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            "creators": [
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                    "firstName": "Juhan",
                    "lastName": "Lee"
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            "abstractNote": "BACKGROUND: Advice to quit smoking and cessation patterns vary by race/ethnicity in the United States. This study aims to provide the up-to-date prevalence of quit advice, quit attempts and use of smoking cessation methods (particularly e-cigarettes) by race/ethnicity among US adult smokers.\nMETHODS: We used data from Wave 4 (2016-2018) of the Population Assessment of Tobacco and Health (PATH) Study. Using past-12-month and current adult cigarette smokers (n = 9,272), we conducted multivariable models to examine the association between race/ethnicity and advice to quit and quit attempts. Further, using a subset of those who made quit attempts (n = 5,046), we examined the use of smoking cessation methods, including e-cigarettes, by race/ethnicity, controlling for associated factors.\nRESULTS: Compared to Non-Hispanic [NH] White smokers, Hispanic smokers were less likely to receive quit advice (aPR [95 % CI] = 0.88 [0.78, 1.00]), but more likely to make quit attempts (1.14 [1.06, 1.23]). NH Black smokers (vs. NH Whites) were more likely to receive quit advice (1.06 [1.00, 1.12]) and more likely to make quit attempts (1.22 [1.15, 1.29]). NH Black smokers (vs. NH Whites) were more likely to use behavioral treatment (e.g., counseling) (1.84 [1.22, 2.77]). Hispanic smokers were less likely to use e-cigarettes to quit smoking than Whites (0.48 [0.33, 0.71]) and use pharmacotherapy (0.62 [0.44, 0.88]).\nCONCLUSIONS: We found different patterns in cessation attempts and cessation methods by race/ethnicity among US adult smokers. Efforts to eliminate disparities must increase access and use of proven cessation therapies for these groups.",
            "publicationTitle": "Addictive Behaviors",
            "publisher": "",
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            "title": "Esomeprazole versus other proton pump inhibitors in erosive esophagitis: a meta-analysis of randomized clinical trials",
            "creators": [
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                    "creatorType": "author",
                    "firstName": "Ian M.",
                    "lastName": "Gralnek"
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                {
                    "creatorType": "author",
                    "firstName": "Gareth S.",
                    "lastName": "Dulai"
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                {
                    "creatorType": "author",
                    "firstName": "M. Brian",
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                },
                {
                    "creatorType": "author",
                    "firstName": "Brennan M. R.",
                    "lastName": "Spiegel"
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            ],
            "abstractNote": "BACKGROUND & AIMS: There are limited data comparing the effectiveness of available proton pump inhibitors (PPIs) in erosive esophagitis (EE). We performed a meta-analysis to calculate the pooled effect of esomeprazole on healing rates, symptom relief, and adverse events versus competing PPIs in EE.\nMETHODS: We performed a structured electronic search of MEDLINE and EMBASE and reviewed published abstracts to identify English-language, randomized clinical trials from 1995-2005, comparing rates of endoscopic healing, symptom relief, and adverse events with esomeprazole versus alternative PPIs in the treatment of gastroesophageal reflux disease (GERD)/EE. We then performed meta-analysis to compare the relative risk (RR) of EE healing, symptom relief, and adverse events between study arms and calculated the absolute risk reduction and number needed to treat (NNT) for each outcome.\nRESULTS: Meta-analysis was performed on 10 studies (n=15,316). At 8 weeks, there was a 5% (RR, 1.05; 95% confidence interval, 1.02-1.08) relative increase in the probability of healing of EE with esomeprazole, yielding an absolute risk reduction of 4% and NNT of 25. The calculated NNTs by Los Angeles grade of EE (grades A-D) were 50, 33, 14, and 8, respectively. Last, esomeprazole conferred an 8% (RR, 1.08; 95% confidence interval, 1.05-1.11) relative increase in the probability of GERD symptom relief at 4 weeks.\nCONCLUSIONS: As compared with other PPIs, esomeprazole confers a statistically significant improvement, yet, clinically, only a modest overall benefit in 8-week healing and symptom relief in all-comers with EE. The clinical benefit of esomeprazole appears negligible in less severe erosive disease but might be important in more severe disease.",
            "publicationTitle": "Clinical Gastroenterology and Hepatology: The Official Clinical Practice Journal of the American Gastroenterological Association",
            "publisher": "",
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            "date": "Dec 2006",
            "volume": "4",
            "issue": "12",
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            "pages": "1452-1458",
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            "DOI": "10.1016/j.cgh.2006.09.013",
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            "accessDate": "",
            "PMID": "",
            "PMCID": "",
            "ISSN": "1542-3565",
            "archive": "",
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            "language": "eng",
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            "extra": "PMID: 17162239",
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            "itemType": "journalArticle",
            "title": "Limited value of alarm features in the diagnosis of upper gastrointestinal malignancy: systematic review and meta-analysis",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Nimish",
                    "lastName": "Vakil"
                },
                {
                    "creatorType": "author",
                    "firstName": "Paul",
                    "lastName": "Moayyedi"
                },
                {
                    "creatorType": "author",
                    "firstName": "M Brian",
                    "lastName": "Fennerty"
                },
                {
                    "creatorType": "author",
                    "firstName": "Nicholas J",
                    "lastName": "Talley"
                }
            ],
            "abstractNote": "BACKGROUND & AIMS: Alarm features such as dysphagia, weight loss, or anemia raise concern of an upper gastrointestinal malignancy in patients with dyspepsia. The aim of this study was to determine the diagnostic accuracy of alarm features in predicting malignancy by performing a metaanalysis based on the published literature.\nMETHODS: English-language studies were identified by searching MEDLINE, EMBASE, Cochrane Controlled Trials Register, and CINAHL. Cohort studies that measured alarm features and compared them with the endoscopic findings were included. Studies were screened for inclusion by 2 authors who independently extracted the data. Sensitivity, specificity, and likelihood ratios were calculated by comparing the alarm feature with the endoscopic diagnosis. The summary receiver operating characteristic curve method was used to summarize test characteristics across studies. Individual alarm features were also assessed when the study report permitted.\nRESULTS: Eighty-three of 2600 studies met the initial screening criteria; 15 met inclusion criteria after detailed review. These 15 studies evaluated a total of 57,363 patients, of whom 458 (.8%) had cancer. The sensitivity of alarm symptoms varied from 0% to 83% with considerable heterogeneity between studies. The specificity also varied significantly from 40% to 98%. A clinical diagnosis made by a physician was very specific (range, 97%-98%) but not very sensitive (range, 11%-53%).\nCONCLUSIONS: Alarm features have limited predictive value for an underlying malignancy. Their use in dyspepsia management strategies needs further refinement and study.",
            "publicationTitle": "Gastroenterology",
            "publisher": "",
            "place": "",
            "date": "Aug 2006",
            "volume": "131",
            "issue": "2",
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            "partNumber": "",
            "partTitle": "",
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                    "lastName": "Jones"
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