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"itemType": "webpage", "title": "Rinitis tratamientos, síntomas e información en Dmedicina", "creators": [], "abstractNote": "", "websiteTitle": "", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://www.dmedicina.com/enfermedades/alergias/rinitis", "accessDate": "2014-09-15T22:34:42Z", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-09-15T22:34:42Z", "dateModified": "2014-09-15T22:34:42Z" } }, { "key": "EKJ7CBCA", "version": 2, "library": { "type": "group", "id": 286032, "name": "informatica 02l", "links": { "alternate": { "href": "https://www.zotero.org/groups/informatica_02l", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/286032/items/EKJ7CBCA", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/informatica_02l/items/EKJ7CBCA", "type": "text/html" }, "up": { "href": 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"application/json" }, "alternate": { "href": "https://www.zotero.org/groups/informatica_02l/items/VHC4MBME", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2056148, "username": "geraldine_andrade", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/geraldine_andrade", "type": "text/html" } } }, "creatorSummary": "Lecka et al.", "parsedDate": "2014", "numChildren": 1 }, "data": { "key": "VHC4MBME", "version": 2, "itemType": "journalArticle", "title": "Ticlopidine in Its Prodrug Form Is a Selective Inhibitor of Human NTPDase1", "creators": [ { "creatorType": "author", "firstName": "Joanna", "lastName": "Lecka" }, { "creatorType": "author", "firstName": "Michel", "lastName": "Fausther" }, { "creatorType": "author", "firstName": "Beat", "lastName": "Künzli" }, { "creatorType": "author", "firstName": "Jean", "lastName": "Sévigny" } ], "abstractNote": "Nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), like other ectonucleotidases, controls extracellular nucleotide levels and consequently their (patho)physiological responses such as in thrombosis, inflammation, and cancer. Selective NTPDase1 inhibitors would therefore be very useful. We previously observed that ticlopidine in its prodrug form, which does not affect P2 receptor activity, inhibited the recombinant form of human NTPDase1 (K i = 14 μM). Here we tested whether ticlopidine can be used as a selective inhibitor of NTPDase1. We confirmed that ticlopidine inhibits NTPDase1 in different forms and in different assays. The ADPase activity of intact HUVEC as well as of COS-7 cells transfected with human NTPDase1 was strongly inhibited by 100 µM ticlopidine, 99 and 86%, respectively. Ticlopidine (100 µM) completely inhibited the ATPase activity of NTPDase1 in situ as shown by enzyme histochemistry with human liver and pancreas sections. Ticlopidine also inhibited the activity of rat and mouse NTPDase1 and of potato apyrase. At 100 µM ticlopidine did not affect the activity of human NTPDase2, NTPDase3, and NTPDase8, nor of NPP1 and NPP3. Weak inhibition (10-20%) of NTPDase3 and -8 was observed at 1 mM ticlopidine. These results show that ticlopidine is a specific inhibitor of NTPDase1 that can be used in enzymatic and histochemistry assays.", "publicationTitle": "Mediators of Inflammation", "publisher": "", "place": "", "date": "2014", "volume": "2014", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "547480", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Mediators Inflamm.", "DOI": "10.1155/2014/547480", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1466-1861", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 25180024 \nPMCID: PMC4144158", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-09-08T22:49:20Z", "dateModified": "2014-09-08T22:49:20Z" } }, { "key": "GSPKGCUM", "version": 2, "library": { "type": "group", "id": 286032, "name": "informatica 02l", "links": { "alternate": { "href": "https://www.zotero.org/groups/informatica_02l", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/286032/items/GSPKGCUM", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/informatica_02l/items/GSPKGCUM", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/286032/items/DTK5MTTA", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2056148, "username": "geraldine_andrade", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/geraldine_andrade", "type": "text/html" } } } }, "data": { "key": "GSPKGCUM", "version": 2, "parentItem": "DTK5MTTA", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-09-08T22:49:20Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/25185771", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-09-08T22:49:20Z", "dateModified": "2014-09-08T22:49:20Z" } }, { "key": "F4P5EDVK", "version": 2, "library": { "type": "group", "id": 286032, "name": "informatica 02l", "links": { "alternate": { "href": "https://www.zotero.org/groups/informatica_02l", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/286032/items/F4P5EDVK", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/informatica_02l/items/F4P5EDVK", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/286032/items/IQ8J4Z6D", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2056148, "username": "geraldine_andrade", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/geraldine_andrade", "type": "text/html" } } } }, "data": { "key": "F4P5EDVK", "version": 2, "parentItem": "IQ8J4Z6D", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-09-08T22:49:20Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/25191517", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-09-08T22:49:20Z", "dateModified": "2014-09-08T22:49:20Z" } }, { "key": "DTK5MTTA", "version": 2, "library": { "type": "group", "id": 286032, "name": "informatica 02l", "links": { "alternate": { "href": "https://www.zotero.org/groups/informatica_02l", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/286032/items/DTK5MTTA", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/informatica_02l/items/DTK5MTTA", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2056148, "username": "geraldine_andrade", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/geraldine_andrade", "type": "text/html" } } }, "creatorSummary": "Greggio et al.", "parsedDate": "2014-09-03", "numChildren": 1 }, "data": { "key": "DTK5MTTA", "version": 2, "itemType": "journalArticle", "title": "In Vitro-Produced Pancreas Organogenesis Models In Three Dimensions: Self-Organization From Few Stem Cells Or Progenitors", "creators": [ { "creatorType": "author", "firstName": "Chiara", "lastName": "Greggio" }, { "creatorType": "author", "firstName": "Filippo", "lastName": "De Franceschi" }, { "creatorType": "author", "firstName": "Anne", "lastName": "Grapin-Botton" } ], "abstractNote": "Three dimensional models of organ biogenesis have recently flourished. They promote a balance between stem/progenitor cell expansion and differentiation without the constraints of flat tissue culture vessels, allowing for autonomous self-organization of cells. Such models allow the formation of miniature organs in a dish and are emerging for the pancreas, starting from embryonic progenitors and adult cells. This review focusses on the currently available systems and how these allow new types of questions to be addressed. We discuss the expected advancements including their potential to study human pancreas development and function as well as to develop diabetes models and therapeutic cells. Stem Cells 2014.", "publicationTitle": "Stem Cells (Dayton, Ohio)", "publisher": "", "place": "", "date": "Sep 3, 2014", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Stem Cells", "DOI": "10.1002/stem.1828", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1549-4918", "archive": "", "archiveLocation": "", "shortTitle": "In Vitro-Produced Pancreas Organogenesis Models In Three Dimensions", "language": "ENG", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 25185771", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-09-08T22:49:20Z", "dateModified": "2014-09-08T22:49:20Z" } }, { "key": "IQ8J4Z6D", "version": 2, "library": { "type": "group", "id": 286032, "name": "informatica 02l", "links": { "alternate": { "href": "https://www.zotero.org/groups/informatica_02l", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/286032/items/IQ8J4Z6D", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/informatica_02l/items/IQ8J4Z6D", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2056148, "username": "geraldine_andrade", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/geraldine_andrade", "type": "text/html" } } }, "creatorSummary": "Pitman et al.", "parsedDate": "2014", "numChildren": 1 }, "data": { "key": "IQ8J4Z6D", "version": 2, "itemType": "journalArticle", "title": "Standardized terminology and nomenclature for pancreatobiliary cytology: The Papanicolaou Society of Cytopathology Guidelines", "creators": [ { "creatorType": "author", "firstName": "Martha B.", "lastName": "Pitman" }, { "creatorType": "author", "firstName": "Barbara A.", "lastName": "Centeno" }, { "creatorType": "author", "firstName": "Syed Z.", "lastName": "Ali" }, { "creatorType": "author", "firstName": "Muriel", "lastName": "Genevay" }, { "creatorType": "author", "firstName": "Ed", "lastName": "Stelow" }, { "creatorType": "author", "firstName": "Mari", "lastName": "Mino-Kenudson" }, { "creatorType": "author", "firstName": "Carlos Fernandez-Del", "lastName": "Castillo" }, { "creatorType": "author", "firstName": "C. Max", "lastName": "Schmidt" }, { "creatorType": "author", "firstName": "William R.", "lastName": "Brugge" }, { "creatorType": "author", "firstName": "Lester J.", "lastName": "Layfield" } ], "abstractNote": "The Papanicolaou Society of Cytopathology has developed a set of guidelines for pancreatobiliary cytology including indications for endoscopic ultrasound (EUS) guided fine-needle aspiration (FNA) biopsy, techniques of EUS-FNA, terminology and nomenclature of pancreatobiliary disease, ancillary testing and post-biopsy treatment and management. All documents are based on the expertise of the authors, a review of the literature, discussion of the draft document at several national and international meetings over an 18 month period and synthesis of online comments of the draft document on the Papanicolaou Society of Cytopathology web site [www.papsociety.org]. This document selectively presents the results of these discussions and focuses on a proposed standardized terminology scheme for pancreatobiliary specimens that correlate cytological diagnosis with biological behavior and increasingly conservative patient management of surveillance only. The proposed terminology scheme recommends a six-tiered system: Non-diagnostic, negative, atypical, neoplastic [benign or other], suspicious and positive. Unique to this scheme is the \"neoplastic\" category separated into \"benign\" (serous cystadenoma) or \"other\" (premalignant mucinous cysts, neuroendocrine tumors and solid-pseudopapillary neoplasms (SPNs)). The positive or malignant category is reserved for high-grade, aggressive malignancies including ductal adenocarcinoma, acinar cell carcinoma, poorly differentiated neuroendocrine carcinomas, pancreatoblastoma, lymphoma and metastases. Interpretation categories do not have to be used. Some pathology laboratory information systems require an interpretation category, which places the cytological diagnosis into a general category. This proposed scheme provides terminology that standardizes the category of the various diseases of the pancreas, some of which are difficult to diagnose specifically by cytology. In addition, this terminology scheme attempts to provide maximum flexibility for patient management, which has become increasingly conservative for some neoplasms.", "publicationTitle": "CytoJournal", "publisher": "", "place": "", "date": "2014", "volume": "11", "issue": "Suppl 1", "section": "", "partNumber": "", "partTitle": "", "pages": "3", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Cytojournal", "DOI": "10.4103/1742-6413.133343", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1742-6413", "archive": "", "archiveLocation": "", "shortTitle": "Standardized terminology and nomenclature for pancreatobiliary cytology", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 25191517 \nPMCID: PMC4153338", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-09-08T22:49:20Z", "dateModified": "2014-09-08T22:49:20Z" } } ]