[ { "key": "3PXMJ6HF", "version": 2, "library": { "type": "group", "id": 285981, "name": "informaticgroup", "links": { "alternate": { "href": "https://www.zotero.org/groups/informaticgroup", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/285981/items/3PXMJ6HF", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/informaticgroup/items/3PXMJ6HF", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/285981/items/B2SZFCXT", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2053349, "username": "paola_orrego", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/paola_orrego", "type": "text/html" } } } }, "data": { "key": "3PXMJ6HF", "version": 2, "parentItem": "B2SZFCXT", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-09-08T21:15:39Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/25191518", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-09-08T21:15:39Z", "dateModified": "2014-09-08T21:15:39Z" } }, { "key": "PDUPEKDK", "version": 2, "library": { "type": "group", "id": 285981, "name": "informaticgroup", "links": { "alternate": { "href": "https://www.zotero.org/groups/informaticgroup", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/285981/items/PDUPEKDK", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/informaticgroup/items/PDUPEKDK", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/285981/items/9N5CEF4W", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2053349, "username": "paola_orrego", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/paola_orrego", "type": "text/html" } } } }, "data": { "key": "PDUPEKDK", "version": 2, "parentItem": "9N5CEF4W", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-09-08T21:15:39Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/25194022", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-09-08T21:15:39Z", "dateModified": "2014-09-08T21:15:39Z" } }, { "key": "8K2SZW9Q", "version": 2, "library": { "type": "group", "id": 285981, "name": "informaticgroup", "links": { "alternate": { "href": "https://www.zotero.org/groups/informaticgroup", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/285981/items/8K2SZW9Q", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/informaticgroup/items/8K2SZW9Q", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2053349, "username": "paola_orrego", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/paola_orrego", "type": "text/html" } } }, "creatorSummary": "Pitman et al.", "parsedDate": "2014", "numChildren": 1 }, "data": { "key": "8K2SZW9Q", "version": 2, "itemType": "journalArticle", "title": "Standardized terminology and nomenclature for pancreatobiliary cytology: The Papanicolaou Society of Cytopathology Guidelines", "creators": [ { "creatorType": "author", "firstName": "Martha B.", "lastName": "Pitman" }, { "creatorType": "author", "firstName": "Barbara A.", "lastName": "Centeno" }, { "creatorType": "author", "firstName": "Syed Z.", "lastName": "Ali" }, { "creatorType": "author", "firstName": "Muriel", "lastName": "Genevay" }, { "creatorType": "author", "firstName": "Ed", "lastName": "Stelow" }, { "creatorType": "author", "firstName": "Mari", "lastName": "Mino-Kenudson" }, { "creatorType": "author", "firstName": "Carlos Fernandez-Del", "lastName": "Castillo" }, { "creatorType": "author", "firstName": "C. Max", "lastName": "Schmidt" }, { "creatorType": "author", "firstName": "William R.", "lastName": "Brugge" }, { "creatorType": "author", "firstName": "Lester J.", "lastName": "Layfield" } ], "abstractNote": "The Papanicolaou Society of Cytopathology has developed a set of guidelines for pancreatobiliary cytology including indications for endoscopic ultrasound (EUS) guided fine-needle aspiration (FNA) biopsy, techniques of EUS-FNA, terminology and nomenclature of pancreatobiliary disease, ancillary testing and post-biopsy treatment and management. All documents are based on the expertise of the authors, a review of the literature, discussion of the draft document at several national and international meetings over an 18 month period and synthesis of online comments of the draft document on the Papanicolaou Society of Cytopathology web site [www.papsociety.org]. This document selectively presents the results of these discussions and focuses on a proposed standardized terminology scheme for pancreatobiliary specimens that correlate cytological diagnosis with biological behavior and increasingly conservative patient management of surveillance only. The proposed terminology scheme recommends a six-tiered system: Non-diagnostic, negative, atypical, neoplastic [benign or other], suspicious and positive. Unique to this scheme is the \"neoplastic\" category separated into \"benign\" (serous cystadenoma) or \"other\" (premalignant mucinous cysts, neuroendocrine tumors and solid-pseudopapillary neoplasms (SPNs)). The positive or malignant category is reserved for high-grade, aggressive malignancies including ductal adenocarcinoma, acinar cell carcinoma, poorly differentiated neuroendocrine carcinomas, pancreatoblastoma, lymphoma and metastases. Interpretation categories do not have to be used. Some pathology laboratory information systems require an interpretation category, which places the cytological diagnosis into a general category. This proposed scheme provides terminology that standardizes the category of the various diseases of the pancreas, some of which are difficult to diagnose specifically by cytology. In addition, this terminology scheme attempts to provide maximum flexibility for patient management, which has become increasingly conservative for some neoplasms.", "publicationTitle": "CytoJournal", "publisher": "", "place": "", "date": "2014", "volume": "11", "issue": "Suppl 1", "section": "", "partNumber": "", "partTitle": "", "pages": "3", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Cytojournal", "DOI": "10.4103/1742-6413.133343", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1742-6413", "archive": "", "archiveLocation": "", "shortTitle": "Standardized terminology and nomenclature for pancreatobiliary cytology", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 25191517 \nPMCID: PMC4153338", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-09-08T21:15:39Z", "dateModified": "2014-09-08T21:15:39Z" } }, { "key": "9N5CEF4W", "version": 2, "library": { "type": "group", "id": 285981, "name": "informaticgroup", "links": { "alternate": { "href": "https://www.zotero.org/groups/informaticgroup", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/285981/items/9N5CEF4W", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/informaticgroup/items/9N5CEF4W", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2053349, "username": "paola_orrego", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/paola_orrego", "type": "text/html" } } }, "creatorSummary": "Chung et al.", "parsedDate": "2014-09-01", "numChildren": 1 }, "data": { "key": "9N5CEF4W", "version": 2, "itemType": "journalArticle", "title": "Maternal embryonic leucine zipper kinase regulates pancreatic ductal, but not β-cell, regeneration", "creators": [ { "creatorType": "author", "firstName": "Cheng-Ho", "lastName": "Chung" }, { "creatorType": "author", "firstName": "Amber", "lastName": "Miller" }, { "creatorType": "author", "firstName": "Andreas", "lastName": "Panopoulos" }, { "creatorType": "author", "firstName": "Ergeng", "lastName": "Hao" }, { "creatorType": "author", "firstName": "Robert", "lastName": "Margolis" }, { "creatorType": "author", "firstName": "Alexey", "lastName": "Terskikh" }, { "creatorType": "author", "firstName": "Fred", "lastName": "Levine" } ], "abstractNote": "The maternal embryonic leucine zipper kinase (MELK) is expressed in stem/progenitor cells in some adult tissues, where it has been implicated in diverse biological processes, including the control of cell proliferation. Here, we described studies on its role in adult pancreatic regeneration in response to injury induced by duct ligation and β-cell ablation. MELK expression was studied using transgenic mice expressing GFP under the control of the MELK promoter, and the role of MELK was studied using transgenic mice deleted in the MELK kinase domain. Pancreatic damage was initiated using duct ligation and chemical beta-cell ablation. By tracing MELK expression using a MELK promoter-GFP transgene, we determined that expression was extremely low in the normal pancreas. However, following duct ligation and β-cell ablation, it became highly expressed in pancreatic ductal cells while remaining weakly expressed in α-cells and β- cells. In a mutant mouse in which the MELK kinase domain was deleted, there was no effect on pancreatic development. There was no apparent effect on islet regeneration, either. However, following duct ligation there was a dramatic increase in the number of small ducts, but no change in the total number of duct cells or duct cell proliferation. In vitro studies indicated that this was likely due to a defect in cell migration. These results implicate MELK in the control of the response of the pancreas to injury, specifically controlling cell migration in normal and transformed pancreatic duct cells.", "publicationTitle": "Physiological Reports", "publisher": "", "place": "", "date": "Sep 1, 2014", "volume": "2", "issue": "9", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Physiol Rep", "DOI": "10.14814/phy2.12131", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "2051-817X", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 25194022", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-09-08T21:15:39Z", "dateModified": "2014-09-08T21:15:39Z" } }, { "key": "PD7BRX7N", "version": 2, "library": { "type": "group", "id": 285981, "name": "informaticgroup", "links": { "alternate": { "href": "https://www.zotero.org/groups/informaticgroup", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/285981/items/PD7BRX7N", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/informaticgroup/items/PD7BRX7N", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/285981/items/8K2SZW9Q", "type": "application/json" } }, "meta": { "createdByUser": { "id": 2053349, "username": "paola_orrego", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/paola_orrego", "type": "text/html" } } } }, "data": { "key": "PD7BRX7N", "version": 2, "parentItem": "8K2SZW9Q", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-09-08T21:15:39Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/25191517", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-09-08T21:15:39Z", "dateModified": "2014-09-08T21:15:39Z" } }, { "key": "B2SZFCXT", "version": 2, "library": { "type": "group", "id": 285981, "name": "informaticgroup", "links": { "alternate": { "href": "https://www.zotero.org/groups/informaticgroup", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/285981/items/B2SZFCXT", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/informaticgroup/items/B2SZFCXT", "type": "text/html" } }, "meta": { "createdByUser": { "id": 2053349, "username": "paola_orrego", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/paola_orrego", "type": "text/html" } } }, "creatorSummary": "Layfield et al.", "parsedDate": "2014", "numChildren": 1 }, "data": { "key": "B2SZFCXT", "version": 2, "itemType": "journalArticle", "title": "Utilization of ancillary studies in the cytologic diagnosis of biliary and pancreatic lesions: The Papanicolaou Society of Cytopathology Guidelines", "creators": [ { "creatorType": "author", "firstName": "Lester J.", "lastName": "Layfield" }, { "creatorType": "author", "firstName": "Hormoz", "lastName": "Ehya" }, { "creatorType": "author", "firstName": "Armando C.", "lastName": "Filie" }, { "creatorType": "author", "firstName": "Ralph H.", "lastName": "Hruban" }, { "creatorType": "author", "firstName": "Nirag", "lastName": "Jhala" }, { "creatorType": "author", "firstName": "Loren", "lastName": "Joseph" }, { "creatorType": "author", "firstName": "Philippe", "lastName": "Vielh" }, { "creatorType": "author", "firstName": "Martha B.", "lastName": "Pitman" } ], "abstractNote": "The Papanicolaou Society of Cytopathology has developed a set of guidelines for pancreatobiliary cytology including indications for endoscopic ultrasound guided fine needle aspiration, terminology and nomenclature of pancreatobiliary disease, ancillary testing and post-biopsy management. All documents are based on the expertise of the authors, a review of the literature, discussion of the draft document at several national and international meetings and synthesis of selected online comments of the draft document. This document presents the results of these discussions regarding the use of ancillary testing in the cytologic diagnosis of biliary and pancreatic lesions. Currently, fluorescence in-situ hybridization (FISH) appears to be the most clinically relevant ancillary technique for cytology of bile duct strictures. The addition of FISH analysis to routine cytologic evaluation appears to yield the highest sensitivity without loss in specificity. Loss of immunohistochemical staining for the protein product of the SMAD4 gene and positive staining for mesothelin support a diagnosis of ductal adenocarcinoma. Immunohistochemical markers for endocrine and exocrine differentiation are sufficient for a diagnosis of endocrine and acinar tumors. Nuclear staining for beta-catenin supports a diagnosis of solid-pseudopapillary neoplasm. Cyst fluid analysis for amylase and carcinoembryonic antigen aids in the pre-operative classification of pancreatic cysts. A number of gene mutations (KRAS, GNAS, von Hippel-Lindau, RNF43 and CTNNB1) may be of aid in the diagnosis of cystic neoplasms. Other ancillary techniques do not appear to improve diagnostic sensitivity sufficiently to justify their increased costs.", "publicationTitle": "CytoJournal", "publisher": "", "place": "", "date": "2014", "volume": "11", "issue": "Suppl 1", "section": "", "partNumber": "", "partTitle": "", "pages": "4", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Cytojournal", "DOI": "10.4103/1742-6413.133352", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1742-6413", "archive": "", "archiveLocation": "", "shortTitle": "Utilization of ancillary studies in the cytologic diagnosis of biliary and pancreatic lesions", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 25191518 \nPMCID: PMC4153340", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-09-08T21:15:39Z", "dateModified": "2014-09-08T21:15:39Z" } } ]