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}, "links": { "self": { "href": "https://api.zotero.org/groups/274495/items/RW2QJGV3", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/mycotoxins/items/RW2QJGV3", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1645585, "username": "rjnelson7", "name": "Rebecca Nelson", "links": { "alternate": { "href": "https://www.zotero.org/rjnelson7", "type": "text/html" } } }, "creatorSummary": "Sorenson et al.", "parsedDate": "1967", "numChildren": 1 }, "data": { "key": "RW2QJGV3", "version": 36, "itemType": "journalArticle", "title": "Effect of temperature on production of aflatoxin on rice by Aspergillus flavus", "creators": [ { "creatorType": "author", "firstName": "W. 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These toxins are human liver carcinogens, especially in combination with chronic infection with hepatitis B virus. However, in an agricultural setting, the effects on growth, immune status, and susceptibility to infectious disease in farm animals are also well recognized. These latter effects have been far less explored in human populations. OBJECTIVES: To review some of the more recent work on aflatoxins where the health outcomes seen in the agricultural setting, including growth impairment and immune suppression, have been investigated in human populations. The paper draws largely on examples from West Africa. The paper also sets out how knowledge gained about aflatoxins in the agricultural setting can be used to design intervention studies in human populations. METHODS: A review of the relevant literature. RESULTS: Human exposure to aflatoxins begins early in life, and recent studies in West Africa have demonstrated an association between exposure and growth faltering, particularly stunting, in young children. At present the underlying mechanisms for the latter effects are unknown but may include impairment of immunity and increased susceptibility to infections. Simple postharvest intervention strategies were successful in reducing aflatoxin exposure in a subsistence farm setting, providing a rationale for prevention of aflatoxin-related disease. CONCLUSIONS: There are potential benefits to public health from intervention strategies combining expertise in the agricultural and health settings to address the aflatoxin problem.", "publicationTitle": "Food and nutrition bulletin", "publisher": "", "place": "", "date": "June 2007", "volume": "28", "issue": "2 Suppl", "section": "", "partNumber": "", "partTitle": "", "pages": "S372–80", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/17658084", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0379-5721", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "PMID: 17658084", "tags": [ { "tag": "Aflatoxins" }, { "tag": "Aflatoxins: administration & dosage" }, { "tag": "Aflatoxins: adverse effects" }, { "tag": "Africa" }, { "tag": "Age Factors" }, { "tag": "Body Height" }, { "tag": "Body Height: drug effects" }, { "tag": "Carcinogens" }, { "tag": "Carcinogens: analysis" }, { "tag": "Child" }, { "tag": "Child Nutritional Physiological Phenomena" }, { "tag": "Developing Countries" }, { "tag": "Female" }, { "tag": "Food Contamination" }, { "tag": "Food Contamination: analysis" }, { "tag": "Food Contamination: prevention & control" }, { "tag": "Growth: drug effects" }, { "tag": "Humans" }, { "tag": "Infant" }, { "tag": "Male" }, { "tag": "Preschool" }, { "tag": "Public Health" }, { "tag": "Western" }, { "tag": "agriculture" }, { "tag": "growth" } ], "collections": [ "34N5P7FK", "M5UA46TP", "TFPXCU5D" ], "relations": { "dc:replaces": [ "http://zotero.org/groups/274495/items/6M9SK7PJ", "http://zotero.org/groups/274495/items/BC82P8VH", "http://zotero.org/groups/274495/items/TC6A8NEP" ] }, "dateAdded": "2014-07-17T16:25:36Z", "dateModified": "2014-11-20T22:28:08Z" } }, { "key": "EB4C83FR", "version": 31, "library": { "type": "group", "id": 274495, "name": "Mycotoxins", "links": { "alternate": { "href": "https://www.zotero.org/groups/mycotoxins", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/274495/items/EB4C83FR", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/mycotoxins/items/EB4C83FR", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/274495/items/8UHJ98JP", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1645585, "username": "rjnelson7", "name": "Rebecca Nelson", "links": { "alternate": { "href": "https://www.zotero.org/rjnelson7", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "EB4C83FR", "version": 31, "parentItem": "8UHJ98JP", "itemType": "attachment", "linkMode": "imported_file", "title": "Hell and Mutegi - 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2005 - Aflatoxin Contamination of Commercial Maize Produc.pdf", "accessDate": "", "url": "", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Lewis et al. - 2005 - Aflatoxin Contamination of Commercial Maize Produc.pdf", "md5": "3e573cd824c570ed3f947a31b07c5aa6", "mtime": 1405689270891, "tags": [], "relations": {}, "dateAdded": "2014-07-18T14:24:17Z", "dateModified": "2014-11-20T22:28:06Z" } }, { "key": "PAANIDT7", "version": 31, "library": { "type": "group", "id": 274495, "name": "Mycotoxins", "links": { "alternate": { "href": "https://www.zotero.org/groups/mycotoxins", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/274495/items/PAANIDT7", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/mycotoxins/items/PAANIDT7", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1645585, "username": "rjnelson7", "name": "Rebecca Nelson", "links": { "alternate": { "href": "https://www.zotero.org/rjnelson7", "type": "text/html" } } }, "creatorSummary": "Lewis et al.", "parsedDate": "2005-08", "numChildren": 2 }, "data": { "key": "PAANIDT7", "version": 31, "itemType": "journalArticle", "title": "Aflatoxin Contamination of Commercial Maize Products during an Outbreak of Acute Aflatoxicosis in Eastern and Central Kenya", "creators": [ { "creatorType": "author", "firstName": "Lauren", "lastName": "Lewis" }, { "creatorType": "author", "firstName": "Mary", "lastName": "Onsongo" }, { "creatorType": "author", "firstName": "Henry", "lastName": "Njapau" }, { "creatorType": "author", "firstName": "Helen", "lastName": "Schurz-Rogers" }, { "creatorType": "author", "firstName": "George", "lastName": "Luber" }, { "creatorType": "author", "firstName": "Stephanie", "lastName": "Kieszak" }, { "creatorType": "author", "firstName": "Jack", "lastName": "Nyamongo" }, { "creatorType": "author", "firstName": "Lorraine", "lastName": "Backer" }, { "creatorType": "author", "firstName": "Abdikher Mohamud", "lastName": "Dahiye" }, { "creatorType": "author", "firstName": "Ambrose", "lastName": "Misore" }, { "creatorType": "author", "firstName": "Kevin", "lastName": "DeCock" }, { "creatorType": "author", "firstName": "Carol", "lastName": "Rubin" } ], "abstractNote": "", "publicationTitle": "Environmental Health Perspectives", "publisher": "", "place": "", "date": "August 2005", "volume": "113", "issue": "12", "section": "", "partNumber": "", "partTitle": "", "pages": "1763–1767", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1289/ehp.7998", "citationKey": "", "url": "http://www.ehponline.org/ambra-doi-resolver/10.1289/ehp.7998", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0091-6765", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "M5UA46TP", "TFPXCU5D" ], "relations": { "dc:replaces": [ "http://zotero.org/groups/274495/items/HSUA3TNM", "http://zotero.org/groups/274495/items/7ZMPH6BB" ] }, "dateAdded": "2014-07-17T16:25:36Z", "dateModified": "2014-11-20T22:28:06Z" } }, { "key": "JPU4XUC4", "version": 31, "library": { "type": "group", "id": 274495, "name": "Mycotoxins", "links": { "alternate": { "href": "https://www.zotero.org/groups/mycotoxins", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/274495/items/JPU4XUC4", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/mycotoxins/items/JPU4XUC4", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/274495/items/KXB4GSHS", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1645585, "username": "rjnelson7", "name": "Rebecca Nelson", "links": { "alternate": { "href": "https://www.zotero.org/rjnelson7", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "JPU4XUC4", "version": 31, "parentItem": "KXB4GSHS", "itemType": "attachment", "linkMode": "imported_file", "title": "Jiang et al. - 2005 - Aflatoxin B1 albumin adduct levels and cellular im.pdf", "accessDate": "", "url": "", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Jiang et al. - 2005 - Aflatoxin B1 albumin adduct levels and cellular im.pdf", "md5": "0ce0671925657d634dc4c4963af3a981", "mtime": 1405689268517, "tags": [], "relations": {}, "dateAdded": "2014-07-18T14:24:17Z", "dateModified": "2014-11-20T22:28:05Z" } }, { "key": "KXB4GSHS", "version": 31, "library": { "type": "group", "id": 274495, "name": "Mycotoxins", "links": { "alternate": { "href": "https://www.zotero.org/groups/mycotoxins", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/274495/items/KXB4GSHS", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/mycotoxins/items/KXB4GSHS", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1645585, "username": "rjnelson7", "name": "Rebecca Nelson", "links": { "alternate": { "href": "https://www.zotero.org/rjnelson7", "type": "text/html" } } }, "creatorSummary": "Jiang et al.", "parsedDate": "2005-06", "numChildren": 2 }, "data": { "key": "KXB4GSHS", "version": 31, "itemType": "journalArticle", "title": "Aflatoxin B1 albumin adduct levels and cellular immune status in Ghanaians.", "creators": [ { "creatorType": "author", "firstName": "Yi", "lastName": "Jiang" }, { "creatorType": "author", "firstName": "Pauline E", "lastName": "Jolly" }, { "creatorType": "author", "firstName": "William O", "lastName": "Ellis" }, { "creatorType": "author", "firstName": "Jia-Sheng", "lastName": "Wang" }, { "creatorType": "author", "firstName": "Timothy D", "lastName": "Phillips" }, { "creatorType": "author", "firstName": "Jonathan H", "lastName": "Williams" } ], "abstractNote": "Although aflatoxins (AFs) have been shown to be immune-suppressive agents in animals, the potential role of AFs in modifying the distribution and function of leukocyte subsets in humans has never been assessed. We examined the cellular immune status of 64 Ghanaians in relation to levels of aflatoxin B1 (AFB1)-albumin adducts in plasma. The percentages of leukocyte immunophenotypes in peripheral blood, CD4+ T cell proliferative response, CD4+ T(h) and CD8+ T cell cytokine profiles and monocyte phagocytic activity were measured using flow cytometry. NK cell cytotoxic function was determined by perforin and tumor necrosis factor-alpha expression in CD3-CD56+ NK cells. AFB1-albumin adducts levels ranged from 0.3325 to 2.2703 (mean = 0.9972 +/- 0.40, median = 0.9068) pmol mg(-1) albumin. Study participants with high AFB1 levels had significantly lower percentages of CD3+ and CD19+ cells that showed the CD69+ activation marker (CD3+CD69+ and CD19+CD69+) than participants with low AFB1 levels (P = 0.002 for both). Also, the percentages of CD8+ T cells that contained perforin or both perforin and granzyme A were significantly lower in participants with high AFB1 levels compared with those with low AFB1 (P = 0.012 for both). Low levels of CD3+CD69+ (r = -0.32, P = 0.016) and CD19+CD69+ (r = -0.334, P = 0.010) cells were significantly associated with high AFB1 levels using correlation analysis. By multivariate analysis, there were strong negative correlations between the percentages of these cells (CD3+CD69+: b = -0.574, P = 0.001, and CD19+CD69+: b = -0.330, P = 0.032) and AFB1 levels. These alterations in immunological parameters in participants with high AFB1 levels could result in impairments in cellular immunity that could decrease host resistance to infections.", "publicationTitle": "International immunology", "publisher": "", "place": "", "date": "June 2005", "volume": "17", "issue": "6", "section": "", "partNumber": "", "partTitle": "", "pages": "807–14", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1093/intimm/dxh262", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/15944194", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0953-8178", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "PMID: 15944194", "tags": [ { "tag": "Adult" }, { "tag": "Aflatoxin B1" }, { "tag": "Aflatoxin B1: blood" }, { "tag": "Aflatoxin B1: immunology" }, { "tag": "Aged" }, { "tag": "Antigens" }, { "tag": "CD" }, { "tag": "CD: analysis" }, { "tag": "CD: immunology" }, { "tag": "Cytokines" }, { "tag": "Cytokines: biosynthesis" }, { "tag": "Cytokines: immunology" }, { "tag": "Female" }, { "tag": "Ghana" }, { "tag": "Humans" }, { "tag": "Immunophenotyping" }, { "tag": "Killer Cells" }, { "tag": "Lymphocyte Activation" }, { "tag": "Lymphocyte Subsets" }, { "tag": "Lymphocyte Subsets: immunology" }, { "tag": "Male" }, { "tag": "Middle Aged" }, { "tag": "Natural" }, { "tag": "Natural: immunology" } ], "collections": [ "M5UA46TP", "TFPXCU5D" ], "relations": { "dc:replaces": [ "http://zotero.org/groups/274495/items/RUZXSW8Z", "http://zotero.org/groups/274495/items/NQ9MAKC2" ] }, "dateAdded": "2014-07-17T16:25:36Z", "dateModified": "2014-11-20T22:28:05Z" } }, { "key": "8KISE77U", "version": 31, "library": { "type": "group", "id": 274495, "name": "Mycotoxins", "links": { "alternate": { "href": "https://www.zotero.org/groups/mycotoxins", "type": "text/html" } } }, "links": { "self": { "href": 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"type": "text/html" } } }, "creatorSummary": "Abbas et al.", "parsedDate": "2002", "numChildren": 3 }, "data": { "key": "5IZWBWNU", "version": 31, "itemType": "journalArticle", "title": "Aflatoxin and Fumonisin Contamination of Commercial Corn ( Zea mays ) Hybrids in Mississippi", "creators": [ { "creatorType": "author", "firstName": "Hamed K", "lastName": "Abbas" }, { "creatorType": "author", "firstName": "W Paul", "lastName": "Williams" }, { "creatorType": "author", "firstName": "Gary L", "lastName": "Windham" }, { "creatorType": "author", "firstName": "Horace C", "lastName": "Pringle" }, { "creatorType": "author", "firstName": "Weiping", "lastName": "Xie" }, { "creatorType": "author", "firstName": "W Thomas", "lastName": "Shier" } ], "abstractNote": "", "publicationTitle": "Journal of Agricultural Food Chemistry", "publisher": "", "place": "", "date": "2002", "volume": "50", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "5246–5254", "series": "", 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