[ { "key": "WJ24I7Z7", "version": 2, "library": { "type": "group", "id": 286001, "name": "informaticaa", "links": { "alternate": { "href": "https://www.zotero.org/groups/informaticaa", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/286001/items/WJ24I7Z7", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/informaticaa/items/WJ24I7Z7", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/286001/items/ZAPH6NCC", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2055917, "username": "piaore", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/piaore", "type": "text/html" } } } }, "data": { "key": "WJ24I7Z7", "version": 2, "parentItem": "ZAPH6NCC", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-09-08T21:09:39Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/25188067", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-09-08T21:09:39Z", "dateModified": "2014-09-08T21:09:39Z" } }, { "key": "2MW29HDJ", "version": 2, "library": { "type": "group", "id": 286001, "name": "informaticaa", "links": { "alternate": { "href": "https://www.zotero.org/groups/informaticaa", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/286001/items/2MW29HDJ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/informaticaa/items/2MW29HDJ", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2055917, "username": "piaore", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/piaore", "type": "text/html" } } }, "creatorSummary": "Jang", "parsedDate": "2014-10", "numChildren": 1 }, "data": { "key": "2MW29HDJ", "version": 2, "itemType": "journalArticle", "title": "Hepatobiliary/Pancreas Pathology: SY11-2 INTRACHOLECYSTIC PAPILLARY-TUBULAR NEOPLASM OF THE GALLBLADDER", "creators": [ { "creatorType": "author", "firstName": "Kee-Taek", "lastName": "Jang" } ], "abstractNote": "The pathologic description for neoplastic polyps of the gallbladder (GB) was controversial. Although current WHO suggest adenoma and papillary neoplasm for precursor lesions, the distinction is not clear. In recent study for 123 GB cases, we found tumoral preinvasive neoplasms (≥1 cm) were analogous to their pancreatic and biliary counterparts. They show variable cellular lineages, a spectrum of dysplasia, and a mixture of papillary or tubular growth patterns, often with significant overlap, warranting their classification under one unified parallel category, intracholecystic papillary-tubular neoplasm (ICPN). We found that ICPN have similarity with intraductal papillary-mucinous neoplasm of pancreas (IPMN) and intraductal papillary neoplasm of bile duct (IPNB). ICPN of GB showed similar cell lineage and mucin core protein expression pattern with IPMN and IPNB. It is suspected that ICPN might be a GB counterpart with IPMN and IPNB. We think these polypoid precursor lesions of pancreatobiliary tract and GB may correspond to tumoral intraepithelial neoplasia, whereas the pancreatic intraepithelial neoplasia and biliary intraepithelial neoplasia correspond to the flat intraepithelial neoplasia. We also found there is a geographic difference of ICPN incidence between East and West. ICPN was more common in East whereas conventional flat dysplasia was more frequently found in West.", "publicationTitle": "Pathology", "publisher": "", "place": "", "date": "Oct 2014", "volume": "46 Suppl 2", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "S24", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Pathology", "DOI": "10.1097/01.PAT.0000454132.74211.66", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1465-3931", "archive": "", "archiveLocation": "", "shortTitle": "Hepatobiliary/Pancreas Pathology", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 25188106", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-09-08T21:09:39Z", "dateModified": "2014-09-08T21:09:39Z" } }, { "key": "GT9QNQN3", "version": 2, "library": { "type": "group", "id": 286001, "name": "informaticaa", "links": { "alternate": { "href": "https://www.zotero.org/groups/informaticaa", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/286001/items/GT9QNQN3", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/informaticaa/items/GT9QNQN3", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/286001/items/2MW29HDJ", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2055917, "username": "piaore", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/piaore", "type": "text/html" } } } }, "data": { "key": "GT9QNQN3", "version": 2, "parentItem": "2MW29HDJ", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-09-08T21:09:39Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/25188106", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-09-08T21:09:39Z", "dateModified": "2014-09-08T21:09:39Z" } }, { "key": "6WHXUIHE", "version": 2, "library": { "type": "group", "id": 286001, "name": "informaticaa", "links": { "alternate": { "href": "https://www.zotero.org/groups/informaticaa", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/286001/items/6WHXUIHE", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/informaticaa/items/6WHXUIHE", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/286001/items/UXUZKJA7", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2055917, "username": "piaore", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/piaore", "type": "text/html" } } } }, "data": { "key": "6WHXUIHE", "version": 2, "parentItem": "UXUZKJA7", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-09-08T21:09:39Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/25191518", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-09-08T21:09:39Z", "dateModified": "2014-09-08T21:09:39Z" } }, { "key": "ZAPH6NCC", "version": 2, "library": { "type": "group", "id": 286001, "name": "informaticaa", "links": { "alternate": { "href": "https://www.zotero.org/groups/informaticaa", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/286001/items/ZAPH6NCC", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/informaticaa/items/ZAPH6NCC", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2055917, "username": "piaore", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/piaore", "type": "text/html" } } }, "creatorSummary": "Osamura", "parsedDate": "2014-10", "numChildren": 1 }, "data": { "key": "ZAPH6NCC", "version": 2, "itemType": "journalArticle", "title": "Endocrine Pathology: SY08-2 SURGICAL ENDOCRINE PATHOLOGY DIAGNOSTIC UPDATE: NEUROENDOCRINE TUMORS", "creators": [ { "creatorType": "author", "firstName": "Robert Y.", "lastName": "Osamura" } ], "abstractNote": "In our daily practice of surgical pathology, neuroendcorine tumors are not very frequent specimens, but do get them from time to time and we have to be prepared to give appropriate diagnosis and information, both prognostic and predictive. In this lecture, gastro-entero-pancreatic neuroendocrine tumors (GEPNET) are discussed based on the WHO classification 2010. The tumors are designated as neuroendocrine neoplasms (NEN) and are subdivided into neuroendocrine tumor (NET) Grade (G)1, G2, neuroendocrine carcinoma (NEC) and mixed adenoneuroendocrine carcinoma (MANEC). The classification of NET G1, NET G2, NEC is done by the proliferative activities of the tumor cells, i.e., either mitotic index or Ki-67 index (%). This classification suggests prognostic and predictive information, i.e., the better prognosis and biotherapy for NET G1, NET G and the poorer prognosis and chemotherapy for NEC. TNM and vascular invasion are also important factors which should be included in the pathology report. Immunohistochemistry for neuroendocrine markers and somatostatin receptor 2 (SSTR2) are performed for definitive diagnosis and octreotide therapy. Mutational analysis is also recommended in the suspected cases for MEN1 and VHL. This lecture emphasizes what to look for and how to make diagnosis of neuroendocrine tumors.", "publicationTitle": "Pathology", "publisher": "", "place": "", "date": "Oct 2014", "volume": "46 Suppl 2", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "S14", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Pathology", "DOI": "10.1097/01.PAT.0000454097.75997.2d", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1465-3931", "archive": "", "archiveLocation": "", "shortTitle": "Endocrine Pathology", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 25188067", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-09-08T21:09:39Z", "dateModified": "2014-09-08T21:09:39Z" } }, { "key": "UXUZKJA7", "version": 2, "library": { "type": "group", "id": 286001, "name": "informaticaa", "links": { "alternate": { "href": "https://www.zotero.org/groups/informaticaa", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/286001/items/UXUZKJA7", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/informaticaa/items/UXUZKJA7", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2055917, "username": "piaore", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/piaore", "type": "text/html" } } }, "creatorSummary": "Layfield et al.", "parsedDate": "2014", "numChildren": 1 }, "data": { "key": "UXUZKJA7", "version": 2, "itemType": "journalArticle", "title": "Utilization of ancillary studies in the cytologic diagnosis of biliary and pancreatic lesions: The Papanicolaou Society of Cytopathology Guidelines", "creators": [ { "creatorType": "author", "firstName": "Lester J.", "lastName": "Layfield" }, { "creatorType": "author", "firstName": "Hormoz", "lastName": "Ehya" }, { "creatorType": "author", "firstName": "Armando C.", "lastName": "Filie" }, { "creatorType": "author", "firstName": "Ralph H.", "lastName": "Hruban" }, { "creatorType": "author", "firstName": "Nirag", "lastName": "Jhala" }, { "creatorType": "author", "firstName": "Loren", "lastName": "Joseph" }, { "creatorType": "author", "firstName": "Philippe", "lastName": "Vielh" }, { "creatorType": "author", "firstName": "Martha B.", "lastName": "Pitman" } ], "abstractNote": "The Papanicolaou Society of Cytopathology has developed a set of guidelines for pancreatobiliary cytology including indications for endoscopic ultrasound guided fine needle aspiration, terminology and nomenclature of pancreatobiliary disease, ancillary testing and post-biopsy management. All documents are based on the expertise of the authors, a review of the literature, discussion of the draft document at several national and international meetings and synthesis of selected online comments of the draft document. This document presents the results of these discussions regarding the use of ancillary testing in the cytologic diagnosis of biliary and pancreatic lesions. Currently, fluorescence in-situ hybridization (FISH) appears to be the most clinically relevant ancillary technique for cytology of bile duct strictures. The addition of FISH analysis to routine cytologic evaluation appears to yield the highest sensitivity without loss in specificity. Loss of immunohistochemical staining for the protein product of the SMAD4 gene and positive staining for mesothelin support a diagnosis of ductal adenocarcinoma. Immunohistochemical markers for endocrine and exocrine differentiation are sufficient for a diagnosis of endocrine and acinar tumors. Nuclear staining for beta-catenin supports a diagnosis of solid-pseudopapillary neoplasm. Cyst fluid analysis for amylase and carcinoembryonic antigen aids in the pre-operative classification of pancreatic cysts. A number of gene mutations (KRAS, GNAS, von Hippel-Lindau, RNF43 and CTNNB1) may be of aid in the diagnosis of cystic neoplasms. Other ancillary techniques do not appear to improve diagnostic sensitivity sufficiently to justify their increased costs.", "publicationTitle": "CytoJournal", "publisher": "", "place": "", "date": "2014", "volume": "11", "issue": "Suppl 1", "section": "", "partNumber": "", "partTitle": "", "pages": "4", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Cytojournal", "DOI": "10.4103/1742-6413.133352", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1742-6413", "archive": "", "archiveLocation": "", "shortTitle": "Utilization of ancillary studies in the cytologic diagnosis of biliary and pancreatic lesions", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 25191518 \nPMCID: PMC4153340", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-09-08T21:09:39Z", "dateModified": "2014-09-08T21:09:39Z" } } ]