tag": "Models, Biological", "type": 1 }, { "tag": "Quality of Life", "type": 1 }, { "tag": "Quality-Adjusted Life Years", "type": 1 }, { "tag": "Reproducibility of Results", "type": 1 }, { "tag": "Risk Factors", "type": 1 }, { "tag": "Risk equation simulation model", "type": 1 }, { "tag": "Treatment Outcome", "type": 1 }, { "tag": "UKPDS", "type": 1 } ], "collections": [ "GTV5VUZN" ], "relations": { "owl:sameAs": [ 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"lastModifiedByUser": { "id": 1863147, "username": "exifoqua", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/exifoqua", "type": "text/html" } } } }, "data": { "key": "4WTTU6DT", "version": 13, "parentItem": "AV2QNVZ9", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-11-12T10:29:14Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/12020335", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": { "owl:sameAs": "http://zotero.org/groups/264915/items/89NREZ8N" }, "dateAdded": "2014-11-13T07:48:30Z", "dateModified": "2014-11-13T09:58:12Z" } }, { "key": "AV2QNVZ9", "version": 13, "library": { "type": "group", "id": 287487, "name": "WP4-Mathematical Modelling", "links": { "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/287487/items/AV2QNVZ9", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/wp4-mathematical_modelling/items/AV2QNVZ9", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1863873, "username": "KleaPan", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/kleapan", "type": "text/html" } } }, "lastModifiedByUser": { "id": 1863147, "username": "exifoqua", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/exifoqua", "type": "text/html" } } }, "creatorSummary": "CDC Diabetes Cost-effectiveness Group", "parsedDate": "2002-05-15", "numChildren": 2 }, "data": { "key": "AV2QNVZ9", "version": 13, "itemType": "journalArticle", "title": "Cost-effectiveness of intensive glycemic control, intensified hypertension control, and serum cholesterol level reduction for type 2 diabetes", "creators": [ { "creatorType": "author", "name": "CDC Diabetes Cost-effectiveness Group" } ], "abstractNote": "CONTEXT: Several treatment interventions can reduce complications of type 2 diabetes, but their relative cost-effectiveness is not known.\nOBJECTIVE: To estimate the incremental cost-effectiveness of intensive glycemic control (relative to conventional control), intensified hypertension control, and reduction in serum cholesterol level for patients with type 2 diabetes.\nDESIGN, SETTING, AND PATIENTS: Cost-effectiveness analysis of a hypothetical cohort of individuals living in the United States, aged 25 years or older, who were newly diagnosed as having type 2 diabetes. The results of the United Kingdom Prospective Diabetes Study (UKPDS) and other studies were used to create a model of disease progression and treatment patterns. Costs were based on those used in community practices in the United States.\nINTERVENTIONS: Insulin or sulfonylurea therapy for intensive glycemic control; angiotensin-converting enzyme inhibitor or beta-blocker for intensified hypertension control; and pravastatin for reduction of serum cholesterol level.\nMAIN OUTCOME MEASURES: Cost per quality-adjusted life-year (QALY) gained. Costs (in 1997 US dollars) and QALYs were discounted at a 3% annual rate.\nRESULTS: The incremental cost-effectiveness ratio for intensive glycemic control is $41 384 per QALY; this ratio increased with age at diagnosis from $9614 per QALY for patients aged 25 to 34 years to $2.1 million for patients aged 85 to 94 years. For intensified hypertension control the cost-effectiveness ratio is -$1959 per QALY. The cost-effectiveness ratio for reduction in serum cholesterol level is $51 889 per QALY; this ratio varied by age at diagnosis and is lowest for patients diagnosed between the ages of 45 and 84 years.\nCONCLUSIONS: Intensified hypertension control reduces costs and improves health outcomes relative to moderate hypertension control. Intensive glycemic control and reduction in serum cholesterol level increase costs and improve health outcomes. The cost-effectiveness ratios for these 2 interventions are comparable with those of several other frequently adopted health care interventions.", "publicationTitle": "JAMA: the journal of the American Medical Association", "publisher": "", "place": "", "date": "May 15, 2002", "volume": "287", "issue": "19", "section": "", "partNumber": "", "partTitle": "", "pages": "2542-2551", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "JAMA", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0098-7484", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "00032 PMID: 12020335", "tags": [ { "tag": "Adrenergic beta-Antagonists", "type": 1 }, { "tag": "Adult", "type": 1 }, { "tag": "Aged", "type": 1 }, { "tag": "Aged, 80 and over", "type": 1 }, { "tag": "Angiotensin-Converting Enzyme Inhibitors", "type": 1 }, { "tag": "Anticholesteremic Agents", "type": 1 }, { "tag": "Antihypertensive Agents", "type": 1 }, { "tag": "Cholesterol", "type": 1 }, { "tag": "Cost-Benefit Analysis", "type": 1 }, { "tag": "Diabetes Mellitus, Type 2", "type": 1 }, { "tag": "Diabetic Angiopathies", "type": 1 }, { "tag": "Diabetic Nephropathies", "type": 1 }, { "tag": "Diabetic Neuropathies", "type": 1 }, { "tag": "Disease Progression", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Hypoglycemic Agents", "type": 1 }, { "tag": "Insulin", "type": 1 }, { "tag": "Markov Chains", "type": 1 }, { "tag": "Middle Aged", "type": 1 }, { "tag": "Pravastatin", "type": 1 }, { "tag": "Quality-Adjusted Life Years", "type": 1 }, { "tag": "Sulfonylurea Compounds", "type": 1 }, { "tag": "United States", "type": 1 } ], "collections": [ "GTV5VUZN" ], "relations": { "owl:sameAs": [ "http://zotero.org/groups/264915/items/849JEN7E", "http://zotero.org/groups/264915/items/ZRKW5K5S" ], "dc:replaces": 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