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Se utilizaron cuatro grupos de ratas (n=10), se implantó una cánula guía en el PVN y se realizó una adrenalectomía (ADX) en tres grupos, en un cuarto grupo se practicó una falsa cirugía (grupo Sham). Los sujetos experimentales (ratas) fueron asignados a uno de cuatro tratamientos: al grupo Sham se le administró solución salina, al grupo ADX se le aplicó solución salina, al grupo 8-OH-DPAT se le su- ministró 8-OH-DPAT (agonista 5-HT1A) y el grupo pretratado recibió el antagonista 5-HT1A WAY100635 + 8-OHDPAT. Los resultados mostraron una disminución significativa en la ingesta de carbohidratos y grasa en el grupo 8-OH-DPAT y el grupo pretratado. El efecto hipofágico no fue dependiente de la interacción con los receptores 5-HT1A. Adicionalmente el análisis conductual sugirió que el efecto hipofágico se debió al desarrollo temprano del proceso de satisfacción y a la prolongación del estado de saciedad., Resumen Adrenalectomía y receptor 5-HT1A: un análisis microestructural de la conducta alimentaria The objective of this research was to evaluate the effect of 5HT1A receptor stimulation of the hypothalamic paraventricular nucleus (PVN) on food intake and microstructural analysis in adrenalectomized rats. Four groups of rats (n = 10) were used, guide cannula was implanted into the PVN and adrenalectomy (ADX) was performed into three groups, a fourth group underwent a sham surgery (Sham group). The experimen- tal subjects (rats) were assigned to one of four treatments: to Sham group saline was given, to group ADX saline was applied, the group 8-OH-DPAT was provided with 8-OH-DPAT (5-HT1A agonist) and the pretreated group received 5-HT1A antagonist WAY100635 + 8-OHDPAT. The results showed a significant decrease in the intake of carbohydrates and fat in the 8-OH-DPAT and pretreated groups. The hypophagic effect was not dependent on the interaction with 5-HT1A receptors. 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