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            "title": "Clinical presentation of cerebral aneurysms",
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                    "creatorType": "author",
                    "firstName": "Alessandro",
                    "lastName": "Cianfoni"
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                    "firstName": "Emanuele",
                    "lastName": "Pravatà"
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                    "lastName": "De Blasi"
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                    "firstName": "Costa Silvia",
                    "lastName": "Tschuor"
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                    "firstName": "Giuseppe",
                    "lastName": "Bonaldi"
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            "abstractNote": "Presentation of a cerebral aneurysm can be incidental, discovered at imaging obtained for unrelated causes, can occur in the occasion of imaging obtained for symptoms possibly or likely related to the presence of an unruptured aneurysm, or can occur with signs and symptoms at the time of aneurismal rupture. Most unruptured intracranial aneurysms are thought to be asymptomatic, or present with vague or non-specific symptoms like headache or dizziness. Isolated oculomotor nerve palsies, however, may typically indicate the presence of a posterior circulation aneurysm. Ruptured intracranial aneurysms are by far the most common cause of non-traumatic subarachnoid hemorrhage and represent a neurological emergency with potentially devastating consequences. Subarachnoid hemorrhage may be easily suspected in the presence of sudden and severe headache, vomiting, meningism signs, and/or altered mental status. However, failure to recognize milder and more ambiguous clinical pictures may result in a delayed or missed diagnosis. In this paper we will describe the clinical spectrum of unruptured and ruptured intracranial aneurysms by discussing both typical and uncommon clinical features emerging from the literature review. We will additionally provide the reader with descriptions of the underlying pathophysiologic mechanisms, and main diagnostic pitfalls.",
            "publicationTitle": "European Journal of Radiology",
            "publisher": "",
            "place": "",
            "date": "Oct 2013",
            "volume": "82",
            "issue": "10",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "1618-1622",
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            "journalAbbreviation": "Eur J Radiol",
            "DOI": "10.1016/j.ejrad.2012.11.019",
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            "url": "",
            "accessDate": "",
            "PMID": "",
            "PMCID": "",
            "ISSN": "1872-7727",
            "archive": "",
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            "shortTitle": "",
            "language": "eng",
            "libraryCatalog": "NCBI PubMed",
            "callNumber": "",
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            "extra": "PMID: 23238357",
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                    "tag": "Brain Ischemia",
                    "type": 1
                },
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                    "type": 1
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                {
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                    "type": 1
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                    "tag": "Dizziness",
                    "type": 1
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                    "type": 1
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                    "tag": "Humans",
                    "type": 1
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                    "tag": "Incidental Findings",
                    "type": 1
                },
                {
                    "tag": "Intracranial Aneurysm",
                    "type": 1
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                    "tag": "Physical Examination",
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            "dateAdded": "2014-09-08T21:14:04Z",
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            "version": 2,
            "itemType": "journalArticle",
            "title": "Clipping versus coiling for ruptured intracranial aneurysms: a systematic review and meta-analysis",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Hui",
                    "lastName": "Li"
                },
                {
                    "creatorType": "author",
                    "firstName": "Rui",
                    "lastName": "Pan"
                },
                {
                    "creatorType": "author",
                    "firstName": "Hongxuan",
                    "lastName": "Wang"
                },
                {
                    "creatorType": "author",
                    "firstName": "Xiaoming",
                    "lastName": "Rong"
                },
                {
                    "creatorType": "author",
                    "firstName": "Zi",
                    "lastName": "Yin"
                },
                {
                    "creatorType": "author",
                    "firstName": "Daniel P.",
                    "lastName": "Milgrom"
                },
                {
                    "creatorType": "author",
                    "firstName": "Xiaolei",
                    "lastName": "Shi"
                },
                {
                    "creatorType": "author",
                    "firstName": "Yamei",
                    "lastName": "Tang"
                },
                {
                    "creatorType": "author",
                    "firstName": "Ying",
                    "lastName": "Peng"
                }
            ],
            "abstractNote": "BACKGROUND AND PURPOSE: Endovascular treatment has increasingly been used for aneurismal subarachnoid aneurismal hemorrhage. The aim of this analysis is to assess the current evidence regarding safety and efficiency of clipping compared with coiling.\nMETHODS: We conducted a meta-analysis of studies that compared clipping with coiling between January 1999 and July 2012. Comparison of binary outcomes between treatment groups was described using odds ratios (OR; clip versus coil).\nRESULTS: Four randomized controlled trials and 23 observational studies were included. Randomized controlled trials showed that coiling reduced the 1-year unfavorable outcome rate (OR, 1.48; 95% confidence interval [CI], 1.24-1.76). However, there was no statistical deference in nonrandomized controlled trials (OR, 1.11; 95% CI, 0.96-1.28). Subgroup analysis revealed coiling yielded better outcomes for patients with good preoperative grade (OR, 1.51; 95% CI, 1.24-1.84) than for poor preoperative patients (OR, 0.88; 95% CI 0.56-1.38). Additionally, the incidence of rebleeding is higher after coiling (OR, 0.43; 95% CI, 0.28-0.66), corresponding to a better complete occlusion rate of clipping (OR, 2.43; 95% CI, 1.88-3.13). The 1-year mortality showed no significant difference (OR, 1.07; 95% CI, 0.88-1.30). Vasospasm was more common after clipping (OR, 1.43; 95% CI, 1.07-1.91), whereas the ischemic infarct (OR, 0.74; 95% CI, 0.52-1.06), shunt-dependent hydrocephalus (OR, 0.84; 95% CI, 0.66-1.07), and procedural complication rates (OR, 1.19; 95% CI, 0.67-2.11) did not differ significantly between techniques.\nCONCLUSIONS: Coiling yields a better clinical outcome, the benefit being greater in those with a good preoperative grade than those with a poor preoperative grade. However, coiling leads to a greater risk of rebleeding. Well-designed randomized trials with special considerations to the aspect are needed.",
            "publicationTitle": "Stroke; a Journal of Cerebral Circulation",
            "publisher": "",
            "place": "",
            "date": "Jan 2013",
            "volume": "44",
            "issue": "1",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "29-37",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "Stroke",
            "DOI": "10.1161/STROKEAHA.112.663559",
            "citationKey": "",
            "url": "",
            "accessDate": "",
            "PMID": "",
            "PMCID": "",
            "ISSN": "1524-4628",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "Clipping versus coiling for ruptured intracranial aneurysms",
            "language": "eng",
            "libraryCatalog": "NCBI PubMed",
            "callNumber": "",
            "rights": "",
            "extra": "PMID: 23238862",
            "tags": [
                {
                    "tag": "Aneurysm, Ruptured",
                    "type": 1
                },
                {
                    "tag": "Embolization, Therapeutic",
                    "type": 1
                },
                {
                    "tag": "Endovascular Procedures",
                    "type": 1
                },
                {
                    "tag": "Humans",
                    "type": 1
                },
                {
                    "tag": "Intracranial Aneurysm",
                    "type": 1
                },
                {
                    "tag": "Randomized Controlled Trials as Topic",
                    "type": 1
                },
                {
                    "tag": "Surgical Instruments",
                    "type": 1
                },
                {
                    "tag": "Treatment Outcome",
                    "type": 1
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            ],
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            "dateAdded": "2014-09-08T21:14:04Z",
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            "creatorSummary": "July et al.",
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            "version": 2,
            "itemType": "journalArticle",
            "title": "Cortisol dynamics are associated with electrocardiographic abnormalities following the aneurysmal subarachnoid hemorrhage",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Julius",
                    "lastName": "July"
                },
                {
                    "creatorType": "author",
                    "firstName": "Suryani",
                    "lastName": "As'ad"
                },
                {
                    "creatorType": "author",
                    "firstName": "F. X. Budhianto",
                    "lastName": "Suhadi"
                },
                {
                    "creatorType": "author",
                    "firstName": "Andi A.",
                    "lastName": "Islam"
                }
            ],
            "abstractNote": "CONTEXT: Electrocardiographic (ECG) abnormalities are common following subarachnoid hemorrhage (SAH). It probably represents cardiovascular stress after SAH.\nAIMS: The purpose of this study was to assess cortisol dynamics in relation to the ECG abnormality and disease course of SAH.\nSETTINGS AND DESIGN: The study follows a consecutive cohort of aneurysmal SAH patients, who underwent surgery within 72 hours of onset, and they were followed up for 10 days.\nMATERIALS AND METHODS: Serum cortisols, cortisol-binding globulin (CGB), adenocorticotropic hormone were measured (between 08.00-09.00 hours) preoperatively and then on postoperative days (PODs) 2, 4, 7, and 10. Electrocardiographs (ECG) were recorded on initial assessment and after surgery on daily basis in ICU. ECG abnormalities will be followed up by measurement of cardiac troponin T to quantify the myocyte necrosis.\nSTATISTICAL ANALYSIS USED: Logistic regression analysis using commercial available software STATA 9.\nRESULTS: A total of 44 patients (20 M and 24 F) were eligible for the cohort analysis. Average patient age is 52.02 years (52.02 ± 11.23), and 86% (6/44) arrived with World Federation of Neurosurgical Society Scale grade 3 or better. The ECG abnormality was found in 10 cases (22.7%), but the abnormal TnT (>1 μg/l) were found in eight cases, and two cases contribute to the mortality. The ECG abnormalities are significantly associated with total cortisol on day 4 (P < 0.05) and free cortisol on day 2 (P = 0.0065).\nCONCLUSIONS: Elevated levels of morning cortisol within the first four days after surgery are associated with the ECG abnormality.",
            "publicationTitle": "Journal of Cardiovascular Disease Research",
            "publisher": "",
            "place": "",
            "date": "Oct 2012",
            "volume": "3",
            "issue": "4",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "315-318",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "J Cardiovasc Dis Res",
            "DOI": "10.4103/0975-3583.102717",
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            "PMID": "",
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